메뉴 건너뛰기




Volumn 9, Issue 4, 2004, Pages 587-595

Gene therapy platform for bone regeneration using an exogenously regulated, AAV-2-based gene expression system

Author keywords

Adeno associated virus; Adult mesenchymal stem cells; Bone; Bone morphogenetic protein 2; Gene regulation systems; Gene therapy; TetON

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; DOXYCYCLINE; OSTEOCALCIN; PARVOVIRUS VECTOR; TETRACYCLINE DERIVATIVE;

EID: 2342646914     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2003.12.009     Document Type: Article
Times cited : (113)

References (60)
  • 1
    • 0025114650 scopus 로고
    • The non-osteogenic mouse pluripotent cell line C3H10T1/2 is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2
    • Katagiri, T., et al. (1990). The non-osteogenic mouse pluripotent cell line C3H10T1/2 is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2. Biochem. Biophys. Res. Commun. 172: 295-299.
    • (1990) Biochem. Biophys. Res. Commun. , vol.172 , pp. 295-299
    • Katagiri, T.1
  • 2
    • 0025789151 scopus 로고
    • Stimulation of chondrogenesis in limb bud mesoderm cells by recombinant human bone morphogenetic protein 2b (BMP-2b) and modulation by transforming growth factor-β1 and β2
    • Chen, P., Carrington, J. L., Hammonds, R. G., and Reddi, A. H. (1991). Stimulation of chondrogenesis in limb bud mesoderm cells by recombinant human bone morphogenetic protein 2b (BMP-2b) and modulation by transforming growth factor-β1 and β2. Exp. Cell Res. 195: 509-515.
    • (1991) Exp. Cell Res. , vol.195 , pp. 509-515
    • Chen, P.1    Carrington, J.L.2    Hammonds, R.G.3    Reddi, A.H.4
  • 3
    • 0026603456 scopus 로고
    • Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells
    • Theis, R. S., et al. (1992). Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells. Endocrinology 130: 1318-1324.
    • (1992) Endocrinology , vol.130 , pp. 1318-1324
    • Theis, R.S.1
  • 4
    • 0027947566 scopus 로고
    • Responsiveness of clonal limb bud cell line to bone morphogenetic protein 2 reveals sequential relationship between cartilage and bone cell phenotypes
    • Rosen, V., et al. (1994). Responsiveness of clonal limb bud cell line to bone morphogenetic protein 2 reveals sequential relationship between cartilage and bone cell phenotypes. J. Bone Miner. Res. 9: 1759-1768.
    • (1994) J. Bone Miner. Res. , vol.9 , pp. 1759-1768
    • Rosen, V.1
  • 5
    • 0031044104 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2 stimulates differentiation in primary cultures of fetal rat calvarial osteoblasts
    • Chaudhari, A., Ron, E., and Rethman, M. P. (1997). Recombinant human bone morphogenetic protein-2 stimulates differentiation in primary cultures of fetal rat calvarial osteoblasts. Mol. Cell. Biochem. 167: 31-39.
    • (1997) Mol. Cell. Biochem. , vol.167 , pp. 31-39
    • Chaudhari, A.1    Ron, E.2    Rethman, M.P.3
  • 6
    • 0029317997 scopus 로고
    • Regulation of differentiation pathway of skeletal mesenchymal cells in cell lines by transforming growth factor-β superfamily
    • Yamaguchi, A. (1995). Regulation of differentiation pathway of skeletal mesenchymal cells in cell lines by transforming growth factor-β superfamily. Semin. Cell Biol. 6: 165-173.
    • (1995) Semin. Cell Biol. , vol.6 , pp. 165-173
    • Yamaguchi, A.1
  • 7
    • 0029914457 scopus 로고    scopus 로고
    • Effects of BMP-2, BMP-4, and BMP-6 on osteoblastic differentiation of bone marrow-derived stromal cell lines, ST2 and MC3T3 G2/PA6
    • Yamaguchi, A., et al. (1996). Effects of BMP-2, BMP-4, and BMP-6 on osteoblastic differentiation of bone marrow-derived stromal cell lines, ST2 and MC3T3 G2/PA6. Biochem. Biophys. Res. Commun. 220: 366-371.
