메뉴 건너뛰기




Volumn 104, Issue 3, 2004, Pages 775-780

IL-2-induced CD4+ T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferation

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; BROXURIDINE; CD4 ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; KI 67 ANTIGEN;

EID: 3242773778     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-12-4355     Document Type: Article
Times cited : (82)

References (37)
  • 1
    • 0013610170 scopus 로고    scopus 로고
    • Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus
    • Kovacs JA, Vogel S, Albert JM, et al. Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus. N Engl J Med. 1996;335:1350-1356.
    • (1996) N Engl J Med , vol.335 , pp. 1350-1356
    • Kovacs, J.A.1    Vogel, S.2    Albert, J.M.3
  • 2
    • 0004781509 scopus 로고    scopus 로고
    • Immunologic and virologic effects of subcutaneous interleukin 2 in combination with antiretroviral therapy: A randomized controlled trial
    • Davey RT Jr, Murphy RL, Graziano FM, et al. Immunologic and virologic effects of subcutaneous interleukin 2 in combination with antiretroviral therapy: a randomized controlled trial. JAMA. 2000;284:183-189.
    • (2000) JAMA , vol.284 , pp. 183-189
    • Davey Jr., R.T.1    Murphy, R.L.2    Graziano, F.M.3
  • 3
    • 0037105607 scopus 로고    scopus 로고
    • Long-term effects of intermittent interleukin 2 therapy in patients with HIV infection: Characterization of a novel subset of CD4(+)/CD25(+) T cells
    • Sereti I, Martinez-Wilson H, Metcalf JA, et al. Long-term effects of intermittent interleukin 2 therapy in patients with HIV infection: characterization of a novel subset of CD4(+)/CD25(+) T cells. Blood. 2002;100:2159-2167.
    • (2002) Blood , vol.100 , pp. 2159-2167
    • Sereti, I.1    Martinez-Wilson, H.2    Metcalf, J.A.3
  • 4
    • 0037436193 scopus 로고    scopus 로고
    • Effects of interleukin-2 therapy combined with highly active antiretroviral therapy on immune restoration in HIV-1 infection: A randomized controlled trial
    • Levy Y, Durier C, Krzysiek R, et al. Effects of interleukin-2 therapy combined with highly active antiretroviral therapy on immune restoration in HIV-1 infection: a randomized controlled trial. AIDS. 2003;17:343-351.
    • (2003) AIDS , vol.17 , pp. 343-351
    • Levy, Y.1    Durier, C.2    Krzysiek, R.3
  • 5
    • 0037169251 scopus 로고    scopus 로고
    • Lymphocytes proliferate in blood and lymph nodes following interleukin-2 therapy in addition to highly active antiretroviral therapy
    • Hengge UR, Borchard C, Esser S, Schroder M, Mirmohammadsadegh A, Goos M. Lymphocytes proliferate in blood and lymph nodes following interleukin-2 therapy in addition to highly active antiretroviral therapy. AIDS. 2002;16:151-160.
    • (2002) AIDS , vol.16 , pp. 151-160
    • Hengge, U.R.1    Borchard, C.2    Esser, S.3    Schroder, M.4    Mirmohammadsadegh, A.5    Goos, M.6
  • 7
    • 0032550369 scopus 로고    scopus 로고
    • + T lymphocytes in HIV-1 infection as measured by Ki-67 antigen
    • + T lymphocytes in HIV-1 infection as measured by Ki-67 antigen. J Exp Med. 1998;187:1295-1303.
    • (1998) J Exp Med , vol.187 , pp. 1295-1303
    • Sachsenberg, N.1    Perelson, A.S.2    Yerly, S.3
  • 9
    • 0343920019 scopus 로고    scopus 로고
    • T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: A longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART)
    • Hazenberg MD, Stuart JW, Otto SA, et al. T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART). Blood. 2000;95:249-255.
    • (2000) Blood , vol.95 , pp. 249-255
    • Hazenberg, M.D.1    Stuart, J.W.2    Otto, S.A.3
  • 10
    • 0035169609 scopus 로고    scopus 로고
    • Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy
    • Mohri H, Perelson AS, Tung K, et al. Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy. J Exp Med. 2001;194:1277-1287.
