-
1
-
-
0033615678
-
A direct estimate of the human αβT cell receptor diversity
-
Arstila, T. P. et al. A direct estimate of the human αβT cell receptor diversity. Science 286, 958-961 (1999).
-
(1999)
Science
, vol.286
, pp. 958-961
-
-
Arstila, T.P.1
-
2
-
-
0032171644
-
A very high level of crossreactivity is an essential feature of the T-cell receptor
-
Mason, D. A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol. Today 19, 395-404 (1998).
-
(1998)
Immunol. Today
, vol.19
, pp. 395-404
-
-
Mason, D.1
-
3
-
-
0035171545
-
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
-
Derbinski, J., Schulte, A., Kyewski, B. & Klein, L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nature Immunol. 2, 1032-1039 (2001).
-
(2001)
Nature Immunol.
, vol.2
, pp. 1032-1039
-
-
Derbinski, J.1
Schulte, A.2
Kyewski, B.3
Klein, L.4
-
4
-
-
0030175881
-
T cell clones to epitopes of glutamic acid decarboxylase 65 raised from normal subjects and patients with insulin-dependent diabetes
-
Lohmann, T., Leslie, R. D. & Londei, M. T cell clones to epitopes of glutamic acid decarboxylase 65 raised from normal subjects and patients with insulin-dependent diabetes. J. Autoimmun. 9, 385-389 (1996).
-
(1996)
J. Autoimmun.
, vol.9
, pp. 385-389
-
-
Lohmann, T.1
Leslie, R.D.2
Londei, M.3
-
5
-
-
0033023871
-
T cell autoreactivity to proinsulin epitopes in diabetic patients and healthy subjects
-
Semana, G., Gausling, R., Jackson, R. A. & Hafler, D. A. T cell autoreactivity to proinsulin epitopes in diabetic patients and healthy subjects. J. Autoimmun. 12, 259-267 (1999).
-
(1999)
J. Autoimmun.
, vol.12
, pp. 259-267
-
-
Semana, G.1
Gausling, R.2
Jackson, R.A.3
Hafler, D.A.4
-
6
-
-
0034507693
-
Impact of negative selection on the T cell repertoire reactive to a self-peptide: A large fraction of T cell clones escapes clonal deletion
-
Bouneaud, C., Kourilsky, P. & Bousso, P. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity 13, 829-840 (2000).
-
(2000)
Immunity
, vol.13
, pp. 829-840
-
-
Bouneaud, C.1
Kourilsky, P.2
Bousso, P.3
-
7
-
-
0032515016
-
Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking
-
Alferink, J. et al. Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking. Science 282, 1338-1341 (1998).
-
(1998)
Science
, vol.282
, pp. 1338-1341
-
-
Alferink, J.1
-
8
-
-
0030024279
-
Immunology taught by viruses
-
Zinkernagel, R. M. Immunology taught by viruses. Science 271, 173-178 (1996).
-
(1996)
Science
, vol.271
, pp. 173-178
-
-
Zinkernagel, R.M.1
-
9
-
-
0031821976
-
Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction
-
Kurts, C., Miller, J. F., Subramaniam, R. M., Carbone, F. R. & Heath, W. R. Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction J. Exp. Med. 188, 409-414 (1998).
-
(1998)
J. Exp. Med.
, vol.188
, pp. 409-414
-
-
Kurts, C.1
Miller, J.F.2
Subramaniam, R.M.3
Carbone, F.R.4
Heath, W.R.5
-
10
-
-
0033579875
-
Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes
-
Hoglund, P. et al. Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes. J. Exp. Med. 189, 331-339 (1999). Pancreatic, but not renal, antigen presentation is compromised in juvenile mice, probably explaining the delay in onset of disease in diabetes-prone mouse strains.
-
(1999)
J. Exp. Med.
, vol.189
, pp. 331-339
-
-
Hoglund, P.1
-
11
-
-
0029978038
-
Checkpoints in the progression of autoimmune disease: Lessons from diabetes models
-
Andre, I. et al. Checkpoints in the progression of autoimmune disease: lessons from diabetes models. Proc. Natl Acad. Sci. USA 93, 2260-2263 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 2260-2263
-
-
Andre, I.1
-
12
-
-
0023143676
-
Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
-
Jenkins, M. K. & Schwartz, R. H. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165, 302-319 (1987).
