Saturable accumulation and diuretic activity of hydrochlorothiazide in the isolated perfused rat kidney

Pharmacology

Volumn 54, Issue 1, 1997, Pages 33-42

  Masereeuw, R ^a   Moons, W M ^a   Russel, F G M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Diuretic effect; Hydrochlorothiazide; Perfused rat kidney; Renal secretion; Saturable accumulation

Indexed keywords

CHLORIDE; DIURETIC AGENT; HYDROCHLOROTHIAZIDE; POTASSIUM; SODIUM;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIURESIS; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DIFFUSION; DRUG EXCRETION; DRUG TISSUE LEVEL; DRUG UPTAKE; ISOLATED KIDNEY; KIDNEY CLEARANCE; KIDNEY TUBULE; MICHAELIS MENTEN KINETICS; NONHUMAN; POTASSIUM EXCRETION; PRIORITY JOURNAL; RAT; REGRESSION ANALYSIS; SODIUM EXCRETION; URINE FLOW RATE; URINE PH;

EID: 0031050381     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000139467     Document Type: Article

References (21)

1. Besseghir K. Roch-Ramel F: Rena! excretion of drugs and other xeno-biotics. Renal Physiol 1987; 10:221-241.
2. Pritchard JB, Miller DS: Proximal tubular transport of organic anions and cations: in Scldin DW.Gicbisch G (eds): The Kidney: Physiology and Pathophysiology. New York, Raven Press, 1992. pp 2921-2945.
3. Bennett WM. Porter GA: Overview of clinical nephrotoxicity; in Hook JB. Goldstein RS (eds): Toxicology of the Kidney. New York, Raven Press, 1993, pp 61-97.
4. Chennavasin P, Seiwell R. Brater DC, Liang WMM: Pharmacodynamic analysis of the furosemide-probenecid interaction in man. Kidney lnl 1979:16:187-195.
5. Cox PGF, Moons MM. Siegers JFG. Russel FGM. Van Ginnekcn CAM: The isolated perfused rat kidney as a tool in the investigation of renal handling and effects of nonsteroidal anti-inflammatory drugs. J Pharmacol Methods 1990;24:89-103.
6. Boom SPA, Moons MM, Russel FGM: Renal tubular transport of ci-metidinc in the isolated perfused kidney of the rat. Drug Metab Dispos 1994;22:148-153.
7. Ullrich KJ, Rumrich G, Kloss S: Contraluminal organic anion and cation transport in the proximal tubule. V. interaction with sulfamoyl-and phcnoxy-diuretics, and with β-lactam antibiotics. Kidney Int 1989: 36:78-88.
8. Bartel C, Wirtz C. Brandle E, Grcven J: Interaction of thiazide and loop diuretics with the basolateral para-aminohippurate transport system in isolated S? segments of rabbit kidney proximal tubules. J Pharmacol ExpThcr 1993:266:972-977.
9. Russel FGM, Van dcr Linden PEM. Vermeulen WG, Heijn M, Van Os CH. Van Ginneken CAM: Na* and H* gradient-dependent transport of p-aminohippurate in membrane vesicles from dog kidney cortex. Biochem Pharmacol 1988:37:2639-2649.
10. Duggan DE: The accumulation of chlorothiazide and related saluretic agents by isolated renal tubules. J Pharmacol Exp Thcr 1966; 152:122-129.
11. Welling PG: Pharmacokinetics of the thiazide diuretics. Biopharm Drug Dispos 1986;7:501-535.
12. Velazquez H: Thiazide diuretics. Renal Physiol 1987;10:184-197.
13. Suki WN. Eknoyan G: Physiology of diuretic action: in Scldin DW. Gie-bisch G (eds): The Kidney: Physiology and Pathophysiology. New York, Raven Press. 1992, pp 3629-3670.
14. Van Ginneken CAM. Russel FGM: Saturable pharmacokinetics in the renal excretion of drugs. Clin Phar-macokinet 1989:16:38-54.
15. Mascreeuw R, Moons MM. Russel FGM: Renal excretion and accumulation kinetics of 2-mcthylbenzoyl-glycine in the isolated perfused rat kidney. J Pharm Pharmacol 1996; 48:560-565.
16. Hoi ford NHG. Sheiner LB: Understanding the dose-effect relationship: Clinical application of pharmacokinetic-pharmacodynamic models. Clin Pharmacokinet 1981:6:429-453.
17. Metzler CM, Weiner DL: Software for the Statistical Analysis of Nonlinear Models on Micros. Lexington. SCI Software, 1989.
18. Lee LJ, Cook JA, Smith DE: Renal transport kinetics of chlorothiazide in the isolated perfused rat kidney. J Pharmacol Exp Ther 1988:247:203-208.
19. Lajeunesse D, Mailloux J, Brunette MG: The hypocalciuric effect of thiazides: Subccllular localization of the action. Pflügers Arch 1991:417: 454-462.
20. Manitius A, Silva P. Epstein FH: Effect of hydrochlorothiazide on calcium excretion by the isolated perfused rat kidney. Proc Soc Exp Biol Med 1979;160:160-163.
21. Beermann B, Groschinsky-Grind M: Pharmacokinetics of hydrochlorothiazide in man. Eur J Clin Pharmacol 1977;12:297-303.