CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells

Journal of Immunology

Volumn 174, Issue 5, 2005, Pages 2591-2601

  Antony, Paul A ^a   Piccirillo, Ciriaco A ^e   Akpinarli, Akgül ^b   Finkelstein, Steven E ^a   Speiss, Paul J ^a   Surman, Deborah R ^a   Palmer, Douglas C ^a   Chan, Chi Chao ^c   Klebanoff, Christopher A ^d   Overwijk, Willem W ^f   Rosenberg, Steven A ^a   Restifo, Nicholas P ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c NATIONAL EYE INSTITUTE   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e MCGILL UNIVERSITY   (Canada)

^f NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; TUMOR ANTIGEN;

ADOPTIVE IMMUNOTHERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; HELPER CELL; LYMPHOCYTE FUNCTION; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VACCINATION;

EID: 20044363610     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.5.2591     Document Type: Article

References (62)

1. + T cells: it may get by with a little help from its friends. J. Clin. Invest. 110:1415.
2. + T-cell response. Nat. Rev. Immunol. 4:595.
3. Bourgeois, C., H. Veiga-Fernandes, A. M. Joret, B. Rocha, and C. Tanchot. 2002. CD8 lethargy in the absence of CD4 help. Eur. J. Immunol. 32:2199.
4. + T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity. J. Exp. Med. 186:2057.
5. Sun, J. C., and M. J. Bevan. 2003. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300:339.
6. + T cells after acute infection. Nat. Immunol. 5:927.
7. + T lymphocytes. Nature 421:852.
8. + T cells have a major "post-licensing" role in CTL mediated anti-tumor immunity. J. Immunol. 165:6047.
9. + regulatory T cells in vivo. J. Exp. Med. 198:249.
10. + regulatory T cells in the steady state. J. Exp. Med. 198:737.
11. Bluestone, J. A., and A. K. Abbas. 2003. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 3:253.
12. Asano, M., M. Toda, N. Sakaguchi, and S. Sakaguchi. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:387.
13. Sakaguchi, S. 2004. Naturally arising CD4 regulatory T cells for immunological self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22:531.
14. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:389.
15. Nelson, B. H. 2004. IL-2, regulatory T cells, and tolerance. J. Immunol. 172:3983.
16. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J. Immunol. 160:1212.
17. + regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J. Immunol. 168:5979.
18. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162:5317.
19. + regulatory cells uncovers immune responses to shared murine tumor rejection antigens. Eur. J. Immunol. 32:3267.
20. + regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J. Exp. Med 194:823.
21. Malek, T., A. Yu, V. Vincek, P. Scibelli, and L. Kong. 2002. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice: implications for the nonredundant function of IL-2. Immunity 17:167.
22. + regulatory T cell homeostasis and the maintenance of self-tolerance. J. Immunol. 171:3435.
23. + T cells. J. Exp. Med. 198:569.
24. + T cells. Proc. Natl. Acad. Sci. USA 101:1969.
25. + T lymphocytes. Proc. Natl. Acad. Sci. USA 96:2982.
26. + immunoregulatory cells. J. Immunol. 167:1137.
27. Mintern, J. D., G. M. Davey, G. T. Belz, F. R. Carbone, and W. R. Heath. 2002. Cutting edge: precursor frequency affects the helper dependence of cytotoxic T cells. J. Immunol 168:977.
28. Berendt, M. J., and R. J. North. 1980. T-cell-mediated suppression of anti-tumor immunity: explanation for progressive growth of an immunogenic tumor. J. Exp. Med. 151:69.
29. Dummer, W., A. G. Niethammer, R. Baccala, B. R. Lawson, N. Wagner, R. A. Reisfeld, and A. N. Theofilopoulos. 2002. T cell homeostatic proliferation elicits effective antitumor autoimmunity. J. Clin. Invest. 110:185.
