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Volumn 2, Issue 8, 2002, Pages 569-579

Exosomes: Composition, biogenesis and function

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; AMINOPEPTIDASE; ANNEXIN; CYTOSKELETON PROTEIN; DIPEPTIDYL PEPTIDASE IV; ENOLASE; EPITOPE; HEAT SHOCK PROTEIN; HLA A1 ANTIGEN; HLA ANTIGEN; HLA DP ANTIGEN; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; MAGE3 EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PADGEM PROTEIN; RAB PROTEIN; RNA; TETRASPANIN; THIOREDOXIN PEROXIDASE; TUBULIN; UNCLASSIFIED DRUG;

EID: 0036676445     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri855     Document Type: Review
Times cited : (4412)

References (69)
  • 1
    • 0019874126 scopus 로고
    • Exfoliation of membrane ecto-enzymes in the form of microvesicles
    • Trams, E. G., Lauter C. J., Salem, N. Jr & Heine, U. Exfoliation of membrane ecto-enzymes in the form of microvesicles, Biochim. Biophys. Acta 645, 63-70 (1981).
    • (1981) Biochim. Biophys. Acta , vol.645 , pp. 63-70
    • Trams, E.G.1    Lauter, C.J.2    Salem N., Jr.3    Heine, U.4
  • 2
    • 0022201056 scopus 로고
    • Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes
    • Pan, B. T., Teng, K., Wu, C., Adam, M. & Johnstone, R. M. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J. Cell Biol. 101, 942-948 (1985).
    • (1985) J. Cell Biol. , vol.101 , pp. 942-948
    • Pan, B.T.1    Teng, K.2    Wu, C.3    Adam, M.4    Johnstone, R.M.5
  • 3
    • 0020804037 scopus 로고
    • Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes
    • Harding, C., Heuser, J. & Stahl, P. Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. J. Cell Biol. 97, 329-339 (1983). References 2 and 3 describe very detailed and careful electron-microscopy analyses of the fate of an endocytosed protein in reticulocytes, and point out, for the first time, the possible secretion of the content of multivesicular late endosomes into the extracellular space.
    • (1983) J. Cell Biol. , vol.97 , pp. 329-339
    • Harding, C.1    Heuser, J.2    Stahl, P.3
  • 4
    • 0023645106 scopus 로고
    • Vesicle formation during reticulocyte maturation. Association of plasma-membrane activities with released vesicles (exosomes)
    • Johnstone, R. M., Adam, M., Hammond, J. R., Orr, L. & Turbide, C. Vesicle formation during reticulocyte maturation. Association of plasma-membrane activities with released vesicles (exosomes). J. Biol. Chem. 262, 9412-9420 (1987).
    • (1987) J. Biol. Chem. , vol.262 , pp. 9412-9420
    • Johnstone, R.M.1    Adam, M.2    Hammond, J.R.3    Orr, L.4    Turbide, C.5
  • 5
    • 0024419921 scopus 로고
    • Molecules relevant for T-cell-target-cell interaction are present in cytolytic granules of human T lymphocytes
    • Peters, P. J. et al. Molecules relevant for T-cell-target-cell interaction are present in cytolytic granules of human T lymphocytes. Eur. J. Immunol. 19, 1469-1475 (1989).
    • (1989) Eur. J. Immunol. , vol.19 , pp. 1469-1475
    • Peters, P.J.1
  • 6
    • 0029989258 scopus 로고    scopus 로고
    • B lymphocytes secrete antigen-presenting vesicles
    • Raposo, G. et al. B lymphocytes secrete antigen-presenting vesicles. J. Exp. Med. 183, 1161-1172 (1996). This study shows, for the first time, the secretion of vesicles that are derived from multivesicular late endosomes by an antigen-presenting cell, and the presence of functional MHC class II molecules on the released exosomes.
