Intrathymic expression of genes involved in organ specific autoimmune disease

Journal of Autoimmunity

Volumn 11, Issue 4, 1998, Pages 309-318

  Heath, Victoria L ^a,c   Moore, Nel C ^b   Parnell, Sonia M ^b   Mason, Don W ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Central tolerance; Insulin; Myelin basic protein; Thymus; Thyroglobulin

Indexed keywords

INSULIN; MYELIN BASIC PROTEIN; THYROGLOBULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGENICITY; ARTICLE; AUTOIMMUNITY; CLONAL ANERGY; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE;

EID: 0031755882     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1998.0210     Document Type: Article

References (61)

1. Anderson G., Moore N.C., Owen J.J., Jenkinson E.J. 1996. Cellular interactions in thymocyte development. Annu. Rev. Immunol. 14: 73-99
2. Ramsdell F., Lantz T., Fowlkes B.J. 1989. A nondeletional mechanism of thymic self tolerance. Science 246: 1038-1041
3. Gao E.K., Lo D., Sprent J. 1990. Strong T cell tolerance in parent-F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy. J. Exp. Med. 171: 1101-1121
4. Hoffman M.W., Allison J., Miller J.F. 1992. Tolerance induction by thymic medullary epithelium. Proc. Natl. Acad. Sci. USA 89: 2526-2530
5. Schonrich G., Momburg F., Hammerling G.J., Arnold B. 1992. Anergy induced by thymic medullary epithelium. Eur. J. Immunol. 22: 1687-1691
6. Kawai K., Ohashi P.S. 1995. Immunological function of a defined T-cell population tolerized to low-affinity self antigens. Nature 374: 68-69 [published erratum appears in Nature 378 419].
7. Oukka M., Colucci-Guyon E., Tran P.L., Cohen-Tannoudji M., Babinet C., Lotteau V., Kosmatopoulos K. 1996. CD4 cell tolerance to nuclear proteins induced by medullary thymic epithelium. Immunity 4: 545-553
8. Modigliani Y., Thomas-Vaslin V., Bandeira A., Coltey M., Le-Douarin N.M., Coutinho A., Salaun J. 1995. Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype. Proc. Natl. Acad. Sci. USA 92: 7555-7559
9. Le-Douarin N., Corbel C., Bandeira A., Thomas-Vaslin V., Modigliani Y, Coutinho A., Salaun J. 1996. Evidence for a thymus-dependent form of tolerance that is not based on elimination or anergy of reactive T cells. Immunol. Rev. 149: 35-53
10. Saoudi A., Seddon B., Heath V., Fowell D., Mason D. 1996. The physiological role of regulatory T cells in the prevention of autoimmunity: the function of the thymus in the generation of the regulatory T cell subset. Imm. Rev. 149: 195-216
11. Mueller D.L., Jenkins M.K., Schwartz R.H. 1989. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7: 445-480
12. Ohashi P.S., Oehen S., Buerki K., Pircher H., Ohashi C.T., Odermatt B., Malissen B., Zinkernagel R.M., Hengartner H. 1991. Ablation of 'tolerance' and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65: 305-317
13. Webb S., Morris C., Sprent J. 1990. Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell 63: 1249-1256
14. Jolicoeur C., Hanahan D., Smith K. 1994. T-cell tolerance toward a transgenic beta cell antigen and transcription of endogenous pancreatic genes in thymus. Proc. Natl. Acad. Sci. USA 91: 6707-6711
15. Heath W.R., Allison J., Hoffmann M.W., Schonrich G., Hammerling G., Arnold B., Miller J.F. 1992. Autoimmune diabetes as a consequence of locally produced interleukin-2. Nature 359: 547-549
16. Sponaas A.M., Tomlinson P.D., Antoniou J., Auphan N., Langlet C., Malissen B., Schmitt-Verhulst A.M., Mellor A.L. 1994. Induction of tolerance to self MHC class I molecules expressed under the control of milk protein or beta-globin gene promoters. Int. Immunol. 6: 277-287
17. Antonia S.J., Geiger T., Miller J., Flavell R.A. 1995. Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein. Int. Immunol. 7: 715-725
18. Grima B., Zelenika D., Pessac B. 1992. A novel transcript overlapping the myelin basic protein gene. J. Neurochem. 59: 2318-2323