-
(1987)
J. Exp. Med.
, vol.165
, pp. 302-319
-
-
Jenkins, M.K.1
Schwartz, R.H.2
-
13
-
-
0029986723
-
+ T cells from tolerance induction by the superantigen staphylococcal enterotoxin B
-
+ T cells from tolerance induction by the superantigen staphylococcal enterotoxin B. Eur. J. Immunol. 26, 858-862 (1996).
-
(1996)
Eur. J. Immunol.
, vol.26
, pp. 858-862
-
-
Lane, P.1
Haller, C.2
McConnell, F.3
-
14
-
-
0029120245
-
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
-
Krummel, M. F. & Allison, J. P. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182, 459-465 (1995).
-
(1995)
J. Exp. Med.
, vol.182
, pp. 459-465
-
-
Krummel, M.F.1
Allison, J.P.2
-
15
-
-
0029953858
-
CTLA-4 ligation blocks CD28-dependent T cell activation
-
Walunas, T. L., Bakker, C. Y. & Bluestone, J. A. CTLA-4 ligation blocks CD28-dependent T cell activation. J. Exp. Med. 183, 2541-2550 (1996).
-
(1996)
J. Exp. Med.
, vol.183
, pp. 2541-2550
-
-
Walunas, T.L.1
Bakker, C.Y.2
Bluestone, J.A.3
-
16
-
-
0030966217
-
Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
-
Perez, V. L. et al. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6, 411-417 (1997).
-
(1997)
Immunity
, vol.6
, pp. 411-417
-
-
Perez, V.L.1
-
17
-
-
0032522488
-
CTLA-4 regulates tolerance induction and T cell differentiation in vivo
-
Walunas, T. L. & Bluestone, J. A. CTLA-4 regulates tolerance induction and T cell differentiation in vivo. J. Immunol. 160, 3855-3860 (1998).
-
(1998)
J. Immunol.
, vol.160
, pp. 3855-3860
-
-
Walunas, T.L.1
Bluestone, J.A.2
-
18
-
-
0028867420
-
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
-
Tivol, E. A. et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3, 541-547 (1995).
-
(1995)
Immunity
, vol.3
, pp. 541-547
-
-
Tivol, E.A.1
-
19
-
-
0028791059
-
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
-
Waterhouse, P. et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270, 985-988 (1995).
-
(1995)
Science
, vol.270
, pp. 985-988
-
-
Waterhouse, P.1
-
20
-
-
0035901597
-
Fingerprints of anergic T cells
-
Lechner, O. et al. Fingerprints of anergic T cells. Curr. Biol. 11, 587-595 (2001).
-
(2001)
Curr. Biol.
, vol.11
, pp. 587-595
-
-
Lechner, O.1
-
21
-
-
0033180181
-
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
-
Nishimura, H., Nose, M., Hiai, H., Minato, N. & Honjo, T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11, 141-151 (1999). Mice on a C57/BL6 background that lack PD-1 exhibit glomerulonephritis and arthritis that is exacerbated if the Fas pathway is also defective. Lymphocytic infiltration of multiple organs is observed in 2C TCR transgenic mice that lack PD1.
-
(1999)
Immunity
, vol.11
, pp. 141-151
-
-
Nishimura, H.1
Nose, M.2
Hiai, H.3
Minato, N.4
Honjo, T.5
-
22
-
-
0035846991
-
Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
-
Nishimura, H. et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 291, 319-322 (2001).
-
(2001)
Science
, vol.291
, pp. 319-322
-
-
Nishimura, H.1
-
23
-
-
0034596948
-
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
-
Freeman, G. J. et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192, 1027-1034 (2000).
-
(2000)
J. Exp. Med.
, vol.192
, pp. 1027-1034
-
-
Freeman, G.J.1
-
24
-
-
5844264920
-
PD-L2 is a second ligand for PD-I and inhibits T cell activation
-
Latchman, Y. et al. PD-L2 is a second ligand for PD-I and inhibits T cell activation. Nature Immunol. 2, 261-268 (2001).
-
(2001)
Nature Immunol.
