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Volumn 12, Issue 15, 2005, Pages 1163-1170

A hypoxia-inducible vigilant vector system for activating therapeutic genes in ischemia

Author keywords

Heart myocardial ischemia; Hypoxia; Ischemic diseases; Regulatable gene delivery

Indexed keywords

HEME OXYGENASE 1; HYPOXIA INDUCIBLE FACTOR 2ALPHA; VIRUS VECTOR;

EID: 23744451791     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302513     Document Type: Article
Times cited : (33)

References (41)
  • 1
    • 0034464872 scopus 로고    scopus 로고
    • Hypoxia, HIF-1, and the pathophysiology of common human diseases
    • Semenza GL et al. Hypoxia, HIF-1, and the pathophysiology of common human diseases. Adv Exp Med Biol 2000; 475: 123-130.
    • (2000) Adv. Exp. Med. Biol. , vol.475 , pp. 123-130
    • Semenza, G.L.1
  • 2
    • 0036380377 scopus 로고    scopus 로고
    • A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology
    • Acker T, Plate KH. A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology. J Mol Med 2002; 80: 562-575.
    • (2002) J. Mol. Med. , vol.80 , pp. 562-575
    • Acker, T.1    Plate, K.H.2
  • 3
    • 0037297359 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Therapeutic angiogenesis for limb and myocardial ischemia
    • Khan TA, Selke FW, Laham RJ. Gene therapy progress and prospects: therapeutic angiogenesis for limb and myocardial ischemia. Gene Therapy 2003; 10: 285-291.
    • (2003) Gene Therapy , vol.10 , pp. 285-291
    • Khan, T.A.1    Selke, F.W.2    Laham, R.J.3
  • 4
    • 0034702905 scopus 로고    scopus 로고
    • VEGF gene delivery to myocardium: Deleterious effects of unregulated expression
    • Lee RJ et al. VEGF gene delivery to myocardium: deleterious effects of unregulated expression. Circulation 2000; 102: 898-901.
    • (2000) Circulation , vol.102 , pp. 898-901
    • Lee, R.J.1
  • 5
    • 0032215354 scopus 로고    scopus 로고
    • VEGF gene delivery to muscle: Potential role for vasculogenesis in adults
    • Springer ML et al. VEGF gene delivery to muscle: potential role for vasculogenesis in adults. Mol Cell 1998; 2: 549-558.
    • (1998) Mol. Cell , vol.2 , pp. 549-558
    • Springer, M.L.1
  • 6
    • 0037386279 scopus 로고    scopus 로고
    • Hypoxia-mediated tumour targeting
    • Binley K et al. Hypoxia-mediated tumour targeting. Gene Therapy 2003; 10: 540-549.
    • (2003) Gene Therapy , vol.10 , pp. 540-549
    • Binley, K.1
  • 7
    • 0036773458 scopus 로고    scopus 로고
    • Novel chimeric gene promoters responsive to hypoxia and ionizing radiation
    • Greco O et al. Novel chimeric gene promoters responsive to hypoxia and ionizing radiation. Gene Therapy 2002; 9: 1403-1411.
    • (2002) Gene Therapy , vol.9 , pp. 1403-1411
    • Greco, O.1
  • 8
    • 0037047038 scopus 로고    scopus 로고
    • Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model
    • Su H, Arakawa-Hoyt J, Kan YW. Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model. Proc Natl Acad Sci USA 2002; 99: 9480-9485.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 9480-9485
    • Su, H.1    Arakawa-Hoyt, J.2    Kan, Y.W.3
  • 9
    • 0035300474 scopus 로고    scopus 로고
    • Gene therapy targeting for hepatocellular carcinoma: Selective and enhanced suicide gene expression regulated by a hypoxia-inducible enhancer linked to a human alpha-fetoprotein promoter
    • Ido A et al. Gene therapy targeting for hepatocellular carcinoma: selective and enhanced suicide gene expression regulated by a hypoxia-inducible enhancer linked to a human alpha-fetoprotein promoter. Cancer Res 2001; 61: 3016-3021.
    • (2001) Cancer Res. , vol.61 , pp. 3016-3021
    • Ido, A.1
  • 10
