-
2
-
-
0023947965
-
Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985)
-
R. A. Prentis, Y. Lis, and S. R. Walker. Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985). Br. J. Clin. Pharmacol 25:387-396 (1988).
-
(1988)
Br. J. Clin. Pharmacol
, vol.25
, pp. 387-396
-
-
Prentis, R.A.1
Lis, Y.2
Walker, S.R.3
-
4
-
-
3042772026
-
Identification of functionally variant MDR1 alleles among European Americans and African Americans
-
R. B. Kim, B. F. Leake, E. F. Choo, G. K. Dresser, S. V. Kubba, U. I. Schwarz, A. Taylor, H. G. Xie, J. McKinsey, S. Zhou, L. B. Lan, J. D. Schuetz, E. G. Schuetz, and G. R. Wilkinson. Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin. Pharmacol. Ther. 70:189-199 (2001).
-
(2001)
Clin. Pharmacol. Ther.
, vol.70
, pp. 189-199
-
-
Kim, R.B.1
Leake, B.F.2
Choo, E.F.3
Dresser, G.K.4
Kubba, S.V.5
Schwarz, U.I.6
Taylor, A.7
Xie, H.G.8
McKinsey, J.9
Zhou, S.10
Lan, L.B.11
Schuetz, J.D.12
Schuetz, E.G.13
Wilkinson, G.R.14
-
5
-
-
0036286921
-
Effect of St John's wort on the pharmacokinetics of fexofenadine
-
Z. Wang, M. A. Hamman, S. M. Huang, L. J. Lesko, and S. D. Hall. Effect of St John's wort on the pharmacokinetics of fexofenadine. Clin. Pharmacol. Ther. 71:414-420 (2002).
-
(2002)
Clin. Pharmacol. Ther.
, vol.71
, pp. 414-420
-
-
Wang, Z.1
Hamman, M.A.2
Huang, S.M.3
Lesko, L.J.4
Hall, S.D.5
-
6
-
-
0000096993
-
Mass balance and pharmacokinetics of MDL 16,455A in healthy male volunteers
-
C. Lippert, J. Ling, P. Brown, S. Burmaster, M. Eller, L. Cheng, R. Thompson, and S. Weir. Mass balance and pharmacokinetics of MDL 16,455A in healthy male volunteers. Pharm. Res. s390 (1999).
-
(1999)
Pharm. Res.
-
-
Lippert, C.1
Ling, J.2
Brown, P.3
Burmaster, S.4
Eller, M.5
Cheng, L.6
Thompson, R.7
Weir, S.8
-
7
-
-
0033323809
-
FDA evaluations using in vitro metabolism to predict and interpret in vivo metabolic drug-drug interactions: Impact on labeling
-
B. Davit, K. Reynolds, R. Yuan, F. Ajayi, D. Conner, E. Fadiran, B. Gillespie, C. Sahajwalla, S. M. Huang, and L. J. Lesko. FDA evaluations using in vitro metabolism to predict and interpret in vivo metabolic drug-drug interactions: impact on labeling. J. Clin. Pharmacol. 39:899-910 (1999).
-
(1999)
J. Clin. Pharmacol.
, vol.39
, pp. 899-910
-
-
Davit, B.1
Reynolds, K.2
Yuan, R.3
Ajayi, F.4
Conner, D.5
Fadiran, E.6
Gillespie, B.7
Sahajwalla, C.8
Huang, S.M.9
Lesko, L.J.10
-
8
-
-
0035049380
-
Pharmacokinetic and safety profile of desloratadine and fexofenadine when coadministered with azithromycin: A randomized, placebo-controlled, parallel-group study
-
S. Gupta, C. Banfield, B. Kantesaria, M. Marino, R. Clement, M. Affrime, and V. Batra. Pharmacokinetic and safety profile of desloratadine and fexofenadine when coadministered with azithromycin: a randomized, placebo-controlled, parallel-group study. Clin. Ther. 23:451-466 (2001).