    • (2001) J Exp Med , vol.194 , pp. 1277-1287
    • Mohri, H.1    Perelson, A.S.2    Tung, K.3
  • 11
    • 0035905463 scopus 로고    scopus 로고
    • Identification of dynamically distinct subpopulations of T lymphocytes that are differentially affected by HIV
    • Kovacs JA, Lempicki RA, Sidorov IA, et al. Identification of dynamically distinct subpopulations of T lymphocytes that are differentially affected by HIV. J Exp Med. 2001;194:1731-1741.
    • (2001) J Exp Med , vol.194 , pp. 1731-1741
    • Kovacs, J.A.1    Lempicki, R.A.2    Sidorov, I.A.3
  • 12
    • 0038417311 scopus 로고    scopus 로고
    • Incomplete CD4 T cell recovery in HIV-1 infection after 12 months of highly active antiretroviral therapy is associated with ongoing increased CD4 T cell activation and turnover
    • Anthony KB, Yoder C, Metcalf JA, et al. Incomplete CD4 T cell recovery in HIV-1 infection after 12 months of highly active antiretroviral therapy is associated with ongoing increased CD4 T cell activation and turnover. J Acquir Immune Defic Syndr. 2003;33:125-133.
    • (2003) J Acquir Immune Defic Syndr , vol.33 , pp. 125-133
    • Anthony, K.B.1    Yoder, C.2    Metcalf, J.A.3
  • 13
    • 0031439413 scopus 로고    scopus 로고
    • Effects of subcutaneous interleukin-2 therapy on CD4 subsets and in vitro cytokine production in HIV+ subjects
    • De Paoli P, Zanussi S, Simonelli C, et al. Effects of subcutaneous interleukin-2 therapy on CD4 subsets and in vitro cytokine production in HIV+ subjects. J Clin Invest. 1997;100:2737-2743.
    • (1997) J Clin Invest , vol.100 , pp. 2737-2743
    • De Paoli, P.1    Zanussi, S.2    Simonelli, C.3
  • 14
    • 0033526641 scopus 로고    scopus 로고
    • Comparison of subcutaneous and intravenous interleukin-2 in asymptomatic HIV-1 infection: A randomised controlled trial
    • ANRS 048 study group
    • Levy Y, Capitant C, Houhou S, et al. Comparison of subcutaneous and intravenous interleukin-2 in asymptomatic HIV-1 infection: a randomised controlled trial. ANRS 048 study group. Lancet. 1999;353:1923-1929.
    • (1999) Lancet , vol.353 , pp. 1923-1929
    • Levy, Y.1    Capitant, C.2    Houhou, S.3
  • 15
    • 0032955651 scopus 로고    scopus 로고
    • Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage
    • Giorgi JV, Hultin LE, McKeating JA, et al. Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis. 1999;179:859-870.
    • (1999) J Infect Dis , vol.179 , pp. 859-870
    • Giorgi, J.V.1    Hultin, L.E.2    McKeating, J.A.3
  • 17
    • 0033624622 scopus 로고    scopus 로고
    • The impact of HIV on naive T-cell homeostasis
    • Grossman Z, Paul WE. The impact of HIV on naive T-cell homeostasis. Nat Med. 2000;6:976-977.
    • (2000) Nat Med , vol.6 , pp. 976-977
    • Grossman, Z.1    Paul, W.E.2
  • 19
    • 0013109560 scopus 로고    scopus 로고
    • Reduced naive and increased activated CD4 and CD8 cells in healthy adult Ethiopians compared with their Dutch counterparts
    • Messele T, Abdulkadir M, Fontanet AL, et al. Reduced naive and increased activated CD4 and CD8 cells in healthy adult Ethiopians compared with their Dutch counterparts. Clin Exp Immunol. 1999;115:443-450.
    • (1999) Clin Exp Immunol , vol.115 , pp. 443-450
    • Messele, T.1    Abdulkadir, M.2    Fontanet, A.L.3
  • 20
    • 0031736997 scopus 로고    scopus 로고
    • Decreased CD4 and increased CD8 counts with T cell activation is associated with chronic helminth infection
    • Kalinkovich A, Weisman Z, Greenberg Z, et al. Decreased CD4 and increased CD8 counts with T cell activation is associated with chronic helminth infection. Clin Exp Immunol. 1998;114:414-421.
