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Volumn 42, Issue 12, 1998, Pages 3157-3162

Human immunodeficiency virus protease inhibitors serve as substrates for multidrug transporter proteins MDR1 and MRP1 but retain antiviral efficacy in cell lines expressing these transporters

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; CALCEIN; DOXORUBICIN; GLYCOPROTEIN P; INDINAVIR; NELFINAVIR; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR;

EID: 0031788927     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.42.12.3157     Document Type: Article
Times cited : (154)

References (35)
  • 1
    • 0031896882 scopus 로고    scopus 로고
    • Active apical secretory efflux of the HIV protease inhibitors saquinavir and ritonavir in caco-2 cell monolayers
    • Alsenz, J., H. Steffen, and R. Alex. 1998. Active apical secretory efflux of the HIV protease inhibitors saquinavir and ritonavir in caco-2 cell monolayers. Pharm. Res. 15:423-428.
    • (1998) Pharm. Res. , vol.15 , pp. 423-428
    • Alsenz, J.1    Steffen, H.2    Alex, R.3
  • 2
    • 0029846735 scopus 로고    scopus 로고
    • Abnormal expression of a 170 kilodalton P-glycoprotein encoded by MDR1 gene, a metabolically active efflux pump, in CD4+ and CD8+ T cells from patients with human immunodeficiency virus type 1 infection
    • Andreana, A., S. Aggarwal, S. Gollapudi, D. Wien, T. Tsuruo, and S. Gupta. 1996. Abnormal expression of a 170 kilodalton P-glycoprotein encoded by MDR1 gene, a metabolically active efflux pump, in CD4+ and CD8+ T cells from patients with human immunodeficiency virus type 1 infection. AIDS Res. Hum. Retroviruses 12:1457-1462.
    • (1996) AIDS Res. Hum. Retroviruses , vol.12 , pp. 1457-1462
    • Andreana, A.1    Aggarwal, S.2    Gollapudi, S.3    Wien, D.4    Tsuruo, T.5    Gupta, S.6
  • 4
    • 0021055789 scopus 로고
    • Vinca alkaloid-resistant phenotype in cultured human leukemic lymphoblasts
    • Beck, W. T. 1983. Vinca alkaloid-resistant phenotype in cultured human leukemic lymphoblasts. Cancer Treat. Rep. 67:875-882.
    • (1983) Cancer Treat. Rep. , vol.67 , pp. 875-882
    • Beck, W.T.1
  • 5
    • 0020082647 scopus 로고
    • Continued expression of vinca alkaloid resistance by CCRF-CEM cells after treatment with tunicamycin or pronase
    • Beck, W. T., and M. C. Cirtain. 1982. Continued expression of vinca alkaloid resistance by CCRF-CEM cells after treatment with tunicamycin or pronase. Cancer Res. 42:184-189.
    • (1982) Cancer Res. , vol.42 , pp. 184-189
    • Beck, W.T.1    Cirtain, M.C.2
  • 6
    • 0031460605 scopus 로고    scopus 로고
    • Multidrug resistant proteins
    • Borst, P. 1997. Multidrug resistant proteins. Semin. Cancer Biol. 8:131-134.
    • (1997) Semin. Cancer Biol. , vol.8 , pp. 131-134
    • Borst, P.1
  • 7
    • 0030332234 scopus 로고    scopus 로고
    • Multidrug resistance associated with overexpression of MRP
    • Cole, S. P., and R. G. Deeley. 1996. Multidrug resistance associated with overexpression of MRP. Cancer Treat. Res. 87:39-62.
    • (1996) Cancer Treat. Res. , vol.87 , pp. 39-62
    • Cole, S.P.1    Deeley, R.G.2
  • 9
    • 0023158059 scopus 로고
    • Atypical multiple drug resistance human leukemic cell line selected for resistance to teniposide (VM-26)
    • Danks, M. K., J. C. Yalowich, and W. T. Beck. 1987. Atypical multiple drug resistance human leukemic cell line selected for resistance to teniposide (VM-26). Cancer Res. 47:1297-1301.