    • (1996) Biochem. Biophys. Res. Commun. , vol.220 , pp. 366-371
    • Yamaguchi, A.1
  • 8
    • 0027185702 scopus 로고
    • Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells
    • Wang, E. A., Israel, D. I., Kelly, S., and Luxenberg, D. P. (1993). Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells. Growth Factors 9: 57-71.
    • (1993) Growth Factors , vol.9 , pp. 57-71
    • Wang, E.A.1    Israel, D.I.2    Kelly, S.3    Luxenberg, D.P.4
  • 9
    • 0032889842 scopus 로고    scopus 로고
    • Effects of bone morphogenetic protein-2 on human neonatal calvaria cell differentiation
    • Hay, E., Hott, M., Graulet, A. N., Lomri, A., and Marie, P. J. (1999). Effects of bone morphogenetic protein-2 on human neonatal calvaria cell differentiation. J. Cell. Biochem. 72: 81-93.
    • (1999) J. Cell. Biochem. , vol.72 , pp. 81-93
    • Hay, E.1    Hott, M.2    Graulet, A.N.3    Lomri, A.4    Marie, P.J.5
  • 10
    • 0024256133 scopus 로고
    • Novel regulation of bone formation: Molecular clones and activities
    • Wozney, J. M., et al. (1988). Novel regulation of bone formation: molecular clones and activities. Science 242: 1528-1534.
    • (1988) Science , vol.242 , pp. 1528-1534
    • Wozney, J.M.1
  • 11
    • 0025216220 scopus 로고
    • Recombinant human bone morphogenetic protein induces bone formation
    • Wang, E. A., et al. (1990). Recombinant human bone morphogenetic protein induces bone formation. Proc. Natl. Acad. Sci. USA 87: 2220-2224.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 2220-2224
    • Wang, E.A.1
  • 12
    • 0029934670 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein (rhBMP) induces heterotopic bone development in vivo and in vitro
    • Volek-Smith, H., and Urist, M. R. (1996). Recombinant human bone morphogenetic protein (rhBMP) induces heterotopic bone development in vivo and in vitro. Proc. Soc. Exp. Biol. Med. 211: 265-272.
    • (1996) Proc. Soc. Exp. Biol. Med. , vol.211 , pp. 265-272
    • Volek-Smith, H.1    Urist, M.R.2
  • 13
    • 0034993673 scopus 로고    scopus 로고
    • Exogenously regulated stem cell-mediated gene therapy for bone regeneration
    • Moutsatsos, M. I., et al. (2001). Exogenously regulated stem cell-mediated gene therapy for bone regeneration. Mol. Ther. 3: 449-461.
    • (2001) Mol. Ther. , vol.3 , pp. 449-461
    • Moutsatsos, M.I.1
  • 14
    • 0033084785 scopus 로고    scopus 로고
    • Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: A novel cell-mediated gene therapy
    • Gazit, D., et al. (1999). Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy. J. Gene Med. 1: 121-133.
    • (1999) J. Gene Med. , vol.1 , pp. 121-133
    • Gazit, D.1
  • 15
    • 0035345628 scopus 로고    scopus 로고
    • Engineered human mesenchymal stem cells: A novel platform for skeletal cell mediated gene therapy
    • Turgeman, G., et al. (2001). Engineered human mesenchymal stem cells: a novel platform for skeletal cell mediated gene therapy. J. Gene Med. 3: 240-251.
    • (2001) J. Gene Med. , vol.3 , pp. 240-251
    • Turgeman, G.1
  • 16
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen, M., and Bujard, H. (1992). Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89: 5547-5551.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 17
    • 0000609138 scopus 로고    scopus 로고
    • Adeno-associated viral vectors
    • (T. Friedmann Ed.),. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Samulski, R. J., Sally, M., and Muzyczka, N. (1999). Adeno-associated viral vectors. In The Development of Human Gene Therapy (T. Friedmann Ed.), pp. 131-172. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • (1999) The Development of Human Gene Therapy , pp. 131-172
    • Samulski, R.J.1    Sally, M.2    Muzyczka, N.3
  • 18
    • 0032788451 scopus 로고    scopus 로고
    • Reporter expression persists 1 year after adeno-associated virus-mediated gene transfer to the optic nerve
    • Guy, J., Qi, X., Muzyczka, N., and Hauswirth, W. W. (1999). Reporter expression persists 1 year after adeno-associated virus-mediated gene transfer to the optic nerve. Arch. Ophthalmol. 117: 929-937.
