Anti-sperm antibodies from infertile patients and their cognate sperm antigens: A review. Identity between SAGA-1, the H6-3C4 antigen, and CD52

American Journal of Reproductive Immunology

Volumn 43, Issue 3, 2000, Pages 134-143

  Diekman, Alan B ^a   Norton, Elizabeth J ^a   Westbrook, V Anne ^a   Klotz, Kenneth L ^a   Naaby Hansen, Søren ^a   Herr, John C ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Anti sperm antibodies; Immunologic infertility; Sperm antigens

Indexed keywords

CARBOHYDRATE; CD52 ANTIGEN; COMPLEMENTARY DNA; GLYCOPROTEIN; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; SPERM ANTIBODY; SPERM ANTIGEN;

ARTICLE; AUTOIMMUNITY; CARBOHYDRATE ANALYSIS; DNA LIBRARY; HUMAN; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INFERTILITY; LYMPHOCYTE; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL; VASECTOMY;

EID: 0033961572     PISSN: 10467408     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.8755-8920.2000.430302.x     Document Type: Article

References (94)

1. Meaker SR: Some aspects of the problem of sterility. Boston Med Surg J 1922; 187:535-539.
2. Rümke P, Hellinga G: Autoantibodies against spermatozoa in sterile men. J Clin Pathol 1959; 32:357-363.
3. Franklin RR, Dukes CD: Antispermatozoal antibody and unexplained infertility. Am J Obstet Gynecol 1964; 89:6-9.
4. Isojima S, Li TS, Ashitaka Y: Immunologic analysis of sperm-immobilizing factor found in sera of women with unexplained sterility. Am J Obstet Gynecol 1968; 101:677-683.
5. Ansbacher R, Keung-Yeung K, Behrman SJ: Clinical significance of sperm antibodies in infertile couples. Fertil Steril 1973; 24:305-308.
6. Ingerslev HJ, Ingerslev M: Clinical findings in infertile women with circulating antibodies against spermatozoa. Fertil Steril 1980; 33:514-520.
7. Etribi A, Ibrahim A, Mahmoud K, El-Haggar S, Hamada T, El-Ahmadi I: Antisperm antibodies and human infertility. Fertil Steril 1982; 37:236-239.
8. Menge A: The incidence and influence of antisperm antibodies in infertile couples on sperm-cervical mucus interactions and subsequent fertility. Fertil Steril 1982; 38:439-446.
9. Clarke GN: Immunoglobulin class and regional specificity of antispermatozoal autoantibodies blocking cervical mucus penetration by human spermatozoa. Am J Reprod Immunol 1988; 16:135-138.
10. Mathur S, Rosenlund C, Carlton M, Caldwell J, Barber M, Rust PF, Williamson HO: Studies on sperm survivaland motility in the presence of cytotoxic sperm antibodies. Am J Reprod Immunol 1988; 17:41-47.
11. Witkin SS, David SS: Effect of sperm antibodies on pregnancy outcome in a subfertile population. Am J Obstet Gynecol 1988; 158:59-62.
12. Menge AC, Beitner O: Interrelationships among semen characteristics, antisperm antibodies, and cervical mucus penetration assays in infertile human couples. Fertil Steril 1989; 51:486-492.
13. Dym M, Cavicchia JC: Further observations on the blood-testis barrier in monkeys. Biol Reprod 1977; 17:390-403.
14. Ritchie AWS, Hargreave TB, James K, Chisholm GD: Intra-epithelial lymphocytes in the normal epididymis. A mechanism for tolerance to sperm autoantigens? Br J Urol 1984; 56:79-83.
15. Mahi-Brown SA, Yule TD, Tung KSK: Evidence for active immunological regulation in prevention of testicular autoimmune disease independent of the blood-testis barrier. Am J Reprod Immunol 1988; 16:165-170.
16. Lord EM, Sensabough GF, Stites DP: Immunosuppressive activity of human seminal plasma. J Immunol 1977; 118:1704-1711.
17. Alexander NJ, Anderson DJ: Immunology of semen. Fertil Steril 1987; 47:192-205.
