Promiscuous thymic expression of an autoantigen gene does not result in negative selection of pathogenic T cells

Journal of Immunology

Volumn 175, Issue 9, 2005, Pages 5759-5764

  Allen, Stacey ^a   Read, Simon ^a   DiPaolo, Richard ^b   McHugh, Rebecca S ^c,d   Shevach, Ethan M ^b   Gleeson, Paul A ^a   Van Driel, Ian R ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c MALAGHAN INSTITUTE OF MEDICAL RESEARCH   (New Zealand)

^d MILTENYI BIOTEC GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; CD4 ANTIGEN; CD8 ANTIGEN; EPITOPE; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; CELL SELECTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FLOW CYTOMETRY; GASTRITIS; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; T LYMPHOCYTE; THYMECTOMY; THYMUS; TRANSGENIC MOUSE;

EID: 27144445820     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.9.5759     Document Type: Article

References (34)

1. Kyewski, B., J. Derbinski, J. Gotter, and L. Klein. 2002. Promiscuous gene expression and central T-cell tolerance: more than meets the eye. Trends Immunol. 23: 364-371.
2. Gotter, J., B. Brors, M. Hergenhahn, and B. Kyewski. 2004. Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters. J. Exp. Med. 199: 155-166.
3. Derbinski, J., A. Schulte, B. Kyewski, and L. Klein. 2001. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2: 1032-1039.
4. Klein, L., M. Klugmann, K. A. Nave, V. K. Tuohy, and B. Kyewski. 2000. Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. Nat. Med. 6: 56-61.
5. Klein, L., B. Roettinger, and B. Kyewski. 2001. Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance. Eur. J. Immunol 31: 2476-2486.
6. Avichezer, D., R. S. Grajewski, C.-C. Chan, M. J. Mattapallil, P. B. Silver, J. A. Raber, G. I. Liou, B. Wiggert, G. M. Lewis, L. A. Donoso, and R. R. Caspi. 2003. An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms. J. Exp. Med. 198: 1665-1676.
7. Liston, A., S. Lesage, J. Wilson, L. Peltonen, and C. C. Goodnow. 2003. Aire regulates negative selection of organ-specific T cells. Nat Immunol. 4: 350-354.
8. Hoffmann, M. W., J. Allison, and J. F. Miller. 1992. Tolerance induction by thymic medullary epithelium. Proc. Natl. Acad. Sci. USA 89: 2526-2530.
9. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2: 301-306.
10. Anderson, M. S., E. S. Venanzi, L. Klein, Z. Chen, S. P. Berzins, S. J. Turley, H. von Boehmer, R. Bronson, A. Dierich, C. Benoist, and D. Mathis. 2002. Projection of an immunological self shadow within the thymus by the aire protein. Science 298: 1395-1401.
11. Johnnidis, J. B., E. S. Venanzi, D. J. Taxman, J. P. Ting, C. O. Benoist, and D. J. Mathis. 2005. Chromosomal clustering of genes controlled by the aire transcription factor. Proc. Natl. Acad. Sci. USA 102: 7233-7238.
12. Peterson, P., K. Nagamine, H. Scott, M. Heino, J. Kudoh, N. Shimizu, S. E. Antonarakis, and K. J. Krohn. 1998. APECED: a monogenic autoimmune disease providing new clues to self-tolerance. Immunol. Today 19: 384-386.
13. Alderuccio, F., B. H. Toh, S. S. Tan, P. A. Gleeson, and I. R. van Driel. 1993. An autoimmune disease with multiple molecular targets abrogated by the transgenic expression of a single autoantigen in the thymus. J. Exp. Med. 178: 419-426.
14. van Driel, I. R., A. G. Baxter, K. L. Laurie, T. D. Zwar, N. L. La Grata, L. M. Judd, K. L. Scarff, P. A. Silveira, and P. A. Gleeson. 2002. Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritis. AutoImmun. Rev. 1: 290-297.
15. De Silva, H. D., P. A. Gleeson, B. H. Toh, I. R. van Driel, and F. R. Carbone. 1999. Identification of a gastritogenic epitope of the H/K ATPase β-subunit. Immunology 96: 145-151.