    • (1996) J. Exp. Med. , vol.183 , pp. 1161-1172
    • Raposo, G.1
  • 7
    • 0030687649 scopus 로고    scopus 로고
    • Accumulation of major histocompatibility complex class II molecules in mast-cell secretory granules and their release upon degranulation
    • Raposo, G. et al. Accumulation of major histocompatibility complex class II molecules in mast-cell secretory granules and their release upon degranulation. Mol. Biol. Cell 8, 2631-2645 (1997).
    • (1997) Mol. Biol. Cell , vol.8 , pp. 2631-2645
    • Raposo, G.1
  • 8
    • 0031863853 scopus 로고    scopus 로고
    • Eradication of established murine tumors using a novel cell-free vaccine: Dendritic-cell-derived exosomes
    • Zitvogel, L. et al. Eradication of established murine tumors using a novel cell-free vaccine: dendritic-cell-derived exosomes. Nature Med 4, 594-600 (1998). This study shows that exosomes can be secreted by dendritic cells, and that such exosomes can induce antigen-dependent T-cell-mediated immune responses in mice.
    • (1998) Nature Med. , vol.4 , pp. 594-600
    • Zitvogel, L.1
  • 9
    • 0040089526 scopus 로고    scopus 로고
    • Molecular characterization of dendritic-cell-derived exosomes. Selective accumulation of the heat-shock protein hsc73
    • Thery, C. et al. Molecular characterization of dendritic-cell-derived exosomes. Selective accumulation of the heat-shock protein hsc73. J. Cell Biol. 147, 599-610 (1999).
    • (1999) J. Cell Biol. , vol.147 , pp. 599-610
    • Thery, C.1
  • 10
    • 0033485648 scopus 로고    scopus 로고
    • Activated platelets release two types of membrane vesicles: Microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and α-granules
    • Heijnen, H. F., Schiel, A. E., Fijnheer, R., Geuze, H. J. & Sixma, J. J. Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and α-granules. Blood 94, 3791-3799 (1999).
    • (1999) Blood , vol.94 , pp. 3791-3799
    • Heijnen, H.F.1    Schiel, A.E.2    Fijnheer, R.3    Geuze, H.J.4    Sixma, J.J.5
  • 11
    • 0023038425 scopus 로고
    • Selective externalization of an ATP-binding protein structurally related to the clathrin-uncoating ATPase/heat-shock protein in vesicles containing terminal transferrin receptors during reticulocyte maturation
    • Davis, J. Q. Dansereau, D. Johnstone, R. M. & Bennett, V. Selective externalization of an ATP-binding protein structurally related to the clathrin-uncoating ATPase/heat-shock protein in vesicles containing terminal transferrin receptors during reticulocyte maturation. J. Biol. Chem. 261, 15368-15371 (1986).
    • (1986) J. Biol. Chem. , vol.261 , pp. 15368-15371
    • Davis, J.Q.1    Dansereau, D.2    Johnstone, R.M.3    Bennett, V.4
  • 12
    • 0035877018 scopus 로고    scopus 로고
    • Proteomic analysis of dendritic-cell-derived exosomes: A secreted subcellular compartment distinct from apoptotic vesicles
    • Thery, C. et al. Proteomic analysis of dendritic-cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J. Immunol. 166, 7309-7318 (2001). A detailed analysis, together with reference 9, of the protein composition of dendritic-cell-derived exosomes, and a demonstration that they are distinct from apoptotic-cell-derived microvesicles.