18. Mellinger B, Goldstein M: New areas of research in male infertility. Urol Clin N Am 1987; 14:619-632.
19. Castilla JA, Molina R, Lopez-Nevot MA, Vergara F, Garrido F, Herruzo AJ: Immunosuppressive properties of human follicular fluid. Fertil Steril 1990; 53:271-275.
20. Peters AJ, Coulam CB: Sperm antibodies. Am J Reprod Immunol 1992; 27:156-162.
21. Alexander NJ, Anderson DJ: Vasectomy: Consequences of autoimmunity to sperm antigens. Fertil Steril 1979; 32:253-260.
22. Meinertz H, Linnet L, Fogh-Andersen P, Hjort T: Antisperm antibodies and fertility after vasovasostomy: A follow-up study of 216 men. Fertil Steril 1990; 54:315-321.
23. Tung KSK, Okada A, Yanagimachi R: Sperm autoantigens and fertilization. I. Effects of antisperm autoantibodies on rouleaux formation, viability, and acrosome reaction of guinea pig spermatozoa. Biol Reprod 1980; 23:877-886.
24. Bronson RG, Cooper G, Rosenfeld D: Sperm antibodies: Their role in infertility. Fertil Steril 1984; 42:171-183.
25. Carron CP, Saling PM: Sperm antigens and immunological interference of fertilization. In Elements of Mammalian Fertilitzation, PM Wassarman (ed.). Boca Raton, FL. CRC Press, 1991, pp 147-176.
26. Lee C-YG, Liu M-S, Su M-W, Zhu J-B: Studies of sperm antigens reactive to HS-11 and HS-63 monoclonal antibodies. In Gamete Interaction: Prospects for Immunocontraception. NJ Alexander, D Griffin, JM Spieler, GMH Waites (eds). New York, Wiley-Liss, Inc, 1990, pp 37-52.
27. D'Cruz OJ, Haas GG, Wang B, DeBault LE: Activation of human complement by IgG antisperm antibody and the demonstration of C3 and C5b-9-mediated immune injury to human sperm. J Immunol 1991; 146:611-620.
28. Menge AC: Effects of isoimmunization and isoantisera against seminal antigens on fertility process in female rabbits. Biol Reprod 1971; 4:137-144.
29. Menge AC: Antiserum inhibition of rabbit spermatozoal adherence of ova. Proc Soc Exp Biol Med 1971; 138:98-102.
30. Yanagimachi R, Okada A, Tung KSK: Sperm autoantigens and fertilization: II. Effects of anti-guinea pig sperm autoantibodies on sperm ovum interactions. Biol Reprod 1981; 24:512-518.
31. Seke M, Mettler L: Influence of spermatozoal antibodies in the reproduction of mice. Am J Reprod Immunol 1982; 2:225-232.
32. Mathur S, Chao L, Schulte BA, Woodley-Miller C, Abdel-Latif A, Fredericks CM, Rust PF, Williamson HO: Sperm and seminal plasma antigens from autoimmune men induce immunological infertility. Arch Androl 1987; 19:161-175.
33. O'Rand MG, Irons GP, Porter JP: Monoclonal antibodies to rabbit sperm autoantigens. I. Inhibition of in vitro fertilitzation and localization on the egg. Biol Reprod 1984; 30:721-729.
34. Wiley LM, OBasaji MF, Overstreet JW, Cross NE, Hanson FW, Chang RJ: Detection of antisperm antibodies: Their localization to human sperm antigens that are transferred to the surface of zona-free hamster oocytes during the sperm penetration assay. Fertil Steril 1987; 48:292-298.
35. Andersen DJ, Alexander NJ: A new look at antifertility vaccines. Fertil Steril 1983; 40:557-571.
36. Hjort T, Griffin PD: The identification of candidate antisens for the development of birth control vaccines. J Reprod Immunol 1985; 8:271-278.
37. Lee C-YG, Huang Y-S, Hu P-C, Gomel V, Menge AC: Analysis of sperm antigens by sodium dodecyl sulfate gel protein blot radioimmunobinding method. Anal Biochem 1982; 123:14-22.
38. Lee C-YG, Lum V, Wong E, Menge A, Huang Y-S: Identification of human sperm antigens to antisperm antibodies. Am J Reprod Immunol 1983; 3:183-187.