-
(2001)
Clin. Ther.
, vol.23
, pp. 451-466
-
-
Gupta, S.1
Banfield, C.2
Kantesaria, B.3
Marino, M.4
Clement, R.5
Affrime, M.6
Batra, V.7
-
9
-
-
0026795241
-
Regional jejunal perfusion, a new in vivo approach to study oral drug absorption in man
-
H. Lennernas, O. Ahrenstedt, R. Hallgren, L. Knutson, M. Ryde, and L. K. Paalzow. Regional jejunal perfusion, a new in vivo approach to study oral drug absorption in man. Pharm. Res. 9:1243-1251 (1992).
-
(1992)
Pharm. Res.
, vol.9
, pp. 1243-1251
-
-
Lennernas, H.1
Ahrenstedt, O.2
Hallgren, R.3
Knutson, L.4
Ryde, M.5
Paalzow, L.K.6
-
10
-
-
0344687432
-
The effect of ketoconazole on the in vivo intestinal permeability of fexofenadine using a regional perfusion technique
-
C. Tannergren, T. Knutson, L. Knutson, and H. Lennernas. The effect of ketoconazole on the in vivo intestinal permeability of fexofenadine using a regional perfusion technique. Br. J. Clin. Pharmacol. 55:182-190 (2003).
-
(2003)
Br. J. Clin. Pharmacol.
, vol.55
, pp. 182-190
-
-
Tannergren, C.1
Knutson, T.2
Knutson, L.3
Lennernas, H.4
-
11
-
-
0242351210
-
Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine
-
C. Tannergren, N. Petri, L. Knutson, M. Hedeland, U. Bondesson, and H. Lennernas. Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine. Clin. Pharmacol. Ther. 74:423-436 (2003).
-
(2003)
Clin. Pharmacol. Ther.
, vol.74
, pp. 423-436
-
-
Tannergren, C.1
Petri, N.2
Knutson, L.3
Hedeland, M.4
Bondesson, U.5
Lennernas, H.6
-
12
-
-
0032793959
-
OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine
-
M. Cvetkovic, B. Leake, M. F. Fromm, G. R. Wilkinson, and R. B. Kim. OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab. Dispos. 27:866-871 (1999).
-
(1999)
Drug Metab. Dispos.
, vol.27
, pp. 866-871
-
-
Cvetkovic, M.1
Leake, B.2
Fromm, M.F.3
Wilkinson, G.R.4
Kim, R.B.5
-
13
-
-
0036839477
-
Fexofenadine transport in Caco-2 cells: Inhibition with verapamil and ritonavir
-
M. D. Perloff, L. L. von Moltke, and D. J. Greenblatt. Fexofenadine transport in Caco-2 cells: inhibition with verapamil and ritonavir. J. Clin. Pharmacol. 42:1269-1274 (2002).
-
(2002)
J. Clin. Pharmacol.
, vol.42
, pp. 1269-1274
-
-
Perloff, M.D.1
Von Moltke, L.L.2
Greenblatt, D.J.3
-
14
-
-
0035870289
-
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues
-
M. Maliepaard, G. L. Scheffer, I. F. Faneyte, M. A. van Gastelen, A. C. Pijnenborg, A. H. Schinkel, M. J. van De Vijver, R. J. Scheper, and J. H. Schellens. Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Res. 61:3458-3464 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 3458-3464
-
-
Maliepaard, M.1
Scheffer, G.L.2
Faneyte, I.F.3
Van Gastelen, M.A.4
Pijnenborg, A.C.5
Schinkel, A.H.6
Van De Vijver, M.J.7
Scheper, R.J.8
Schellens, J.H.9
-
15
-
-
0034099587
-
Localization, substrate specificity, and drug resistance conferred by conjugate export pumps of the MRP family
-
D. Keppler, T. Kamisako, I. Leier, Y. Cui, A. T. Nies, and H. Tsujii. and J. Konig. Localization, substrate specificity, and drug resistance conferred by conjugate export pumps of the MRP family. Adv. Enzyme Regul. 40:339-349 (2000).