    • (2001) J. Immunol. , vol.166 , pp. 7309-7318
    • Thery, C.1
  • 13
    • 0035863818 scopus 로고    scopus 로고
    • Mast-cell-dependent B- and T-lymphocyte activation is mediated by the secretion of immunologically active exosomes
    • Skokos, D. et al. Mast-cell-dependent B- and T-lymphocyte activation is mediated by the secretion of immunologically active exosomes. J. Immunol. 166, 868-876 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 868-876
    • Skokos, D.1
  • 14
    • 0344731338 scopus 로고    scopus 로고
    • Activated human T cells release bioactive Fas ligand and APO2 ligand in microvesicles
    • Martinez-Lorenzo, M. J. et al. Activated human T cells release bioactive Fas ligand and APO2 ligand in microvesicles. J. Immunol. 163, 1274-1281 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 1274-1281
    • Martinez-Lorenzo, M.J.1
  • 15
    • 0036533633 scopus 로고    scopus 로고
    • TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/ζ complex
    • Blanchard, N. et al. TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/ζ complex. J. Immunol. 168, 3235-3241 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 3235-3241
    • Blanchard, N.1
  • 16
    • 20244373139 scopus 로고    scopus 로고
    • Tumor-derived exosomes area source of shared tumor rejection antigens for CTL cross-priming
    • Wolfers, J. et al. Tumor-derived exosomes area source of shared tumor rejection antigens for CTL cross-priming. Nature Med 7, 297-303 (2001).
    • (2001) Nature Med. , vol.7 , pp. 297-303
    • Wolfers, J.1
  • 17
    • 0034909926 scopus 로고    scopus 로고
    • Intestinal epithelial cells secrete exosome-like vesicles
    • van Niel, G. et al. Intestinal epithelial cells secrete exosome-like vesicles. Gastroenterology 121, 337-349 (2001).
    • (2001) Gastroenterology , vol.121 , pp. 337-349
    • Van Niel, G.1
  • 18
    • 0033255046 scopus 로고    scopus 로고
    • Expression of prostasome-like granules by the prostate cancer cell lines PC3, Du145 and LnCaP growth in monolayer
    • Nilsson, B. O., Lennartsson, L., Carlsson, L., Nilsson, S. & Ronquist, G. Expression of prostasome-like granules by the prostate cancer cell lines PC3, Du145 and LnCaP growth in monolayer. Ups. J. Med. Sci. 104, 199-206 (1999).
    • (1999) Ups. J. Med. Sci. , vol.104 , pp. 199-206
    • Nilsson, B.O.1    Lennartsson, L.2    Carlsson, L.3    Nilsson, S.4    Ronquist, G.5
  • 19
    • 0032828462 scopus 로고    scopus 로고
    • Ectosomes released by human neutrophils are specialized functional units
    • Hess, C., Sadallah, S. Hefti, A., Landmann, R. & Schifferli, J. A. Ectosomes released by human neutrophils are specialized functional units. J. Immunol. 163, 4564-4573 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 4564-4573
    • Hess, C.1    Sadallah, S.2    Hefti, A.3    Landmann, R.4    Schifferli, J.A.5
  • 20
    • 0033929004 scopus 로고    scopus 로고
    • Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: A mechanism for cellular human immunodeficiency virus 1 infection
    • Mack, M. et al. Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: a mechanism for cellular human immunodeficiency virus 1 infection. Nature Med. 6, 759-775 (2000).
    • (2000) Nature Med. , vol.6 , pp. 759-775
    • Mack, M.1
  • 21
    • 0035655395 scopus 로고    scopus 로고
    • Rapid secretion of interleukin-1β by microvesicle shedding
    • MacKenzie, A. et al. Rapid secretion of interleukin-1β by microvesicle shedding. Immunity 15, 825-835 (2001).
    • (2001) Immunity , vol.15 , pp. 825-835
    • MacKenzie, A.1
  • 22
    • 0032493658 scopus 로고    scopus 로고
    • Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B lymphocytes
    • Escola, J. M. et al. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B lymphocytes. J. Biol. Chem. 273, 20121-20127 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 20121-20127
    • Escola, J.M.1
  • 23
    • 0032055112 scopus 로고    scopus 로고
    • Decay-accelerating factor (CD55) and membrane inhibitor of reactive lysis (CD59) are released within exosomes during in vitro maturation of reticulocytes
    • Rabesandratana, H., Toutant, J. P., Reggio, H. & Vidal, M. Decay-accelerating factor (CD55) and membrane inhibitor of reactive lysis (CD59) are released within exosomes during in vitro maturation of reticulocytes. Blood 91, 2573-2580 (1998).