, vol.2
, pp. 261-268
-
-
Latchman, Y.1
-
25
-
-
0034921235
-
The expanding world of co-stimulation: The two-signal model revisited
-
Chambers, C. A. The expanding world of co-stimulation: the two-signal model revisited. Trends Immunol. 22, 217-223 (2001).
-
(2001)
Trends Immunol.
, vol.22
, pp. 217-223
-
-
Chambers, C.A.1
-
27
-
-
0034177889
-
H2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis
-
H2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis. J. Immunol. 164, 3563-3572 (2000).
-
(2000)
J. Immunol.
, vol.164
, pp. 3563-3572
-
-
Young, D.A.1
-
28
-
-
0033104725
-
H2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes
-
H2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes. J. Immunol. 162, 2511-2520 (1999).
-
(1999)
J. Immunol.
, vol.162
, pp. 2511-2520
-
-
Bradley, L.M.1
-
29
-
-
0030742237
-
H2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice
-
H2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice. J. Exp. Med 186, 299-306 (1997).
-
(1997)
J. Exp. Med.
, vol.186
, pp. 299-306
-
-
Pakala, S.V.1
Kurrer, M.O.2
Katz, J.D.3
-
31
-
-
0035809311
-
Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice
-
Chensue, S. W. et al. Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice. J. Exp. Med. 193, 573-584 (2001).
-
(2001)
J. Exp. Med.
, vol.193
, pp. 573-584
-
-
Chensue, S.W.1
-
32
-
-
0028466130
-
Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo
-
Kearney, E. R., Pape, K. A., Loh, D. Y. & Jenkins, M. K. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1, 327-339 (1994).
-
(1994)
Immunity
, vol.1
, pp. 327-339
-
-
Kearney, E.R.1
Pape, K.A.2
Loh, D.Y.3
Jenkins, M.K.4
-
33
-
-
0032753621
-
Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers
-
Walker, L. S. et al. Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers. J. Exp. Med. 190, 1115-1122 (1999)
-
(1999)
J. Exp. Med.
, vol.190
, pp. 1115-1122
-
-
Walker, L.S.1
-
34
-
-
0032701695
-
In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines
-
Ansel, K. M., McHeyzer-Williams, L. J., Ngo, V. N., McHeyzer-Williams, M. G. & Cyster J. G. In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J. Exp. Med. 190, 1123-1134 (1999).
-
(1999)
J. Exp. Med.
, vol.190
, pp. 1123-1134
-
-
Ansel, K.M.1
McHeyzer-Williams, L.J.2
Ngo, V.N.3
McHeyzer-Williams, M.G.4
Cyster, J.G.5
-
35
-
-
0033679060
-
BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis
-
Luther, S. A., Lopez, T., Bai, W., Hanahan, D. & Cyster J. G. BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis. Immunity 12, 471-481 (2000).
-
(2000)
Immunity
, vol.12
, pp. 471-481
-
-
Luther, S.A.1
Lopez, T.2
Bai, W.3
Hanahan, D.4
Cyster, J.G.5
-
36
-
-
0035908021
-
+ dendritic cells in murine lupus and preferential chemotaxis of B1 cells towards BLC
-
+ dendritic cells in murine lupus and preferential chemotaxis of B1 cells towards BLC. J. Exp. Med. 193, 1393-1402 (2001).
-
(2001)
J. Exp. Med.
, vol.193
, pp. 1393-1402
-
-
Ishikawa, S.1
-
37
-
-
0026568919
-
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
-
Watanabe-Fukunaga, R., Brannan, C. I., Copeland, N. G., Jenkins, N. A. & Nagata, S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356, 314-317 (1992). First direct evidence for a non-redundant role of the Fas pathway in maintaining self-tolerance.
-
(1992)
Nature
, vol.356
, pp. 314-317
-
-
Watanabe-Fukunaga, R.1
Brannan, C.I.2
Copeland, N.G.3
Jenkins, N.A.4
Nagata, S.5
-
38
-
-
0027500801
-
Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene
-
Sobel, E. S., Kakkanaiah, V. N., Cohen, P. L. & Eisenberg, R. A. Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene. Int. Immunol. 5, 127-1278 (1993).
-
(1993)
Int. Immunol.
