Generation of a complete thymic microenvironment by MTS24+ thymic epithelial cells

Nature Immunology

Volumn 3, Issue 7, 2002, Pages 635-642

  Gill, Jason ^a   Malin, Mark ^a   Hollander, Georg A ^b   Boyd, Richard ^b  

^a MONASH UNIVERSITY MEDICAL SCHOOL   (Australia)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE PROTEIN;

ANIMAL CELL; ARTICLE; CELL LINEAGE; CELL SUBPOPULATION; CONTROLLED STUDY; EMBRYO; EPITHELIUM CELL; IMMUNOCOMPETENCE; LYMPHOCYTOPOIESIS; MICROENVIRONMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGENY; PROLYMPHOCYTE; STEM CELL; T LYMPHOCYTE; THYMOCYTE;

ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL LINEAGE; DNA-BINDING PROTEINS; EMBRYONIC AND FETAL DEVELOPMENT; EPITHELIAL CELLS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; HEMATOPOIESIS, EXTRAMEDULLARY; HEMATOPOIETIC STEM CELLS; HOMEODOMAIN PROTEINS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; PAIRED BOX TRANSCRIPTION FACTORS; STEM CELL FACTOR; T-LYMPHOCYTES; THYMUS GLAND; TRANSCRIPTION FACTORS;

EID: 0036305567     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni812     Document Type: Article

References (49)

1. Lymphostromal interactions in thymic development and function
2. The effect of thymus environment on T cell development and tolerance
3. Development of thymus, parathyroids, and ultimobranchial bodies in NMRI and nude mice
4. Role of neural crest in congenital heart disease
5. Tracing of cells of the avian thymus through embryonic life in interspecific chimeras
6. Morphogenetic interactions in the development of the mouse thymus
7. Dependence of thymus development on derivatives of the neural crest
8. Thymus organogenesis and molecular mechanisms of thymic epithelial cell differentiation
9. The role of Hoxa-3 in mouse thymus and thyroid development
10. Hoxa3 and pax1 transcription factors regulate the ability of fetal thymic epithelial cells to promote thymocyte development
11. Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities
12. Characterization and developmental expression of Pax9, a paired-box- containing gene related to Pax1
13. Pax3 is required for cardiac neural crest migration in the mouse: Evidence from the splotch (Sp2H) mutant
14. Two distinct steps of immigration of hematopoietic progenitors into the early thymus anlage
15. The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors
16. FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi- organ development
17. Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4
18. Development of the thymus requires signaling through the fibroblast growth factor receptor r2-iiib
19. Analysis of thymic stromal cell populations using flow cytometry
20. Difference in antigen presentation pathways between cortical and medullary thymic epithelial cells
21. The antigen presentation pathway in medullary thymic epithelial cells, but not that in cortical thymic epithelial cells, conforms to the endocytic pathway
22. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
23. Epithelial heterogeneity in the murine thymus: A cell surface glycoprotein expressed by subcapsular and medullary epithelium
24. A common stem cell for murine cortical and medullary thymic epithelial cells?
25. Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment
26. Transgenic expression of cyclin DI in thymic epithelial precursors promotes epithelial and T cell development
27. Thymus medulla consisting of epithelial islets each derived from a single progenitor
28. The phenotypic heterogeneity of mouse thymic stromal cells
29. Clonality and life cycles of intestinal crypts explained by a state dependent stochastic model of epithelial stem cell organization
30. Stem cell patterning and fate in human epidermis
31. A gene trap integration provides an early in situ marker for hepatic specification of the foregut endoderm
32. Stem cells: A new lease on life
33. Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
34. Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes
35. Fibroblast dependency during early thymocyte development maps to the CD25+ CD44+ stage and involves interactions with fibroblast matrix molecules
36. An essential role for thymic mesenchyme in early T cell development
37. MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus
38. Selectivity of the major histocompatibility complex class II presentation pathway of cortical thymic epithelial cell lines
39. Discrimination between maintenance- and differentiation-inducing signals during initial and intermediate stages of positive selection
40. CD69 expression discriminates MHC-dependent and- independent stages of thymocyte positive selection
41. Tolerance induction by thymic medullary epithelium
42. CD4 T cell tolerance to nuclear proteins induced by medullary thymic epithelium
43. Mucin-like molecules as modulators of the survival and proliferation of primitive hematopoietic cells
44. Identification of a role for the sialomucin CD164 in myogenic differentiation by signal sequence trapping in yeast
45. The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis
46. Molecular and cellular events in early thymocyte development
47. Thymic stromal elements defined by M. Abs: Ontogeny, and modulation in vivo by immunosuppression
48. Thymic shared antigen-2: A novel cell surface marker associated with T cell differentiation and activation
49. Identification and characterization of thymic epithelial progenitor cells