    • (1998) Clin Exp Immunol , vol.114 , pp. 414-421
    • Kalinkovich, A.1    Weisman, Z.2    Greenberg, Z.3
  • 21
    • 0037343278 scopus 로고    scopus 로고
    • Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia
    • Silvestri G, Sodora DL, Koup RA, et al. Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. Immunity. 2003;18:441-452.
    • (2003) Immunity , vol.18 , pp. 441-452
    • Silvestri, G.1    Sodora, D.L.2    Koup, R.A.3
  • 22
    • 0037105617 scopus 로고    scopus 로고
    • CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load
    • Sousa AE, Carneiro J, Meier-Schellersheim M, Grossman Z, Victorino RM. CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load. J Immunol. 2002;169:3400-3406.
    • (2002) J Immunol , vol.169 , pp. 3400-3406
    • Sousa, A.E.1    Carneiro, J.2    Meier-Schellersheim, M.3    Grossman, Z.4    Victorino, R.M.5
  • 23
    • 0041327667 scopus 로고    scopus 로고
    • Persistent immune activation in HiV-1 infection is associated with progression to AIDS
    • Hazenberg MD, Otto SA, van Benthem BH, et al. Persistent immune activation in HiV-1 infection is associated with progression to AIDS. AIDS. 2003;17:1881-1888.
    • (2003) AIDS , vol.17 , pp. 1881-1888
    • Hazenberg, M.D.1    Otto, S.A.2    Van Benthem, B.H.3
  • 24
    • 0036468120 scopus 로고    scopus 로고
    • + T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment with protease inhibitor-based therapy
    • + T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment with protease inhibitor-based therapy. J Infect Dis. 2002;185:315-323.
    • (2002) J Infect Dis , vol.185 , pp. 315-323
    • Deeks, S.G.1    Hoh, R.2    Grant, R.M.3
  • 25
    • 0037339351 scopus 로고    scopus 로고
    • A study of the immunology, virology, and safety of prednisone in HIV-1-infected subjects with CD4 cell counts of 200 to 700 mm(-3)
    • Wallis RS, Kalayjian R, Jacobson JM, et al. A study of the immunology, virology, and safety of prednisone in HIV-1-infected subjects with CD4 cell counts of 200 to 700 mm(-3). J Acquir Immune Defic Syndr. 2003;32:281-286.
    • (2003) J Acquir Immune Defic Syndr , vol.32 , pp. 281-286
    • Wallis, R.S.1    Kalayjian, R.2    Jacobson, J.M.3
  • 26
    • 0036534889 scopus 로고    scopus 로고
    • Placebo-controlled trial of cyclosporin-A in HIV-1 disease: Implications for solid organ transplantation
    • Calabrese LH, Lederman MM, Spritzler J, et al. Placebo-controlled trial of cyclosporin-A in HIV-1 disease: implications for solid organ transplantation. J Acquir Immune Defic Syndr. 2002;29:356-362.
    • (2002) J Acquir Immune Defic Syndr , vol.29 , pp. 356-362
    • Calabrese, L.H.1    Lederman, M.M.2    Spritzler, J.3
  • 27
    • 0033942250 scopus 로고    scopus 로고
    • Effects of mycopheholic acid on human immunodeficiency virus infection in vitro and in vivo
    • Chapuis AG, Paolo Rizzardi G, D'Agostino C, et al. Effects of mycopheholic acid on human immunodeficiency virus infection in vitro and in vivo. Nat Med. 2000;6:762-768.
    • (2000) Nat Med , vol.6 , pp. 762-768
    • Chapuis, A.G.1    Paolo Rizzardi, G.2    D'Agostino, C.3
  • 28
    • 0037008037 scopus 로고    scopus 로고
    • High prevalence of osteonecrosis of the femoral head in HIV-infected adults
    • Miller KD, Masur H, Jones EC, et al. High prevalence of osteonecrosis of the femoral head in HIV-infected adults. Ann Intern Med. 2002;137:17-25.
