T cell response in experimental autoimmune encephalomyelitis (EAE): Role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire

Annual Review of Immunology

Volumn 20, Issue , 2002, Pages 101-123

  Kuchroo, Vijay K ^a   Anderson, Ana C ^a   Waldner, Hanspeter ^a   Munder, Markus ^a   Bettelli, Estelle ^a   Nicholson, Lindsay B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Myelin antigens (MBP, PLP); Pathogenic protective repertoires; Selective tolerance; Susceptibility resistance; Thymic selection

Indexed keywords

AUTOANTIGEN; CYTOKINE; EPITOPE; MYELIN; MYELIN BASIC PROTEIN; PROTEOLIPID PROTEIN; T LYMPHOCYTE RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; AUTOIMMUNE DISEASE; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; HUMAN; IMMUNOLOGICAL MEMORY; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE DIFFERENTIATION; MEMORY CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; THYMUS;

AMINO ACID SEQUENCE; ANIMALS; AUTOANTIGENS; AUTOIMMUNITY; CELL DIFFERENTIATION; CROSS REACTIONS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MYELIN PROTEOLIPID PROTEIN; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 0036219003     PISSN: 07320582     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.immunol.20.081701.141316     Document Type: Review

References (107)

1. Passive transfer of adjuvant-induced arthritis and allergic encephalomyelitis in rats using thoracic duct lymphocytes
2. The T lymphocyte in experimental allergic encephalomyelitis
3. Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis
4. Experimental allergic encephalomyelitis mediated by cloned T cells specific for a synthetic peptide of myelin proteolipid protein. Fine specificity and T cell receptor Vβ usage
5. Surface expression of α4 integrin by CD4 T cells is required for their entry into brain parenchyma
6. Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis
7. Immunology of multiple sclerosis
8. The immunopathology of acute allergic encephalomyelitis induced with myelin proteolipid protein
9. Increased frequency of interleukin 2-responsive cells specific for myelin basic protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis
10. T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans
11. High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: Mechanisms of selection of the self-reactive repertoire
12. Fulminant spontaneous autoimmunity of the central nervous system in myelin proteolipid protein specific T cell receptor transgenic mice
13. Negative selection of lymphocytes
14. Positive selection of lymphocytes
15. Traffic of hematogenous cells through the central nervous system
16. Lymphocyte targeting of the central nervous system: A review of afferent and efferent CNS-immune pathways
17. The human myelin basic protein gene is included within a 179-kilobase transcription unit: Expression in the immune and central nervous systems
18. Expression of the myelin proteolipid protein gene in the human fetal thymus
19. Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo
20. Thymic expression of myelin basic protein (MBP)
21. Myelin protein expression in lymphoid tissues: Implications for peripheral tolerance
22. Expression of thyroid-related genes in human thymus
23. Transcription of a broad range of self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigens
24. Expression of ocular autoantigens in the mouse thymus
25. Intrathymic expression of genes involved in organ specific autoimmune disease
26. Thymic expression of auto-antigens correlates with resistance to autoimmune disease
27. Endogenous myelin basic protein inactivates the high avidity T cell repertoire
28. Differential recognition of MBP epitopes in BALB/c mice determines the site of inflammatory disease induction
29. Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells
30. The shaping of the T cell repertoire
31. Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon gamma by T cells
32. Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein
33. Low avidity recognition of self-antigen by T cells permits escape from central tolerance
34. The human myelin basic protein gene is included within a 179-kilobase transcription unit: Expression in the immune and central nervous systems
35. Age-dependent T cell tolerance and autoimmunity to myelin basic protein
36. Genetic control of autoimmune diabetes in the NOD mouse
37. Breaking self-tolerance in nonobese diabetic mice
38. Autoreactivity of T cells from nonobese diabetic mice: An I-Ag7-dependent reaction
39. Analysis of the role of variation of major histocompatibility complex class II expression on nonobese diabetic (NOD) peripheral T cell response
40. The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders
41. Molecular characterization of the diabetes-associated mouse MHC class II protein, I-Ag7
42. The inability of the nonobese diabetic class II molecule to form stable peptide complexes does not reflect a failure to interact productively with DM
