Peptide transporters in the intestine and the kidney

Annual Review of Nutrition

Volumn 16, Issue , 1996, Pages 99-119

  Leibach, Frederick H ^a   Ganapathy, Vadivel ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

peptidomimetic drugs; primary structure; proton gradient; regulation

Indexed keywords

BETA LACTAM ANTIBIOTIC; CARRIER PROTEIN; CEFADROXIL; CEPHALOSPORIN DERIVATIVE; CYCLACILLIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; PENICILLIN DERIVATIVE; PEPTIDE TRANSPORTER PEPT 1; PEPTIDE TRANSPORTER PEPT 2; UNCLASSIFIED DRUG;

DRUG PROTEIN BINDING; ENDOPLASMIC RETICULUM; ENZYME SPECIFICITY; HUMAN; INTESTINE BRUSH BORDER; KIDNEY EPITHELIUM; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; PROTON MOTIVE FORCE; REVIEW; STEREOCHEMISTRY;

EID: 0029820968     PISSN: 01999885     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.nu.16.070196.000531     Document Type: Review

References (112)

1. Adibi SA. 1987. Experimental basis for use of peptides as substrates for parenteral nutrition: a review. Metabolism 36:1001-11
2. Amidon GL, Lee HJ. 1994. Absorption of peptides and peptidomimetic drugs. Annu. Rev. Pharmacol. Toxicol. 34:321-41
3. + secretion in the proximal tubule. Am. J. Physiol. 245:F647-59
4. Asatoor AM, Chadha A, Milne MD, Prosser DI. 1973. Intestinal absorption of stereoisomers of dipeptides in the rat. Clin. Sci. Mol. Med. 45:199-212
5. Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T. 1991. Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region. Proc. Natl. Acad. Sci. USA 88:10094-98
6. Barfuss DW, Ganapathy V, Leibach FH. 1988. Evidence for active dipeptide transport in isolated proximal straight tubules. Am. J. Physiol. 255:F177-81
7. Bertran J, Werner A, Moore ML, Stange G, Markovich D, et al. 1992. Expression cloning of a cDNA from rabbit kidney cortex that induces a single transport system for cystine and dibasic and neutral amino acids. Proc. Natl. Acad. Sci. USA 89:5601-5
8. Bird SJ, Lloyd JB. 1990. Evidence for a dipeptide porter in the lysosomal membrane. Biochim. Biophys. Acta 1024:267-70
9. Boll M, Markovich D, Weber WM, Korte H, Daniel H, Murer H. 1994. Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, β-lactam antibiotics, and ACE-inhibitors. Pflugers Arch. Eur. J. Physiol. 429:146-49
10. +/peptide cotransporter. FASEB J. 9:1489-95
11. +-peptide cotransport in Madin-Darby canine kidney cells: expression and calmodulin-dependent regulation. Am. J. Physiol. 268:F391-97
12. + cotransport system in the Caco-2 human colon carcinoma cell line. Biochem. J. 299:253-60
13. Chou HF, Vadgama J, Jonas AJ. 1992. Lysosomal transport of small molecules. Biochem. Med. Metab. Biol. 48:179-93
14. Daniel H, Adibi SA. 1995. Selective effect of zinc on uphill transport of oligopeptides into kidney brush border membrane vesicles. FASEB J. 9:1112-17
15. Daniel H, Morse EL, Adibi SA. 1991. The high and low affinity transport systems for dipeptides in kidney brush border membrane respond differently to alterations in pH gradient and membrane potential. J. Biol. Chem. 266:19917-24
16. + symporter in the renal brush border membrane. J. Biol. Chem. 267:9565-73
17. Dantzig AH, Bergin L. 1990. Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2. Biochim. Biophys. Acta 1027:211-17
18. Dantzig AH, Duckworth DC, Tabas LB. 1994. Transport mechanisms responsible for the absorption of loracarbef, cefixime, and cefuroxime axetil into human intestinal Caco-2 cells. Biochim. Biophys. Acta 1191:7-13
19. Dantzig AH, Hoskins J, Tabas LB, Bright S, Shepard RL, et al. 1994. Association of intestinal peptide transport with a protein related to the cadherin superfamily. Science 264:430-33