    • (2002) Ann Intern Med , vol.137 , pp. 17-25
    • Miller, K.D.1    Masur, H.2    Jones, E.C.3
  • 30
    • 0037178320 scopus 로고    scopus 로고
    • Effects of interleukin-2 plus highly active antiretrovital therapy on HIV-1 replication and proviral DNA (COSMIC trial)
    • Stellbrink HJ, van Lunzen J, Westby M, et al. Effects of interleukin-2 plus highly active antiretrovital therapy on HIV-1 replication and proviral DNA (COSMIC trial). AIDS. 2002;16:1479-1487.
    • (2002) AIDS , vol.16 , pp. 1479-1487
    • Stellbrink, H.J.1    Van Lunzen, J.2    Westby, M.3
  • 31
    • 0003329081 scopus 로고    scopus 로고
    • Randomised study of intermittent subcutaneous interleukin-2 (IL-2) therapy without antiretrovirals versus no treatment
    • South Africa
    • Youle M, Fisher M, Nelson M, et al. Randomised study of intermittent subcutaneous interleukin-2 (IL-2) therapy without antiretrovirals versus no treatment [abstract]. XIII International AIDS Conference, Durban, South Africa, 2000.
    • (2000) XIII International AIDS Conference, Durban
    • Youle, M.1    Fisher, M.2    Nelson, M.3
  • 32
    • 0035964685 scopus 로고    scopus 로고
    • CD4 T cell expansions are associated with increased apoptosis rates of T lymphocytes during IL-2 cycles in HIV infected patients
    • Sereti I, Herpin B, Metcalf JA, et al. CD4 T cell expansions are associated with increased apoptosis rates of T lymphocytes during IL-2 cycles in HIV infected patients. AIDS. 2001;15:1765-1775.
    • (2001) AIDS , vol.15 , pp. 1765-1775
    • Sereti, I.1    Herpin, B.2    Metcalf, J.A.3
  • 33
    • 0033801154 scopus 로고    scopus 로고
    • Effects of intermittent interleukin-2 therapy on plasma and tissue human immunodeficiency virus levels and quasi-species expression
    • Kovacs JA, Imamichi H, Vogel S, et al. Effects of intermittent interleukin-2 therapy on plasma and tissue human immunodeficiency virus levels and quasi-species expression. J Infect Dis. 2000;182:1063-1069.
    • (2000) J Infect Dis , vol.182 , pp. 1063-1069
    • Kovacs, J.A.1    Imamichi, H.2    Vogel, S.3
  • 34
    • 0042943133 scopus 로고    scopus 로고
    • A randomized, double-blinded, placebo-controlled trial of intermittent administration of interleukin-2 and prednisone in subjects infected with human immunodeficiency virus
    • Tavel JA, Sereti I, Walker RE, et al. A randomized, double-blinded, placebo-controlled trial of intermittent administration of interleukin-2 and prednisone in subjects infected with human immunodeficiency virus. J Infect Dis. 2003;188:531-536.
    • (2003) J Infect Dis , vol.188 , pp. 531-536
    • Tavel, J.A.1    Sereti, I.2    Walker, R.E.3
  • 35
    • 0037222169 scopus 로고    scopus 로고
    • + T cells that preferentially respond to recall antigen
    • + T cells that preferentially respond to recall antigen. J Immunol. 2003;170:28-32.
    • (2003) J Immunol , vol.170 , pp. 28-32
    • Hengel, R.L.1    Thaker, V.2    Pavlick, M.V.3
  • 36
    • 0033554726 scopus 로고    scopus 로고
    • Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    • Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999;401:708-712.
    • (1999) Nature , vol.401 , pp. 708-712
    • Sallusto, F.1    Lenig, D.2    Forster, R.3    Lipp, M.4    Lanzavecchia, A.5
  • 37
    • 0036209488 scopus 로고    scopus 로고
    • The evaluation of subcutaneous proleukin (interleukin-2) in a randomized international trial: Rationale, design, and methods of ESPRIT
    • Emery S, Abrams DI, Cooper DA, et al. The evaluation of subcutaneous proleukin (interleukin-2) in a randomized international trial: rationale, design, and methods of ESPRIT. Control Clin Trials. 2002;23:198-220.
    • (2002) Control Clin Trials , vol.23 , pp. 198-220
    • Emery, S.1    Abrams, D.I.2    Cooper, D.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.