30. + cytotoxic T-cell responses during chronic viral infection. J. Virol. 68:8056.
31. + regulatory T cell function. J. Exp. Med. 196:851.
32. Depper, J. M., W. J. Leonard, C. Drogula, M. Kronke, T. A. Waldmann, and W. C. Greene. 1985. Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene. Proc. Natl. Acad. Sci. USA 82:4230.
33. Schreurs, M. W., A. J. de Boer, A. Schmidt, C. G. Figdor, and G. J. Adema. 1997. Cloning, expression and tissue distribution of the murine homologue of the melanocyte lineage-specific antigen gp100. Melanoma Res. 7:463.
34. + regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice. Cancer Immun. 2:1.
35. + T cells: a common basis between tumor immunity and autoirrununity. J. Immunol. 163:5211.
36. Apostolou, I., A. Sarukhan, L. Klein, and H. von Boehmer. 2002. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3:756.
37. + immunoregulatory T cells hinder tumor immunotherapy? J. Immunother. 25:202.
38. + regulatory T cells. J. Immunol. 171:5678.
39. Yu, P., Y. Lee, W. Liu, R. K. Chin, J. Wang, Y. Wang, A. Schietinger, M. Philip, H. Schreiber, and Y. X. Fu. 2004. Priming of naive T cells inside tumors leads to eradication of established tumors. Nat. Immunol. 5:141.
40. + T cell adoptive immunotherapy. Immunity 13:265.
41. + T cell- and IL-2-dependent mechanism. Immunity 11:483.
42. Rosenberg, S. A. 2004. Shedding light on immunotherapy for cancer. N. Engl. J. Med. 350:1461.
43. + regulatory T cell function. Eur. J. Immunol. 34:2480.
44. Malek, T. R., and A. L. Bayer. 2004. Tolerance, not immunity, crucially depends on IL-2. Nat. Rev. Immunol. 4:665.
45. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287.
46. + T cell suppressor function. J. Immunol. 172:6519.
47. + regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells. Eur. J. Immunol. 30:1538.
48. + regulatory T cells by peripheral expansion. J. Immunol. 173:7259.
49. Kundig, T. M., H. Schorle, M. F. Bachmann, H. Hengartner, R. M. Zinkernagel, and I. Horak. 1993. Immune responses in interleukin-2-deficient mice. Science 262:1059.
50. Horak, I., J. Lohler, A. Ma, and K. A. Smith. 1995. Interleukin-2 deficient mice: a new model to study autoimmunity and self-tolerance. Immunol Rev. 148:35.
51. + T cell numbers. J. Immunol 169:4850.
52. Overwijk, W. W., and N. P. Restifo. 2000. Autoimmunity and the immunotherapy of cancer: targeting the "self" to destroy the "other." Crit. Rev. Immunol. 20:433.
53. Gilboa, E. 2001. The risk of autoimmunity associated with tumor immunotherapy. Nat. Immunol 2:789.
54. Rosenberg, S. A. 2001. Progress in human tumour immunology and immunotherapy. Nature 411:380.
55. Papiernik, M., M. L. de Moraes, C. Pontoux, F. Vasseur, and C. Penit. 1998. Regulatory CD4 T cells: expression of IL-2Rα chain, resistance to clonal deletion and IL-2 dependency. Int. Immunol 10:371.
56. Foss, F. M. 2001. Interleukin-2 fusion toxin: targeted therapy for cutaneous T cell lymphoma. Ann. NY Acad. Sci. 941:166.
57. + T cells in antitumor immunity. Trends Immunol. 22:269.
58. Dudley, M. E., J. R. Wunderlich, P. F. Robbins, J. C. Yang, P. Hwu, D. J. Schwartzentruber, S. L. Topalian, R. Sherry, N. P. Restifo, A. M. Hubicki, et al. 2002. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 298:850.
59. Klebanoff, C, A., H. T. Khong, P. A. Antony, D. C. Palmer, and N. P. Restifo. Sinks, suppressors, and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy. Trends Immunol. In press.
60. + cells. J. Exp. Med. 195:1523.
61. Di Carlo, E., A. Comes, A. M. Orengo, O. Rosso, R. Meazza, P. Musiani, M. P. Colombo, and S. Ferrini. 2004. IL-21 induces tumor rejection by specific CTL and IFN-γ-dependent CXC chemokines in syngeneic mice. J. Immunol. 172:1540.
62. King, C., A. Ilic, K. Koelsch, and N. Sarvetnick. 2004. Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 117:265.