19. Mathisen P.M., Pease S., Garvey J., Hood L., Readhead C. 1993. Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo. Proc. Natl. Acad. Sci. USA 90: 10125-10129
20. Pribyl T.M., Campagnoni C.W., Kampf K., Kashima T., Handley V.W., McMahon J., Campagnoni A.T. 1993. The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems. Proc. Natl. Acad. Sci. USA 90: 10695-10699
21. Wekerle H., Bradl M., Linington C., Kaab G., Kojima K. 1996. The shaping of the brain-specific T lymphocyte repertoire in the thymus. Immunol. Rev. 149: 231-243
22. Weetman A.P., McGregor A.M. 1984. Autoimmune thyroid disease: developments in our understanding. Endocrin. Rev. 5: 308-355
23. Hafler D.A., Benjamin D.S., Burks J., Weiner H.L. 1987. Myelin basic protein and proteolipid protein reactivity of brain- and cerebrospinal fluid-derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis. J. Immunol. 139: 68-72
24. Wegmann D.R., Norbury-Glaser M., Daniel D. 1994. Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice. Eur. J. Immunol. 24: 1853-1857
25. Ruf J., Czarnocka B., De-Micco C., Dutoit C., Ferrand M., Carayon P. 1987. Thyroid peroxidase is the organ-specific 'microsomal' autoantigen involved in thyroid autoimmunity Acta. Endocrinol. Suppl. Copenh. 281: 49-56
26. Nudel U., Zakut R., Shani M., Neuman S., Levy Z., Yaffe D. 1983. The nucleotide sequence of the rat cytoplasmic beta-actin gene. Nucleic Acids Res. 11: 1759-1771
27. Lomedico P., Rosenthal N., Efstratidadis A., Gilbert W., Kolodner R., Tizard R. 1979. The structure and evolution of the two nonallelic rat preproinsulin genes. Cell 18: 545-558
28. Wentworth B.M., Schaefer I.M., Villa-Komaroff L., Chirgwin J.M. 1986. Characterization of the two nonallelic genes encoding mouse preproinsulin. J. Mol. Evol. 23: 305-312
29. Roach A., Boylan K., Horvath S., Prusiner S.B., Hood L.E. 1983. Characterization of cloned cDNA representing rat myelin basic protein: absence of expression in brain of shiverer mutant mice. Cell 34: 799-806
30. Di-Lauro R., Obici S., Condliffe D., Ursini V.M., Musti A., Moscatelli C., Avvedimento V.E. 1985. The sequence of 967 amino acids at the carboxyl-end of rat thyroglobulin. Location and surroundings of two thyroxine-forming sites. Eur. J. Biochem. 148: 7-11
31. Derwahl M., Seto P., Rapoport B. 1989. Complete nucleotide sequence of the cDNA for thyroid peroxidase in FRTL5 rat thyroid cells. Nucleic Acids Res. 17: 8380
32. Anderson G., Jenkinson E.J., Moore N.C., Owen J.J. 1993. MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus. Nature 362: 70-73
33. Moore N.C., Anderson G., McLoughlin D.E., Owen J.J., Jenkinson E.J. 1994. Differential expression of Mtv loci in MHC class II-positive thymic stromal cells. J. Immunol. 152: 4826-4831
34. Jenkinson E.J., Anderson G., Owen J.J. 1992. Studies on T cell maturation on defined thymic stromal cell populations in vitro. J. Exp. Med. 176: 845-853
35. Anderson G., Owen J.J., Moore N.C., Jenkinson E.J. 1994. Characteristics of an in vitro system of thymocyte positive selection. J. Immunol. 153: 1915-1920
36. Moore N.C., Girdlestone J., Anderson G., Owen J.J., Jenkinson E.J. 1995. Stimulation of thymocytes before and after positive selection results in the induction of different NF-kappa B/Rel protein complexes. J. Immunol 155: 4653-4660
37. Moore N.C., Anderson G., Smith C.A., Owen J.J., Jenkinson E.J. 1993. Analysis of cytokine gene expression in subpopulations of freshly isolated thymocytes and thymic stromal cells using semiquantitative polymerase chain reaction. Eur. J. Immunol. 23: 922-927
38. Sambrook J., Fritsch E.F., Maniatis T. 1989. Molecular Cloning. In A laboratory manual. C. Nolan, ed. Cold Spring Harbor Laboratory Press, NY, pp. 7.6-7.9
39. Dallman M.J., Shiho O., Page T.H., Wood K.J., Morris P.J. 1991. Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway. J. Exp. Med. 173: 79-87