    • (1999) Arch. Ophthalmol. , vol.117 , pp. 929-937
    • Guy, J.1    Qi, X.2    Muzyczka, N.3    Hauswirth, W.W.4
  • 19
    • 0036606007 scopus 로고    scopus 로고
    • rAAV-mediated long-term liver-generated expression of an angiogenesis inhibitor can restrict renal tumor growth in mice
    • Davidoff, A. M., Nathwani, A. C., Spurbeck, W. W., Ng, C. Y., Zhou, J., and Vanin, E. F. (2002). rAAV-mediated long-term liver-generated expression of an angiogenesis inhibitor can restrict renal tumor growth in mice. Cancer Res. 62: 3077-3083.
    • (2002) Cancer Res. , vol.62 , pp. 3077-3083
    • Davidoff, A.M.1    Nathwani, A.C.2    Spurbeck, W.W.3    Ng, C.Y.4    Zhou, J.5    Vanin, E.F.6
  • 20
    • 0034724209 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus type 2, 4, and 5 vectors: Transduction of variant cell types and regions in the mammalian central nervous system
    • Davidson, B. L., et al. (2000). Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system. Proc. Natl. Acad. Sci. USA 97: 3428-3432.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 3428-3432
    • Davidson, B.L.1
  • 21
    • 0033544010 scopus 로고    scopus 로고
    • Progress in adeno-associated virus type 2 vector production: Promises and prospects for clinical use
    • Grimm, D., and Kleinschmidt, J. A. (1999). Progress in adeno-associated virus type 2 vector production: promises and prospects for clinical use. Hum. Gene Ther. 10: 2445-2450.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 2445-2450
    • Grimm, D.1    Kleinschmidt, J.A.2
  • 22
    • 0034030443 scopus 로고    scopus 로고
    • Nonrandom transduction of recombinant adeno-associated viral vectors in mouse hepatocytes in vivo: Cell cycling does not influence hepatocyte transduction
    • Miao, C. H., et al. (2000). Nonrandom transduction of recombinant adeno-associated viral vectors in mouse hepatocytes in vivo: cell cycling does not influence hepatocyte transduction. J. Virol. 74: 3793-3803.
    • (2000) J. Virol. , vol.74 , pp. 3793-3803
    • Miao, C.H.1
  • 23
    • 0031691257 scopus 로고    scopus 로고
    • Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue
    • Duan, D., et al. (1999). Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue. J. Virol. 73: 8568-8577.
    • (1999) J. Virol. , vol.73 , pp. 8568-8577
    • Duan, D.1
  • 24
    • 0032990410 scopus 로고    scopus 로고
    • Isolation of recombinant adeno-associated virus vector-cellular DNA junctions from mouse liver
    • Nakai, T., Iwaki, Y., Kay, M. A., and Couto, L. B. (1999). Isolation of recombinant adeno-associated virus vector-cellular DNA junctions from mouse liver. J. Virol. 73: 5438-5447.
    • (1999) J. Virol. , vol.73 , pp. 5438-5447
    • Nakai, T.1    Iwaki, Y.2    Kay, M.A.3    Couto, L.B.4
  • 25
    • 0032064006 scopus 로고    scopus 로고
    • The kinetics of rAAV integration in the liver
    • Miao, C. H., et al. (1998). The kinetics of rAAV integration in the liver. Nat. Genet. 19: 13-15.
    • (1998) Nat. Genet. , vol.19 , pp. 13-15
    • Miao, C.H.1
  • 26
    • 0037370758 scopus 로고    scopus 로고
    • Molecular imaging of the skeleton: Quantitative real time bioluminescence in transgenic mice
    • Bar, I., et al. (2003). Molecular imaging of the skeleton: quantitative real time bioluminescence in transgenic mice. J. Bone Miner. Res. 18: 570-578.
    • (2003) J. Bone Miner. Res. , vol.18 , pp. 570-578
    • Bar, I.1
  • 27
    • 0032415073 scopus 로고    scopus 로고
    • Inducible long-term gene expression in brain with adeno-associated virus gene transfer
    • Haberman, R. P., McCown, T. J., and Samulski, R. J. (1998). Inducible long-term gene expression in brain with adeno-associated virus gene transfer. Gene Ther. 5: 1604-1611.
