메뉴 건너뛰기




Volumn 25, Issue 4, 2005, Pages 312-318

Insulin alleles and autoimmune regulator (AIRE) gene expression both influence insulin expression in the thymus

Author keywords

Autoimmunity; Insulin; Thymus; Tolerance; Type 1 diabetes

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; INSULIN; MESSENGER RNA;

EID: 27844563909     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2005.08.006     Document Type: Article
Times cited : (42)

References (20)
  • 1
    • 0041335584 scopus 로고    scopus 로고
    • Evidence for a primary islet autoantigen (preproinsulin 1) in the non-diabetic obese mouse
    • H. Moriyama, N. Abiru, J. Paronen, K. Sikora, E. Liu, and D. Miao Evidence for a primary islet autoantigen (preproinsulin 1) in the non-diabetic obese mouse Proc Natl Acad Sci USA 100 2003 10371 10376
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10371-10376
    • Moriyama, H.1    Abiru, N.2    Paronen, J.3    Sikora, K.4    Liu, E.5    Miao, D.6
  • 2
    • 18744366947 scopus 로고    scopus 로고
    • Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
    • M. Nakayama, N. Abiru, H. Moriyama, N. Babaya, E. Liu, and D. Miao Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice Nature 435 2005 220 223
    • (2005) Nature , vol.435 , pp. 220-223
    • Nakayama, M.1    Abiru, N.2    Moriyama, H.3    Babaya, N.4    Liu, E.5    Miao, D.6
  • 3
    • 18744385526 scopus 로고    scopus 로고
    • Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope
    • S.C. Kent, Y. Chen, L. Bregoli, S.M. Clemmings, N.S. Kenyon, and C. Ricordi Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope Nature 435 2005 224 228
    • (2005) Nature , vol.435 , pp. 224-228
    • Kent, S.C.1    Chen, Y.2    Bregoli, L.3    Clemmings, S.M.4    Kenyon, N.S.5    Ricordi, C.6
  • 4
    • 0021343570 scopus 로고
    • A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus
    • G.I. Bell, S. Horita, and J.H. Karam A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus Diabetes 33 1984 176 183
    • (1984) Diabetes , vol.33 , pp. 176-183
    • Bell, G.I.1    Horita, S.2    Karam, J.H.3
  • 6
    • 0027200763 scopus 로고
    • Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR
    • A.M. Lucassen, C. Julier, J.P. Beressi, C. Boitard, P. Froguel, and M. Lathrop Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR Nat Genet 4 1993 305 310
    • (1993) Nat Genet , vol.4 , pp. 305-310
    • Lucassen, A.M.1    Julier, C.2    Beressi, J.P.3    Boitard, C.4    Froguel, P.5    Lathrop, M.6
  • 7
    • 0001017310 scopus 로고    scopus 로고
    • IDDM2-VNTR-encoded susceptibility to type 1 diabetes: Dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus
    • S.T. Bennett, A.J. Wilson, F. Cucca, J. Nerup, F. Pociot, and P.A. McKinney IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus J Autoimmun 9 1996 415 421
    • (1996) J Autoimmun , vol.9 , pp. 415-421
    • Bennett, S.T.1    Wilson, A.J.2    Cucca, F.3    Nerup, J.4    Pociot, F.5    McKinney, P.A.6
  • 9
    • 18244421874 scopus 로고    scopus 로고
    • The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
    • A. Pugliese, M. Zeller, A. Fernandez Jr., L.J. Zalcberg, R.J. Bartlett, and C. Ricordi The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes Nat Genet 15 1997 293 297
    • (1997) Nat Genet , vol.15 , pp. 293-297
    • Pugliese, A.1    Zeller, M.2    Fernandez Jr., A.3    Zalcberg, L.J.4    Bartlett, R.J.5    Ricordi, C.6
  • 10
    • 0031018819 scopus 로고    scopus 로고
    • Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
    • P. Vafiadis, S.T. Bennett, J.A. Todd, J. Nadeau, R. Grabs, and C.G. Goodyer Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus Nat Genet 15 1997 289 292
    • (1997) Nat Genet , vol.15 , pp. 289-292
    • Vafiadis, P.1    Bennett, S.T.2    Todd, J.A.3    Nadeau, J.4    Grabs, R.5    Goodyer, C.G.6
  • 11
    • 0036644686 scopus 로고    scopus 로고
    • Promiscuous gene expression and central T-cell tolerance: More than meets the eye
    • B. Kyewski, J. Derbinski, J. Gotter, and L. Klein Promiscuous gene expression and central T-cell tolerance: more than meets the eye Trends Immunol 23 2002 364 371
    • (2002) Trends Immunol , vol.23 , pp. 364-371
    • Kyewski, B.1    Derbinski, J.2    Gotter, J.3    Klein, L.4
  • 13
    • 0346599403 scopus 로고    scopus 로고
    • An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
    • J. Aaltonen, P. Björses, J. Perheentupa, N. Horelli-Kuitunen, A. Palotie, and L. Peltonen An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains Nat Genet 17 1997 399 403
    • (1997) Nat Genet , vol.17 , pp. 399-403
    • Aaltonen, J.1    Björses, P.2    Perheentupa, J.3    Horelli-Kuitunen, N.4    Palotie, A.5    Peltonen, L.6
  • 14
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow within the thymus by the aire protein
    • M.S. Anderson, E.S. Venanzi, L. Klein, Z. Chen, S.P. Berzins, and S.J. Turley Projection of an immunological self shadow within the thymus by the aire protein Science 298 2002 1395 1401
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1    Venanzi, E.S.2    Klein, L.3    Chen, Z.4    Berzins, S.P.5    Turley, S.J.6
  • 17
    • 0033740378 scopus 로고    scopus 로고
    • Unusual DNA structure of the diabetes susceptibility locus IDDM2 and its effect on transcription by the insulin promoter factor Pur-1/MAZ
    • A. Lew, W.J. Rutter, and G.C. Kennedy Unusual DNA structure of the diabetes susceptibility locus IDDM2 and its effect on transcription by the insulin promoter factor Pur-1/MAZ Proc Natl Acad Sci USA 97 23 2000 12508 12512
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.23 , pp. 12508-12512
    • Lew, A.1    Rutter, W.J.2    Kennedy, G.C.3
  • 18
    • 2342458361 scopus 로고    scopus 로고
    • Autoimmune polyendocrine syndromes
    • G.S. Eisenbarth, and P.A. Gottlieb Autoimmune polyendocrine syndromes N Engl J Med 50 2004 2068 2079
    • (2004) N Engl J Med , vol.50 , pp. 2068-2079
    • Eisenbarth, G.S.1    Gottlieb, P.A.2
  • 19
    • 22344449972 scopus 로고    scopus 로고
    • Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
    • J. Derbinski, J. Gäbler, B. Brors, S. Tierling, S. Jonnakuty, and M. Hergenhahn Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels J Exp Med 202 2005 33 45
    • (2005) J Exp Med , vol.202 , pp. 33-45
    • Derbinski, J.1    Gäbler, J.2    Brors, B.3    Tierling, S.4    Jonnakuty, S.5    Hergenhahn, M.6
  • 20
    • 7244227646 scopus 로고    scopus 로고
    • Gene dosage-limiting role of AIRE in thymic expression, clonal deletion and organ-specific autoimmunity
    • A. Liston, D.H.D. Gray, S. Lesage, A.L. Fletcher, J. Wilson, and K.E. Webster Gene dosage-limiting role of AIRE in thymic expression, clonal deletion and organ-specific autoimmunity J Exp Med 200 8 2004 1015 1026
    • (2004) J Exp Med , vol.200 , Issue.8 , pp. 1015-1026
    • Liston, A.1    Gray, D.H.D.2    Lesage, S.3    Fletcher, A.L.4    Wilson, J.5    Webster, K.E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.