, vol.5
, pp. 127-1278
-
-
Sobel, E.S.1
Kakkanaiah, V.N.2
Cohen, P.L.3
Eisenberg, R.A.4
-
39
-
-
0027145632
-
Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family
-
Suda, T., Takahashi, T., Golstein, P. & Nagata, S. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75, 1169-1178 (1993).
-
(1993)
Cell
, vol.75
, pp. 1169-1178
-
-
Suda, T.1
Takahashi, T.2
Golstein, P.3
Nagata, S.4
-
40
-
-
0029025441
-
Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome
-
Fisher, G. H. et al. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell 81, 935-946 (1995).
-
(1995)
Cell
, vol.81
, pp. 935-946
-
-
Fisher, G.H.1
-
41
-
-
0034995242
-
T cell-specific loss of Pten leads to defects in central and peripheral tolerance
-
Suzuki, A. et al. T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity 14, 523-534 (2001).
-
(2001)
Immunity
, vol.14
, pp. 523-534
-
-
Suzuki, A.1
-
42
-
-
0035920554
-
Requirement for transforming growth factor β1 in controlling T cell apoptosis
-
Chen, W. et al. Requirement for transforming growth factor β1 in controlling T cell apoptosis. J. Exp. Med. 194, 439-454 (2001).
-
(2001)
J. Exp. Med.
, vol.194
, pp. 439-454
-
-
Chen, W.1
-
43
-
-
0026017971
-
Interleukin-2 programs mouse αβ T lymphocytes for apoptosis
-
Lenardo, M. J. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature 353, 858-861 (1991).
-
(1991)
Nature
, vol.353
, pp. 858-861
-
-
Lenardo, M.J.1
-
44
-
-
0031569514
-
Functional responses and apoptosis of CD25 (IL-2Rα)-deficient T cells expressing a transgenic antigen receptor
-
Van Parijs, L. et al. Functional responses and apoptosis of CD25 (IL-2Rα)-deficient T cells expressing a transgenic antigen receptor. J. Immunol. 158, 3738-3745 (1997).
-
(1997)
J. Immunol.
, vol.158
, pp. 3738-3745
-
-
Van Parijs, L.1
-
45
-
-
0033199317
-
Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death
-
Van Parijs, L. et al. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity 11, 281-288 (1999).
-
(1999)
Immunity
, vol.11
, pp. 281-288
-
-
Van Parijs, L.1
-
46
-
-
17544398702
-
Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis
-
Refaeli, Y., Van Parijs, L., London, C. A., Tschopp, J. & Abbas, A. K. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 8, 615-623 (1998).
-
(1998)
Immunity
, vol.8
, pp. 615-623
-
-
Refaeli, Y.1
Van Parijs, L.2
London, C.A.3
Tschopp, J.4
Abbas, A.K.5
-
48
-
-
0028784289
-
Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
-
Willerford, D. M. et al. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3, 521-530 (1995).
-
(1995)
Immunity
, vol.3
, pp. 521-530
-
-
Willerford, D.M.1
-
49
-
-
0034654319
-
Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors
-
Malek, T. R., Porter, B. O., Codias, E. K., Scibelli, P. & Yu, A. Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors. J. Immunol. 164, 2905-2914 (2000).
-
(2000)
J. Immunol.
, vol.164
, pp. 2905-2914
-
-
Malek, T.R.1
Porter, B.O.2
Codias, E.K.3
Scibelli, P.4
Yu, A.5
-
50
-
-
0028485743
-
The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice
-
Singer, G. G. & Abbas, A. K. The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1, 365-371 (1994). In vivo peptide administration induces thymic deletion even in the absence of Fas signalling, but peripheral T-cell deletion is impaired.
-
(1994)
Immunity
, vol.1
, pp. 365-371
-
-
Singer, G.G.1
Abbas, A.K.2
-
51
-
-
0029097729
-
Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo
-
Mogil, R. J. et al. Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo. Int. Immunol. 7, 1451-1458 (1995).
-
(1995)
Int. Immunol.
, vol.7
, pp. 1451-1458
-
-
Mogil, R.J.1
-
52
-
-
0029036647
-
+ T cells responding to a bacterial superantigen
-
+ T cells responding to a bacterial superantigen. J. Immunol. 154, 4302-4308 (1995).
