Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy- candidiasis-ectodermal dystrophy (APECED)

Journal of Immunology

Volumn 165, Issue 4, 2000, Pages 1976-1983

  Zuklys, S ^a   Balciunaite, G ^a   Agarwal, A ^a   Fasler Kan, E ^a   Palmer, E ^a   Hollander, G A ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNE POLYENDOCRINOPATHY CANDIDIASIS ECTODERMAL DYSTROPHY; CANDIDIASIS; GENE EXPRESSION; IMMUNOLOGICAL TOLERANCE; MOUSE; MULTIPLE ENDOCRINE ADENOMATOSIS; NONHUMAN; PRIORITY JOURNAL; REGULATOR GENE; T LYMPHOCYTE; THYMUS;

EID: 0034662906     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.4.1976     Document Type: Article

References (68)

1. Dependence of thymus development on derivatives of the neural crest
2. A common stem cell for murine cortical and medullary thymic epithelial cells?
3. The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors
4. Limited development capacity of the earliest embryonic murine thymus
5. Functional histology of the human thymus
6. Thymic microenvironments, 3-D versus 2-D?
7. Thymic T cell development
8. - triple-negative adult mouse thymocytes defined by CD44 and CD25 expression
9. Selection of the T cell repertoire
10. The thymic microenvironment
11. Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes
12. Reorganisation and restoration of thymic medullary epithelial cells in T cell receptor-negative SCID mice: Evidence that receptor-bearing lymphocytes influence maturation of the thymic microenvironment
13. Severe colitis in mice with aberrant thymic selection
14. T-cell differentiation is influenced by thymic microenvironments
15. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex
16. A comparative analysis of the murine thymic microenvironment in normal, autoimmune, and immunodeficiency states
17. The physiological role of regulatory T cells in the prevention of autoimmunity: The function of the thymus in the generation of the regulatory T cell subset
18. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
19. +CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
20. +CD8- thymocytes
21. An inherited disorder of lymphocyte apoptosis: The autoimmune lymphoproliferative syndrome
22. Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II
23. An autosomal locus causing autoimmune disease: Autoimmune polyglandular disease type I assigned to chromosome 21
24. Positional cloning of the APECED gene
25. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
26. Cloning of Aire, the mouse homologue of the autoimmune regulator (AIRE) gene responsible for autoimmune polyglandular syndrome type 1 (ASP1)
27. The mouse Aire gene: Comparative genomic sequencing, gene organization, and expression
28. Isolation and characterization of the mouse Aire gene
29. Gene defect behind APECED: A new clue to autoimmunity
30. The APECED polyglandular autoimmune syndrome protein, AIRE-1, contains the SAND domain and is probably a transcription factor
31. The PHD finger: Implications for chromatin-mediated transcriptional regulation
32. Localization of the APECED protein in distinct nuclear structures
33. Chronic mucocutaneous candidiasis, deficiency of delayed hypersensitivity, and selective local antibody defect
34. The role of cell-mediated immunity in candidiasis
35. Positive selection through a motif in the αβ T cell receptor
36. Thymocytes and RelB-dependant medullary epithelial cells provide growth-promoting and organization signals, respectively, to thymic medullary stromal cells
37. Thymic dendritic cell precursors: Relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny
38. Epithelial heterogeneity in the murine thymus: A cell surface glycoprotein expressed by subcapsular and medullary epithelium
39. Monoclonal antibodies reactive with subsets of mouse and human thymic epithelial cells
40. A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: In situ hybridisation using digoxigenin-labelled cRNA probes
41. Two genetically separable steps in the differentiation of thymic epithelium
42. The nude gene encodes a sequence-specific DNA binding protein with homologs in organisms that lack an anticipatory immune system
43. Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells
44. Analysis and expression of a cloned pre-T cell receptor gene
45. Pleiotropic changes controlled by the T-cell receptor
46. Maturation of medullary thymic epithelium requires thymocytes expressing fully assembled CD3-TCR complexes
47. Differences in turnover between thymic medullary dendritic cells and a subset of cortical macrophages
48. Immunohistological analysis of immigration of thymocyte-precursors into the thymus: Evidence for immigration of peripheral T cells into the thymic medulla
49. Monoclonal antibodies to stromal cell types of the mouse thymus
50. Two subsets of epithelial cells in the thymic medulla
51. Development, organization and function of the thymic medulla in normal immunodeficient or autoimmune mice
52. Tolerance induction by thymic medullary epithelium
53. + thymocytes
54. + T cells by transgenic I-E restricted to thymic medullary epithelium
55. Thymic emigration: Conveyer belts or lucky dips?
56. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family
57. Expression of relB is required for the development of thymic medulla and dendritic cells
58. Direct visualization of thymocyte apoptosis in neglect, acute and steady-state negative selection
59. An analysis of sequence variation in the B chain framework and complementarity determining regions of an allo-reactive T cell receptor
60. Expression and alternative splicing of the mouse autoimmune regulator gene (Aire)
61. A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins
62. Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1
63. Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen
64. Expression of relB transcripts during lymphoid organ development: Specific expression in dendritic antigen-presenting cells
65. The NF-κB and IκB proteins: New discoveries and insights
66. + dendritic cells
67. Thymic stromal organization is regulated by the specificity of T cell receptor/major histocompatibility complex interactions
68. Deletion of high-avidity T cells by thymic epithelium