20. Dantzig AH, Tabas LB, Bergin L. 1992. Cefaclor uptake by the proton-dependent dipeptide transport carrier of human intestinal Caco-2 cells and comparison to cephalexin uptake. Biochim. Biophys. Acta 1112:167-73
21. Das M, Radhakrishnan AN. 1975. Studies on a wide-spectrum intestinal dipeptide uptake system in the monkey and in the human. Biochem. J. 146:133-39
22. Dudrick PS, Souba WW. 1991. Amino acids in surgical nutrition. Principles and practice. Surg. Clin. North Am. 71:459-76
23. Fei YJ, Kanai Y, Nussberger S, Ganapathy V, Leibach FH, et al. 1994. Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 368:563-66
24. Ferraris RP, Diamond JM. 1989. Specific regulation of intestinal nutrient transporters by their dietary substrates. Annu. Rev. Physiol. 51:125-41
25. +/Di-tripeptide transporter (PEPT 1) expression in the rabbit intestine. Pflugers Arch. Eur. J. Physiol. 430:394-400
26. Furst P, Albers S, Stehle P. 1990. Dipeptides in clinical nutrition. Proc. Nutr. Soc. UK 49:343-59
27. Ganapathy ME, Brandsch M, Prasad PD, Ganapathy V, Leibach FH. 1995. Differential recognition of β-lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. J. Biol. Chem. 270:25672-77
28. + exchanger. Biochem. J. 245:473-77
29. Ganapathy V, Brandsch M, Leibach FH. 1994. Intestinal transport of amino acids and peptides. In Physiology of the Gastrointestinal Tract, ed. LR Johnson, pp. 1773-94. New York: Raven
30. Ganapathy V, Burckhardt G, Leibach FH. 1984. Characteristics of glycylsarcosine transport in rabbit intestinal brush-border membrane vesicles. J. Biol. Chem. 259:8954-59
31. Ganapathy V, Leibach FH. 1982. Peptide transport in rabbit kidney. Studies with L-carnosine. Biochim. Biophys. Acta 691:362-66
32. Ganapathy V, Leibach FH. 1983. Role of pH gradient and membrane potential in dipeptide transport in intestinal and renal brush border membrane vesicles. Studies with glycyl-L-proline and L-carnosine. J. Biol. Chem. 258:14189-92
33. Ganapathy V, Leibach FH. 1985. Is intestinal peptide transport energized by a proton gradient? Am. J. Physiol. 249:G153-60
34. Ganapathy V, Leibach FH. 1986. Carrier-mediated reabsorption of small peptides in renal proximal tubule. Am. J. Physiol. 251:F945-53
35. Ganapathy V, Leibach FH. 1991. Proton-coupled solute transport in the animal cell plasma membrane. Curr. Opin. Cell Biol. 3:695-701
36. Ganapathy V, Miyamoto Y, Leibach FH. 1987. Driving force for peptide transport in mammalian kidney and intestine. Contrib. Infusion Ther. Clin. Nutr. 17:54-68
37. Ganapathy V, Pashley DH, Fonteles MC, Leibach FH. 1984. Peptidases and peptide transport in mammalian kidney. Contr. Nephrol. 42:10-18
38. Garcia CK, Li X, Luna J, Francke U. 1994. cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC 16A1 locus to 1p13.2-p12. Genomics 23:500-3
39. Gardner MLG. 1994. Absorption of intact proteins and peptides. In Physiology of the Gastrointestinal Tract, ed. LR Johnson, pp. 1795-820. New York: Raven
40. Grimble GK. 1994. The significance of peptides in clinical nutrition. Annu. Rev. Nutr. 14:419-47
41. Grimble GK, Raimundo AH, Rees RG, Hunjan MK, Silk DBA. 1988. Parenteral utilization of a purified short-chain enzymic hydrolysate of ovalbumin in man. J. Parenter. Enter. Nutr. 12:15S
42. Grimble GK, Silk DBA. 1989. Peptides in human nutrition. Nutr. Res. Rev. 2:87-108
43. Guandalini S, Rubino A. 1982. Development of dipeptide transport in the intestinal mucosa of rabbits. Pediatr. Res. 16:99-103
44. Hagting A, Kunji ERS, Leenhouts KJ, Poolman B, Konings WN. 1994. The di- and tripeptide transport protein of Lactococcus lactis. A new type of bacterial peptide transporter. J. Biol. Chem. 296:11391-99
45. Himukai M, Konno T, Hoshi T. 1980. Age-dependent change in the intestinal absorption of dipeptides and their constituent amino acids in the guinea pig. Pediatr. Res. 14:1272-75