-
(1995)
J. Immunol.
, vol.154
, pp. 4302-4308
-
-
Ettinger, R.1
-
53
-
-
0033151622
-
Reactive oxygen species regulate activation-induced T cell apoptosis
-
Hildeman, D. A. et al. Reactive oxygen species regulate activation-induced T cell apoptosis. Immunity 10, 735-744 (1999).
-
(1999)
Immunity
, vol.10
, pp. 735-744
-
-
Hildeman, D.A.1
-
54
-
-
0032005484
-
The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens
-
Van Parijs, L., Peterson, D. A. & Abbas, A. K. The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens. Immunity 8, 265-274 (1998).
-
(1998)
Immunity
, vol.8
, pp. 265-274
-
-
Van Parijs, L.1
Peterson, D.A.2
Abbas, A.K.3
-
55
-
-
0026791975
-
The immune system evolved to discriminate infectious nonself from noninfectious self
-
Janeway, C. A. Jr. The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol. Today 13, 11-16 (1992).
-
(1992)
Immunol. Today
, vol.13
, pp. 11-16
-
-
Janeway C.A., Jr.1
-
56
-
-
0030831210
-
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
-
Medzhitov, R., Preston-Hurlburt, P. & Janeway, C. A. Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388, 394-397 (1997). Cloning and characterization of a human homologue of the Drosophila Toll protein that can activate the NF-κB pathway.
-
(1997)
Nature
, vol.388
, pp. 394-397
-
-
Medzhitov, R.1
Preston-Hurlburt, P.2
Janeway C.A., Jr.3
-
57
-
-
0034680145
-
Toll-like receptors in the induction of the innate immune response
-
Aderem, A. & Ulevitch, R. J. Toll-like receptors in the induction of the innate immune response. Nature 406, 782-787 (2000).
-
(2000)
Nature
, vol.406
, pp. 782-787
-
-
Aderem, A.1
Ulevitch, R.J.2
-
58
-
-
0032509295
-
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
-
Poltorak, A. et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085-2088 (1998).
-
(1998)
Science
, vol.282
, pp. 2085-2088
-
-
Poltorak, A.1
-
59
-
-
0028201732
-
Tolerance, danger, and the extended family
-
Matzinger, P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12, 991-1045 (1994).
-
(1994)
Annu. Rev. Immunol.
, vol.12
, pp. 991-1045
-
-
Matzinger, P.1
-
60
-
-
0033747044
-
Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway
-
Basu, S., Binder, R. J., Suto, R., Anderson, K. M. & Srivastava, P. K. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway. Int. Immunol. 12, 1539-1546 (2000).
-
(2000)
Int. Immunol.
, vol.12
, pp. 1539-1546
-
-
Basu, S.1
Binder, R.J.2
Suto, R.3
Anderson, K.M.4
Srivastava, P.K.5
-
61
-
-
0029812040
-
Constitutive class I-restricted exogenous presentation of self antigens in vivo
-
Kurts, C. et al. Constitutive class I-restricted exogenous presentation of self antigens in vivo. J. Exp. Med. 184, 923-930 (1996). First demonstration of how tissue-associated antigens, which are not accessible to recirculating T cells, can be presented by bone-marrow-derived APCs to CD8 T cells in the context of MHC class I.
-
(1996)
J. Exp. Med.
, vol.184
, pp. 923-930
-
-
Kurts, C.1
-
62
-
-
0032543225
-
+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells
-
+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells. J. Exp. Med. 187, 1555-1564 (1998).
-
(1998)
J. Exp. Med.
, vol.187
, pp. 1555-1564
-
-
Adler, A.J.1
-
63
-
-
0035253699
-
Dendritic cells are sufficient to cross-present self-antigens to CD8 T cells in vivo
-
Kurts, C., Cannarile, M., Klebba, I. & Brocker, T. Dendritic cells are sufficient to cross-present self-antigens to CD8 T cells in vivo. J. Immunol. 166, 1439-1442 (2001).