39. Poulsen F: The nature of an iso-antigen of the human sperm membrane. J Reprod Immunol 1983; 5:49-54.
40. Lehmann D, Temminck B, Rugna DD, Leibundgut B, Müller H: Blot-immunoblotting test for the detection of anti-sperm antibodies. J Reprod Immunol 1985; 8:329-336.
41. Naaby-Hansen S, Bjerrum OJ: Auto-and iso-antigens of human spermatozoa detected by immunoblotting with human sera after SDS-PAGE. J Reprod Immunol 1985; 7:41-57.
42. Aitken RJ, Hulme MJ, Henderson CJ, Hargreave TB, Ross A: Analysis of the surface labelling characteristics of human spermatozoa and the interaction with antisperm antibodies. J Reprod Fertil 1987; 80:473-485.
43. Hald J, Naaby-Hansen S, Egense J, Hjort T, Bjerrum OJ: Autoantibodies against spermatozoal antigens detected by immunoblotting and agglutination. A longitudinal study of vasectomized males. J Reprod Immunol 1987; 10:15-26.
44. Parslow JMM, Poulton TA, Hay FC: Characterization of sperm antigens reacting with human antisperm antibodies. Clin Exp Immunol 1987; 69:179-187.
45. Aitken RJ, Parslow JM, Hargreave TB, Hendry WF: Influence of antisperm antibodies on human sperm function. Br J Urol 1988; 62:367-373.
46. Mathur S, Chao L, Goust JM, Milroy GT, Woodley-Miller C, Caldwell JZ: Special antigens on sperm from autoimmune infertile men. Am J Reprod Immunol 1988; 17:5-13.
47. Saji F, Ohashi K, Kamiura S, Negoro T, Tanizawa O: Identification and characterization of a human sperm antigen corresponding to sperm-immobilizing antibodies. Am J Reprod Immunol 1988; 17:128-133.
48. Primakoff P, Lathrop W, Bronson R: Identification of human sperm surface glycoproteins recognized by autoantisera from immune infertile men, women, and vasectomized men. Biol Reprod 1990; 42:929-942.
49. Shaha C, Sheshadri T, Talwar GP, Suri A: Sperm antigens defined from polyclonal antisera. In Gamete Interaction: Prospects for Immunocontraception, NJ Alexander, D Griffin, JM Spieler, GMH Waites (eds). New York, Wiley-Liss, Inc, 1990, pp 75-88.
50. Cunningham DS, Fulgham DL, Rayl DL, Hansen KA, Alexander NJ: Antisperm antibodies to sperm suface antigens in women with genital tract infection. Am J Obstet Gynecol 1991; 164:791-796.
51. Shai S, Naot Y: Identification of human sperm antigens reacting with antisperm antibodies from sera and genital tract secretions. Fertil Steril 1992; 58:593-598.
52. Snow K, Ball GD: Characterization of human sperm antisens and antisperm antibodies in infertile patients. Fertil Steril 1992; 58:1011-1019.
53. D'Cruz OJ, Haas GG, Lambert H: Heterogeneity of human sperm surface antigens identified by indirect immunoprecipitation of antisperm antibody bound to biotinylated sperm. J Immunol 1993; 151:1062-1074.
54. de Beer PM, Wind ML, Bouic PJD: Analysis of human sperm membrane antigens reacting with sera from antisperm antibody positive and negative patients by Western blotting. Andrologia 1993; 25:149-152.
55. Wingate EW, Patrick RT, Mathur S: Antigens in capacitated spermatozoa eliciting autoimmune responses. J Urol 1993; 149:1331-1337.
56. Auer J, Pignot-Paintrand I, De Almeida M: Identification of human sperm surface glycoproteins by sperm membrane-specific autoantibodies. Hum Reprod 1995; 10:551-557.
57. Paradisi R, Bellavia APE, Focacci M, Flamigm C: Characterization of human sperm antigens reacting with antisperm antibodies from autologous sera and seminal plasma in a fertile population. J Reprod Immunol 1995; 28:61-73.
58. Suri A, Chhabra S, Upadhyay S: Identification of human sperm antigen recognized by serum of an immunoinfertile woman: A candidate for immunocontraception. Am J Reprod Immunol 1996; 36:317-326.