46. +/organic cation transport system in rat renal brush border membranes. J. Biol. Chem. 264:12232-37
47. + transport. Jpn. J. Physiol. 35:179-91
48. Hu M, Subramanian P, Mosberg HI, Amidon GL. 1989. Use of the peptide carrier system to improve the intestinal absorption of L-alpha-methyldopa: carrier kinetics, intestinal permeabilities, and in vitro hydrolysis of dipeptidyl derivatives of L-alpha-methyldopa. Pharm. Res. 6:66-70
49. + coupled transport of p.o. cephalosporins via dipeptide carriers in rabbit intestinal brush-border membranes: difference of transport characteristics between cefixime and cephradine. J. Pharmacol. Exp. Ther. 247:235-41
50. Inui K, Okano T, Takano M, Saito H, Hori R. 1984. Carrier-mediated transport of cephalexin via the dipeptide transport system in rat renal brush border membrane vesicles. Biochim. Biophys. Acta 679:449-54
51. +-coupled active transport of bestatin via the dipeptide transport system in rabbit intestinal brush-border membranes. J. Pharmacol. Exp. Ther. 260:482-86
52. Inui KI, Yamamoto M, Saito H. 1992. Transepithelial transport of oral cephalosporins by monolayers of intestinal epithelial cell line Caco-2: specific transport systems in apical and basolateral membranes. J. Pharmacol. Exp. Ther. 261:195-201
53. Isenman LD, Dice JF. 1993. Selective release of peptides from lysosomes. J. Biol. Chem. 268:23856-59
54. Kaback HR. 1989. Molecular biology of membrane transport: from membrane to molecule to mechanism. Harvey Lect. 83:77-105
55. + coupled transport of cephradine via dipeptide carriers in rabbit intestinal brush border membranes: role of histidine residues. J. Pharmacol. Exp. Ther. 251:745-49
56. Kramer W. 1987. Identification of identical binding polypeptides for cephalosporins and dipeptides in intestinal brush border membrane vesicles by photoaffinity labeling. Biochim. Biophys. Acta 905:65-74
57. Kramer W, Girbig F, Gutjahr U, Kleemann HW, Leipe I, et al. 1990. Interaction of renin inhibitors with the intestinal uptake system for oligopeptides and β-lactam antibiotics. Biochim. Biophys. Acta 1027:25-30
58. Kramer W, Girbig F, Petzoldt E, Leipe I. 1990. Inactivation of the intestinal uptake system for β-lactam antibiotics by diethylpyrocarbonate. Biochim. Biophys. Acta 943:288-96
59. Kramer W, Leipe I, Petzoldt E, Girbig F. 1988. Characterization of the transport system for β-lactam antibiotics and dipeptides in rat renal brush border membrane vesicles by photoaffinity labelling. Biochim. Biophys. Acta 939:167-72
60. +/peptide cotransporter: cloning, functional characterization, and chromosomal localization. J. Biol. Chem. 270:6456-63
61. Lis MT, Matthews DM, Crampton RF. 1972. Effects of dietary restriction and protein deprivation on intestinal absorption of protein digestion products in the rat. Br. J. Nutr. 28:443-46
62. Lister N, Sykes AP, Bailey PD, Boyd CAR, Bronk JR. 1995. Dipeptide transport and hydrolysis in isolated loops of rat small intestine: effects of stereospecificity. J. Physiol. 484:173-82
63. +/peptide cotransporter family, from human kidney. Biochim. Biophys. Acta 1235:461-66
64. Lucas M, Blair JA, Cooper BT, Cooke WT. 1976. Relationship of the acid microclimate in rat and human intestine to malabsorption. Biochem. Soc. Trans. 4:154-56
65. +-coupled oligopeptide transporter hPEPT I. J. Biol. Chem. 271:5430-37
66. Matthews DM. 1975. Intestinal absorption of peptides. Physiol. Rev. 55:537-608
67. Matthews DM. 1991. Protein Absorption. Development and Present State of the Subject. New York: Wiley-Liss
68. Matthews DM, Adibi SA. 1976. Peptide absorption. Gastroenterology 71:151-61
69. Miyamoto Y, Ganapathy V, Leibach FH. 1986. Identification of histidyl and thiol groups at the active site of rabbit renal dipeptide transporter. J. Biol. Chem. 261:16133-40