-
(2001)
J. Immunol.
, vol.166
, pp. 1439-1442
-
-
Kurts, C.1
Cannarile, M.2
Klebba, I.3
Brocker, T.4
-
64
-
-
0034655262
-
CC chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: Critical role in migration from the tumor site to draining lymph nodes
-
Hirao, M. et al. CC chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: critical role in migration from the tumor site to draining lymph nodes. Cancer Res. 60, 2209-2217 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 2209-2217
-
-
Hirao, M.1
-
65
-
-
0032695108
-
Natural adjuvants: Endogenous activators of dendritic cells
-
Gallucci, S., Lolkema, M. & Matzinger, P. Natural adjuvants: endogenous activators of dendritic cells. Nature Med. 5, 1249-1255 (1999).
-
(1999)
Nature Med.
, vol.5
, pp. 1249-1255
-
-
Gallucci, S.1
Lolkema, M.2
Matzinger, P.3
-
66
-
-
0034614897
-
Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
-
Sauter, B. et al. Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J. Exp. Med. 191, 423-434 (2000).
-
(2000)
J. Exp. Med.
, vol.191
, pp. 423-434
-
-
Sauter, B.1
-
67
-
-
0034614894
-
A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes
-
Huang, F. P. et al. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J. Exp. Med. 191, 435-444 (2000).
-
(2000)
J. Exp. Med.
, vol.191
, pp. 435-444
-
-
Huang, F.P.1
-
68
-
-
0031798137
-
Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells
-
Inaba, K. et al. Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells. J. Exp. Med. 188, 2163-2173 (1998).
-
(1998)
J. Exp. Med.
, vol.188
, pp. 2163-2173
-
-
Inaba, K.1
-
69
-
-
0040089526
-
Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein HSC 73
-
Thery, C. et al. Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein HSC 73. J. Cell. Biol. 147, 599-610 (1999).
-
(1999)
J. Cell. Biol.
, vol.147
, pp. 599-610
-
-
Thery, C.1
-
70
-
-
0035862333
-
Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells
-
Dhodapkar, M. V. Steinman, R. M., Krasovsky, J., Munz, C. & Bhardwaj, N. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J. Exp. Med. 193, 233-238 (2001).
-
(2001)
J. Exp. Med.
, vol.193
, pp. 233-238
-
-
Dhodapkar, M.V.1
Steinman, R.M.2
Krasovsky, J.3
Munz, C.4
Bhardwaj, N.5
-
72
-
-
0033985780
-
+ immunoregulatory T cells is antigen nonspecific
-
+ immunoregulatory T cells is antigen nonspecific. J. Immunol. 164, 183-190 (2000).
-
(2000)
J. Immunol.
, vol.164
, pp. 183-190
-
-
Thornton, A.M.1
Shevach, E.M.2
-
73
-
-
0031821875
-
+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
-
+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production J. Exp. Med. 186, 287-296 (1998).
-
(1998)
J. Exp. Med.
, vol.186
, pp. 287-296
-
-
Thornton, A.M.1
Shevach, E.M.2
-
74
-
-
0033853625
-
+ T functionally and phenotypically distinct immunoregulatory T cell subpopulation
-
+ T functionally and phenotypically distinct immunoregulatory T cell subpopulation. Int. Immunol. 12, 1145-1155 (2000).
-
(2000)
Int. Immunol.
, vol.12
, pp. 1145-1155
-
-
Kuniyasu, Y.1
-
75
-
-
0033682056
-
+ immunoregulatory T cells that control autoimmune diabetes
-
+ immunoregulatory T cells that control autoimmune diabetes. Immunity 12, 431-440 (2000).
-
(2000)
Immunity
, vol.12
, pp. 431-440
-
-
Salomon, B.1
-
76
-
-
0034679567
-
+ regulatory cells that control intestinal inflammation
-
+ regulatory cells that control intestinal inflammation. J. Exp. Med. 192, 295-302 (2000).
-
(2000)
J. Exp. Med.
, vol.192
, pp. 295-302
-
-
Read, S.1
Malmstrom, V.2
Powrie, F.3
-
77
-
-
0034679560
-
+ regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
-
+ regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192, 303-310 (2000).
-
(2000)
J. Exp. Med.
, vol.192
, pp. 303-310
-
-
Takahashi, T.1
-
78
-
-
0035102196
-
CTLA-4 regulates induction of anergy in vivo
-
Greenwald, R. J., Boussiotis, V. A., Lorsbach, R. B., Abbas, A. K. & Sharpe, A. H. CTLA-4 regulates induction of anergy in vivo. Immunity 14, 145-155 (2001).