    • (1998) Blood , vol.91 , pp. 2573-2580
    • Rabesandratana, H.1    Toutant, J.P.2    Reggio, H.3    Vidal, M.4
  • 24
    • 0035166047 scopus 로고    scopus 로고
    • Analysis of antigen-presenting-cell-derived exosomes, based on immuno-magnetic isolation and flow cytometry
    • Clayton, A. et al. Analysis of antigen-presenting-cell-derived exosomes, based on immuno-magnetic isolation and flow cytometry. J. Immunol. Methods 247, 163-174 (2001).
    • (2001) J. Immunol. Methods , vol.247 , pp. 163-174
    • Clayton, A.1
  • 25
    • 0036214288 scopus 로고    scopus 로고
    • Interaction of heat-shock proteins with peptides and antigen-presenting cells: Chaperoning of the innate and adaptive immune responses
    • Srivastava, P. Interaction of heat-shock proteins with peptides and antigen-presenting cells: chaperoning of the innate and adaptive immune responses. Annu. Rev. Immunol. 20, 395-425 (2002).
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 395-425
    • Srivastava, P.1
  • 26
    • 0025087144 scopus 로고
    • cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences
    • Stubbs, J. D. et al. cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences. Proc. Natl Acad. Sci. USA 87, 8417-8421 (1990).
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 8417-8421
    • Stubbs, J.D.1
  • 27
    • 0034254524 scopus 로고    scopus 로고
    • Follicular dendritic cells carry MHC class-II-expressing microvesicles at their surface
    • Denzer, K. et al. Follicular dendritic cells carry MHC class-II-expressing microvesicles at their surface. J. Immunol. 165, 1259-1265 (2000). The first direct observation of exosomes in a human tissue (tonsils) in the absence of any in vitro culture step. Most of the other data in this paper, however, are obtained after the in vitro culture of B cells.
    • (2000) J. Immunol. , vol.165 , pp. 1259-1265
    • Denzer, K.1
  • 28
    • 0036144685 scopus 로고    scopus 로고
    • Immunoelectron microscopic localization of cholesterol using biotinylated and non-cytolytic perfringolysin O
    • Mobius, W. et al. Immunoelectron microscopic localization of cholesterol using biotinylated and non-cytolytic perfringolysin O. J. Histochem. Cytochem. 50, 43-55 (2002).
    • (2002) J. Histochem. Cytochem. , vol.50 , pp. 43-55
    • Mobius, W.1
  • 29
    • 0029100974 scopus 로고
    • Membrane transport in the endocytic pathway
    • Gruenberg, J. & Maxfield, F. R. Membrane transport in the endocytic pathway. Curr. Opin. Cell Biol. 7, 552-563 (1995).
    • (1995) Curr. Opin. Cell Biol. , vol.7 , pp. 552-563
    • Gruenberg, J.1    Maxfield, F.R.2
  • 30
    • 0034157875 scopus 로고    scopus 로고
    • Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking
    • Babst, M., Odorizzi, G., Estepa, E. J. & Emr, S. D. Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking. Traffic 1, 248-258 (2000).
    • (2000) Traffic , vol.1 , pp. 248-258
    • Babst, M.1    Odorizzi, G.2    Estepa, E.J.3    Emr, S.D.4
  • 31
    • 0036319374 scopus 로고    scopus 로고
    • Exosomes bearing HLA-DR1 molecules need dendritic cells to efficiently stimulate specific T cells
    • Vincent-Schneider, H. et al. Exosomes bearing HLA-DR1 molecules need dendritic cells to efficiently stimulate specific T cells. Int. Immunol. 14, 713-722 (2002).