40. Devaskar S.U., Giddings S.J., Rajakumar P.A., Carnaghi L.R., Menon R.K., Zahm D.S. 1994. Insulin gene expression and insulin synthesis in mammalian neuronal cells. J. Biol. Chem. 269: 8445-8454
41. Campagnoni A.T., Pribyl T.M., Campagnoni C.W., Kampf K., Amur-Umarjee S., Landry C.F., Handley V.W., Newman S.L., Garbay B., Kitamura K. 1993. Structure and developmental regulation of Golli-mbp, a 105-kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain. J. Biol. Chem. 268: 4930-4938
42. Zelenika D., Grima B., Pessac B. 1993. A new family of transcripts of the myelin basic protein gene: expression in brain and in immune system. J. Neurochem. 60: 1574-1577
43. Fritz R.B., Zhao M.L. 1996. Thymic expression of myelin basic protein (MPB) Activation of MBP-specific T cells by thymic cells in the absence of exogenous MBP. J. Immunol. 157: 5249-5253
44. Anderson W.A., Kang Y.H., Mohla S. 1979. Mammalian endogenous peroxidases as cellular markers and as biosynthetic endpoints of hormone- mediated activity: viewpoint from cytochemistry. Pro. Histochem. Cytochem. 11: 1-27
45. Smith K.M., Olson D.C., Hirose R., Hanahan D. 1997. Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance. Int. Immunol. 9: 1355-1365
46. Soares M.B., Schon E., Henderson A., Karathanasis S.K., Cate R., Zeitlin S., Chirgwin J., Efstratiadis A. 1985. RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon. Mol. Cell Biol. 5: 2090-2103
47. Lakshmikumaran M.S., D'Ambrosio E., Laimins L.A., Lin D.T., Furano A.V. 1985. Long interspersed repeated DNA (LINE) causes polymorphism at the rat insulin 1 locus. Mol. Cell Biol. 5: 2197-2203
48. Daniel D., Gill R.G., Schloot N., Wegmann D. 1995. Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur. J. Immunol. 25: 1056-1062
49. Roberts J.L., Sharrow S.O., Singer A. 1990. Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities. J. Exp. Med. 171: 935-940
50. Speiser D.E., Pircher H., Ohashi P.S., Kyburz D., Hengartner H., Zinkernagel R.M. 1992. Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogeny. J. Exp. Med. 175: 1277-1283
51. Burkly L.C., Degermann S., Longley J., Hagman J., Brinster R.L., Lo D., Flavell R.A. 1993. Clonal deletion of V beta 5+ T cells by transgenic I-E restricted to thymic medullary epithelium. J. Immunol. 151: 3954-3960
52. Laufer T.M., DeKoning J., Markowitz J.S., Lo D., Glimcher L.H. 1996. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature 383: 81-85
53. Modigliani Y., Pereira P., Thomas-Vaslin V., Salaun J., Burlen-Defranoux O., Coutinho A., Le-Douarin N., Bandeira A. 1995. Regulatory T cells in thymic epithelium-induced tolerance. I. Suppression of mature peripheral non-tolerant T. cells. Eur. J. Immunol. 25: 2563-2571
54. Saoudi A., Seddon B., Fowell D., Mason D. 1996. The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients. J. Exp. Med. 184: 2393-2398
55. Schonrich G., Strauss G., Muller K.P., Dustin L., Loh D.Y., Auphan N., Schmitt-Verhulst A.M., Arnold B., Hammerling G.J. 1993. Distinct requirements of positive and negative selection for selecting cell type and CD8 interaction. J. Immunol. 151: 4098-4105
56. b molecules in transgenic mice. Int. Immunol. 5: 189-198
57. Kappler J.W., Roehm M., Marrack P. 1987. T cell tolerance by clonal elimination in the thymus. Cell 49: 273-280
58. von-Herrath M.G., Dockter J., Oldstone M.B. 1994. How virus induces a rapid or slow onset insulin- dependent diabetes mellitus in a transgenic model. Immunity 1: 231-242
59. Kennedy G.C., German M.S., Rutter W.J. 1995. The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription. Nat. Genet. 9: 293-298
60. Vafiadis P., Bennett S.T., Todd J.A., Nadeau J., Grabs R., Goodyer C.G., Wickramasinghe S., Colle E., Polychronakos C. 1997. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nature Genetics 15: 289-292
61. Egwuagu C.E., Charukamnoetkanok P., Gery I. 1997. Thymic expression of autoantigen correlates with resistance to autoimmune disease. J. Immunol. 159: 3109-3112