    • (1998) Gene Ther. , vol.5 , pp. 1604-1611
    • Haberman, R.P.1    McCown, T.J.2    Samulski, R.J.3
  • 28
    • 0035666134 scopus 로고    scopus 로고
    • Insulators coupled to a minimal bidirectional tet cassette for tight regulation of rAAV-mediated gene transfer in the mammalian brain
    • Fitzsimons, H. L., Mckenzie, J. M., and During, M. J. (2001). Insulators coupled to a minimal bidirectional tet cassette for tight regulation of rAAV-mediated gene transfer in the mammalian brain. Gene Ther. 8: 1675-1681.
    • (2001) Gene Ther. , vol.8 , pp. 1675-1681
    • Fitzsimons, H.L.1    Mckenzie, J.M.2    During, M.J.3
  • 29
    • 0034984667 scopus 로고    scopus 로고
    • Recombinant AAV-mediated delivery of a tet-inducible reporter gene to the rat retina
    • McGee Sanftner, L. H., et al. (2001). Recombinant AAV-mediated delivery of a tet-inducible reporter gene to the rat retina. Mol. Ther. 3: 688-696.
    • (2001) Mol. Ther. , vol.3 , pp. 688-696
    • McGee Sanftner, L.H.1
  • 30
    • 0037262106 scopus 로고    scopus 로고
    • Tetracycline-inducible transgene expression mediated by a single AAV vector
    • Chtarto, A., et al. (2003). Tetracycline-inducible transgene expression mediated by a single AAV vector. Gene Ther. 10: 84-94.
    • (2003) Gene Ther. , vol.10 , pp. 84-94
    • Chtarto, A.1
  • 31
    • 0037310130 scopus 로고    scopus 로고
    • An in vivo doxycycline-controlled expression system for functional studies of the retina
    • Angeletti, B., et al. (2003). An in vivo doxycycline-controlled expression system for functional studies of the retina. Invest. Ophthalmol. Visual Sci. 44: 755-760.
    • (2003) Invest. Ophthalmol. Visual Sci. , vol.44 , pp. 755-760
    • Angeletti, B.1
  • 32
    • 0036428811 scopus 로고    scopus 로고
    • Regulation of gene expression in adeno-associated virus vectors in the brain
    • Haberman, R. P., and McCown, T. J. (2002). Regulation of gene expression in adeno-associated virus vectors in the brain. Methods 28: 219-226.
    • (2002) Methods , vol.28 , pp. 219-226
    • Haberman, R.P.1    McCown, T.J.2
  • 33
    • 0038365487 scopus 로고    scopus 로고
    • Regulated expression of erythropoietin from an AAV vector safely improves the anemia of β-thalassemia in a mouse model
    • Johnston, J., Tazelaar, J., Rivera, V. M., Clackson, T., Gao, G. P., and Wilson, J. M. (2003). Regulated expression of erythropoietin from an AAV vector safely improves the anemia of β-thalassemia in a mouse model. Mol. Ther. 7: 493-497.
    • (2003) Mol. Ther. , vol.7 , pp. 493-497
    • Johnston, J.1    Tazelaar, J.2    Rivera, V.M.3    Clackson, T.4    Gao, G.P.5    Wilson, J.M.6
  • 34
    • 0033766932 scopus 로고    scopus 로고
    • Glucose-responsive gene delivery in pancreatic islet cells via recombinant adeno-associated viral vectors
    • Yang, Y. W., and Kotin, R. M. (2000). Glucose-responsive gene delivery in pancreatic islet cells via recombinant adeno-associated viral vectors. Pharm. Res. 17: 1056-1061.
    • (2000) Pharm Res. , vol.17 , pp. 1056-1061
    • Yang, Y.W.1    Kotin, R.M.2
  • 35
    • 0034907233 scopus 로고    scopus 로고
    • Tissue-specific gene expression in medullary thyroid carcinoma cells employing calcitonin regulatory elements and AAV vectors
    • Jiang, S., et al. (2001). Tissue-specific gene expression in medullary thyroid carcinoma cells employing calcitonin regulatory elements and AAV vectors. Cancer Gene Ther. 8: 469-472.
