Tight junction-related structures in the absence of a lumen: Occludin, claudins and tight junction plaque proteins in densely packed cell formations of stratified epithelia and squamous cell carcinomas

European Journal of Cell Biology

Volumn 82, Issue 8, 2003, Pages 385-400

  Langbein, Lutz ^a   Pape, Ulrich Frank ^a   Grund, Christine ^a   Kuhn, Caecilia ^a   Praetzel, Silke ^a   Moll, Ingrid ^b   Moll, Roland ^c   Franke, Werner W ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Claudins; Hassall's corpuscles; Occludin; Squamous cell carcinoma; Stratified epithelia; Thymus; Tight junctions

Indexed keywords

CINGULIN; CLAUDIN; CLAUDIN 1; CLAUDIN 4; GAP JUNCTION PROTEIN; MEMBRANE PROTEIN; OCCLUDIN; PROTEIN ZO1; SYMPLEKIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; CATTLE; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOTHELIUM; EPIDERMIS; EPIDERMIS CELL; EPITHELIUM; ESOPHAGUS CARCINOMA; GAS; HUMAN; HUMAN TISSUE; HYDROPHOBICITY; IMMUNOHISTOCHEMISTRY; LIQUID; LUNG CARCINOMA; MESENCHYME; METASTASIS; MOUTH CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; REVIEW; SKIN CARCINOMA; SQUAMOUS CELL CARCINOMA; THYMOCYTE; TIGHT JUNCTION; UTERINE CERVIX CARCINOMA;

ANIMALIA; BOS TAURUS; BOVINAE;

EID: 0141828565     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1078/0171-9335-00330     Document Type: Article

References (75)

1. Balercia, G., Accordini, C., Franceschini, F., Blazsek, I., Osculati, F. (1990): An ultrastructural study of normal human thymic epithelium in primary cultures. J. Submicrosc. Cytol. Pathol, 22, 311-325.
2. Bearman, R. M., Levine, G. D., Bensch, K. G. (1978): The ultrastructure of the normal human thymus: A study of 36 cases. Anat. Rec. 190, 755-782.
3. Brandner, J. M., Houdek, P., Kuhn, C., Grund, C., Kief, S., Langbein, L., Moll, I., Franke, W. W. (2001): Tight junction-systems in mammalian squamous stratified epithelia. Abstract. DGZ/SBCF: First German/French Cell Biology Congress, Strasbourg, November 7-9, 2001. Biol. Cell 93, 247.
4. Brandner, J. M., Kief, S., Grund, C., Rendl, M., Houdek, P., Kuhn, C., Tschachler, E., Franke, W. W., Moll, I. (2002): Organization and formation of the tight junction system in human epidermis and cultured keratinocytes. Eur. J. Cell Biol. 81, 253-263.
5. Derbinski, J., Schulte, A., Kyewski, B., Klein, L. (2001): Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self Nat. Immunol. 2, 1032-1039.
6. Dickersin, G. R. (2000): Diagnostic Electron Microscopy: A Text/Atlas. 2. Edn. Springer-Verlag, New York.
7. Elias, P. M., Friend, D. S. (1975): The permeability barrier in mammalian epidermis. J. Cell Biol. 65, 180-191.
8. Elias, P. M., Friend, D. S. (1976): Vitamin-A-induced mucous metaplasia. An in vitro system for modulating tight and gap junction differentiation. J. Cell Biol. 68, 173-188.
9. Elias, P. M., McNutt, N. S., Friend, D. S. (1977): Membrane alterations during cornification of mammalian squamous epithelia: a freeze-fracture, tracer and thin-section study. Anat. Rec. 189, 577-594.
10. Erlandson, R. A. (1981): Diagnostic Transmission Electron Microscopy of Human Tumors. The Interpretation of Submicroscopic Structures in Human Neoplastic Cells. Masson Publishing USA, New York.
11. Farquhar, M. G., Palade, G. E. (1963): Junctional complexes in various epithelia. J. Cell Biol. 17, 375-412.
12. Farr, A. G., Braddy, S. C. (1989): Patterns of keratin expression in the murine thymus. Anat. Rec. 224, 374-378.
13. Fawcett, D. W. (1994): A Textbook of Histology. Chapman and Hall, New York, p. 69.
14. Franke, W. W., Appelhans, B., Schmid, E., Freudenstein, C., Osborn, M., Weber, K. (1979): Identification and characterization of epithelial cells in mammalian tissues by immunofluorescence microscopy using antibodies to prekeratin. Differentiation 15, 7-25.
15. Fukai, I., Masaoka, A., Hashimoto, T., Yamakawa, Y., Mizuno, T., Tanamura, O. (1992): The distribution of epithelial membrane antigen in thymic epithelial neoplasms. Cancer 70, 2077-2081.
16. Fukai, I., Masaoka, A., Hashimoto, T., Yamakawa, Y., Mizuno, T., Tanamura, O (1993): Cytokeratins in normal thymus and thymic epithelial tumors. Cancer 71, 99-105.
17. Furuse, M., Hata, M., Furuse, K., Yoshida, Y., Haratake, A., Sugitani, Y., Noda, T., Kubo, A., Tsukita, Sh. (2002): Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J. Cell Biol. 156, 1099-1111.
18. Ghadially, F. N. (1988): Ultrastructural Pathology of the Cell and Matrix, Vol. 2. 3. Edn. Butterworths, London.
19. Goldstein, J. L., Watkins, J. L., Greager, J. A., Layden, T. J. (1994): The esophageal mucosal resistance: Structure and function of an unique gastrointestinal epithelial barrier. J. Lab. Clin. Med. 123, 653-659.
20. Heid, H. W., Moll, I., Franke, W. W. (1988): Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues. II. Concomitant and mutually exclusive synthesis of trichocytic and epithelial cytokeratins in diverse human and bovine tissues (hair follicle, nail bed and matrix, lingual papilla, thymic reticulum). Differentiation 37, 215-230.
21. Heid, H. W., Schmidt, A., Zimbelmann, R., Schäfer, S., Winter-Simanowski, S., Stumpp, S., Keith, M., Figge, U., Schnölzer, M., Franke, W. W. (1994): Cell type-specific desmosomal plaque proteins of the plakoglobin family: plakophilin 1 (band 6 protein). Differentiation 58, 113-131.
22. Henderson, D. W., Papadimitriou, J. M., Coleman, M. (1986): Ultrastructural Appearances of Tumours. Diagnosis and Classification of Human Neoplasia by Electron Microscopy. 2. Edn. Churchill Livingstone, Edinburgh.
23. Henry, L., Anderson, G. (1987): Epithelial-cell architecture during involution of the human thymus. J. Pathol. 153, 149-155.
24. Hill, M. W., Squier, C. A., Linder, J. E. (1982): A histological method for the visualization of the intercellular permeability barrier in mammalian stratified squamous epithelia. Histochem. J. 14, 641-648.
25. Huszar, M., Gigi-Leitner, O., Moll, R., Franke, W. W., Geiger, B. (1986): Monoclonal antibodies to various acidic (type I) cytokeratins of stratified epithelia. Selective markers for stratification and squamous cell carcinomas. Differentiation 31, 141-153.
26. Itoh, T., Kasahara, S., Aizu, S., Kato, K., Takeuchi, M., Mori, T. (1982): Formation of Hassall's corpuscles in vitro by the thymic epithelial cell line IT-26R21 of the rat. Cell Tissue Res. 226, 469-476.
27. Kaneshima, H., Ito, M., Asai, J., Taguchi, O., Hiai, H. (1987): Thymic epithelial reticular cell subpopulations in mice defined by monoclonal antibodies. Lab. Invest. 56, 372-380.
28. Kitajima, Y., Eguchi, K., Ohno, T., Mori, S., Yaoita, H. (1983): Tight junctions of human keratinocytes in primary culture: a freeze-fracture study. J. Ultrastruct. Res. 82, 309-313.
29. Kubota, H., Chiba, H., Takakuwa, Y., Osanai, M., Tobioka, H., Kohama, G.-I., Mori, M., Sawada, N. (2001): Retinoid X receptor a and retinoic acid receptor g mediate expression of genes encoding tight-junction proteins and barrier function in F9 cells during visceral endodermal differentiation. Exp. Cell Res. 263, 163-172.
30. Kuo, T.-t. (2000): Cytokeratin profiles of the thymus and thymomas: histogenetic correlations and proposal for a histological classification of thymomas. Histopathology 36, 403-414.
31. Kuo. T.-t., Chang, J.-P., Lin, F.-J., Wu, W.-C., Chang, C.-H. (1990): Thymic carcinomas: histopathological varieties and immunohistochemical study. Am. J. Surg. Pathol. 14, 24-34.
32. Langbein, L., Grund, C., Kuhn, C., Praetzel, S., Kartenbeck, J., Brandner, J. M., Moll, I., Franke, W. W. (2002): Tight junctions and compositionally related junctional structures in mammalian stratified epithelia and cell cultures derived therefrom. Eur. J. Cell Biol. 81, 419-435.
33. Laster, A. J., Itoh, T., Palker, T. J., Haynes, B. F. (1986): The human thymic microenvironment: Thymic epithelium contains specific keratins associated with early and late stages of epidermal keratinocyte maturation. Differentiation 31, 67-77.
34. Lee, D., Wright, D. H. (1988): Immunohistochemical study of 22 cases of thymoma. J. Clin. Pathol. 41, 1297-1304.
35. Löning, T., Caselitz, J., Otto, H. F. (1981): The epithelial framework of the thymus in normal and pathological conditions. Virchows Arch. Pathol. Anat. 392, 7-20.
36. Masunaga, A., Sugawara, I., Nakamura, H., Yoshitake, T., Itoyama, S. (1997): Cytokeratin expression in normal human thymus at different ages. Pathol. Int. 47, 842-847.
37. Matter, K., Balda, M. S. (2003): Signalling to and from tight junctions. Nat. Rev. Mol. Cell Biol. 4, 225-237.
38. Meyle, J., Gültig, K., Rascher, G., Wolburg, H. (1999): Transepithelial electrical resistance and tight junctions of human gingival keratinocytes. J. Periodont. Res. 34, 214-222.
39. Moll, R. (1998): Cytokeratins as markers of differentiation in the diagnosis of epithelial tumors. In: H. Herrmann, J. R. Harris (eds.): Subcellular Biochemistry, Volume 31: Intermediate Filaments. Plenum Press, New York, pp. 205-262.
40. Moll, R., Franke, W. W., Schiller, D., Geiger, B., Krepler, R. (1982): The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells. Cell 31, 11-24.
41. Moll, R., Krepler, R., Franke, W. W. (1983): Complex cytokeratin polypeptide patterns observed in certain human carcinomas. Differentiation 23, 256-269.
42. Morinaga, S., Sato, Y., Shimosato, Y., Sinkai, T., Tsuchiya, R. (1987): Multiple thymic squamous cell carcinomas associated with mixed type thymoma. Am. J. Surg. Pathol. 11, 982-988.
43. Morita, K., Itoh, M., Saitou, M., Ando-Akatsuka, Y., Furuse, M., Yoneda, K., Imamura, S., Fujimoto, K., Tsukita, S. (1998): Subcellular distribution of tight junction-associated proteins (occludin, ZO-1, ZO-2) in rodent skin. J. Invest. Dermatol. 110, 862-866.
44. Nagle, R. B., Moll, R., Weidauer, H., Nemetschek, H., Franke, W. W. (1985): Cytokeratin patterns of human oral epithelia: Differences of cytokeratin synthesis in gingival epithelium and the adjacent alveolar mucosa. Differentiation 30, 123-129.
45. Nelson, W. G., Battifora, H., Santana, H., Sun, T.-T. (1984): Specific keratins as molecular markers for neoplasms with a stratified epithelial origin. Cancer Res. 44, 1600-1603.
46. Nicolas, J. F., Savino, W, Reano, A., Viac, J., Brochier, J., Dardenne, M. (1985): Heterogeneity of thymic epithelial cell (TEC) keratins. Immunohistochemical and biochemical evidence for a subset of highly differentiated TEC in the mouse. J. Histochem. Cytochem. 33, 687-694.
47. Nicolas, J.-F., Reano, A., Kaiserlian, D., Thivolet, J. (1989): Epithelial cell heterogeneity in mammalian thymus: monoclonal antibody to high molecular weight keratins exclusively binds to Hassall's corpuscles. Histochem. J. 21, 357-364.
48. Nuber, U. A., Schäfer, S., Stehr, S., Rackwitz, H.-R., Franke, W. W. (1996): Patterns of desmocollin synthesis in human epithelia: Immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells. Eur. J. Cell Biol. 71, 1-13.
49. Orlando, R. C., Lacy, E. R., Tobey, N. A., Cowart, K. (1992): Barriers to paracellular permeability in rabbit esophageal epithelium. Gastroenterology 102, 910-923.
50. Osculati, E, Balercia, G., Morroni, M., Cinti, S., Canon, C., Dantchev, D., Mathé, G. (1986): Human thymocyte differentiation: an ultrastructural study using monoclonal antibodies and immunogold staining method. Biomed. Pharmacother. 40, 253-260.
51. Papadopoulos, T., Kirchner, T., Marx, A., Müller-Hermelink, H. K. (1989): Primary cultures of human thymic epithelial tumors. Morphological and immunocytochemial characterization, Virchows Arch. B Cell Pathol. 56, 363-370.
52. Posalaky, Z., McGinley, D., Cutler, B., Katz, H. I. (1979): Intercellular junctional specializations in human basal cell carcinoma. Virchows Arch. A Path. Anat. Histol. 384, 53-63.
53. Peitsch, W. K., Hofmann, I., Prätzel, S., Grund, C., Kuhn, C., Moll, I., Langbein, L., Franke, W. W. (2001): Drebrin particles: components in the ensemble of proteins regulating actin dynamics of lamellipodia and filopodia. Eur. J. Cell Biol. 80, 567-579.
54. Prutkin, L. (1975): Demonstration of gap junctions by lanthanum in the vitamin A acid-treated skin tumor, keratoacanthoma. Experientia 31, 1346-1348.
55. Pummi, K., Malminen, M., Aho, H., Karvonen, S.-L., Peltonen, J., Peltonen, S. (2001): Epidermal tight junctions: ZO-1 and occludin are expressed in mature, developing, and affected skin and in vitro differentiating keratinocytes. J. Invest. Dermatol. 117, 1050-1058.
56. Quinlan, R. A., Schiller, D. L., Hatzfeld, M., Achtstätter, T, Moll, R., Jorcano, J. L., Magin, T. M., Franke, W. W. (1985): Patterns of expression and organization of cytokeratin intermediate filaments. In: E. Wang, D. Fischman, R. K. H. Liem, T.-T Sun (eds.): Annals New York Acad. Sci., Volume 455: Intermediate Filaments. The New York Acad. Sci., New York, pp. 282-306.
57. Ring, N. P., Addis, B. J. (1986): Thymoma: An integrated clinicopathological and immunohistochemical study. J. Pathol. 149, 327-337.
58. Rose, O., Grund, C., Reinhardt, S., Starzinski-Powitz, A., Franke, W. W. (1995): Contactus adherens, a special type of plaque-bearing adhering junction containing M-cadherin, in the granule cell layer of the cerebellar glomerulus. Proc. Natl. Acad. Sci. USA 92, 6022-6026.
59. Savino, W, Durand, D., Dardenne, M. (1985): Immunobistochemical evidence for the expression of the carcinoembryonic antigen by human thymic epithelial cells in vitro and in neoplastic conditions. Am. J. Pathol. 121, 418-425.
60. Savino, W., Itoh, T., Imhof, B. A., Dardenne, M. (1986): Immunohistochemical studies on the phenotype of murine and human thymic stromal cell lines. Thymus 8, 245-256.
61. Schmid, E., Tapscott, S., Bennett, G. S., Croop, J., Fellini, S. A., Holtzer, H., Franke, W. W. (1979): Differential location of different types of intermediate-sized filaments in various tissues of the chicken embryo. Differentiation 15, 27-40.
62. Schmidt, A., Langbein, L., Rode, M., Praetzel, S., Zimbelmann, R., Franke, W. W. (1997): Plakophilins 1a and 1b: widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque components. Cell Tissue Res. 290, 481-499.
63. Schmidt, A., Langbein, L., Praetzel, S., Rode, M., Rackwitz, H.-R., Franke, W. W. (1999): Plakophilin 3 - a novel cell-type-specific desmosomal plaque protein. Differentiation 64, 291-306.
64. Staehelin, L. A. (1974): Structure and function of intercellular junctions. Annu. Rev. Cytol. 39, 191-283.
65. Stevenson, B. R., Keon, B. H. (1998): The tight junction: morphology to molecules. Annu. Rev. Cell Dev. Biol. 14, 89-109.
66. Sun, T.-T., Shih, C., Green, H. (1979): Keratin cytoskeletons in epithelial cells of internal organs. Proc. Natl. Acad. Sci. USA 76, 2813-2817.
67. Sun, T.-T., Bonitz, R, Burns, W. H. (1984): Cell culture of mammalian thymic epithelial cells: Growth, structural, and antigenic properties. Cell. Immunol. 83, 1-13.
68. Suo, Z., Holm, R., Nesland, J. M. (1993): Squamous cell carcinomas. An immunohistochemical study of cytokeratins and involucrin in primary and metastatic tumours. Histopathology 23, 45-54.
69. Tebbe, B., Mankertz, J., Schwarz, C., Amasheh, S., Fromm, M., Assaf, C., Schultz-Ehrenburg, U., Sanchez Ruderish, H., Schulzke, J.-D., Orfanos, C. E. (2002): Tight junction proteins: a novel class of integral membrane proteins. Expression in human epidermis and in HaCaT keratinocytes. Arch. Dermatol. Res. 294, 14-18.
70. Truong, L. D., Mody, D. R., Cagle, P. T., Jackson-York, G. L., Schwartz, M. R., Wheeler, T. M. (1990): Thymic carcinoma. A clinicopathological study of 13 cases. Am. J. Surg. Pathol. 14, 151-166.
71. Tsukita, S., Furuse, M., Itoh, M. (2001): Multifunctional strands in tight junctions. Nature Rev. Mol. Cell Biol. 2, 285-293.
72. van der Kwast, T. H., van Vliet, E., Cristen, E., van Ewijk, W., van der Heul, R. O. (1985): An immunohistologic study of the epithelial and lymphoid components of six thymomas: Hum. Pathol. 16, 1001-1008.
73. Van Itallie, C. M., Balda, M. S., Anderson, J. M. (1995): Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells. J. Cell Sci. 108, 1735-1742.
74. Viac, J., Schmitt, D., Staquet, M. J., Thivolet, J. (1980): Epidermisthymus antigenic relations with special reference to Hassall's corpuscles. Thymus 1, 319-328.
75. Walts, A. E., Said, J. W., Siegel, M. B., Banks-Schlegel, S. (1985): Involucrin, a marker of squamous and urothelial differentiation. An immunohistochemical study on its distribution in normal and neoplastic tissues. J. Pathol. 145, 329-340.