    • (2002) Int. Immunol. , vol.14 , pp. 713-722
    • Vincent-Schneider, H.1
  • 32
    • 0035958546 scopus 로고    scopus 로고
    • Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-1
    • Katzmann, D. J., Babst, M. & Emr, S. D. Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-1. Cell 106, 145-155 (2001).
    • (2001) Cell , vol.106 , pp. 145-155
    • Katzmann, D.J.1    Babst, M.2    Emr, S.D.3
  • 33
    • 0035823032 scopus 로고    scopus 로고
    • A new ticket for entry into budding vesicles - Ubiquitin
    • Hicke, L. A new ticket for entry into budding vesicles - ubiquitin. Cell 106, 527-530 (2001).
    • (2001) Cell , vol.106 , pp. 527-530
    • Hicke, L.1
  • 34
    • 0035903635 scopus 로고    scopus 로고
    • Sorting of proteins into multivesicular bodies: Ubiquitin-dependent and -independent targeting
    • Reggiori, F. & Pelham, H. R. Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting. EMBO J. 20, 5176-5186 (2001).
    • (2001) EMBO J. , vol.20 , pp. 5176-5186
    • Reggiori, F.1    Pelham, H.R.2
  • 35
    • 0030896981 scopus 로고    scopus 로고
    • The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection
    • Aupeix, K. et al. The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection. J. Clin. Invest. 99, 1546-1554 (1997).
    • (1997) J. Clin. Invest. , vol.99 , pp. 1546-1554
    • Aupeix, K.1
  • 36
    • 0001329891 scopus 로고
    • (eds Neville, M. C. & Daniel, C. W.) (Plenum, New York)
    • Mather, I. H. in The Mammary Gland (eds Neville, M. C. & Daniel, C. W.) 217-267 (Plenum, New York, 1987).
    • (1987) The Mammary Gland , pp. 217-267
    • Mather, I.H.1
  • 37
    • 0031844095 scopus 로고    scopus 로고
    • Glycoproteins of the human milk fat globule in the protection of the breast-fed infant against infections
    • Peterson, J. A., Patton, S. & Hamosh, M. Glycoproteins of the human milk fat globule in the protection of the breast-fed infant against infections. Biol. Neonate 74, 143-162 (1998).
    • (1998) Biol. Neonate , vol.74 , pp. 143-162
    • Peterson, J.A.1    Patton, S.2    Hamosh, M.3
  • 38
    • 17944363138 scopus 로고    scopus 로고
    • Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding
    • Garrus, J. E. et al. Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell 107, 55-65 (2001).
    • (2001) Cell , vol.107 , pp. 55-65
    • Garrus, J.E.1
  • 39
    • 0034940214 scopus 로고    scopus 로고
    • Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55(Gag)
    • VerPlank, L. et al. Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55(Gag). Proc. Natl Acad. Sci. USA 98, 7724-7729 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 7724-7729
    • VerPlank, L.1
  • 40
    • 0035658023 scopus 로고    scopus 로고
    • HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress
    • Martin-Serrano, J., Zang, T. & Bieniasz, P. D. HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress. Nature Med. 7, 1313-1319 (2001).
    • (2001) Nature Med. , pp. 1313-1319
    • Martin-Serrano, J.1    Zang, T.2    Bieniasz, P.D.3
  • 42
    • 0035279058 scopus 로고    scopus 로고
    • SNAREs and the specificity of membrane fusion
    • Pelham, H. R. SNAREs and the specificity of membrane fusion. Trends Cell Biol. 11, 99-101 (2001).
    • (2001) Trends Cell Biol. , vol.11 , pp. 99-101
    • Pelham, H.R.1
  • 43
    • 0034081439 scopus 로고    scopus 로고
    • Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: Functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein-8-containing secretory compartment
    • Paumet, F. et al. Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein-8-containing secretory compartment. J. Immunol. 164, 5850-5857 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 5850-5857
    • Paumet, F.1
  • 44
    • 0034728786 scopus 로고    scopus 로고
    • Rat basophilic leukemia cells express syntaxin-3 and VAMP-7 in granule membranes
    • Hibi, T., Hirashima, N. & Nakanishi, M. Rat basophilic leukemia cells express syntaxin-3 and VAMP-7 in granule membranes. Biochem. Biophys. Res. Commun. 271, 36-41 (2000).