    • (2001) Cancer Gene Ther. , vol.8 , pp. 469-472
    • Jiang, S.1
  • 36
    • 0034880629 scopus 로고    scopus 로고
    • A hypoxia-regulated adeno-associated virus vector for cancer-specific gene therapy
    • Ruan, H., Su, H., Hu, L., Lamborn, K. R., Kan, Y. W., and Deen, D. F. (2001). A hypoxia-regulated adeno-associated virus vector for cancer-specific gene therapy. Neoplasia 3: 255-263.
    • (2001) Neoplasia , vol.3 , pp. 255-263
    • Ruan, H.1    Su, H.2    Hu, L.3    Lamborn, K.R.4    Kan, Y.W.5    Deen, D.F.6
  • 37
    • 0034657760 scopus 로고    scopus 로고
    • Dose response to a single intramuscular injection of recombinant adeno-associated virus-erythropoietin in monkeys
    • Rudich, S. M., Zhou, S., Srivastava, R., Escobedo, J. A., Perez, R. V., and Manning, W. C. (2000). Dose response to a single intramuscular injection of recombinant adeno-associated virus-erythropoietin in monkeys. J. Surg. Res. 90: 102-108.
    • (2000) J. Surg. Res. , vol.90 , pp. 102-108
    • Rudich, S.M.1    Zhou, S.2    Srivastava, R.3    Escobedo, J.A.4    Perez, R.V.5    Manning, W.C.6
  • 38
    • 0032170592 scopus 로고    scopus 로고
    • Control of erythropoietin delivery by doxycycline in mice after intramuscular injection of adeno-associated vector
    • Bohl, D., Salvetti, A., Moullier, P., and Heard, J. M. (1998). Control of erythropoietin delivery by doxycycline in mice after intramuscular injection of adeno-associated vector. Blood 92: 1512-1517.
    • (1998) Blood , vol.92 , pp. 1512-1517
    • Bohl, D.1    Salvetti, A.2    Moullier, P.3    Heard, J.M.4
  • 39
    • 0036147230 scopus 로고    scopus 로고
    • Adeno-associated virus mediated expression of human erythropoietin in vitro
    • Diao, Y., Xu, R. A., Wang, G. J., and Zhao, X. C. (2004). Adeno-associated virus mediated expression of human erythropoietin in vitro. Acta. Pharmacol. Sin. 23: 55-58.
    • (2004) Acta. Pharmacol. Sin. , vol.23 , pp. 55-58
    • Diao, Y.1    Xu, R.A.2    Wang, G.J.3    Zhao, X.C.4
  • 40
    • 0036664935 scopus 로고    scopus 로고
    • Pharmacological regulation of protein expression from adeno-associated viral vectors in the eye
    • Auricchio, A., et al. (2002). Pharmacological regulation of protein expression from adeno-associated viral vectors in the eye. Mol. Ther. 6: 238-242.
    • (2002) Mol. Ther. , vol.6 , pp. 238-242
    • Auricchio, A.1
  • 41
    • 0034655597 scopus 로고    scopus 로고
    • Improved muscle-derived expression of human coagulation factor IX from a skeletal actin/CMV hybrid enhancer/promoter
    • Hagstrom, J. N., et al. (2000). Improved muscle-derived expression of human coagulation factor IX from a skeletal actin/CMV hybrid enhancer/promoter. Blood 95: 2536-2542.
    • (2000) Blood , vol.95 , pp. 2536-2542
    • Hagstrom, J.N.1
  • 42
    • 0037109052 scopus 로고    scopus 로고
    • Long-term systemic therapy of Fabry disease in a knockout mouse by adeno-associated virus-mediated muscle-directed gene transfer
    • Takahashi, H., et al. (2002). Long-term systemic therapy of Fabry disease in a knockout mouse by adeno-associated virus-mediated muscle-directed gene transfer. Proc. Natl. Acad. Sci. USA 99: 13777-13782.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 13777-13782
    • Takahashi, H.1
  • 43
    • 0036932835 scopus 로고    scopus 로고
    • Mechanisms leading to sustained reversion of β-thalassemia in mice by doxycycline-controlled Epo delivery from muscles
    • Samakoglu, S., Bohl, D., and Heard, J. M. (2002). Mechanisms leading to sustained reversion of β-thalassemia in mice by doxycycline-controlled Epo delivery from muscles. Mol. Ther. 6: 793-803.