    • (1987) Cancer Res. , vol.47 , pp. 1297-1301
    • Danks, M.K.1    Yalowich, J.C.2    Beck, W.T.3
  • 11
    • 0029096211 scopus 로고
    • Functional detection MDR1/P170 and MRP/P190-mediated multidrug resistance in tumour cells by flow cytometry
    • Feller, N., C. M. Kuiper, J. Lankelma, J. K. Ruhdal, R. J. Scheper, H. M. Pinedo, and H. J. Broxterman. 1995. Functional detection MDR1/P170 and MRP/P190-mediated multidrug resistance in tumour cells by flow cytometry. Br. J. Cancer 72:543-549.
    • (1995) Br. J. Cancer , vol.72 , pp. 543-549
    • Feller, N.1    Kuiper, C.M.2    Lankelma, J.3    Ruhdal, J.K.4    Scheper, R.J.5    Pinedo, H.M.6    Broxterman, H.J.7
  • 13
    • 0029889967 scopus 로고    scopus 로고
    • Protein kinase C-mediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoprotein
    • Goodfellow, H. R., A. Sardini, S. Ruetz, R. Callaghan, P. Gros, P. A. McNaughton, and C. F. Higgins. 1996. Protein kinase C-mediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoprotein. J. Biol. Chem. 271:13668-13674.
    • (1996) J. Biol. Chem. , vol.271 , pp. 13668-13674
    • Goodfellow, H.R.1    Sardini, A.2    Ruetz, S.3    Callaghan, R.4    Gros, P.5    McNaughton, P.A.6    Higgins, C.F.7
  • 14
    • 0028332661 scopus 로고
    • Calcein accumulation as a fluorometric functional assay of the multidrug transporter
    • Hollo, Z., L. Homolya, C. W. Davis, and B. Sarkardi. 1994. Calcein accumulation as a fluorometric functional assay of the multidrug transporter. Biochim. Biophys. Acta 1191:384.
    • (1994) Biochim. Biophys. Acta , vol.1191 , pp. 384
    • Hollo, Z.1    Homolya, L.2    Davis, C.W.3    Sarkardi, B.4
  • 15
    • 0029878923 scopus 로고    scopus 로고
    • A new method for a quantitative assessment of P-glycoprotein-related multidrug resistance in tumour cells
    • Homolya, L., M. Hollo, M. Muller, E. B. Mechetner, and B. Sarkadi. 1996. A new method for a quantitative assessment of P-glycoprotein-related multidrug resistance in tumour cells. Br. J. Cancer 73:849-855.
    • (1996) Br. J. Cancer , vol.73 , pp. 849-855
    • Homolya, L.1    Hollo, M.2    Muller, M.3    Mechetner, E.B.4    Sarkadi, B.5
  • 16
    • 0027432409 scopus 로고
    • Fluorescent cellular indicators are extruded by the multidrug resistance protein
    • Homolya, L., Z. Hollo, U. A. Germann, I. Pastan, M. M. Gottesman, and B. Sarkadi. 1994. Fluorescent cellular indicators are extruded by the multidrug resistance protein. J. Biol. Chem. 268:21493-21496.
    • (1994) J. Biol. Chem. , vol.268 , pp. 21493-21496
    • Homolya, L.1    Hollo, Z.2    Germann, U.A.3    Pastan, I.4    Gottesman, M.M.5    Sarkadi, B.6
  • 17
    • 0028843163 scopus 로고
    • Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase inhibitor Ro 31-8959
    • Jacobsen, H., K. Yasargil, D. L. Winslow, J. C. Craig, A. Kröhn, I. B. Duncan, and J. Mous. 1995. Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase inhibitor Ro 31-8959. Virology 206:527-534.