    • 0033198913 scopus 로고    scopus 로고
    • Characterization of physiologically regulated vectors for the treatment of ischemic disease
    • Boast K et al. Characterization of physiologically regulated vectors for the treatment of ischemic disease. Hum Gene Ther 1999; 10: 2197-2208.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 2197-2208
    • Boast, K.1
  • 11
    • 0032866070 scopus 로고    scopus 로고
    • An adenoviral vector regulated by hypoxia for the treatment of ischaemic disease and cancer
    • Binley K et al. An adenoviral vector regulated by hypoxia for the treatment of ischaemic disease and cancer. Gene Therapy 1999; 6: 1721-1727.
    • (1999) Gene Therapy , vol.6 , pp. 1721-1727
    • Binley, K.1
  • 12
    • 0034880629 scopus 로고    scopus 로고
    • A hypoxia-regulated adeno-associated virus vector for cancer-specific gene therapy
    • Ruan et al. A hypoxia-regulated adeno-associated virus vector for cancer-specific gene therapy. Neoplasia 2001; 3: 255-263.
    • (2001) Neoplasia , vol.3 , pp. 255-263
    • Ruan1
  • 13
    • 0037564988 scopus 로고    scopus 로고
    • Hypoxia-regulated transgene expression in experimental retinal and choroidal neovascularization
    • Bainbridge JW et al. Hypoxia-regulated transgene expression in experimental retinal and choroidal neovascularization. Gene Therapy 2003; 10: 1049-1054.
    • (2003) Gene Therapy , vol.10 , pp. 1049-1054
    • Bainbridge, J.W.1
  • 14
    • 0036785428 scopus 로고    scopus 로고
    • Long-term reversal of chronic anemia using a hypoxia-regulated erythropoietin gene therapy
    • Binley K et al. Long-term reversal of chronic anemia using a hypoxia-regulated erythropoietin gene therapy. Blood 2002; 100: 2406-2413.
    • (2002) Blood , vol.100 , pp. 2406-2413
    • Binley, K.1
  • 15
    • 0030815312 scopus 로고    scopus 로고
    • Regulated expression of a foreign gene targeted to the ischaemic myocardium
    • Prentice H et al. Regulated expression of a foreign gene targeted to the ischaemic myocardium. Cardiovasc Res 1997; 35: 567-574.
    • (1997) Cardiovasc. Res. , vol.35 , pp. 567-574
    • Prentice, H.1
  • 16
    • 0036179778 scopus 로고    scopus 로고
    • Hypoxia inducible double plasmid system for myocardial ischemia gene therapy
    • Tang Y, Jackson M, Qian K, Phillips MI. Hypoxia inducible double plasmid system for myocardial ischemia gene therapy. Hypertension 2002; 39: 695-698.
    • (2002) Hypertension , vol.39 , pp. 695-698
    • Tang, Y.1    Jackson, M.2    Qian, K.3    Phillips, M.I.4
  • 17
    • 0036178177 scopus 로고    scopus 로고
    • Vigilant vector: Heart-specific promoter in an adeno-associated virus vector for cardioprotection
    • Phillips M et al. Vigilant vector: heart-specific promoter in an adeno-associated virus vector for cardioprotection. Hypertension 2002; 39: 651-655.
    • (2002) Hypertension , vol.39 , pp. 651-655
    • Phillips, M.1
  • 18
    • 4344573909 scopus 로고    scopus 로고
    • Hypoxia-regulated therapeutic gene as a preemptive treatment strategy against ischemia/reperfusion tissue injury
    • Pachori AS et al. Hypoxia-regulated therapeutic gene as a preemptive treatment strategy against ischemia/reperfusion tissue injury. Proc Natl Acad Sci USA 2004; 101: 12282-12287.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 12282-12287
    • Pachori, A.S.1
  • 19
    • 0036430035 scopus 로고    scopus 로고
    • Vigilant vectors: Adeno-associated virus with a biosensor to switch on amplified therapeutic genes in specific tissues in life-threatening diseases
    • Tang Y et al. Vigilant vectors: adeno-associated virus with a biosensor to switch on amplified therapeutic genes in specific tissues in life-threatening diseases. Methods 2002; 28: 259-266.