    • (2002) Mol. Ther. , vol.6 , pp. 793-803
    • Samakoglu, S.1    Bohl, D.2    Heard, J.M.3
  • 44
    • 0037302975 scopus 로고    scopus 로고
    • Long-term correction of glycogen storage disease type II with a hybrid Ad-AAV vector
    • Sun, B., Chen, Y. T., Bird, A., Amalfitano, A., and Koeberl, D. D. (2003). Long-term correction of glycogen storage disease type II with a hybrid Ad-AAV vector. Mol. Ther. 7: 193-201.
    • (2003) Mol. Ther. , vol.7 , pp. 193-201
    • Sun, B.1    Chen, Y.T.2    Bird, A.3    Amalfitano, A.4    Koeberl, D.D.5
  • 45
    • 0013442744 scopus 로고    scopus 로고
    • AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B
    • Manno, C. S., et al. (2003). AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B. Blood 101: 2963-2972.
    • (2003) Blood , vol.101 , pp. 2963-2972
    • Manno, C.S.1
  • 46
    • 0035808170 scopus 로고    scopus 로고
    • In vivo bone formation by human bone marrow stromal cells: Effect of carrier particle size and shape
    • Mankani, M. H., Kuznetsov, S. A., Fowler, B., Kingman, A., and Robey, P. G. (2001). In vivo bone formation by human bone marrow stromal cells: effect of carrier particle size and shape. Biotechnol. Bioeng. 72: 96-107.
    • (2001) Biotechnol. Bioeng. , vol.72 , pp. 96-107
    • Mankani, M.H.1    Kuznetsov, S.A.2    Fowler, B.3    Kingman, A.4    Robey, P.G.5
  • 47
    • 0036019191 scopus 로고    scopus 로고
    • Tetracycline-inducible interleukin-10 gene transfer mediated by an adeno-associated virus: Application to experimental arthritis
    • Apparailly, F., Millet, V., Noel, D., Jacquet, C., Sany, J., and Jorgensen, C. (2002). Tetracycline-inducible interleukin-10 gene transfer mediated by an adeno-associated virus: application to experimental arthritis. Hum. Gene Ther. 13: 1179-1188.
    • (2002) Hum. Gene Ther. , vol.13 , pp. 1179-1188
    • Apparailly, F.1    Millet, V.2    Noel, D.3    Jacquet, C.4    Sany, J.5    Jorgensen, C.6
  • 48
    • 0032506752 scopus 로고    scopus 로고
    • Novel tools for production and purification of recombinant adenoassociated virus vectors
    • Grimm, D., Kern, A., Rittner, K., and Kleinschmidt, J. A. (1998). Novel tools for production and purification of recombinant adenoassociated virus vectors. Hum. Gene. Ther. 9: 2745-2760.
    • (1998) Hum. Gene. Ther. , vol.9 , pp. 2745-2760
    • Grimm, D.1    Kern, A.2    Rittner, K.3    Kleinschmidt, J.A.4
  • 49
    • 0032958736 scopus 로고    scopus 로고
    • Gene delivery to the myocardium by intrapericardial injection
    • Fromes, Y., et al. (1999). Gene delivery to the myocardium by intrapericardial injection. Gene Ther. 6: 683-688.
    • (1999) Gene Ther. , vol.6 , pp. 683-688
    • Fromes, Y.1
  • 50
    • 0019351935 scopus 로고
    • SV40-transformed simian cells support the replication of early SV40 mutants
    • Gluzman, Y. (1981). SV40-transformed simian cells support the replication of early SV40 mutants. Cell 23: 175-182.
    • (1981) Cell , vol.23 , pp. 175-182
    • Gluzman, Y.1
  • 51
    • 0030851006 scopus 로고    scopus 로고
    • Analysis of osteocalcin expression in transgenic mice reveals a species difference in vitamin D regulation of mouse and human osteocalcin genes
    • Clemens, T.L., et al. (1997). Analysis of osteocalcin expression in transgenic mice reveals a species difference in vitamin D regulation of mouse and human osteocalcin genes. J. Bone Miner. Res. 12: 1570-1576.
