Lymphotoxin pathway directs thymic Aire expression

Nature Immunology

Volumn 4, Issue 11, 2003, Pages 1121-1127

  Chin, Robert K ^a   Lo, James C ^a   Kim, Oliver ^a   Blink, Sarah E ^a   Christiansen, Peter A ^a   Peterson, Pärt ^b   Wang, Yang ^a   Ware, Carl ^c   Fu, Yang Xin ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF TAMPERE   (Finland)

^c LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; LYMPHOTOXIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE POLYENDOCRINOPATHY CANDIDIASIS ECTODERMAL DYSTROPHY; AUTOIMMUNITY; CELL CULTURE; CONTROLLED STUDY; DOWNSTREAM PROCESSING; EPITHELIUM CELL; GENE EXPRESSION; GENE INDUCTION; GENE TARGETING; IMMUNOLOGICAL TOLERANCE; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; THYMOCYTE; THYMUS;

ANIMALS; AUTOANTIBODIES; IMMUNE TOLERANCE; INSULIN; LYMPHOTOXIN BETA RECEPTOR; LYMPHOTOXIN-ALPHA; MICE; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; SPLEEN; THYMUS GLAND; TRANSCRIPTION FACTORS;

EID: 0242624626     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni982     Document Type: Article

References (31)

1. Derbinski, J., Schulte, A., Kyewski, B. & Klein, L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2, 1032-1039 (2001).
2. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. The Finnish-German APECED Consortium. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Nat. Genet. 17, 399-403 (1997).
3. Ahonen, P. Autoimmune polyendocrinopathy-candidosis-ectodermal dystrophy (APECED): autosomal recessive inheritance. Clin. Genet. 27, 535-542 (1985).
4. Bjorses, P., Aaltonen, J., Horelli-Kuitunen, N., Yaspo, M.L. & Peltonen, L. Gene defect behind APECED: a new clue to autoimmunity. Hum. Mol. Genet. 7, 1547-1553 (1998).
5. Peterson, P. et al. APECED: a monogenic autoimmune disease providing new clues to self-tolerance. Immunol. Today 19, 384-386 (1998).
6. Anderson, M.S. et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 298, 1395-1401 (2002).
7. Fu, Y.X. & Chaplin, D.D. Development and maturation of secondary lymphoid tissues. Annu. Rev. Immunol. 17, 399-433 (1999).
8. Ware, C.F., VanArsdale, T.L., Crowe, P.D. & Browning, J.L. The ligands and receptors of the lymphotoxin system. Curr. Top. Microbiol. Immunol. 198, 175-218 (1995).
9. Cyster, J.G. Chemokines and cell migration in secondary lymphoid organs. Science 286, 2098-2102 (1999).
10. Wu, Q. et al. Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptor. J. Exp. Med. 193, 1327-1332 (2001).
11. Agyekum, S. et al. Expression of lymphotoxin-β (LT-β) in chronic inflammatory conditions. J. Pathol. 199, 115-121 (2003).
12. Mackay, F. et al. Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis. Gastroenterology 115, 1464-1475 (1998).
13. Banks, T.A. et al. Lymphotoxin-α-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness. J. Immunol. 155, 1685-1693 (1995).
14. Futterer, A., Mink, K., Luz, A., Kosco-Vilbois, M.H. & Pfeffer, K. The lymphotoxin-β receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 9, 59-70 (1998).
15. Browning, J.L. & French, L.E. Visualization of lymphotoxin-β and lymphotoxin-β receptor expression in mouse embryos. J. Immunol. 168, 5079-5087 (2002).
16. Heino, M. et al. RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse. Eur. J. Immunol. 30, 1884-1893 (2000).
17. Burkly, L. et al. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 373, 531-536 (1995).
18. Dejardin, E. et al. The lymphotoxin-β receptor induces different patterns of gene expression via two NF-κB pathways. Immunity 17, 525-535 (2002).
19. Klug, D.B., Carter, C., Gimenez-Conti, I.B. & Richie, E.R. Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus. J. Immunol. 169, 2842-2845 (2002).
20. Faas, S.J., Rothstein, J.L., Kreider, B.L., Rovera, G. & Knowles, B.B. Phenotypically diverse mouse thymic stromal cell lines which induce proliferation and differentiation of hematopoietic cells. Eur. J. Immunol. 23, 1201-1214 (1993).
21. Vukmanovic, S., Jameson, S.C. & Bevan, M.J. A thymic epithelial cell line induces both positive and negative selection in the thymus. Int. Immunol. 6, 239-246 (1994).
22. Murumagi, A., Vahamurto, P. & Peterson, P. Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter. J. Biol. Chem. 278, 19784-19790 (2003).
23. Ettinger, R. et al. A critical role for lymphotoxin-β receptor in the development of diabetes in nonobese diabetic mice. J. Exp. Med. 193, 1333-1340 (2001).
24. Liston, A., Lesage, S., Wilson, J., Peltonen, L. & Goodnow, C.C. Aire regulates negative selection of organ-specific T cells. Nat. Immunol. 4, 350-354 (2003).
25. Zuklys, S. et al. Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). J. Immunol. 165, 1976-1983 (2000).
26. Yilmaz, Z.B., Weih, D.S., Sivakumar, V. & Weih, F. RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF. Embo. J. 22, 121-130 (2003).
27. Pomerantz, J.L. & Baltimore, D. Two pathways to NF-κB. Mol. Cell. 10, 693-695 (2002).
28. Grech, A.P. et al. Increased thymic B cells but maintenance of thymic structure, T cell differentiation and negative selection in lymphotoxin-α and TNF gene-targeted mice. Dev. Immunol. 8, 61-74 (2000).
29. Weih, F. et al. Both multiorgan inflammation and myeloid hyperplasia in RelB-deficient mice are T cell dependent. J. Immunol. 157, 3974-3979 (1996).
30. Browning, J.L. et al. Characterization of lymphotoxin-αβ complexes on the surface of mouse lymphocytes. J. Immunol. 159, 3288-3298 (1997).
31. De Togni, P. et al. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 264, 703-707 (1994).