T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: The soluble form is more effective than the membrane-bound form

Journal of Immunology

Volumn 170, Issue 8, 2003, Pages 3954-3962

  Zhang, Meifen ^a   Vacchio, Melanie S ^b   Vistica, Barbara P ^a   Lesage, Sylvie ^c   Egwuagu, Charles E ^a   Yu, Cheng Rong ^a   Gelderman, Monique P ^a   Kennedy, Michael C ^a   Wawrousek, Eric F ^a   Gery, Igal ^a  

^a NATIONAL EYE INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c Biology and Environment   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CRYSTALLIN; LIPOCORTIN 5; LYSOZYME;

ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CELL POPULATION; CONTROLLED STUDY; DENDRITIC CELL; EYE INFLAMMATION; FLOW CYTOMETRY; GENE DELETION; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MOUSE; NICK END LABELING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; THYMOCYTE; TRANSGENIC MOUSE;

EID: 0037446749     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.8.3954     Document Type: Article

References (37)

1. Kappler, J. H., M. Roehm, and P. Marrack. 1987. T cell tolerance by clonal elimination in the thymus. Cell 49:273.
2. Kisielow, P., and H. von Boehmer. 1995. Development and selection of T-cells: facts and puzzles. Adv. Immunol. 58:87.
3. Fowlkes, B. J., and F. Ramsdell. 1993. T-cell tolerance. Curr. Opin. Immunol. 5:873.
4. Sprent, J., and H. Kishimoto. 1998. T cell tolerance and the thymus. Ann. NY Acad. Sci. 841:236.
5. Stockinger, B. 1999. T lymphocyte tolerance: from thymic deletion to peripheral control mechanisms. Adv. Immunol. 71:229.
6. Peterson, D. A., R. J. DiPaolo, O. Kanagawa, and E. R. Unanue. 1999. Quantitative analysis of the T cell repertoire that escapes negative selection. Immunity 11:453.
7. Surh, C. D., and J. Sprent. 1994. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372:100.
8. Klein, L., and B. Kyewski. 2000. Self-antigen presentation by thymic stromal cells: a subtle division of labor. Curr. Opin. Immunol. 12:179.
9. Derbinski J., A. Schulte, B. Kyewski, and L. Klein. 2001. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2:1032.
10. Lai, J. C., A. Fukushima, E. F. Wawrousek, M. C. Lobanoff, P. Charukamnoetkanok, S. J. Smith-Gill, B. P. Vistica, R. S. Lee, C. E. Egwuagu, S. M. Whitcup, and I. Gery. 1998. Immunotolerance against a foreign antigen transgenically expressed in the lens. Invest. Ophthalmol. Vis. Sci. 39:2049.
11. + T cells. J. Exp. Med. 179:1539.
12. Goodnow, C. C., J. Crosbie, S. Adelstein, T. B. Lavoie, S. J. Smith-Gill, R. A. Brink, H. Pritchard-Briscoe, J. S. Wotherspoon, R. H. Loblay, K. Raphael, et al. 1988. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334:676.
13. Hartley, S. B., J. Crosbie, R. Brink, A. B. Kantor, A. Basten, and C. C. Goodnow. 1991. Elimination from the peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature 353:765.
14. Akkaraju, S., W. Y. Ho, D. Leong, K. Canaan, M. M. Davis, and C. C. Goodnow. 1997. A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis and insulitis. Immunity 7:255.
15. Smith-Gill, S. J., A. C. Wilson, M. Potter, R. J. Feldmann, C. R. Mainhart. 1982. Mapping the antigenic epitope for a monoclonal antibody against avian lysozyme. J. Immunol. 128:314.
16. Egwuagu, C. E., C. R. Yu, M. Zhang, R. M. Mahdi, S. J. Kim, and I. Gery. 2002. Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance. J. Immunol. 168:3181.
17. Jiang, S. P., and M. S. Vacchio. 1998. Multiple mechanisms of peripheral T cell tolerance to the fetal "allograft." J. Immunol. 160:3086.