    • (1997) J. Bone Miner. Res. , vol.12 , pp. 1570-1576
    • Clemens, T.L.1
  • 52
    • 0031252491 scopus 로고    scopus 로고
    • Visualizing gene expression in living mammals using a bioluminescent reporter
    • Contag, C. H., et al. (1997). Visualizing gene expression in living mammals using a bioluminescent reporter. Photochem. Photobiol. 66: 523-531.
    • (1997) Photochem. Photobiol. , vol.66 , pp. 523-531
    • Contag, C.H.1
  • 53
    • 0034849299 scopus 로고    scopus 로고
    • Imaging transgene expression in live animals
    • Honigman, A., et al. (2001). Imaging transgene expression in live animals. Mol. Ther. 4: 239-249.
    • (2001) Mol. Ther. , vol.4 , pp. 239-249
    • Honigman, A.1
  • 54
    • 0023277545 scopus 로고
    • Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski, P., and Sacchi, N. (1987). Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156.
    • (1987) Anal. Biochem. , vol.162 , pp. 156
    • Chomczynski, P.1    Sacchi, N.2
  • 55
    • 0028301987 scopus 로고
    • Tyrosine kinase inhibitor AG18 arrests follicle-stimulating hormone-induced granulosa cell differentiation: Use of reverse transcriptase-polymerase chain reaction assay for multiple messenger ribonucleic acids
    • Orly, J., Rei, Z., Greenberg, N. M., and Richards, J. S. (1994). Tyrosine kinase inhibitor AG18 arrests follicle-stimulating hormone-induced granulosa cell differentiation: use of reverse transcriptase-polymerase chain reaction assay for multiple messenger ribonucleic acids. Endocrinology 134: 2336-2346.
    • (1994) Endocrinology , vol.134 , pp. 2336-2346
    • Orly, J.1    Rei, Z.2    Greenberg, N.M.3    Richards, J.S.4
  • 56
    • 0023428521 scopus 로고
    • Cloning and characterization of a cDNA coding for mouse placental alkaline phosphatase
    • Terao, M., and Mintz, B. (1987). Cloning and characterization of a cDNA coding for mouse placental alkaline phosphatase. Proc. Natl. Acad. Sci. USA 84: 7051-7055.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 7051-7055
    • Terao, M.1    Mintz, B.2
  • 57
    • 0030071062 scopus 로고    scopus 로고
    • A microtomographic system for the nondestructive evaluation of bone architecture
    • Rüegsegger, P., Koller, B., and Müller, R. (1996). A microtomographic system for the nondestructive evaluation of bone architecture. Calcif. Tissue Int. 58: 24-29.
    • (1996) Calcif. Tissue Int. , vol.58 , pp. 24-29
    • Rüegsegger, P.1    Koller, B.2    Müller, R.3
  • 58
    • 0030634540 scopus 로고    scopus 로고
    • Micro-tomographic imaging for the nondestructive evaluation of trabecular bone architecture
    • Müller, R., and Rüegsegger, P. (1997). Micro-tomographic imaging for the nondestructive evaluation of trabecular bone architecture. Stud. Health Technol. Inform. 40: 61-79.
    • (1997) Stud. Health Technol. Inform. , vol.40 , pp. 61-79
    • Müller, R.1    Rüegsegger, P.2
  • 59
    • 0345596449 scopus 로고    scopus 로고
    • Morphometric analysis of human bone biopsies: A quantitative structural comparison of histological sections and micro-computed tomography
    • Müller, R., Van Campenhout, H., and Van Damme, B. (1998). Morphometric analysis of human bone biopsies: a quantitative structural comparison of histological sections and micro-computed tomography. Bone 23: 59-66.
    • (1998) Bone , vol.23 , pp. 59-66
    • Müller, R.1    Van Campenhout, H.2    Van Damme, B.3
  • 60
    • 0034439069 scopus 로고    scopus 로고
    • Quantification of periapical bone destruction in mice by micro-computed tomography
    • Balto, K., Muller, R., Carrington, D. C., Dobeck, J., and Stashenko, P. (2000). Quantification of periapical bone destruction in mice by micro-computed tomography, J. Dent. Res. 79: 35-40.
    • (2000) J. Dent. Res. , vol.79 , pp. 35-40
    • Balto, K.1    Muller, R.2    Carrington, D.C.3    Dobeck, J.4    Stashenko, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.