43. pH-dependent peptide binding properties of the type I diabetes-associated I-Ag7 molecule: Rapid release of CLIP at an endosomal pH
44. A new look at MHC and autoimmune disease
45. Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice
46. Cytokine regulation of T-cell function: Potential for therapeutic intervention
47. Two types of murine helper T cell clones
48. Functional diversity of helper T lymphocytes
49. Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties
50. Lymphocyte responses and cytokines
51. Polarized patterns of cytokine secretion
52. + T cells through IL-12 produced by listeria-induced macrophages
53. The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases
54. Experimental allergic encephalomyelitis mediated by cloned T cells specific for a synthetic peptide of myelin proteolipid protein. Fine specificity and T cell receptor Vβ usage
55. T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination
56. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain
57. Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice
58. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
59. + suppressor cells of autoimmune encephalomyelitis respond to T cell receptor-associated determinants on effector cells by interleukin-4 secretion
60. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
61. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery
62. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease
63. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
64. An altered peptide ligand mediates immune deviation and prevents experimental autoimmune encephalomyelitis
65. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-defcient and transgenic mice
66. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease
67. Transgenic interleukin 10 prevents induction of experimental autoimmune encephalomyelitis
68. IL-12 unmasks latent autoimmune disease in resistant mice
69. Microbial products induce autoimmune disease by an IL-12-dependent pathway
70. QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2
71. Genetic susceptibility or resistance to autoimmune encephalomyelitis in MHC congenic mice is associated with differential production of pro- and anti-inflammatory cytokines
72. Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells
73. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease
74. A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire
75. T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis
76. + T cell responses to the dominant encephalitogenic PLP 139-151 peptide in SJL/J mice
77. Myelin proteolipid protein-induced Th1 and Th2 clones express TCR with similar fine specificity for peptide and CDR3 homology despite diverse Vβ usage
78. Auto-pathogenic Th1 and protective Th2 clones differ in their recognition of the autoantigenic peptide of myelin proteolipid protein
79. Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: Implications for autoimmunity
80. Altered peptide ligand modulation of experimental allergic encephalomyelitis: Immune responses within the CNS
81. The T-cell receptor as a diverse signal transduction machine
82. Essential flexibility in the T-cell antigen recognition of antigen
83. Selecting and maintaining a diverse T-cell repertoire
84. The fine specificity of antigen and Ia determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c
85. T cell recognition of self and altered self antigens
86. Specific T cell recognition of minimally homologous peptides: Evidence for multiple endogenous ligands
87. A very high level of cross-reactivity is an essential feature of the T-cell receptor
88. Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry
89. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading
90. Amino acid homology between the encephalitogenic site of myelin basic protein and virus: Mechanism for autoimmunity
91. Expansion by self antigen is necessary for the induction of experimental autoimmune encephalomyelitis by T cells primed with a cross-reactive environmental antigen
92. Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
93. Molecular mimicry by herpes simplex virus-type 1: Autoimmune disease after viral infection
94. A T cell receptor antagonist peptide prevents autoimmune encephalomyelitis induced with multiple myelin antigens: Evidence for bystander suppression
95. A virus-induced molecular mimicry model of multiple sclerosis
96. + cells
97. Microbial epitopes act as altered peptide ligands to prevent experimental autoimmune encephalomyelitis
98. Policing the regulators
99. The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients
100. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
101. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity
102. The genetics and epidemiology of diabetes in NOD mice
103. Adaptive cellular interactions in the immune system: The tunable activation threshold and the significance of subthreshold responses
104. + T cells
105. Tuning T cell activation threshold and effector function with cross-reactive peptide ligands
106. Negative selection during the peripheral immune response to antigen