    • (2000) Biochem. Biophys. Res. Commun. , vol.271 , pp. 36-41
    • Hibi, T.1    Hirashima, N.2    Nakanishi, M.3
  • 45
    • 0032555722 scopus 로고    scopus 로고
    • Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell-surface projections regulates compound exocytosis in mast cells
    • Guo, Z. Turner, C. & Castle, D. Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell-surface projections regulates compound exocytosis in mast cells. Cell 94, 537-548 (1998).
    • (1998) Cell , vol.94 , pp. 537-548
    • Guo, Z.1    Turner, C.2    Castle, D.3
  • 46
    • 0034689023 scopus 로고    scopus 로고
    • +-dependent exocytosis of lysosomes in fibroblasts
    • +-dependent exocytosis of lysosomes in fibroblasts. J. Cell Biol. 148, 1141-1149 (2000).
    • (2000) J. Cell Biol. , vol.148 , pp. 1141-1149
    • Martinez, I.1
  • 47
    • 0033577802 scopus 로고    scopus 로고
    • +-triggered exocytosis of lysosomes in mast cells
    • +-triggered exocytosis of lysosomes in mast cells. J. Exp. Med. 189, 1649-1658 (1999).
    • (1999) J. Exp. Med. , vol.189 , pp. 1649-1658
    • Baram, D.1
  • 48
    • 0034599597 scopus 로고    scopus 로고
    • T cells can use either T-cell receptor or CD28 receptors to absorb and internalize cell-surface molecules derived from antigen-presenting cells
    • Hwang, L. et al. T cells can use either T-cell receptor or CD28 receptors to absorb and internalize cell-surface molecules derived from antigen-presenting cells. J. Exp. Med. 191, 1137-1148 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 1137-1148
    • Hwang, L.1
  • 49
    • 0033615606 scopus 로고    scopus 로고
    • TCR-mediated internalization of peptide-MHC complexes acquired by T cells
    • Huang, J. F. et al. TCR-mediated internalization of peptide-MHC complexes acquired by T cells. Science 286, 952-954 (1999).
    • (1999) Science , vol.286 , pp. 952-954
    • Huang, J.F.1
  • 50
    • 0035869425 scopus 로고    scopus 로고
    • Cutting edge: CTLs rapidly capture membrane fragments from target cells in a TCR signaling-dependent manner
    • Hudrisier, D., Riond, J., Mazarguil, H., Gairin, J. E. & Joly, E. Cutting edge: CTLs rapidly capture membrane fragments from target cells in a TCR signaling-dependent manner. J. Immunol. 166, 3645-3649 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 3645-3649
    • Hudrisier, D.1    Riond, J.2    Mazarguil, H.3    Gairin, J.E.4    Joly, E.5
  • 51
    • 0035655587 scopus 로고    scopus 로고
    • The immunological synapse of CTL contains a secretory domain and membrane bridges
    • Stinchcombe, J. C., Bossi, G., Booth, S. & Griffiths, G. M. The immunological synapse of CTL contains a secretory domain and membrane bridges. Immunity 15, 751-761 (2001).