    • (1995) Virology , vol.206 , pp. 527-534
    • Jacobsen, H.1    Yasargil, K.2    Winslow, D.L.3    Craig, J.C.4    Kröhn, A.5    Duncan, I.B.6    Mous, J.7
  • 18
    • 0029996654 scopus 로고    scopus 로고
    • Cytotoxic activity of calcein acetoxymethyl ester (Calcein/ AM) on primary cultures of human haematological and solid tumours
    • Jonsson, B., G. Liminga, K. Csoka, H. Fridborg, S. Dhar, P. Nygren, and R. Larsson. 1996. Cytotoxic activity of calcein acetoxymethyl ester (Calcein/ AM) on primary cultures of human haematological and solid tumours. Eur. J. Cancer 32A:883-887.
    • (1996) Eur. J. Cancer , vol.32 A , pp. 883-887
    • Jonsson, B.1    Liminga, G.2    Csoka, K.3    Fridborg, H.4    Dhar, S.5    Nygren, P.6    Larsson, R.7
  • 19
    • 0032492398 scopus 로고    scopus 로고
    • CD4-cell count in HIV-infected individuals remaining viremic with highly active antiretroviral therapy (HAART)
    • Kaufmann, D., G. Pantaleo, P. Sudre, and A. Elenti. 1998. CD4-cell count in HIV-infected individuals remaining viremic with highly active antiretroviral therapy (HAART). Lancet 351:723-724.
    • (1998) Lancet , vol.351 , pp. 723-724
    • Kaufmann, D.1    Pantaleo, G.2    Sudre, P.3    Elenti, A.4
  • 20
    • 0032518290 scopus 로고    scopus 로고
    • The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
    • Kim, R. B., M. F. Fromm, C. Wandell, B. Leake, A. J. J. Wood, D. M. Roden, and C. L. Willman. 1998. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J. Clin. Investig. 101:289-294.
    • (1998) J. Clin. Investig. , vol.101 , pp. 289-294
    • Kim, R.B.1    Fromm, M.F.2    Wandell, C.3    Leake, B.4    Wood, A.J.J.5    Roden, D.M.6    Willman, C.L.7
  • 21
    • 0028340044 scopus 로고
    • Expression of multidrug resistance P-glycoprotein on peripheral blood mononuclear cells of patients with granular lymphocyte-proliferative disorders
    • Kobayashi, Y., N. Watanabe, and K. Oshimi. 1994. Expression of multidrug resistance P-glycoprotein on peripheral blood mononuclear cells of patients with granular lymphocyte-proliferative disorders. Leuk. Lymphoma 14:157-161.
    • (1994) Leuk. Lymphoma , vol.14 , pp. 157-161
    • Kobayashi, Y.1    Watanabe, N.2    Oshimi, K.3
  • 23
    • 18744432281 scopus 로고    scopus 로고
    • HIV-1 protease inhibitors and the MDR1 multidrug transporter
    • Lee, S. C., and B. A. Grabowski. 1998. HIV-1 protease inhibitors and the MDR1 multidrug transporter. J. Clin. Investig. 101:287-288.
    • (1998) J. Clin. Investig. , vol.101 , pp. 287-288
    • Lee, S.C.1    Grabowski, B.A.2
  • 24
    • 0032006574 scopus 로고    scopus 로고
    • A multidrug-resistance protein (MRP)-like transmembrane pump is highly expressed by resting murine T helper (Th)2 cells but not Th1 cells and is induced to equal expression levels in Th1 and Th2 cells after antigenic stimulation in vivo
    • Lohoff, M., S. Prechtl, F. Sommer, M. Roellinghoff, E. Schmitt, G. Gradehand, P. Rohwer, B. D. Stride, S. P. C. Cole, and R. G. Deely. 1998. A multidrug-resistance protein (MRP)-like transmembrane pump is highly expressed by resting murine T helper (Th)2 cells but not Th1 cells and is induced to equal expression levels in Th1 and Th2 cells after antigenic stimulation in vivo. J. Clin. Investig. 101:703-710.
    • (1998) J. Clin. Investig. , vol.101 , pp. 703-710
    • Lohoff, M.1    Prechtl, S.2    Sommer, F.3    Roellinghoff, M.4    Schmitt, E.5    Gradehand, G.6    Rohwer, P.7    Stride, B.D.8    Cole, S.P.C.9    Deely, R.G.10
  • 25
    • 0030665969 scopus 로고    scopus 로고
    • Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione
    • Lorico, A., G. Rappa, R. A. Finch, D. Yang, R. A. Flavell, and A. C. Sartorelli. 1997. Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione. Cancer Res. 57:5238-5242.