    • (2002) Methods , vol.28 , pp. 259-266
    • Tang, Y.1
  • 20
    • 0035313697 scopus 로고    scopus 로고
    • HIF-1 and mechanisms of hypoxia sensing
    • Semenza GL. HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol 2001; 13: 167-171.
    • (2001) Curr. Opin. Cell Biol. , vol.13 , pp. 167-171
    • Semenza, G.L.1
  • 21
    • 0034235012 scopus 로고    scopus 로고
    • Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism
    • Salnikow K, Su W, Blagosklonny MV, Costa M. Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism. Cancer Res 2000; 60: 3375-3378.
    • (2000) Cancer Res. , vol.60 , pp. 3375-3378
    • Salnikow, K.1    Su, W.2    Blagosklonny, M.V.3    Costa, M.4
  • 22
    • 0034282388 scopus 로고    scopus 로고
    • Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells
    • Richard DE, Berra E, Pouyssegur J. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells. J Biol Chem 2000; 275: 26765-26771.
    • (2000) J. Biol. Chem. , vol.275 , pp. 26765-26771
    • Richard, D.E.1    Berra, E.2    Pouyssegur, J.3
  • 23
    • 0035864361 scopus 로고    scopus 로고
    • Accumulation of HIF-1alpha under the influence of nitric oxide
    • Sandau KB, Fandrey J, Brune B. Accumulation of HIF-1alpha under the influence of nitric oxide. Blood 2001; 97: 1009-1015.
    • (2001) Blood , vol.97 , pp. 1009-1015
    • Sandau, K.B.1    Fandrey, J.2    Brune, B.3
  • 24
    • 0035159670 scopus 로고    scopus 로고
    • HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia
    • Stroka DM et al. HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia. FASEB J 2001; 15: 2445-2453.
    • (2001) FASEB J. , vol.15 , pp. 2445-2453
    • Stroka, D.M.1
  • 26
    • 0034712939 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
    • Sutter CH, Laughner E, Semenza GL. Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Proc Natl Acad Sci USA 2000; 97: 4748-4753.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 4748-4753
    • Sutter, C.H.1    Laughner, E.2    Semenza, G.L.3
  • 28
    • 0027301056 scopus 로고
    • Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube
    • O'Brien TX, Lee KJ, Chien KR. Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube. Proc Natl Acad Sci USA 1993; 90: 5157-5161.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 5157-5161
    • O'Brien, T.X.1    Lee, K.J.2    Chien, K.R.3
  • 29
    • 0022344716 scopus 로고
    • Time from onset of symptoms to thrombolytic therapy: A major determinant of myocardial salvage in patients with acute transmural infarction
    • Mathey DG, Sheehan FH, Schofer J, Dodge HT. Time from onset of symptoms to thrombolytic therapy: a major determinant of myocardial salvage in patients with acute transmural infarction. J Am Coll Cardiol 1985; 6: 518-525.
    • (1985) J. Am. Coll. Cardiol. , vol.6 , pp. 518-525
    • Mathey, D.G.1    Sheehan, F.H.2    Schofer, J.3    Dodge, H.T.4
  • 30
    • 0018214815 scopus 로고
    • Depression of regional blood flow and wall thickening after brief coronary occlusions
    • Heyndrickx GR et al. Depression of regional blood flow and wall thickening after brief coronary occlusions. Am J Physiol 1978; 234: H653-H659.
    • (1978) Am. J. Physiol. , vol.234
    • Heyndrickx, G.R.1
  • 31
    • 0028231050 scopus 로고
    • Oxygen pressure distribution in the heart in vivo and evaluation of the ischemic 'border zone'
    • Rumsey WL, Pawlowski M, Lejavardi N, Wilson DF. Oxygen pressure distribution in the heart in vivo and evaluation of the ischemic 'border zone'. Am J Physiol 1994; 266: H1676-H1680.
    • (1994) Am. J. Physiol. , vol.266
    • Rumsey, W.L.1    Pawlowski, M.2    Lejavardi, N.3    Wilson, D.F.4