16. Alderuccio, F., V. Cataldo, I. R. van Driel, P. A. Gleeson, and B. H. Toh. 2000. Tolerance and autoimmunity to a gastritogenic peptide in TCR transgenic mice. Int. Immunol. 12: 343-352.
17. Suri-Payer, E., P. Kenn, A. Cheever, and E. Shevach. 1996. Pathogenesis of post-thymectomy autoimmune gastritis: identification of anti-H/K adenosine triphosphatase-reactive T cells. J. Immunol. 157: 1799-1805.
18. Suri-Payer, E., A. Z. Amar, R. McHugh, K. Natarajan, D. H. Margulies, and E. M. Shevach. 1999. Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells. Eur. J. Immunol. 29: 669-677.
19. McHugh, R. S., E. M. Shevach, D. H. Margulies, and K. Natarajan. 2001. A T cell receptor transgenic model of severe, spontaneous organ-specific autoimmunity. Eur. J. Immunol. 31: 2094-2103.
20. +-ATPase T cell epitopes in human autoimmune gastritis. Eur. J. Immunol. 33: 539-545.
21. Spicer, Z., M. L. Miller, A. Andringa, T. M. Riddle, J. J. Duffy, T. Doetschman, and G. E. Shull. 2000. Stomachs of mice lacking the gastric H, K-ATPase α-subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia. J. Biol. Chem. 275: 21555-21565.
22. +-adenosine triphosphatase β subunit is required for normal function, development, and membrane structure of mouse parietal cells. Gastroenterology 117: 605-618.
23. Alderuccio, F., P. A. Gleeson, S. P. Berzins, M. Martin, I. R. van Driel, and B. H. Toh. 1997. Expression of the gastric H/K-ATPase β-subunit in the thymus may explain the dominant role of the β-subunit in the pathogenesis of autoimmune gastritis. Autoimmunity 25: 167-175.
24. Laurie, K. L., N. L. La Gruta, N. Koch, I. R. van Driel, and P. A. Gleeson. 2004. Thymic expression of a gastritogenic epitope results in positive selection of self-reactive pathogenic T cells. J. Immunol. 172: 5994-6002.
25. + T cells have a major "post-licensing" role in CTL mediated anti-tumor immunity. J. Immunol. 165: 6047-6055.
26. Beggah, A. T., P. Beguin, K. Bamberg, G. Sachs, and K. Geering. 1999. β-Sub-unit assembly is essential for the correct packing and the stable membrane insertion of the H, K-ATPase α-subunit. J. Biol. Chem. 274: 8217-8223.
27. Gottardi, C. J., and M. J. Caplan. 1993. Molecular requirements for the cell-surface expression of multisubunit ion-transporting ATPases: identification of protein domains that participate in Na, K-ATPase and H, K-ATPase subunit assembly. [Published erratum appears in 1993 J. Biol. Chem. 268: 25260.] J. Biol. Chem. 268: 14342-14347.
28. +-ATPase β-subunit- and gastrin-deficient mice. Am. J. Physiol. Gastrointest. Liver Physiol. 281: G1502-G1511.
29. Trombetta, E. S., and I. Mellman. 2005. Cell biology of antigen processing in vitro and in vivo. Annu. Rev. Immunol. 23: 975-1028.
30. Starr, T. K., S. C. Jameson, and K. A. Hogquist. 2003. Positive and negative selection of T cells. Annu. Rev. Immunol. 21: 139-176.
31. +-adenosine triphosphatase of parietal cells discerned by a murine gastritogenic T-cell clone. Gastroenterology 107: 1408-1414.
32. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J. Immunol. 160: 1212-1218.
33. Laurie, K. L., I. R. van Driel, T. D. Zwar, S. P. Barrett, and P. A. Gleeson. 2002. Endogenous H/K ATPase β-subunit promotes T cell tolerance to the immunodominant gastritogenic determinant. J. Immunol. 169: 2361-2367.
34. Candon, S., R. S. McHugh, G. Foucras, K. Natarajan, E. M. Shevach, and D. H. Margulies. 2004. Spontaneous organ-specific Th2-mediated autoimmunity in TCR transgenic mice. J. Immunol. 172: 2917-2924.