    • (1997) Cancer Res. , vol.57 , pp. 5238-5242
    • Lorico, A.1    Rappa, G.2    Finch, R.A.3    Yang, D.4    Flavell, R.A.5    Sartorelli, A.C.6
  • 26
    • 0028978727 scopus 로고
    • Transmembrane P-glycoprotein (P-gp/P-170) in HIV infection: Analysis of lymphocyte surface expression and drug-unrelated function
    • Lucia, M. B., R. Cauda, A. L. Landay, W. Malorni, G. Donelli, and L. Ortona. 1995. Transmembrane P-glycoprotein (P-gp/P-170) in HIV infection: analysis of lymphocyte surface expression and drug-unrelated function. AIDS Res. Hum. Retroviruses 11:893-901.
    • (1995) AIDS Res. Hum. Retroviruses , vol.11 , pp. 893-901
    • Lucia, M.B.1    Cauda, R.2    Landay, A.L.3    Malorni, W.4    Donelli, G.5    Ortona, L.6
  • 28
    • 0030782511 scopus 로고    scopus 로고
    • Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities
    • Shapiro, A. B., and V. Ling. 1997. Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities. Eur. J. Biochem. 250:130-137.
    • (1997) Eur. J. Biochem. , vol.250 , pp. 130-137
    • Shapiro, A.B.1    Ling, V.2
  • 29
    • 0344517168 scopus 로고    scopus 로고
    • HIV growth, inhibition and measurement
    • I. Lefkovitz (ed.), Academic Press, New York, N.Y.
    • Srinivas, R. V., and J. L. Hurwitz. 1997. HIV growth, inhibition and measurement, p. 1959-1973. In I. Lefkovitz (ed.), The immunology methods manual Academic Press, New York, N.Y.
    • (1997) The Immunology Methods Manual , pp. 1959-1973
    • Srinivas, R.V.1    Hurwitz, J.L.2
  • 31
    • 0344295689 scopus 로고    scopus 로고
    • Transcriptional suppression of multidrug resistance protein (MRP) gene expression by wild-type p53
    • abstr. 1147
    • Wang, Q., and W. T. Beck. 1998. Transcriptional suppression of multidrug resistance protein (MRP) gene expression by wild-type p53, abstr. 1147. Proc. Am. Assoc. Cancer Res. Annu. Meet. 39:167.
    • (1998) Proc. Am. Assoc. Cancer Res. Annu. Meet. , vol.39 , pp. 167
    • Wang, Q.1    Beck, W.T.2
  • 33
    • 0027175441 scopus 로고
    • Increased function of P-glycoprotein in T lymphocyte subsets of aging mice
    • Witkowski, J. M., and R. A. Miller. 1993. Increased function of P-glycoprotein in T lymphocyte subsets of aging mice. J. Immunol. 150:1296-1306.
    • (1993) J. Immunol. , vol.150 , pp. 1296-1306
    • Witkowski, J.M.1    Miller, R.A.2
  • 34
    • 0027477829 scopus 로고
    • Expression of multidrug resistance P-glycoprotein on peripheral blood mononuclear cells of patients with granular lymphocyte-proliferative disorders
    • Yamamoto, T., T. Iwasaki, N. Watanabe, K. Oshimi, M. Naito, T. Tsuruo, and Y. Kobayashi. 1993. Expression of multidrug resistance P-glycoprotein on peripheral blood mononuclear cells of patients with granular lymphocyte-proliferative disorders. Blood 81:1342-1346.
    • (1993) Blood , vol.81 , pp. 1342-1346
    • Yamamoto, T.1    Iwasaki, T.2    Watanabe, N.3    Oshimi, K.4    Naito, M.5    Tsuruo, T.6    Kobayashi, Y.7


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