A gene expression system offering multiple levels of regulation: The Dual Drug Control (DDC) system

BMC Biotechnology

Volumn 4, Issue , 2004, Pages

  Sudumoina, Marina ^a   Latypova, Ekaterina ^b   Favorova, Olga O ^a   Golemis, Erica A ^b   Serebriiskii, Ilya G ^b  

^a PIROGOV RUSSIAN NATIONAL RESEARCH MEDICAL UNIVERSITY   (Russian Federation)

^b FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; AP 21967; BINDING PROTEIN; COUMAMYCIN; DNA; ECDYSONE; HYBRID PROTEIN; LUCIFERASE; MACROLIDE; NOVOBIOCIN; PLASMID VECTOR; RAPAMYCIN DERIVATIVE; STREPTOGRAMIN; TETRACYCLINE; TETRACYCLINE DERIVATIVE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOMEGALOVIRUS; DISEASE MODEL; DNA BINDING; DRUG CONTROL; FEASIBILITY STUDY; GENE EXPRESSION REGULATION; GENE EXPRESSION SYSTEM; GENE THERAPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VIVO STUDY; NONHUMAN; PROTEIN DOMAIN; PROTEIN FUNCTION; REGULATORY MECHANISM; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; ANIMAL; CELL LINE; DIMERIZATION; EVALUATION; GENETIC PROCEDURES; METABOLISM; PROMOTER REGION;

ANIMALS; CELL LINE; DIMERIZATION; GENE EXPRESSION REGULATION; GENES, REPORTER; GENETIC TECHNIQUES; HUMANS; PROMOTER REGIONS, GENETIC; RECOMBINANT FUSION PROTEINS; TETRACYCLINE; TRANSCRIPTIONAL ACTIVATION;

EID: 3042559640     PISSN: 14726750     EISSN: None     Source Type: Journal    
DOI: 10.1186/1472-6750-4-9     Document Type: Article

References (24)

1. RL Brinster, HY Chen, R Warren, A Sarthy, RD Palmiter: Regulation of metallothionein - thymidine kinase fusion plasmids injected into mouse eggs. Nature 1982, 296:39-42.
2. R Brent, M Ptashne: A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor. Cell 1985, 43:729-736.
3. S Fields, O Song: A novel genetic system to detect protein-protein interaction. Nature 1989, 340:245-246.
4. DM Nettelbeck, V Jerome, R Muller: A dual specificity promoter system combining cell cycle-regulated and tissue-specific transcriptional control. Gene Ther 1999, 6:1276-81.
5. V Jerome, R Muller: Tissue-specific, cell cycle-regulated chimeric transcription factors for the targeting of gene expression to tumor cells. Hum Gene Ther 1998, 9:2653-9.
6. DM Nettelbeck, V Jerome, R Muller: A strategy for enhancing the transcriptional activity of weak cell type-specific promoters. Gene Ther 1998, 5:1656-64.
7. U Baron, H Bujard: Tet repressor-based system for regulated gene expression in eukaryotic cells: principles and advances. Meth. Enz. 2000, 327:401-421.
8. M Fussenegger, RP Morris, C Fux, M Rimann, B von Stockar, CJ Thompson, JE Bailey: Streptogramin-based gene regulation systems for mammalian cells. Nat Biotechnol 2000, 18:1203-8.
9. C Fux, M Fussenegger: Toward higher order control modalities in mammalian cells-independent adjustment of two different gene activities. Biotechnol Prog 2003, 19:109-20.
10. W Weber, RR Marty, B Keller, M Rimann, BP Kramer, M Fussenegger: Versatile macrolide-responsive mammalian expression vectors for multiregulated multigene metabolic engineering. Biotechnol Bioeng 2002, 80:691-705.
11. HF Zhao, J Boyd, N Jolicoeur, SH Shen: A coumermycin/novobiocin-regulated gene expression system. Hum Gene Ther 2003, 14:1619-29.
12. KS Christopherson, MR Mark, V Bajaj, PJ Godowski: Ecdysteroid-dependent regulation of genes in mammalian cells by a Drosophila ecdysone receptor and chimeric transactivators. Proc. Nat. Acad. Sci. USA 1992, 89:6314-6318.
13. VM Rivera, T Clackson, S Natesan, R Pollock, JF Amara, T Keenan, SR Magari, T Phillips, NL Courage, F Cerasoli, Jr., DA Holt, M Gilman: A humanized system for pharmacologic control of gene expression. Nat Med 1996, 2:1028-32.
14. JF Amara, T Clackson, VM Rivera, T Guo, T Keenan, S Natesan, R Pollock, W Yang, NL Courage, DA Holt, M Gilman: A versatile synthetic dimerizer for the regulation of protein-protein interactions. Proc Natl Acad Sci U S A 1997, 94:10618-23.
15. SB von Bodman, JK Ball, MA Faini, CM Herrera, TD Minogue, ML Urbanowski, AM Stevens: The quorum sensing negative regulators EsaR and ExpR(Ecc), homologues within the LuxR family, retain the ability to function as activators of transcription. J Bacteriol 2003, 185:7001-7.
16. S Shimizu-Sato, E Huq, JM Tepperman, PH Quail: A light-switchable gene promoter system. Nat Biotechnol 2002, 20:1041-4
17. VM Rivera, X Ye, NL Courage, J Sachar, F Cerasoli, Jr., JM Wilson, M Gilman: Longterm regulated expression of growth hormone in mice after intramuscular gene transfer. Proc Natl Acad Sci U S A 1999, 96:8657-62.
18. JL Pomerantz, PA Sharp, CO Pabo: Structure-based design of transcription factors. Science 1995, 267:93-6.
19. H Chong, A Ruchatz, T Clackson, VM Rivera, RG Vile: A system for small-molecule control of conditionally replication-competent adenoviral vectors. Mol. Ther. 2002, 5:195-203.
20. M Gossen, H Bujard: Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Nat. Acad. Sci. USA 1992, 89:5547-5551.
21. DM Nettelbeck, V Jerome, R Muller: Gene therapy: designer promoters for tumour targeting. Trends Genet 2000, 16:174-81.
22. KM McGowan, PA Coulombe: Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development. J Cell Biol 1998, 143:469-86.
23. BP Kramer, W Weber, M Fussenegger: Artificial regulatory networks and cascades for discrete multilevel transgene control in mammalian cells. Biotechnol Bioeng 2003, 83:810-20.
24. J Liu, A Escher: Improved assay sensitivity of an engineered secreted Renilla luciferase. Gene 1999, 237:153-159.