Autoregulated, bidirectional and multicistronic gas-inducible mammalian as well as lentiviral expression vectors

Journal of Biotechnology

Volumn 120, Issue 1, 2005, Pages 83-98

  Hartenbach, Shizuka ^a   Fussenegger, Martin ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Acetaldehyde; Autoregulated expression; bi directional expression; Gene regulation; lentiviral expression

Indexed keywords

ALDEHYDES; CELLS; DRUG PRODUCTS; GENES; PROTEINS; STOICHIOMETRY;

ACETALDEHYDES; AUTOREGULATED EXPRESSION; BI-DIRECTIONAL EXPRESSION; GENE REGULATION; LENTIVIRAL EXPRESSION;

VIRUSES;

ACETALDEHYDE; ALCOHOL; ALKALINE PHOSPHATASE; AMYLASE; CHLORAMPHENICOL ACETYLTRANSFERASE; LENTIVIRUS VECTOR; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN 121; VIRUS VECTOR;

ANIMAL CELL; ASPERGILLUS NIDULANS; AUTOREGULATION; CELL LINE; CONFERENCE PAPER; ENZYME RELEASE; ESCHERICHIA COLI; EXPRESSION VECTOR; GAS; GENE CONTROL; GENE EXPRESSION; GENE THERAPY; GENETIC ENGINEERING; GENETIC TRANSCRIPTION; GEOBACILLUS STEAROTHERMOPHILUS; HUMAN; HUMAN CELL; MAMMAL CELL; NONHUMAN; PLACENTA; PRIORITY JOURNAL; PROMOTER REGION; RNA TRANSLATION; STOICHIOMETRY; TISSUE ENGINEERING; TRANSACTIVATION; TRANSGENE; VALIDATION PROCESS; VIRUS EXPRESSION;

ACETALDEHYDE; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; FEEDBACK; GASES; GENE EXPRESSION REGULATION, VIRAL; GENETIC VECTORS; HELA CELLS; HUMANS; LENTIVIRUS; MAMMALS; RECOMBINANT PROTEINS; TRANSFECTION;

CRICETINAE; CRICETULUS GRISEUS; EMERICELLA NIDULANS; ESCHERICHIA COLI; GEOBACILLUS STEAROTHERMOPHILUS; MAMMALIA;

EID: 25644458511     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2005.03.025     Document Type: Conference Paper

References (40)