-
(2000)
Adv. Enzyme Regul.
, vol.40
, pp. 339-349
-
-
Keppler, D.1
Kamisako, T.2
Leier, I.3
Cui, Y.4
Nies, A.T.5
Tsujii, H.6
Konig, J.7
-
16
-
-
0025788721
-
Determination of terfenadine and terfenadine acid metabolite in plasma using solid-phase extraction and high-performance liquid chromatography with fluorescence detection
-
J. E. Coutant, P. A. Westmark, P. A. Nardella, S. M. Walter, and R. A. Okerholm. Determination of terfenadine and terfenadine acid metabolite in plasma using solid-phase extraction and high-performance liquid chromatography with fluorescence detection. J. Chromatogr. 570:139-148 (1991).
-
(1991)
J. Chromatogr.
, vol.570
, pp. 139-148
-
-
Coutant, J.E.1
Westmark, P.A.2
Nardella, P.A.3
Walter, S.M.4
Okerholm, R.A.5
-
17
-
-
0031834404
-
P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: The influence of culturing conditions and drug exposure on P-gp expression levels
-
P. Anderle, E. Niederer, W. Rubas, C. Hilgendorf, H. Spahn-Langguth, H. Wunderli-Allenspach, H. P. Merkle, and P. Langguth. P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels. J. Pharm. Sci. 87:757-762 (1998).
-
(1998)
J. Pharm. Sci.
, vol.87
, pp. 757-762
-
-
Anderle, P.1
Niederer, E.2
Rubas, W.3
Hilgendorf, C.4
Spahn-Langguth, H.5
Wunderli-Allenspach, H.6
Merkle, H.P.7
Langguth, P.8
-
18
-
-
0034960419
-
A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells
-
J. Gao, O. Murase, R. L. Schowen, J. Aube, and R. T. Borchardt. A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells. Pharm. Res. 18:171-176 (2001).
-
(2001)
Pharm. Res.
, vol.18
, pp. 171-176
-
-
Gao, J.1
Murase, O.2
Schowen, R.L.3
Aube, J.4
Borchardt, R.T.5
-
19
-
-
0030023536
-
Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo
-
H. Lennernas, K. Palm, U. Fagerholm, and P. Artursson. Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo. Int. J. Pharm. 127:103-107 (1996).
-
(1996)
Int. J. Pharm.
, vol.127
, pp. 103-107
-
-
Lennernas, H.1
Palm, K.2
Fagerholm, U.3
Artursson, P.4
-
20
-
-
0033922511
-
Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- And MRP2-mediated transport
-
R. Evers, M. Kool, A. J. Smith, L. van Deemter, M. de Haas, and P. Borst. Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2-mediated transport. Br. J. Cancer 83:366-374 (2000).
-
(2000)
Br. J. Cancer
, vol.83
, pp. 366-374
-
-
Evers, R.1
Kool, M.2
Smith, A.J.3
Van Deemter, L.4
De Haas, M.5
Borst, P.6
-
21
-
-
0036288748
-
Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of the coumarinic acid-based cyclic prodrug of the opioid peptide DADLE
-
F. Tangand and R. T. Borchardt. Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of the coumarinic acid-based cyclic prodrug of the opioid peptide DADLE. Pharm. Res. 19:787-793 (2002).
-
(2002)
Pharm. Res.
, vol.19
, pp. 787-793
-
-
Tangand, F.1
Borchardt, R.T.2
-
22
-
-
0029995238
-
Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells
-
R. Evers, G. J. Zaman, L. van Deemter, H. Jansen, J. Calafat, L. C. Oomen, R. P. Oude Elferink, P. Borst, and A. H. Schinkel. Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells. J. Clin. Invest. 97:1211-1218 (1996).
