Macrolide-based transgene control in mammalian cells and mice

Nature Biotechnology

Volumn 20, Issue 9, 2002, Pages 901-907

  Weber, Wilfried ^a   Fux, Cornelia ^a   Daoud El Baba, Marie ^b   Keller, Bettina ^a   Weber, Cornelia C ^a   Kramer, Beat P ^a   Heinzen, Christoph ^c   Aubel, Dominique ^b   Bailey, James E ^a   Fussenegger, Martin ^a  

^a ETH ZURICH   (Switzerland)

^b Institut Universitaire Technologie   (France)

^c Inotech Encapsulation AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CELLS; DRUG PRODUCTS; ESCHERICHIA COLI; TISSUE; TRANSPLANTATION (SURGICAL);

TRANSGENE CONTROL;

GENES;

CLARITHROMYCIN; ERYTHROMYCIN; MACROLIDE; ROXITHROMYCIN; STREPTOGRAMIN; TETRACYCLINE; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANTIBIOTIC RESISTANCE; ARTICLE; CHIMERA; CONTROLLED STUDY; DRUG BINDING; DRUG PROTEIN BINDING; ESCHERICHIA COLI; FEMALE; GENE CONTROL; GENE EXPRESSION REGULATION; GENE THERAPY; HUMAN; HUMAN CELL; MAMMAL CELL; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REGULON; REPRESSOR GENE; TECHNOLOGY; TISSUE ENGINEERING; TRANSACTIVATION; TRANSGENE;

ALKALINE PHOSPHATASE; ANIMALS; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; CELL LINE; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ERYTHROMYCIN; ESCHERICHIA COLI; FEMALE; FIBROBLASTS; FIBROSARCOMA; GENE EXPRESSION REGULATION; HUMANS; KIDNEY; MICE; MOLECULAR SEQUENCE DATA; TRANS-ACTIVATORS; TRANSDUCTION, GENETIC; TRANSGENES; UMBILICAL VEINS;

ANIMALIA; ESCHERICHIA COLI; EUKARYOTA; MAMMALIA; PROKARYOTA;

EID: 0036714926     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt731     Document Type: Article

References (36)

1. The impact of mammalian gene regulation concepts on functional genomic research, metabolic engineering, and advanced gene therapies
2. Essential role for oncogenic Ras in tumour maintenance
3. Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin
4. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
5. Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen
6. Design of a novel mammalian screening system for the detection of bioavailable, non-cytotoxic streptogramin antibiotics
7. A humanized system for pharmacologic control of gene expression
8. Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts
9. Control of erythropoietin secretion by doxycycline or mifepristone in mice bearing polymerencapsulated engineered cells
10. A regulatory system for use in gene transfer
11. Regulation of therapeutic proteins after in vivo somatic cell gene transfer
12. A mathematical model of caspase function in apoptosis
13. Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells
14. Kip1 sense and antisense enables positive and negative growth control of Chinese hamster ovary cells
15. Exogenously regulated stem cell-mediated gene therapy for bone regeneration
16. Tetracycline-regulated factors with distinct dimerization domains allow reversible growth inhibition by p16
17. Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity
18. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
19. Transcriptional activation by tetracyclines in mammalian cells
20. Streptogramin-based gene regulation systems for mammalian cells
21. A novel temperature inducible replicon-based DNA expression system
22. Dual-regulated expression technology: A new era in adjusting heterologous gene expression in mammalian cells
23. Macrolide antibiotics in paediatric infection diseases
24. Comparison of macrolide antibiotics
25. Nucleotide sequence and characterization of erythromycin resistance determinant that encodes macrolide 2′-phosphotransferase I in Escherichia coli
26. Regulation of transcription of the mph(A) gene for macrolide 2′phosphotransferase I in Escherichia coli: Characterization of the regulatory gene mphR(A)
27. Functional dissection of VP16, the transactivator of herpes simplex virus immediate early gene expression
28. A novel cytostatic process enhances the productivity of Chinese hamster ovary cells
29. Clinical pharmacokinetics of clarithromycin
30. Autoregulated multicistronic expression vectors provide one-step cloning of regulated product gene expression in mammalian cells
31. Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of Kox1, a kruppel-type zinc finger factor
32. An update of pTRIDENT multicistronic expression vectors: pTRIDENTS containing novel streptogramin-responsive promoters
33. Pharmacokinetics and pharmacodynamics of epoietin alfa once weekly and three times weekly
34. Adenovirus 5 DNA sequences present and RNA sequences transcribed in transformed human embryo kidney cells (HEK-Ad-5 or 293)
35. SAMY a novel mammalian reporter gene derived from Bacillus stearothermophilus α-amylase
36. A collaborative study for the establishment of a biological reference preparation for erythropoietin