1. D. Aubel, R. Morris, B. Lennon, M. Rimann, H. Kaufmann, M. Folcher, J.E. Bailey, C.J. Thompson, and M. Fussenegger Design of a novel mammalian screening system for the detection of bioavailable, non-cytotoxic streptogramin antibiotics J. Antibiot. (Tokyo) 54 2001 44 55
2. C. Beck, H. Uramoto, J. Boren, and L.M. Akyurek Tissue-specific targeting for cardiovascular gene transfer. Potential vectors and future challenges Curr. Gene Ther. 4 2004 457 467
3. R.R. Beerli, U. Schopfer, B. Dreier, and C.F. Barbas Chemically regulated zinc finger transcription factors J. Biol. Chem. 275 2000 32617 32627
4. M. Belfort, and R.J. Roberts Homing endonucleases: keeping the house in order Nucleic Acids Res. 25 1997 3379 3388
5. J. Berger, J. Hauber, R. Hauber, R. Geiger, and B.R. Cullen Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells Gene 66 1988 1 10
6. M. Boorsma, L. Nieba, D. Koller, M.F. Bachmann, J.E. Bailey, and W.A. Renner A temperature-regulated replicon-based DNA expression system Nat. Biotechnol. 18 2000 429 432
7. S. Braselmann, P. Graninger, and M. Busslinger A selective transcriptional induction system for mammalian cells based on Gal4-estrogen receptor fusion proteins Proc. Natl. Acad. Sci. USA 90 1993 1657 1661
8. S.Q. Cohlan Tetracycline staining of teeth Teratology 15 1997 127 129
9. S. Fillinger, C. Panozzo, M. Mathieu, and B. Felenbok The basal level of transcription of the alc genes in the ethanol regulon in Aspergillus nidulans is controlled both by the specific transactivator AlcR and the general carbon catabolite repressor CreA FEBS Lett. 368 1995 547 550
10. M. Flipphi, J. Kocialkowska, and B. Felenbok Characteristics of physiological inducers of the ethanol utilization (alc) pathway in Aspergillus nidulans Biochem. J. 364 2002 25 31
11. M. Fussenegger, R.P. Morris, C. Fux, M. Rimann, B. von Stockar, C.J. Thompson, and J.E. Bailey Streptogramin-based gene regulation systems for mammalian cells Nat. Biotechnol. 18 2000 1203 1208
12. M. Fussenegger, S. Moser, X. Mazur, and J.E. Bailey Autoregulated multicistronic expression vectors provide one-step cloning of regulated product gene expression in mammalian cells Biotechnol. Prog. 13 1997 733 740
13. M. Fussenegger, S. Schlatter, D. Datwyler, X. Mazur, and J.E. Bailey Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells Nat. Biotechnol. 16 1998 468 472
14. C. Fux, and M. Fussenegger Bidirectional expression units enable streptogramin-adjustable gene expression in mammalian cells Biotechnol. Bioeng. 83 2003 618 625
15. C. Fux, D. Langer, J.M. Kelm, W. Weber, and M. Fussenegger New-generation multicistronic expression platform: pTRIDENT vectors containing size-optimized IRES elements enable homing endonuclease-based cistron swapping into lentiviral expression vectors Biotechnol. Bioeng. 86 2004 174 187
16. V. Gonzalez-Nicolini, C. Fux, and M. Fussenegger A novel mammalian cell-based approach for the discovery of anticancer drugs with reduced cytotoxicity on non-dividing cells Invest. New Drugs 22 2004 253 262
17. M. Gossen, and H. Bujard Tight control of gene expression in mammalian cells by tetracycline-responsive promoters Proc. Natl. Acad. Sci. USA 89 1992 5547 5551
18. M. Gossen, S. Freundlieb, G. Bender, G. Muller, W. Hillen, and H. Bujard Transcriptional activation by tetracyclines in mammalian cells Science 268 1995 1766 1769
19. M. Hennecke, M. Kwissa, K. Metzger, A. Oumard, A. Kroger, R. Schirmbeck, J. Reimann, and H. Hauser Composition and arrangement of genes define the strength of IRES-driven translation in bicistronic mRNAs Nucleic Acids Res. 29 2001 3327 3334
20. B.H. Junker, C. Chu, U. Sonnewald, L. Willmitzer, and A.R. Fernie In plants the alc gene expression system responds more rapidly following induction with acetaldehyde than with ethanol FEBS Lett. 535 2003 136 140
21. J. Lautermann, N. Dehne, J. Schacht, and K. Jahnke Aminoglycoside- and cisplatin-ototoxicity: from basic science to clinics Laryngorhinootologie 83 2004 317 323
22. J.H. Lin, and A.Y. Lu Inhibition and induction of cytochrome P450 and the clinical implications Clin. Pharmacokinet. 35 1998 361 390