59. Shetty J, Naaby-Hansen S, Shibahara H, Bronson R, Flickinger CJ, Herr JC: Human sperm proteome: Immunodominant sperm surface antigens identified with sera from infertile men and women. Biol Reprod 1999; 61:61-69.
60. Witkin SS, Vogel-Roccuzzo R, David SS, Berkely A, Goldstein M, Graf M: Heterogeneity of antigenic determinants on human spermatozoa: Relevance to antisperm antibody testing in infertile couples. Am J Obstet Gynecol 1988; 159:1228-1231.
61. Goldberg E, O'Hern PA: Identification of cDNA clones reactive with sera from infertile individuals. In Serono Symposia Publications: Reproductive Immunology, F Dondero, PM Johnson (eds). New York, Raven Press, 1993, pp 35-39.
62. Naaby-Hansen S, Flickinger CJ, Herr JC: Two-dimensional gel electrophoretic analysis of vectorially labelled surface proteins of human spermatozoa. Biol Reprod 1997; 56:771-787.
63. Herr JC: Update on the Center for Recombinant Gamete Contraceptive Vaccinogens. Am J Reprod Immunol 1996; 35:184-189.
64. Diekman AB, Goldberg E: Characterization of a human antigen with sera from infertile patients. Biol Reprod 1994; 50:1070-1087.
65. Liang ZG, O'Hern PA, Yavetz H, Yavetz B, Goldberg E: Human testis cDNAs identified by sera from infertile patients: A molecular biological approach to immunocontraceptive development. Reprod Fertil Dev 1994; 6:297-305.
66. Liu Q-Y, Wang LF, Miao SY, Caterall JF: Expression and characterization of a novel human sperm membrane protein. Biol Reprod 1996; 54:323-330.
67. Isojima S, Kameda K, Tsuji Y, Shigeta M, Ikeda Y, Koyama K: Establishment and characterization of a human hybridoma secreting monoclonal antibody with high titers of sperm immobilizing and agglutination activities against human seminal plasma. J Reprod Immunol 1987; 10:67-78.
68. Kameda K, Tsuji Y, Koyama K, Isojima S: Comparative studies of the antigens recognized by sperm-immobilizing monoclonal antibodies. Biol Reprod 1992; 46:349-357.
69. Tsuji Y, Clausen H, Nudelman E, Kaizu T, Hakomori S-I, Isojima S: Human sperm carbohydrate antigens defined by an antisperm human monoclonal antibody derived from an infertile woman bearing antisperm antibodies in her serum. J Exp Med 1988; 168:343-356.
70. Kameda K, Tsuji Y, Takemura T, Isojima S: Studies on tissue localization of antigen epitope corresponding to the human sperm immobilizing and agglutination monoclonal antibody (H6-3C4). Jpn J Fertil Steril 1990; 35:313-319.
71. Diekman AB, Westbrook-Case VA, Naaby-Hansen S, Klotz KL, Flickinger CJ, Herr JC: Biochemical characterization of Sperm Agglutination Antigen-1, a human sperm antigen implicated in gamete interactions. Biol Reprod 1997; 57:1136-1145.
72. Diekman AB, Norton EJ, Klotz KL, Westbrook VA, Shibahara H, Naaby-Hansen S, Flickinger CJ, Herr JC: N-linked glycan of a sperm CD52 glycoform associated with human infertility. FASEB J 1999; 13:1301-1313.
73. Isojima S, Tsuji Y, Kameda K, Shigeta M, Hakomori S: Coating antigens of human seminal plasma involved in fertilization. In Gamete Interaction: Propects for Immunocontraception, NJ Alexander, D Griffin, JM Spieler, GMH Waites (eds). New York, Wiley-Liss, Inc, 1990, pp 63-74.
74. Rose NR, Hjort T, Rümke P, Harper MJK, Vyazov O: Techniques for detection of iso-and auto-antibodies to human spermatozoa. Clin Exp Immunol 1976; 23:175-199.
75. Fichorova R, Anderson DJ: Use of sperm viability and acrosomal status assays in combination with immunofluorescence technique to ascertain surface expression of sperm antigens. J Reprod Immunol 1991; 20:1-20.