18. de Vos, A. F., A. Fukushima, M. C. Lobanoff, B. P. Vistica, J. C. Lai, J.-C. Grivel, E. F. Wawrousek, S. M. Whitcup, and I. Gery. 2000. Breakdown of tolerance to a neo-self antigen in double transgenic mice in which B cells present the antigen. J. Immunol. 164:4594.
19. Bird, J., J. D. R. Brown, A. C. Jullen, N. H. Moskowitz, M. A. Mahowald, J. R. Sider, T. F. Gajewski, C.-R. Wang, and S. L. Reiner. 1998. Helper T cell differentiation is controlled by the cell cycle. Immunity 9:229.
20. Mueller, D. L., M. K. Jenkins, and R. H. Schwartz. 1989. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T-cell antigen receptor occupancy. Annu. Rev. Immunol. 7:445.
21. Vermes, I., C. Haanen, H. Steffens-Nakken, and C. Reutelingsperger. 1995. A novel assay for apoptosis: flow cytometric detection of phoshatidylserine expression on early apoptotic cells using fluorescein labeled Annexin V. J. Immunol. Methods 184:39.
22. Gavrieli, Y., Y. Sherman, and S. A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:493.
23. Viret, C., A. K. Barlow, and C. A. Janeway, Jr. 1999. On the intrathymic intercellular transfer of self-determinants. Immunol. Today 20:8.
24. b complex by isolated thymic stromal cells. Int. Immunol. 6:1949.
25. Klein, L., T. Klein, U. Ruther, and B. Kyewski. 1998. CD4 T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by medullary thymic epithelium. J. Exp. Med. 188:5.
26. Wack, A., H. M. Ladyman, O. Williams, K. Roderick, M. A. Ritter, and D. Kioussis. 1996. Direct visualization of thymocyte apoptosis in neglect, acute and steady-state negative selection. Int. Immunol. 8:1537.
27. Douek, D. C., K. T. T. Corley, T. Zal, A. Mellor, P. J. Dyson, and D. Altmann. 1996. Negative selection by endogenous antigen and superantigen occurs at multiple thymic sites. Int. Immunol. 8:1413.
28. Smith, K. M., D. C. Olson, R. Hirose, and D. Hanahan. 1997. Pancreatic gene expression in rare cells of thymic medulla; evidence for functional contribution to T cell tolerance. Int. Immunol. 9:1355.
29. Pugliese, A., D. Brown, D. Garza, D. Murchison, M. Zeller, M. Redondo, J. Diez, J. S. Eisenbarth, D. D. Patel, and C. Ricordi. 2001. Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs. J. Clin. Invest. 107:555.
30. Martin, S., and M. J. Bevan. 1997. Antigen-specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection. Eur. J. Immunol. 27:2726.
31. Lai, J. C., M. C. Lobanoff, A. Fukushima, E. F. Wawrousek, C.-C. Chan, S. M. Whitcup, and I. Gery. 1999. Uveitis induced by lymphocytes sensitized against a transgenically expressed lens protein. Invest. Ophthalmol. Vis. Sci. 40:2735.
32. Zinkemagel, R. M., and A. Althage. 1999. On the role of thymic epithelium vs. bone marrow-derived cells in repertoire selection of T cells. Proc. Natl. Acad. Sci. USA 96:8092.
33. Pietropaolo, M., N. Giannoukakis, and M. Trucco. 2002. Cellular environment and freedom of gene expression. Nat. Immunol. 3:335.
34. Pugliese, A., and J. Diez. 2002. Lymphoid organs contain diverse cells expressing self-molecules. Nat. Immunol. 3:335.
35. Kyewski, B., J. Derbinski, A. Schulte, and L. Klein. 2002. Response. Nat. Immunol. 3:336.
36. Klein, L., B. Roettinger, and B. Kyewski. 2001. Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance. Eur. J. Immunol. 31:2476.
37. Oukka, M., E. Colucci-Guyon, P. L. Tran, M. Cohen-Tannoudji, C. Babinet, V. Lotteau, and K. Kosmatopoulos. 1996. CD4 T cell tolerance to nuclear proteins induced by medullary thymic epithelium. Immunity 4:545.