Clarithromycin-induced digoxin toxicity: A case report and a review of the literature

Connecticut Medicine

Volumn 65, Issue 9, 2001, Pages 527-529

  Xu, Helena ^a   Rashkow, Andrew ^b  

^a BERKSHIRE MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ATENOLOL; CLARITHROMYCIN; CYTOCHROME P450; DIGOXIN;

AGED; ARTICLE; CASE REPORT; CLINICAL FEATURE; COUGHING; CREATININE BLOOD LEVEL; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG INDUCED DISEASE; ENZYME INHIBITION; FEMALE; HEART ATRIUM FIBRILLATION; HUMAN; INTESTINE FLORA; MEDICAL LITERATURE; NAUSEA; SYMPTOM; TIME; VERTIGO; VOMITING;

AGED; ANTI-ARRHYTHMIA AGENTS; ANTI-BACTERIAL AGENTS; CLARITHROMYCIN; DIGOXIN; DRUG INTERACTIONS; FEMALE; HUMANS; TIME FACTORS;

EID: 0034794892     PISSN: 00106178     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Carey CF, Lee HH, Woeltje, KF: Drug interactions. Washington Manual of Medical Therapeutics, 29th Edition. ISBN: 0-7817-1595-4, 1998:540.
2. Physician's Desk Reference. Medical Economics Company. 1999:405-7.
3. Jacob LS: Pharmacology, 3rd ed. 1992:95-6.
4. Friedman HS, Bonventre MV: Erythromycin-induced digoxin toxicity. Chest 1982; 82:202.
5. Gurevitz SL: Erythromycin: Drug interactions. J Dent Hygiene 1997; 71:159-61.
6. Maxwell DL, Gilmour-White SK, Hall MR: Digoxin toxicity due to interaction of digoxin with erythromycin. BMJ 1989; 298:572.
7. Morton MR, Cooper JW: Erythromycin-induced digoxin toxicity. Drug Intell Clin Pharm 1989; 23:668-70.
8. Rodin SM, Johnson BF: Pharmacokinetic interactions with digoxin. Clin Pharmacokinet 1988; 15:227-44.
9. Sutton A, Pilot MA: Digoxin toxicity and erythromycin. BMJ 1989; 298:1101.
10. Gooderham MJ, Bolli P, Fernandez PG: Concomitant digoxin toxicity and warfarin interaction in a patient receiving clarithromycin. Ann Pharmacother 1999; 33:796-9.
11. Gueriero SE, Ehrenpreis E, Gallagher KL: Two cases of clarithromycin-induced digoxin toxicity. Pharmacotherapy 1997; 17:1035-37.
12. Nawarskas JJ, McCarthy DM, Spinler SA: Digoxin toxicity secondary to clarithromycin therapy. Ann Pharmacother 1997; 31:864-6.
13. NordtSP, Williams SR, Manoguerra AS, Clark RF: Clarithromycin induced digoxin toxicity. J Accid Emerg Med 1998; 15:194-5.
14. Laberge P, Martineau P: Clarithromycin-induced digoxin intoxication. Ann Pharmacother 1997; 31:999-1002.
15. Brown BA, Wallace RJ Jr, Griffith DE, Warden R: Clarithromycin-associated digoxin toxicity in the elderly. Clin Infect Dis 1997; 24: 92-3.
16. Ford A, Smith LC, Baltch AL, Smith RP: Clarithromycin-induced digoxin toxicity in a patient with AIDS. Clin Infect Dis 1995; 21: 1051-2.
17. Midoneck SR, Etingin OR: Clarithromycin-related toxic effects of digoxin. N Engl J Med 1995; 333:1505.
18. Wakasugi H, Yano I, Ito T, et al: Effect of clarithromycin on renal excretion of digoxin: Interaction with P-glycoprotein. Clin Pharmacol Ther 1998; 64:123-8.
19. Greiner B, Eichelbaum M, Fritz P, et al: The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin. J Clin Invest 1999; 104:147-53.
20. Bjzjak ED, Mauro VF: Digoxin-macrolide drug interaction. Ann Pharmacother 1997; 31:1077-9.
21. Von Rosensteil NA, Adam D: Macrolide antibacterials. Drug interactions of clinical significance. Drug Saf 1995; 13:105-22.
22. Salphati, L, Benet LZ: Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: Involvement of cytochrome P4503A. Xenobiotica 1999; 29:171-85.