    • (2001) Immunity , vol.15 , pp. 751-761
    • Stinchcombe, J.C.1    Bossi, G.2    Booth, S.3    Griffiths, G.M.4
  • 52
    • 0033082476 scopus 로고    scopus 로고
    • Activated T cells acquire endothelial cell-surface determinants during transendothelial migration
    • Brezinschek, R. I., Oppenheimer-Marks, N. & Upsky, P. E. Activated T cells acquire endothelial cell-surface determinants during transendothelial migration. J. Immunol. 162, 1677-1684 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 1677-1684
    • Brezinschek, R.I.1    Oppenheimer-Marks, N.2    Upsky, P.E.3
  • 53
    • 0034210936 scopus 로고    scopus 로고
    • Acquisition of intact allogeneic human leukocyte antigen molecules by human dendritic cells
    • Russo, V. et al. Acquisition of intact allogeneic human leukocyte antigen molecules by human dendritic cells. Blood 95, 3473-3477 (2000).
    • (2000) Blood , vol.95 , pp. 3473-3477
    • Russo, V.1
  • 54
    • 0035942781 scopus 로고    scopus 로고
    • B cells acquire antigen from target cells after synapse formation
    • Batista, F. D., Iber, D. & Neuberger, M. S. B cells acquire antigen from target cells after synapse formation. Nature 411, 489-494 (2001).
    • (2001) Nature , vol.411 , pp. 489-494
    • Batista, F.D.1    Iber, D.2    Neuberger, M.S.3
  • 55
    • 0033571095 scopus 로고    scopus 로고
    • Class II MHC/peptide complexes are released from APC and are acquired by T-cell responders during specific antigen recognition
    • Patel, D. M., Arnold, P. Y., White, G. A., Nardella, J. R. & Mannie, M. D. Class II MHC/peptide complexes are released from APC and are acquired by T-cell responders during specific antigen recognition. J. Immunol. 163, 5201-5210 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 5201-5210
    • Patel, D.M.1    Arnold, P.Y.2    White, G.A.3    Nardella, J.R.4    Mannie, M.D.5
  • 57
    • 0032717299 scopus 로고    scopus 로고
    • MHC class II molecules transferred between allogeneic dendritic cells stimulate primary mixed leukocyte reactions
    • Bedford, P., Garner, K. & Knight, S. C. MHC class II molecules transferred between allogeneic dendritic cells stimulate primary mixed leukocyte reactions. Int. Immunol. 11, 1739-1744 (1999).
    • (1999) Int. Immunol. , vol.11 , pp. 1739-1744
    • Bedford, P.1    Garner, K.2    Knight, S.C.3
  • 58
    • 0031922605 scopus 로고    scopus 로고
    • Transfer of antigen between dendritic cells in the stimulation of primary T-cell proliferation
    • Knight, S. C., Iqball, S., Roberts, M. S., Macatonia, S. & Bedford, P. A. Transfer of antigen between dendritic cells in the stimulation of primary T-cell proliferation. Eur. J. Immunol. 28, 1636-1644 (1998).
    • (1998) Eur. J. Immunol. , vol.28 , pp. 1636-1644
    • Knight, S.C.1    Iqball, S.2    Roberts, M.S.3    Macatonia, S.4    Bedford, P.A.5
  • 59
    • 0019496788 scopus 로고
    • Cell-surface appearance of unexpected host MHC determinants on thymocytes from radiation bone-marrow chimeras
    • Sharrow, S. O., Mathieson, B. J. & Singer, A. Cell-surface appearance of unexpected host MHC determinants on thymocytes from radiation bone-marrow chimeras. J. Immunol 126, 1327-1335 (1981).
    • (1981) J. Immunol. , vol.126 , pp. 1327-1335
    • Sharrow, S.O.1    Mathieson, B.J.2    Singer, A.3
  • 60
    • 0026033729 scopus 로고
    • Novel pathways of antigen presentation for the maintenance of memory
    • Gray, D., Kosco, M. & Stockinger, B. Novel pathways of antigen presentation for the maintenance of memory. Int. Immunol. 3, 141-148 (1991).