  • 32
    • 0002972851 scopus 로고
    • Oxygenation of solid tumours
    • Teicher BA (ed). Marcel Dekker, Inc.: New York
    • Dekker M. Oxygenation of solid tumours. In: Teicher BA (ed). Drug Resistance in Oncology. Marcel Dekker, Inc.: New York, 1993.
    • (1993) Drug Resistance in Oncology
    • Dekker, M.1
  • 33
    • 0037022253 scopus 로고    scopus 로고
    • Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene
    • Melo LG et al. Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene. Circulation 2002; 105: 602-607.
    • (2002) Circulation , vol.105 , pp. 602-607
    • Melo, L.G.1
  • 34
    • 0036070456 scopus 로고    scopus 로고
    • Cardioselective overexpression of HO-1 prevents I/R-induced cardiac dysfunction and apoptosis
    • Vulapalli SR et al. Cardioselective overexpression of HO-1 prevents I/R-induced cardiac dysfunction and apoptosis. Am J Physiol Heart Circ Physiol 2002; 283: H688-H694.
    • (2002) Am. J. Physiol. Heart Circ. Physiol. , vol.283
    • Vulapalli, S.R.1
  • 35
    • 0141706806 scopus 로고    scopus 로고
    • Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling
    • Yet SF et al. Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling. FASEB J 2003; 17: 1759-1761.
    • (2003) FASEB J. , vol.17 , pp. 1759-1761
    • Yet, S.F.1
  • 36
    • 0035920256 scopus 로고    scopus 로고
    • Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice
    • Yet SF et al. Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ Res 2001; 89: 168-173.
    • (2001) Circ. Res. , vol.89 , pp. 168-173
    • Yet, S.F.1
  • 37
    • 1642501642 scopus 로고    scopus 로고
    • Protection from ischemic heart injury by a vigilant heme oxygenase-1 plasmid system
    • Tang YL et al. Protection from ischemic heart injury by a vigilant heme oxygenase-1 plasmid system. Hypertension 2004; 43: 746-751.
    • (2004) Hypertension , vol.43 , pp. 746-751
    • Tang, Y.L.1
  • 38
    • 0034121397 scopus 로고    scopus 로고
    • A new dual-vector approach to enhance recombinant adeno-associated virus-mediated gene expression through intermolecular cis activation
    • Duan D, Yue Y, Yan Z, Engelhardt JF. A new dual-vector approach to enhance recombinant adeno-associated virus-mediated gene expression through intermolecular cis activation. Nat Med 2000; 6: 595-598.
    • (2000) Nat. Med. , vol.6 , pp. 595-598
    • Duan, D.1    Yue, Y.2    Yan, Z.3    Engelhardt, J.F.4
  • 39
    • 0034121579 scopus 로고    scopus 로고
    • Overcoming adeno-associated virus vector size limitation through viral DNA heterodimerization
    • Sun L, Li J, Xiao X. Overcoming adeno-associated virus vector size limitation through viral DNA heterodimerization. Nat Med 2000; 6: 599-602.
    • (2000) Nat. Med. , vol.6 , pp. 599-602
    • Sun, L.1    Li, J.2    Xiao, X.3
  • 40
    • 0034033447 scopus 로고    scopus 로고
    • Increasing the size of rAAV-mediated expression cassettes in vivo by intermolecular joining of two complementary vectors
    • Nakai H, Storm TA, Kay MA. Increasing the size of rAAV-mediated expression cassettes in vivo by intermolecular joining of two complementary vectors. Nat Biotechnol 2000; 18: 527-532.
    • (2000) Nat. Biotechnol. , vol.18 , pp. 527-532
    • Nakai, H.1    Storm, T.A.2    Kay, M.A.3
  • 41
    • 0031879481 scopus 로고    scopus 로고
    • Regulation of gene expression in vivo following transduction by two separate rAAV vectors
    • Rendahl KG et al. Regulation of gene expression in vivo following transduction by two separate rAAV vectors. Nat Biotechnol 1998; 16: 757-761.
    • (1998) Nat. Biotechnol. , vol.16 , pp. 757-761
    • Rendahl, K.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.