23. G. Malleret, U. Haditsch, D. Genoux, M.W. Jones, T.V. Bliss, A.M. Vanhoose, C. Weitlauf, E.R. Kandel, D.G. Winder, and I.M. Mansuy Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin Cell 104 2001 675 686
24. H. Meents, B. Enenkel, H.M. Eppenberger, R.G. Werner, and M. Fussenegger Impact of coexpression and coamplification of sICAM and antiapoptosis determinants bcl-2/bcl-x(L) on productivity, cell survival, and mitochondria number in CHO-DG44 grown in suspension and serum-free media Biotechnol. Bioeng. 80 2002 706 716
25. B. Mitta, M. Rimann, M.U. Ehrengruber, M. Ehrbar, V. Djonov, J. Kelm, and M. Fussenegger Advanced modular self-inactivating lentiviral expression vectors for multigene interventions in mammalian cells and in vivo transduction Nucleic Acids Res. 30 2002 e113
26. H. Mochizuki, J.P. Schwartz, K. Tanaka, R.O. Brady, and J. Reiser High-titer human immunodeficiency virus type 1-based vector systems for gene delivery into nondividing cells J. Virol. 72 1998 8873 8883
27. S. Moser, M. Rimann, C. Fux, S. Schlatter, J.E. Bailey, and M. Fussenegger Dual-regulated expression technology: a new era in the adjustment of heterologous gene expression in mammalian cells J. Gene Med. 3 2001 529 549
28. I. Nikolaev, M. Mathieu, P. van de Vondervoort, J. Visser, and B. Felenbok Heterologous expression of the Aspergillus nidulans alcR-alcA system in Aspergillus niger Fungal Genet. Biol. 37 2002 89 97
29. D. No, T.P. Yao, and R.M. Evans Ecdysone-inducible gene expression in mammalian cells and transgenic mice Proc. Natl. Acad. Sci. USA 93 1996 3346 3351
30. J. Reiser, G. Harmison, S. Kluepfel-Stahl, R.O. Brady, S. Karlsson, and M. Schubert Transduction of nondividing cells using pseudotyped defective high-titer HIV type 1 particles Proc. Natl. Acad. Sci. USA 93 1996 15266 15271
31. V.M. Rivera, T. Clackson, S. Natesan, R. Pollock, J.F. Amara, T. Keenan, S.R. Magari, T. Phillips, N.L. Courage, F. Cerasoli Jr., D.A. Holt, and M. Gilman A humanized system for pharmacologic control of gene expression Nat. Med. 2 1996 1028 1032
32. O. Sartor, and G.B. Cutler Jr. Mifepristone: treatment of Cushing's syndrome Clin. Obstet. Gynecol. 39 1996 506 510
33. S. Schlatter, M. Rimann, J. Kelm, and M. Fussenegger SAMY, a novel mammalian reporter gene derived from Bacillus stearothermophilus alpha-amylase Gene 282 2002 19 31
34. S. Tascou, T.K. Sorensen, V. Glenat, M. Wang, M.M. Lakich, R. Darteil, E. Vigne, and V. Thuillier Stringent rosiglitazone-dependent gene switch in muscle cells without effect on myogenic differentiation Mol. Ther. 9 2004 637 649
35. W. Weber, C. Fux, M. Daoud-el Baba, B. Keller, C.C. Weber, B.P. Kramer, C. Heinzen, D. Aubel, J.E. Bailey, and M. Fussenegger Macrolide-based transgene control in mammalian cells and mice Nat. Biotechnol. 20 2002 901 907
36. W. Weber, R.R. Marty, N. Link, M. Ehrbar, B. Keller, C.C. Weber, A.H. Zisch, C. Heinzen, V. Djonov, and M. Fussenegger Conditional human VEGF-mediated vascularization in chicken embryos using a novel temperature-inducible gene regulation (TIGR) system Nucleic Acids Res. 31 2003 e69
37. W. Weber, R. Schoenmakers, M. Spielmann, M.D. El-Baba, M. Folcher, B. Keller, C.C. Weber, N. Link, P. van de Wetering, C. Heinzen, B. Jolivet, U. Sequin, D. Aubel, C.J. Thompson, and M. Fussenegger Streptomyces-derived quorum-sensing systems engineered for adjustable transgene expression in mammalian cells and mice Nucleic Acids Res. 31 2003 e71
38. Weber, W., Malphettes, L., de Jesus, M., Schoenmakers, R., El-Baba, M.D., Spielmann, M., Keller, B., Weber, C.C., van de Wetering, P., Aubel, D., Wurm, F.M., Fussenegger, M., 2004a. Engineered Streptomyces quorum-sensing components enable inducible siRNA-mediated translation control in mammalian cells and adjustable transcription control in mice. J. Gene Med., DOI. 10.1002/jgm.682.
39. W. Weber, M. Rimann, M. Spielmann, B. Keller, M. Daoud-El Baba, D. Aubel, C.C. Weber, and M. Fussenegger Gas-inducible transgene expression in mammalian cells and mice Nat. Biotechnol. 22 2004 1440 1444
40. H.F. Zhao, J. Boyd, N. Jolicoeur, and S.H. Shen A coumermycin/novobiocin- regulated gene expression system Hum. Gene Ther. 14 2003 1619 1629