-
(1996)
J. Clin. Invest.
, vol.97
, pp. 1211-1218
-
-
Evers, R.1
Zaman, G.J.2
Van Deemter, L.3
Jansen, H.4
Calafat, J.5
Oomen, L.C.6
Oude Elferink, R.P.7
Borst, P.8
Schinkel, A.H.9
-
23
-
-
0031053478
-
Indomethacin-mediated reversal of multidrug resistance and drug efflux in human and murine cell lines overexpressing MRP, but not P-glycoprotein
-
M. P. Draper, R. L. Martell, and S. B. Levy. Indomethacin-mediated reversal of multidrug resistance and drug efflux in human and murine cell lines overexpressing MRP, but not P-glycoprotein. Br. J. Cancer 75:810-815 (1997).
-
(1997)
Br. J. Cancer
, vol.75
, pp. 810-815
-
-
Draper, M.P.1
Martell, R.L.2
Levy, S.B.3
-
24
-
-
0033812041
-
Probenecid interferes with renal oxidative metabolism: A potential pitfall in its use as an inhibitor of drug transport
-
R. Masereeuw, A. P. van Pelt, S. H. van Os, P. H. Willems, P. Smits, and F. G. Russel. Probenecid interferes with renal oxidative metabolism: a potential pitfall in its use as an inhibitor of drug transport. Br. J. Pharmacol. 131:57-62 (2000).
-
(2000)
Br. J. Pharmacol.
, vol.131
, pp. 57-62
-
-
Masereeuw, R.1
Van Pelt, A.P.2
Van Os, S.H.3
Willems, P.H.4
Smits, P.5
Russel, F.G.6
-
25
-
-
0034709561
-
Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family
-
I. Tamai, J. Nezu, H. Uchino, Y. Sai, A. Oku, M. Shimane, and A. Tsuji. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem. Biophys. Res. Commun. 273:251-260 (2000).
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.273
, pp. 251-260
-
-
Tamai, I.1
Nezu, J.2
Uchino, H.3
Sai, Y.4
Oku, A.5
Shimane, M.6
Tsuji, A.7
-
26
-
-
0038637144
-
Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane
-
D. Kobayashi, T. Nozawa, K. Imai, J. Nezu, A. Tsuji, and I. Tamai. Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. J. Pharmacol. Exp. Ther. 306:703-708 (2003).
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.306
, pp. 703-708
-
-
Kobayashi, D.1
Nozawa, T.2
Imai, K.3
Nezu, J.4
Tsuji, A.5
Tamai, I.6
-
27
-
-
0036293982
-
Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver
-
S. R. Vavricka, J. Van Montfoort, H. R. Ha, P. J. Meier, and K. Fattinger. Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology 36:164-172 (2002).
-
(2002)
Hepatology
, vol.36
, pp. 164-172
-
-
Vavricka, S.R.1
Van Montfoort, J.2
Ha, H.R.3
Meier, P.J.4
Fattinger, K.5
-
28
-
-
0029047741
-
Rifampicin enhances anti-cancer drug accumulation and activity in multidrug-resistant cells
-
O. Fardel, V. Lecureur, P. Loyer, and A. Guillouzo. Rifampicin enhances anti-cancer drug accumulation and activity in multidrug-resistant cells. Biochem. Pharmacol. 49:1255-1260 (1995).
-
(1995)
Biochem. Pharmacol.
, vol.49
, pp. 1255-1260
-
-
Fardel, O.1
Lecureur, V.2
Loyer, P.3
Guillouzo, A.4
-
29
-
-
0032907322
-
Interrelationship between substrates and inhibitors of human CYP3A and P-glyco protein
-
R. B. Kim, C. Wandel, B. Leake, M. Cvetkovic, M. F. Fromm, P. J. Dempsey, M. M. Roden, F. Belas, A. K. Chaudhary, D. M. Roden, A. J. Wood, and G. R. Wilkinson. Interrelationship between substrates and inhibitors of human CYP3A and P-glyco protein. Pharm. Res. 16:408-414 (1999).