-
(2001)
Immunity
, vol.14
, pp. 145-155
-
-
Greenwald, R.J.1
Boussiotis, V.A.2
Lorsbach, R.B.3
Abbas, A.K.4
Sharpe, A.H.5
-
79
-
-
0030704726
-
+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
-
+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389, 737-742 (1997).
-
(1997)
Nature
, vol.389
, pp. 737-742
-
-
Groux, H.1
-
80
-
-
0035885068
-
Differentiation of regulatory T cells 1 is induced by CD2 costimulation
-
Wakkach, A., Cottrez, F. & Groux, H. Differentiation of regulatory T cells 1 is induced by CD2 costimulation. J. Immunol. 167, 3107-3113 (2001).
-
(2001)
J. Immunol.
, vol.167
, pp. 3107-3113
-
-
Wakkach, A.1
Cottrez, F.2
Groux, H.3
-
82
-
-
0034613767
-
+ T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
-
+ T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. 192, 1213-1222 (2000).
-
(2000)
J. Exp. Med.
, vol.192
, pp. 1213-1222
-
-
Jonuleit, H.1
Schmitt, E.2
Schuler, G.3
Knop, J.4
Enk, A.H.5
-
84
-
-
0033523607
-
An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
-
Asseman, C., Mauze, S., Leach, M. W., Coffman, R. L. & Powrie, F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190, 995-1004 (1999).
-
(1999)
J. Exp. Med.
, vol.190
, pp. 995-1004
-
-
Asseman, C.1
Mauze, S.2
Leach, M.W.3
Coffman, R.L.4
Powrie, F.5
-
85
-
-
0035284810
-
Regulatory and effector CD4 T cells in nonobese diabetic mice recognize overlapping determinants on glutamic acid decarboxylase and use distinct Vβ genes
-
Quinn, A. et al. Regulatory and effector CD4 T cells in nonobese diabetic mice recognize overlapping determinants on glutamic acid decarboxylase and use distinct Vβ genes. J. Immunol. 166, 2982-2991 (2001).
-
(2001)
J. Immunol.
, vol.166
, pp. 2982-2991
-
-
Quinn, A.1
-
86
-
-
0030796646
-
Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading
-
Miller, S. D. et al. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading. Nature Med. 3, 1133-1136 (1997).
-
(1997)
Nature Med.
, vol.3
, pp. 1133-1136
-
-
Miller, S.D.1
-
87
-
-
0032570826
-
Molecular mimicry by herpes simplex virus-type 1: Autoimmune disease after viral infection
-
Zhao, Z. S., Granucci, F., Yeh, L., Schaffer, P. A. & Cantor, H. Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection. Science 279, 1344-1347 (1998).
-
(1998)
Science
, vol.279
, pp. 1344-1347
-
-
Zhao, Z.S.1
Granucci, F.2
Yeh, L.3
Schaffer, P.A.4
Cantor, H.5
-
88
-
-
0033605250
-
Chlamydia infections and heart disease linked through antigenic mimicry
-
Bachmaier, K. et al. Chlamydia infections and heart disease linked through antigenic mimicry. Science 283, 1335-1339 (1999).
-
(1999)
Science
, vol.283
, pp. 1335-1339
-
-
Bachmaier, K.1
-
89
-
-
0032521903
-
Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology
-
Hemmer, B. et al. Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology. J. Immunol. 160, 3631-3636 (1998).
-
(1998)
J. Immunol.
, vol.160
, pp. 3631-3636
-
-
Hemmer, B.1
-
90
-
-
0032772850
-
Quantitative determination of TCR cross-reactivity using peptide librades and protein databases
-
Hiemstra, H. S. et al. Quantitative determination of TCR cross-reactivity using peptide librades and protein databases. Eur. J. Immunol. 29, 2385-2391 (1999).
-
(1999)
Eur. J. Immunol.
, vol.29
, pp. 2385-2391
-
-
Hiemstra, H.S.1
-
91
-
-
0034980187
-
Autoimmune mechanisms in antibiotic treatment-resistant lyme arthritis
-
Steere, A. C., Gross, D., Meyer, A. L. & Huber, B. T. Autoimmune mechanisms in antibiotic treatment-resistant lyme arthritis. J. Autoimmun. 16, 263-288 (2001).
