Generation of CD4+CD25+ regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression

Journal of Immunology

Volumn 168, Issue 9, 2002, Pages 4399-4405

  Kawahata, Kimito ^a   Misaki, Yoshikata ^a   Yamauchi, Michiko ^a   Tsunekawa, Shinji ^a   Setoguchi, Keigo ^a   Miyazaki, Jun Ichi ^a   Yamamoto, Kazuhiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; GENE REARRANGEMENT; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; THYMUS; TRANSGENIC MOUSE;

EID: 0036568942     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.9.4399     Document Type: Article

References (30)

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4. Regulatory T cells: Key controllers of immunologic self-tolerance
5. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
6. The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients
7. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
8. The third function of the thymus
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10. + naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
11. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
12. + immonoregulatory T cells is antigen nonspecific
13. + regulatory T cells induced by an agonist self-peptide
14. Policing the regulators
15. + T cells
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17. Lymphocytes rearrange, edit and revise their antigen receptors to be useful yet safe
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19. Ordered and coordinated rearrangement of the TCR α locus: Role of secondary rearrangement in thymic selection
20. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice
21. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice
22. Induction of autoimmune disease in mice by germline alteration of the T cell receptor gene expression
23. Cytokine imbalance and autoantibody production in T cell receptor-α mutant mice with inflammatory bowel disease
24. + T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis
25. + T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice
26. + autoreactive T cells after proliferation
27. Altered expression level of a systemic nuclear autoantigen determines the fate of immune response to self
28. + regulatory cells that control intestinal inflammation
29. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
30. + immunoregulatory T cells that control autoimmune diabetes