    • (1991) Int. Immunol. , vol.3 , pp. 141-148
    • Gray, D.1    Kosco, M.2    Stockinger, B.3
  • 61
    • 0035823004 scopus 로고    scopus 로고
    • Argosomes: A potential vehicle for the spread of morphogens through epithelia
    • Greco, V., Hannus, M. & Eaton, S. Argosomes: a potential vehicle for the spread of morphogens through epithelia. Cell 106, 633-645 (2001). This study shows a visualization in vivo in embryonic tissues of the transfer of membrane structures that are labelled with a fluorescent lipid between adjacent cells. The membrane structures that are involved have not been characterized.
    • (2001) Cell , vol.106 , pp. 633-645
    • Greco, V.1    Hannus, M.2    Eaton, S.3
  • 62
    • 0020956787 scopus 로고
    • Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor
    • Pan, B. T. & Johnstone, R. M. Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell 33, 967-978 (1983).
    • (1983) Cell , vol.33 , pp. 967-978
    • Pan, B.T.1    Johnstone, R.M.2
  • 63
    • 0034771968 scopus 로고    scopus 로고
    • 'Tolerosomes' are produced by intestinal epithelial cells
    • Karlsson, M. et al. 'Tolerosomes' are produced by intestinal epithelial cells. Eur. J. Immunol. 31, 2892-2900 (2001).
    • (2001) Eur. J. Immunol. , vol.31 , pp. 2892-2900
    • Karlsson, M.1
  • 64
    • 0034661694 scopus 로고    scopus 로고
    • Direct immunosuppressive effects of EBV-encoded latent membrane protein 1
    • Dukers, D. F. et al. Direct immunosuppressive effects of EBV-encoded latent membrane protein 1. J. Immunol. 165, 663-670 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 663-670
    • Dukers, D.F.1
  • 65
    • 0035892735 scopus 로고    scopus 로고
    • Differential secretion of Fas ligand- or APO2 ligand/TNF-related apoptosis-inducing ligand-carrying microvesicles during activation-induced death of human T cells
    • Monleon, I. et al. Differential secretion of Fas ligand- or APO2 ligand/TNF-related apoptosis-inducing ligand-carrying microvesicles during activation-induced death of human T cells. J. Immunol. 167, 6736-6744 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 6736-6744
    • Monleon, I.1
  • 66
    • 0037141153 scopus 로고    scopus 로고
    • Induction of lymphocyte apoptosis by tumor-cell secretion of FasL-bearing microvesicles
    • Andreola, G. et al. Induction of lymphocyte apoptosis by tumor-cell secretion of FasL-bearing microvesicles. J. Exp. Med. 195, 1303-1316 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 1303-1316
    • Andreola, G.1
  • 67
    • 0142252184 scopus 로고    scopus 로고
    • Malignant ascitis accumulate immunogenic tumor-derived exosomes: Novel approach for cancer immunotherapy
    • in the press
    • André, F. et al. Malignant ascitis accumulate immunogenic tumor-derived exosomes: novel approach for cancer immunotherapy. Lancet (in the press).
    • Lancet
    • André, F.1
  • 68
    • 0035109189 scopus 로고    scopus 로고
    • Antigen loading of MHC class I molecules in the endocytic tract
    • Kleiimeer, M. J. et al. Antigen loading of MHC class I molecules in the endocytic tract. Traffic 2, 124-137 (2001).
    • (2001) Traffic , vol.2 , pp. 124-137
    • Kleiimeer, M.J.1
  • 69
    • 0038790644 scopus 로고    scopus 로고
    • Exosomes released during reticulocyte maturation bind to fibronectin via integrin α4β1
    • Rieu, S., Geminard, C., Rabesandratana, H., Sainte-Marie, J. & Vidal, M. Exosomes released during reticulocyte maturation bind to fibronectin via integrin α4β1. Eur. J. Biochem. 267, 583-590 (2000).
    • (2000) Eur. J. Biochem. , vol.267 , pp. 583-590
    • Rieu, S.1    Geminard, C.2    Rabesandratana, H.3    Sainte-Marie, J.4    Vidal, M.5


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