-
(2001)
J. Autoimmun.
, vol.16
, pp. 263-288
-
-
Steere, A.C.1
Gross, D.2
Meyer, A.L.3
Huber, B.T.4
-
92
-
-
0031832479
-
A viral peptide with limited homology to a self peptide can induce clinical signs of experimental autoimmune encephalomyelitis
-
Gautam, A. M., Liblau, R., Chelvanayagam, G., Steinman, L. & Boston, T. A viral peptide with limited homology to a self peptide can induce clinical signs of experimental autoimmune encephalomyelitis. J. Immunol. 161, 60-64 (1998).
-
(1998)
J. Immunol.
, vol.161
, pp. 60-64
-
-
Gautam, A.M.1
Liblau, R.2
Chelvanayagam, G.3
Steinman, L.4
Boston, T.5
-
93
-
-
0034910152
-
Analysis of the relationship between viral infection and autoimmune disease
-
Panoutsakopoulou, V. et al. Analysis of the relationship between viral infection and autoimmune disease. Immunity 15, 137-147 (2001).
-
(2001)
Immunity
, vol.15
, pp. 137-147
-
-
Panoutsakopoulou, V.1
-
94
-
-
0026039673
-
Transgenic mice expressing human tumour necrosis factor: A predictive genetic model of arthritis
-
Keffer, J. et al. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J. 10, 4025-4031 (1991).
-
(1991)
EMBO J.
, vol.10
, pp. 4025-4031
-
-
Keffer, J.1
-
95
-
-
0031874342
-
Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry
-
Horwitz, M. S. et al. Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry. Nature Med. 4, 781-785 (1998).
-
(1998)
Nature Med.
, vol.4
, pp. 781-785
-
-
Horwitz, M.S.1
-
96
-
-
0032473581
-
+ T cells to cause immunopathology
-
+ T cells to cause immunopathology. J. Exp. Med. 187, 763-774 (1998).
-
(1998)
J. Exp. Med.
, vol.187
, pp. 763-774
-
-
Ehl, S.1
-
97
-
-
0034280106
-
Natural killer cells determine the outcome of B cell-mediated autoimmunity
-
Shi, F. D. et al. Natural killer cells determine the outcome of B cell-mediated autoimmunity. Nature Immunol. 1, 245-251 (2000).
-
(2000)
Nature Immunol.
, vol.1
, pp. 245-251
-
-
Shi, F.D.1
-
98
-
-
0029825150
-
+-like thymocytes in the NOD mouse
-
+-like thymocytes in the NOD mouse. Eur. J. Immunol. 26, 2989-2998 (1996).
-
(1996)
Eur. J. Immunol.
, vol.26
, pp. 2989-2998
-
-
Gombert, J.M.1
-
99
-
-
0032538904
-
Overexpression of natural killer T cells protects Vα14-Jα281 transgenic nonobese diabetic mice against diabetes
-
Lehuen, A. et al. Overexpression of natural killer T cells protects Vα14-Jα281 transgenic nonobese diabetic mice against diabetes. J. Exp. Med. 188, 1831-1839 (1998).
-
(1998)
J. Exp. Med.
, vol.188
, pp. 1831-1839
-
-
Lehuen, A.1
-
100
-
-
0035817251
-
CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes
-
Wang, B., Geng, Y. B. & Wang, C. R. CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes. J. Exp. Med. 194, 313-320 (2001).
-
(2001)
J. Exp. Med.
, vol.194
, pp. 313-320
-
-
Wang, B.1
Geng, Y.B.2
Wang, C.R.3
-
101
-
-
0035320679
-
+ regulatory T cells induced by an agonist self-peptide
-
+ regulatory T cells induced by an agonist self-peptide. Nature Immunol. 2, 301-306 (2001).
-
(2001)
Nature Immunol.
, vol.2
, pp. 301-306
-
-
Jordan, M.S.1
-
103
-
-
0035164360
-
Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: A role of CD40 in regulatory T cell development
-
Kumanogoh, A. et al. Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development. J. Immunol. 166, 353-360 (2001).
-
(2001)
J. Immunol.
, vol.166
, pp. 353-360
-
-
Kumanogoh, A.1
|