70. Miyamoto Y, Thompson YG, Howard EF, Ganapathy V, Leibach FH. 1991. Functional expression of the intestinal peptide-proton cotransporter in Xenopus laevis oocytes. J. Biol. Chem. 266:4742-45
71. Miyamoto Y, Tiruppathi C, Ganapathy V, Leibach FH. 1989. Involvement of thiol groups in the function of the dipeptide/proton cotransport system in rabbit renal brush border membrane vesicles. Biochim. Biophys. Acta 978:25-31
72. Momburg F, Roelse J, Howard JC, Butcher GW, Hammerling GJ, Neefjes JJ. 1994. Selectivity of MHC-encoded peptide transporters from human, mouse, and rat. Nature 367:648-51
73. Monaco JJ. 1992. A molecular model of MHC class I-restricted antigen processing. Immunol. Today 13:173-79
74. +/peptide cotransporter in the human intestinal cell line Caco-2 by cyclic AMP. Biochem. Biophys. Res. Commun. 218:461-65
75. Noguchi T, Nam TY, Kato H, Naito H. 1988. Further studies on nutritional factors affecting the urinary excretion of acid-soluble peptides in rats. Br. J. Nutr. 60:321-37
76. +coupled uphill transport of aminocephalosporins via the dipeptide transport system in rabbit intestinal brush-border membranes. J. Biol. Chem. 261:14130-34
77. Perry JR, Basrai MA, Steiner HY, Naider F, Becker JM. 1994. Isolation and characterization of a Saccharomyces cerevisiae peptide transport gene. Mol. Cell. Biol. 14:104-15
78. Prasad PD, Ramamoorthy S, Leibach FH, Ganapathy V. 1995. Molecular cloning of the human placental folate transporter. Biochem. Biophys. Res. Commun. 206:681-87
79. Ramamoorthy S, Liu W, Ma YY, Yang-Feng TL, Ganapathy V, Leibach FH. 1995. Proton/peptide cotransporter (PEPT 2) from human kidney: functional characterization and chromosomal localization. Biochim. Biophys. Acta 1240:1-4
80. Sagawa N, Nishimura T, Ogawa M, Inoue A. 1979. Electrogenic absorption of sugars and amino acids in the small intestine of the human fetus. Membr. Biochem. 2:393-404
81. Said HM, Mohammadkhani R. 1993. Folate transport in intestinal brush border membrane: involvement of essential histidine residue(s). Biochem. J. 290: 237-40
82. Saito H, Inui KI. 1993. Dipeptide transporters in apical and basolateral membranes of the human intestinal cell line Caco-2. Am. J. Physiol. 265:G289-94
83. Saito H, Ishii T, Inui K. 1993. Expression of human intestinal dipeptide transporter in Xenopus laevis oocytes. Biochem. Pharmacol. 45:776-79
84. Schlagheck TG, Webb KE. 1984. Characterization of peptides from the gastrointestinal tract of calves. Fed. Proc. 43:671
85. Seal CJ, Parker DS. 1991. Isolation and characterization of circulating low molecular weight peptides in steer, sheep, and rat portal and peripheral blood. Comp. Biochem. Physiol. 99B:679-85
86. + gradient-driven dipeptide reabsorption in proximal tubule of rat kidney. Studies in vivo and in vitro. Am. J. Physiol. 253:F448-57
87. Spies T, Bresnahan M, Bahram S, Arnold D, Blanck G, et al. 1990. A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway. Nature 348:744-47
88. Spies T, Cerundolo V, Colonna M, Cresswell P, Townsend A, DeMars R. 1992. Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer. Nature 355:644-46
89. Stehle P, Zander J, Mertes N, Albers S, Puchstein C, et al. 1989. Effect of parenteral glutamine peptide supplements on muscle glutamine loss and nitrogen balance after major surgery. Lancet 1:231-33
90. Steinhardt HJ, Paleos GA, Brandl M, Fekl WE, Adibi SA. 1984. Efficacy of a synthetic dipeptide mixture as the source of amino acids for total parenteral nutrition in a subhuman primate (baboon). Plasma concentration, metabolic clearance and urinary excretion of a series of dipeptides. Gastroenterology 86:1562-69