76. Homyk M, Herr JC: Light and electron microscopic immunolocalization of sperm proteins identified by monoclonal antibodies from the World Health Organization Task Force on Sperm Antigens. J Reprod Immunol 1993; 22:237-256.
77. Isojima S, Koyama K: Techniques for sperm immobilization test Arch Androl 1989; 23:185-199.
78. Anderson DJ, Johnson PM, Alexander NJ, Jones WR, Griffin PD: Monoclonal antibodies to human trophoblast and sperm antigens: Report of two WHO-sponsored workshops, June 30, 1986 - Toronto, Canada. J Reprod Immunol 1987; 10:231-257.
79. Kremer J, Jager S: The sperm-cervical mucus contact test: A preliminary report. Fertil Steril 1976; 27:335-340.
80. Mahony MC, Fulgham DL, Blackmore PF, Alexander NJ: Evaluation of human sperm-zona pellucida tight binding by presence of monoclonal antibodies to sperm antigens. J Reprod Immunol 1991; 19:269-285.
81. Xia M-Q, Tone M, Packman L, Hale G, Waldmann H: Characterization of the CAMPATH-1 (CDw52) antigen: Biochemical analysis and cDNA cloning reveal an unusually small peptide backbone. Eur J Immunol 1991; 21:1677-1684.
82. Hale G, Xia M-Q, Tighe HP, Dyer MJS, Waldmann H: The CAMPATH-1 antigen (CDw52). Tissue Antigens 1990; 35:118-127.
83. Treumann A, Lifely MR, Schneider P, Ferguson MAJ: Primary structure of CD52. J Biol Chem 1995; 270:6088-6099.
84. Hale G, Rye PD, Warford A, Lander I, Brito-Babapulle A: The glycosylphosphatidylinositol-anchored lymphocyte antigen CDw52 is associated with the epididymal maturation of human spermatozoa. J Reprod Immunol 1993; 23:189-205.
85. Kirchhoff C, Krull N, Pera I, Ivell R: A major mRNA of the human epididymal principal cells, HE5, encodes the leucocyte differentiation CDw52 antigen peptide backbone. Mol Reprod Dev 1993; 34:8-15.
86. Kirchhoff C: CD52 is the major maturation-associated" sperm membrane antigen. Mol Human Reprod 1996; 2:9-17.
87. Kameda K, Takada Y, Hasegawa A, Tsuji Y, Koyama K, Isojima S: Sperm immobilizing and fertilizationblocking monoclonal antibody 2C6 to human seminal plasma antigen and characterization of the antigen epitope corresponding to the monoclonal antibody. J Reprod Immunol 1991; 20:27-41.
88. Kirchhoff C, Hale G: Cell-to-cell transfer of glycosylphosphatidylinositol-anchored membrane proteins during sperm maturation. Mol Hum Reprod 1996; 2:177-184.
89. Yeung CH, Schröter S, Wagenfeld A, Kirchhoff C, Kliesch S, Poser D, Weinbauer GF, Nieschlag E, Cooper TG: Interaction of the human epididymal protein (HE5) with epididymal spermatozoa from men and Cynomologus monkeys. Mol Reprod Dev 1997; 48:267-275.
90. Rademacher TW, Parekh RB, Dwek RA: Glycobiology. Annu Rev Biochem 1988; 57:785-838.
91. Valentin H, Gelin C, Coulombel L, Zoccola D, Morizet J, Bernard A: The distribution of the CDw52 molecule on blood cells and characterization of its involvement in T cell activation. Transplantation 1992; 54:97-104.
92. Fabian I, Flidel O, Gadish M, Kletter Y, Slavin S, Nagler A: Effects of CAMPATH-1 antibodies on the functional activity of monocytes and polymorphonuclear neutrophils. Exp Hematol 1993; 21:1522-1527.
93. Lund-Johansen F, Olweus J, Symington FW, Arli A, Thompson JS, Vildlla R, Skubitz K, Horejsi V: Activation of human monocytes and granulocytes by monoclonal antibodies to glycosylphosphatidylinositol-anchored antigens. Eur J Immunol 1993; 23:2782-2791.
94. Rowan WC, Hale G, Tite JP, Brett SJ: Cross-linking of the CAMPATH-1 antigen (CD52) triggers activation of normal human T lymphocytes. Int Immunol 1994; 7:69-77.