Pharmacologically regulated regeneration of functional human pancreatic islets

Molecular Therapy

Volumn 11, Issue 1, 2005, Pages 105-111

  Kobinger, Gary P ^a,b   Deng, Shaoping ^a   Louboutin, Jean Pierre ^a,b   Vatamaniuk, Marko ^a   Rivera, Victor M ^c   Lian, Moh Moh ^a   Markmann, James F ^a   Clackson, Tim ^c   Raper, Steven E ^a   Matschinsky, Franz ^a   Wilson, James M ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b WISTAR INSTITUTE   (United States)

^c ARIAD PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 1; GLUCOSE; GREEN FLUORESCENT PROTEIN; INSULIN; LENTIVIRUS VECTOR; STREPTOZOCIN;

ADOPTIVE IMMUNOTHERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL COUNT; CELL FUNCTION; CELL PROLIFERATION; CELL REGENERATION; CONTROLLED STUDY; DIABETES MELLITUS; DIMERIZATION; DONOR; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IMMUNE DEFICIENCY; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD GLUCOSE; CELL PROLIFERATION; DIABETES MELLITUS; DIMERIZATION; HUMANS; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; ORGAN CULTURE TECHNIQUES; REGENERATION; TIME FACTORS; TRANSPLANTATION, HETEROLOGOUS;

EID: 19944403877     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.09.010     Document Type: Article

References (31)

1. A.M. Shapiro et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen N. Engl. J. Med. 343 2000 230-238
2. D.F. Emerich Islet transplantation for diabetes: Current status and future prospects Expert Opin. Biol. Ther. 2 2002 793-803
3. T. Yamaoka Regeneration therapy of pancreatic beta cells: Towards a cure for diabetes? Biochem. Biophys. Res. Commun. 296 2002 1039-1043
4. T. Neff et al. Pharmacologically regulated in vivo selection in a large animal Blood 100 2002 2026-2031
5. L. Jin et al. In vivo selection using a cell-growth switch Nat. Genet. 26 2000 64-66
6. T. Clackson et al. Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity Proc. Natl. Acad. Sci. USA 95 1998 10437-10442
7. D.M. Spencer T.J. Wandless S.L. Schreiber G.R. Crabtree Controlling signal transduction with synthetic ligands Science 262 1993 1019-1024
8. Z. Luo G. Tzivion P.J. Belshaw D. Vavvas M. Marshall J. Avruch Oligomerization activates c-Raf-1 through a Ras-dependent mechanism Nature 383 1996 181-185
9. J.W. Yoon H.S. Jun Recent advances in insulin gene therapy for type 1 diabetes Trends Mol. Med. 8 2002 62-68
10. Q. Ju et al. Transduction of non-dividing adult human pancreatic beta cells by an integrating lentiviral vector Diabetologia 41 1998 736-739
11. M.A. Curran et al. Efficient transduction of pancreatic islets by feline immunodeficiency virus vectors, 1 Transplantation 74 2002 299-306
12. W.S. Gallichan T. Kafri T. Krahl I.M. Verma N. Sarvetnick Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis Hum. Gene Ther. 9 1998 2717-2726
13. G.P. Kobinger et al. Transduction of human islets with pseudotyped lentiviral vectors Hum. Gene Ther. 15 2003 211-219
14. M.A. Simon Receptor tyrosine kinases: Specific outcomes from general signals Cell 103 2000 13-15
15. J.H. Nielsen et al. Regulation of beta-cell mass by hormones and growth factors Diabetes 50 Suppl. 1 2001 S25-S29
16. E.S. Fenjves et al. Human, nonhuman primate, and rat pancreatic islets express erythropoietin receptors Transplantation 75 2003 1356-1360
17. A.W. Hart N. Baeza A. Apelqvist H. Edlund Attenuation of FGF signalling in mouse beta-cells leads to diabetes Nature 408 2000 864-868
18. C.A. Blau K.R. Peterson J.G. Drachman D.M. Spencer A proliferation switch for genetically modified cells Proc. Natl. Acad. Sci. USA 94 1997 3076-3081
19. L.A. Megeney R.L. Perry J.E. LeCouter M.A. Rudnicki BFGF and LIF signaling activates STAT3 in proliferating myoblasts Dev. Genet. 19 1996 139-145
20. L.M. Reid D.M. Jefferson Culturing hepatocytes and other differentiated cells Hepatology 4 1984 548-559
21. I.R. Sweet et al. Dynamic perifusion to maintain and assess isolated pancreatic islets Diabetes Technol. Ther. 4 2002 67-76
22. J. Grotzinger Molecular mechanisms of cytokine receptor activation Biochim. Biophys. Acta 1592 2002 215-223
23. I.A. Wilson L.K. Jolliffe The structure, organization, activation and plasticity of the erythropoietin receptor Curr. Opin. Struct. Biol. 9 1999 696-704
24. J.F. Markmann et al. Insulin independence following isolated islet transplantation and single islet infusions Ann. Surg. 237 2003 741-749
25. D.J. Watson G.P. Kobinger M.A. Passini J.M. Wilson J.H. Wolfe Targeted transduction patterns in the mouse brain by lentivirus vectors pseudotyped with VSV, Ebola, Mokola, LCMV, or MuLV envelope proteins Mol. Ther. 5 2002 528-537
26. A. Auricchio et al. Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: The retina as a model Hum. Mol. Genet. 10 2001 3075-3081
27. D.C. Thomis et al. A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease Blood 97 2001 1249-1257
28. W.R. Beyer M. Westphal W. Ostertag D. von Laer Oncoretrovirus and lentivirus vectors pseudotyped with lymphocytic choriomeningitis virus glycoprotein: Generation, concentration, and broad host range J. Virol. 76 2002 1488-1495
29. G.P. Kobinger D.J. Weiner Q.C. Yu J.M. Wilson Filovirus-pseudotyped lentiviral vector can efficiently and stably transduce airway epithelia in vivo Nat. Biotechnol. 1 2001 225-230
30. S. Deng et al. Insulin gene transfer enhances the function of human islet grafts Diabetologia 46 2003 386-393
31. Y. Liang H. Najafi F.M. Matschinsky Glucose regulates glucokinase activity in cultured islets from rat pancreas J. Biol. Chem. 265 1990 16863-16866