91. Swaan PW, Stehouwer MFC, Tukker JJ. 1995. Molecular mechanisms for the relative binding affinity to the intestinal peptide carrier. Comparison of three ACE inhibitors: enalapril, enalaprilat, and lisinopril. Biochim. Biophys. Acta 1236:31-38
92. Tacnet F, Lauthier F, Ripoche P. 1993. Mechanisms of zinc transport into pig small intestine brush-border membrane vesicles. J. Physiol. 465:57-72
93. Tamai I, Ling HY, Timbul SM, Nishikido J, Tsuji A. 1988. Stereospecific absorption and degradation of cephalexin. J Pharm. Pharmacol. 40:320-24
94. Tamai I, Tomizawa N, Kadowaki A, Terasaki T, Nakayama K, et al. 1994. Functional expression of intestinal dipeptide/β-lactam antibiotic transporter in Xenopus laevis oocytes. Biochem. Pharmacol. 48:881-88
95. Tamai I, Tomizawa N, Takeuchi T, Nakayama K, Higashida H, Tsuji A. 1995. Functional expression of transporter for β-lactam antibiotics and dipeptides in Xenopus laevis oocytes injected with messenger RNA from human, rat and rabbit small intestine. J. Pharmacol. Exp. Ther. 273:26-31
96. +-independent neutral amino acid transporter from rat kidney. Proc. Natl. Acad. Sci. USA 889:1-5
97. +-coupled dipeptide (glycylsarcosine) transport across apical and basal borders of human intestinal Caco-2 cell monolayers display distinctive characteristics. Biochim. Biophys. Acta 1151:237-45
98. +-coupled carriers at both apical and basal membranes. J. Biol. Chem. 268:7640-42
99. Tiruppathi C, Ganapathy V, Leibach FH. 1990. Evidence for tripeptide-proton symport in renal brush border membrane vesicles. Studies in a novel rat strain with a genetic absence of dipeptidylpeptidase IV. J. Biol. Chem. 265:2048-53
100. Tiruppathi C, Ganapathy V, Leibach FH. 1990. Kinetic evidence for a common transporter for glycylsarcosine and phenylalanylyprolylalanine in renal brush border membrane vesicles. J. Biol. Chem. 265:14870-74
101. 125I]-labelled tyrosyl peptides as substrates. Biochim. Biophys. Acta 1069:14-20
102. + cotransport in rabbit renal brush border membrane vesicles. Biochem. J. 268:27-33
103. Trowsdale J, Hanson I, Mockridge I, Beck S, Townsend A, Kelley A. 1990. Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters. Nature 348:741-44
104. Tsay YF, Schroeder JI, Feldmann KA, Crawford NM. 1993. The herbicide sensitivity gene CHLI of arabidopsis encodes a nitrate-inducible nitrate transporter. Cell 72:705-13
105. Tsuji A. 1987. Intestinal uptake of β-lactam antibiotics and its relationship to peptide transport. Adv. Biosci. 65:125-31
106. Tsuji A. 1995. Intestinal absorption of β-lactam antibiotics. In Peptide-Based Drug Design, ed. MD Taylor, GL Amidon, pp. 101-34. Washington, DC: Am. Chem. Soc.
107. Tsuji A, Tamai I, Nakanishi M, Amidon GL. 1990. Mechanism of the absorption of the dipeptide α-methyldopa-phe in intestinal brush border membrane vesicles. Pharm. Res. 7:308-9
108. Tsuji A, Tamai I, Nakanishi M, Terasaki T, Hamano S. 1993. Intestinal brush-border transport of the oral cephalosporin antibiotic, cefdinir, mediated by dipeptide and monocarboxylic acid transport systems in rabbits. J. Pharm. Pharmacol. 45:996-98
109. + gradient-dependent and carrier-mediated transport of cefixime, a new cephalosporin antibiotic, across brush-border membrane vesicles from ral small intestine. J. Pharmacol. Exp. Ther. 241:594-601
110. Wells RG, Hediger MA. 1992. Cloning of a rat kidney cDNA that stimulates dibasic and neutral amino acid transport and has sequence similarity to glucosidases. Proc. Natl. Acad. Sci. USA 89:5596-600
111. Williams FMR, Rintoff WF. 1995. Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake. J. Biol. Chem. 270:2987-92
112. Wong SC, Proefke SA, Bhushan A, Matherly LH. 1995. Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells. J. Biol. Chem. 270:17468-75