Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers

Clinical Cancer Research

Volumn 9, Issue 12, 2003, Pages 4404-4408

  Ichihara, Fumiko ^a   Kono, Koji ^a   Takahashi, Akihiro ^a   Kawaida, Hiromichi ^a   Sugai, Hidemitsu ^a   Fujii, Hideki ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CANCER STAGING; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOSE RESPONSE; ESOPHAGUS CANCER; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MALE; MONONUCLEAR CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; STAINING; STOMACH CANCER; STOMACH MUCOSA; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TUMOR ASSOCIATED LEUKOCYTE;

AGED; ANTIGENS, CD4; CASE-CONTROL STUDIES; CELL DIVISION; ESOPHAGEAL NEOPLASMS; FEMALE; GASTRIC MUCOSA; HUMANS; IMMUNE SYSTEM; IMMUNE TOLERANCE; INTERFERON TYPE II; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MIDDLE AGED; RECEPTORS, INTERLEUKIN-2; STOMACH NEOPLASMS; T-LYMPHOCYTES;

EID: 0141891466     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Miescher, S., Whiteside, T. L., Carrel, S., and von Fliender, V. Functional properties of tumor-infiltrating and blood lymphocytes in patients with solid tumors: effects of tumor cells and their supernatants on proliferative responses of lymphocytes, J. Immunol., 136: 1899-1907, 1986.
2. Young, R. C., Corder, M. P., Haynes, H. A., and DeVita, V. T. Delayed hypersensitivity in Hodgkin's disease. A study of 103 untreated patients. Am. J. Med., 52: 63-68, 1972.
3. Alexander, J. P., Kudoh, S., Melsop, K. A., Hamilton, T. A., Edinger, M. G. R., Tubbs, R., Sica, D., Tuason, L., Klein, E., Bukowski, R. M., et al. T cells infiltrating renal cell carcinoma display a poor proliferative response even though they can produce interleukin 2 and express interleukin 2 receptors. Cancer Res., 53: 1380-1387, 1993.
4. Horiguchi, S., Petersson, M., Nakazawa, T., Kanda, M., Zea, A. H., Ochoa, A. C., and Kiessling, R. Primary chemically induced tumors induce profound immunosuppression concomitant with apoptosis and alterations in signal transduction in T cells and NK cells. Cancer Res., 59: 2950-2956, 1999.
5. Kiessling, R., Wasserman, K., Horiguchi, S., Kono, K., Sjoberg, J., Pisa, P., and Petersson, M. Tumor-induced immune dysfunction. Cancer Immunol. Immunother., 48: 353-362, 1999.
6. Kono, K., Ressing, M. E., Brandt, R. M., Melief, C. J., Potkul, R., Andersson, K. B., Petersson, M., Kast, W. M., and Kiessling, R. Decreased expression of signal-transducing ζ chain in peripheral T cells and natural killer cells in patients with cervical cancer. Clin. Cancer Res., 2: 1825-1828, 1996.
7. Saito, T., Kuss, I., Dworacki, G., Gooding, W., Johnson, J. T., and Whiteside, T. L. Spontaneous ex vivo apoptosis of peripheral blood mononuclear cells in patients with head and neck cancer. Clin. Cancer Res., 5: 1263-1273, 1999.
8. Saito, T., Dworacki, G., Gooding, W., Lotze, M. T., and Whiteside, T. L. Spontaneous apoptosis of CD8+ T lymphocytes in peripheral blood of patients with advanced melanoma. Clin. Cancer Res., 6: 1351-1364, 2000.
9. Takahashi, A., Kono, K., Amemiya, H., Iizuka, H., Fujii, H., and Matsumoto, Y. Elevated caspase-3 activity in peripheral blood T cells coexists with increased degree of T-cell apoptosis and down-regulation of TCR ζ molecules in patients with gastric cancer. Clin. Cancer Res., 7: 74-80, 2001.
10. Gastman, B. R., Johnson, D. E., Whiteside, T. L., and Rabinowich, H. Caspase-mediated degradation of T-cell receptor ζ-chain. Cancer Res., 59: 1422-1427, 1999.
11. Kono, K., Salazar-Onfray, F., Petersson, M., