Transcription of a broad range of self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigens

Journal of Immunology

Volumn 161, Issue 11, 1998, Pages 5918-5929

  Sospedra, Mireia ^a   Ferrer Francesch, Xavier ^b   Domínguez, Orlando ^c   Juan, Manel ^b   Foz Sala, Màrius ^b   Pujol Borrell, Ricardo ^a,b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^c Centro de Investigación y Desarrollo   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ANTIGEN; AUTOANTIGEN; CYTOKERATIN; GLUCAGON; GLUTAMATE DECARBOXYLASE; INSULIN; MESSENGER RNA; MYELIN BASIC PROTEIN; RETINA S ANTIGEN; THYROGLOBULIN; THYROID PEROXIDASE;

ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOLOGICAL TOLERANCE; NORTHERN BLOTTING; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYMUS;

ADOLESCENT; AGING; AUTOANTIGENS; CELL SEPARATION; CHILD; CHILD, PRESCHOOL; FLOW CYTOMETRY; HUMANS; INFANT; INFANT, NEWBORN; ORGAN SPECIFICITY; REPRODUCIBILITY OF RESULTS; SELF TOLERANCE; SENSITIVITY AND SPECIFICITY; THYMUS GLAND; TRANSCRIPTION, GENETIC;

EID: 0032402315     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Miller, J. F., and A. Basten. 1996. Mechanisms of tolerance to self. Curr. Opin. Immunol. 8:815.
2. Van Parijs, L., and A. K. Abbas. 1998. Homeostasis of self-tolerance in the immune system: turning lymphocytes off. Science 280:243.
3. Werdelin, O., U. Cordes, and T. Jensen. 1998. Aberrant expression of tissue-specific proteins in the thymus: a hypothesis for the development of central tolerance. Scand. J. Immunol. 47:95.
4. Von Herrath, M. G., S. Guerder, H. Lewicki, R. A. Flavell, and M. A. B. Oldstone. 1995. Coexpression of B7-1 and viral ("self") transgenes in pancreatic β cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes. Immunity 3:727.
5. + T cells specific for a pancreatic β cell neoantigen. Immunity 2:573.
6. Schmidt, D., J. Verdaguer, N. Averill, and P. Santamaria. 1997. A mechanism for the major histocompatibility complex-linked resistance to autoimmunity. J. Exp. Med. 186:1059.
7. Hawke, S., H. Matsuo, M. Nicolle, G. Malcherek, A. Melms, and N. Wilcox. 1996. Autoimmune T cells in Miasthenia gravis: heterogenity and potential for specific immunotargeting. Immunol. Today 17:307.
8. Sospedra, M., O. Domínguez, F. Vargas, and R. Pujol-Borrell. 1995. Peripheral antigen expression in human thymus. Autoimmunity 21:A269.
9. Vafiadis, P., S. T. Bennett, J. A. Todd, J. Nadeau, R. Grabs, C. G. Goodyer, S. Wickramasinghe, E. Colle, and C. Polychronakos. 1997. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat. Genet. 15:289.
10. Pugliese, A., M. Zeller, A. Fernandez, Jr., L. J. Zalcberg, R. J. Bartlett, C. Ricordi, M. Pietropaolo, G. S. Eisenbarth, S. T. Bennett, and D. D. Patel. 1997. The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat. Genet. 15:293.
11. + thymocytes. Nature 333:742.
12. Mackall, C. L., F. T. Hakim, and R. E. Gress. 1997. T-cell regeneration: all repertoires are not created equal. Immunol. Today 18:245.
13. Heath, W. R., J. Allison, M. W. Hoffmann, G. Schönrich, G. Hämmerling, B. Arnold, and J. F. A. P. Miller. 1992. Autoimmune diabetes as a consequence of locally produced interleukin-2. Nature 359:547.
14. Beaulieu, S., D. Landry, D. Bergeron, E. A. Cohen, and S. Montplaisir. 1995. An improved method for purifying human thymic dendritic cells. J. Immunol. Meth. 180:225.
15. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156.
16. Wood, W. I., J. Gitschier, L. A. Lasky, and R. M. Lawn. 1985. Base composition-independent hybridization in tetramethylammonium chloride: a method for oligonucleotide screening of highly complex gene libraries. Proc. Natl. Acad. Sci. USA 82:1585.
17. Church, G. M., and W. Gilbert. 1984. Genomic sequencing. Proc. Natl. Acad. Sci. USA 81:1991.
18. Gaillard, V., G. Vivier, L. Barjhoux, C. Souchier, J. L. Touraine, and N. Blanc-Brunat. 1993. Image analysis of dendritic cells in the human fetal thymus. Thymus 21:75.
19. Ausubel, C. 1987. Current Protocols in Molecular Biology. Vol. 1, Ch. 4.1.6. Greene/Wiley Intersciences, New York.
20. Kappler, J. W., U. Staerz, J. White, and P. C. Marrack. 1987. T cell tolerance by clonal elimination in the thymus. Cell 49:273.
21. Burnet, F. M. 1959. The Clonal Selection Theory of Acquired Immunity. Cambridge University Press, Cambridge.
22. Dayan, C., M. Londei, A. E. Corcoran, B. Grubeck-Loebenstein, R. F. L. James, B. Rapoport, and M. Feldman. 1991. Autoantigen recognition by thyroid-infiltrating T cells in Graves disease. Proc. Natl. Acad. Sci. USA 88:7415.
23. Lacour, M., U. Rudolphi, M. Schlesier, and H.-H. Peter. 1990. Type II collagen-specific human T cell lines established from healthy donors. Eur. J. Immunol. 20:931.
24. Londei, M., C. M. Savill, A. Verhoef, F. Brennan, Z. A. Leeach, V. Duance, R. N. Maini, and M. Feldmann. 1989. Persistence of collagen type II-specific T-cell clones in the synovial membrane of a patient with rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 86:636.
25. Martin, R., D. Jaraquemada, M. Flerlage, J. Richert, J. Whitaker, E. O. Long, D. E. McFarlin, and H. F. McFarland. 1990. Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals. J. Immunol. 145:540.
26. Wekerle, H., M. Bradl, C. Linington, G. Kääb, and K. Kojima. 1996. The shaping of the brain-specific T lymphocyte repertoire in the thymus. Immunol. Rev. 149: 231.
27. Witebsky, E., and N. R. Rose. 1956. Studies on organ specificity. IV. Production of rabbit thyroid antibodies in the rabbit. J. Immunol. 76:408.
28. Rose, N. R., and E. Witebsky. 1956. Studies on organ specificity. V. Changes in the thyroid glands of rabbit following active immunization with rabbit thyroid extracts. J. Immunol. 76:417.
29. Hashim, G. A. 1978. Myelin basic protein: structure, function, and antigenic determinants. Immunol. Rev. 39:60.
30. Weigle, W. O. 1980. Analysis of autoimmunity through experimental models of thyroiditis and allergic encephalomyelitis. Adv. Immunol. 30:159.
31. Pujol-Borrell, R., and G. F. Bottazzo. 1988. Puzzling diabetic transgenic mice: a lesson for human type 1 diabetes? Immunol. Today 9:303.
32. Ferrick, D. A., P. S. Ohashi, V. A. Wallace, M. Schilham, and T. W. Mak. 1990. Transgenic mice as an in vivo model for self-reactivity. Immunol. Rev. 118:257.
33. Bretscher, P., and M. Conn. 1970. A theory of self-nonself discrimination: paralysis and induction involve the recognition of one and two determinants on an antigen, respectively. Science 169:1042.
34. Lafferty, K. J., and R. G. Gill. 1993. The maintenance of self-tolerance. Immunol. Cell Biol. 71:209.
35. Schwart, R. H. 1992. Costimulation of T lymphocytes: the role of CD28, CTLA 4 and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71:1065.
36. Miller, J. F., G. Morahan, and J. Allison. 1989. Extrathymic acquisition of tolerance by T lymphocytes. Cold Sping Harbor Symp. Quant. Biol. 54:807.
37. Miller J. F. A. P., and W. R. Heath. 1993. Self-ignorance in the peripheral T cell pool. Immunol. Rev. 133:131.
38. Hammerling, G. J., G. Schönrich, I. Ferber, and B. Arnold. 1993. Peripheral tolerance as a multi-step mechanism. Immunol. Rev. 133:93.
39. Murakami, M., Y. Hosoi, T. Negishi, Y. Kamiya, K. Miyashita, M. Yamada, T. Iriuchijima, H. Yokoo, I. Yoshida, Y. Tsushima, and M. Mori. 1996. Thymic hyperplasia in patients with Graves' disease. J. Clin. Invest. 98:2228.
40. Pribyl, T. M., C. W. Campagnoni, K. Kampf, T. Kashima, V. W. Handley, J. McMahon, and A. T. Campagnoni. 1993. The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems. Proc. Natl. Acad. Sci. USA 90:10695.
41. Wakkach, A., T. Guyon, C. Bruand, S. Tzartos, S. Cohen-Kaminsky, and S. Berrih-Aknin. 1996. Expression of acetylcholine receptor genes in human thymic epithelial cells: implications for myasthenia gravis. J. Immunol. 157: 3752.
42. Antonia, S. J., T. Geiger, J. Miller, and R. A. Flavell. 1995. Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein. Int. Immunol. 7:715.
43. Jolicoeur, C., D. Hanahan, and K. M. Smith. 1994. T-cell tolerance toward a transgenic β cell antigen and transcription of endogenous pancreatic genes in thymus. Proc. Natl. Acad. Sci. USA 91:6707.
44. Smith, K. M., D. C. Olson, R. Hirose, and D. Hanahan. 1997. Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T-cell tolerance. Int. Immunol. 9:1355.
45. Egwuagu, C. E., P. Charukamnoetkanok, and J. Gery. 1997. Thymic expression of autoantigens correlates with resistance to autoimmune disease. J. Immunol. 159:3109.
46. Dardenne, M., and W. Savino. 1994. Control of thymus physiology by peptidic hormones and neuropeptides. Immunol. Today 15:518.
47. Martens, H., B. Goxe, and V. Geenen. 1996. The thymic repertoire of neuroendocrine self-antigens: physiological implications in T-cell life and death. Immunol. Today 17:312.
48. Boon, T., and A. van Pel. 1989. T cell-recognized antigenic peptides derived from the cellular genome are not protein degradation products but can be generated directly by transcription and translation of short subgenic regions: a hypothesis. Immunogenetics 29:75.
49. Chelly, J., J.-C. Kaplan, P. Marie, S. Gautron, and A. Kahn. 1988. Transcription of the dystrophin gene in human muscle and non-muscle tissues. Nature 333:858.
50. Chelly, J., J.-P. Concordet, J.-C. Kaplan, and A. Kahn. 1989. Illegitimate transcription: transcription of any gene in any cell type. Proc. Natl. Acad. Sci. USA 86:2617.
51. Anderson, G., N. C. Moor, J. J. T. Owen, and E. J. Jenkinson. 1996. Cellular interactions in thymocyte development. Annu. Rev. Immunol. 14:73.
52. Pietropaolo, M., R. P. Friday, G. Stassi, A. Pugliese, D. Patel, and M. Trucco. Selective expression of ICA69 in thymic epithelial cells and neuroendocrine tissues. In Third IDS Meeting, Oak Brook, IL, 10-12th June 1998. J. Palmer, G. Nepom, et al., eds. Immunology of Diabetes Society, Oak Brook, IL, (Abstr 87).
53. + T cells. Immunity 7:209.
54. Carbone, F. R., and M. J. Bevan. 1990. Class I restricted processing and presentation of exogenous cell associated antigen in vivo. J. Exp. Med. 171:377.
55. + T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity. J. Exp. Med. 186:2057.
56. Albert, M. L., B. Sauter, and N. Bhardwaj. 1998. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392:86.
57. Saoudi, A., B. Seddon, D. Fowell, and D. Mason. 1996. The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients. J. Exp. Med. 184:2393.
58. Wang, Y., I. Goldschneider, D. Foss, D. Y. Wu, J. O'Rourke, and R. E. Cone. 1997. Direct thymic involvement in anterior chamber-associated immune deviation. J. Immunol. 158:2150.
59. Boyd, R. L., C. L. Tucek, D. I. Godfrey, D. J. Izon, T. J. Wilson, N. J. Davidson, A. G. D. Bean, H. M. Ladyman, M. A. Ritter, and P. Hugo. 1993. The thymic microenvironment. Immunol. Today 14:445.