-
(1999)
Pharm. Res.
, vol.16
, pp. 408-414
-
-
Kim, R.B.1
Wandel, C.2
Leake, B.3
Cvetkovic, M.4
Fromm, M.F.5
Dempsey, P.J.6
Roden, M.M.7
Belas, F.8
Chaudhary, A.K.9
Roden, D.M.10
Wood, A.J.11
Wilkinson, G.R.12
-
30
-
-
0032422157
-
Pharmacokinetics, pharmacodynamics, and tolerance of single- and multiple-dose fexofenadine hydrochloride in healthy male volunteers
-
T. Russell, M. Stoltz, and S. Weir. Pharmacokinetics, pharmacodynamics, and tolerance of single- and multiple-dose fexofenadine hydrochloride in healthy male volunteers. Clin. Pharmacol. Ther. 64:612-621 (1998).
-
(1998)
Clin. Pharmacol. Ther.
, vol.64
, pp. 612-621
-
-
Russell, T.1
Stoltz, M.2
Weir, S.3
-
31
-
-
0027998369
-
Determinants of apical membrane permeabilities of barrier epithelia
-
M. B. Lande, N. A. Priver, and M. L. Zeidel. Determinants of apical membrane permeabilities of barrier epithelia. Am. J. Physiol. 267:C367-C374 (1994).
-
(1994)
Am. J. Physiol.
, vol.267
-
-
Lande, M.B.1
Priver, N.A.2
Zeidel, M.L.3
-
32
-
-
0033017677
-
Jejunal permeability in humans in vivo and rats in situ: Investigation of molecular size selectivity and solvent drug
-
U. Fagerholm, D. Nilsson, L. Knutson, and H. Lennernas. Jejunal permeability in humans in vivo and rats in situ: investigation of molecular size selectivity and solvent drug. Acta Physiol. Scand. 165:315-324 (1999).
-
(1999)
Acta Physiol. Scand.
, vol.165
, pp. 315-324
-
-
Fagerholm, U.1
Nilsson, D.2
Knutson, L.3
Lennernas, H.4
-
33
-
-
0031780252
-
Jejunal absorption and metabolism of R/S-verapamil in humans
-
R. Sandstrom, A. Karlsson, L. Knutson, and H. Lennernas. Jejunal absorption and metabolism of R/S-verapamil in humans. Pharm. Res. 15:856-862 (1998).
-
(1998)
Pharm. Res.
, vol.15
, pp. 856-862
-
-
Sandstrom, R.1
Karlsson, A.2
Knutson, L.3
Lennernas, H.4
-
34
-
-
0042905800
-
Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium
-
M. D. Troutmanand and D. R. Thakker. Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm. Res. 20:1210-1224 (2003).
-
(2003)
Pharm. Res.
, vol.20
, pp. 1210-1224
-
-
Troutmanand, M.D.1
Thakker, D.R.2
-
35
-
-
0032714220
-
Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs
-
J. Kelder, P. D. Grootenhuis, D. M. Bayada, L. P. Delbressine, and J. P. Ploemen. Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs. Pharm. Res. 16:1514-1519 (1999).
-
(1999)
Pharm. Res.
, vol.16
, pp. 1514-1519
-
-
Kelder, J.1
Grootenhuis, P.D.2
Bayada, D.M.3
Delbressine, L.P.4
Ploemen, J.P.5
-
36
-
-
0032480901
-
Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach
-
S. Winiwarter, N. M. Bonham, F. Ax, A. Hallberg, H. Lennernas, and A. Karlen. Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach. J. Med. Chem. 41:4939-4949 (1998).
-
(1998)
J. Med. Chem.
, vol.41
, pp. 4939-4949
-
-
Winiwarter, S.1
Bonham, N.M.2
Ax, F.3
Hallberg, A.4
Lennernas, H.5
Karlen, A.6
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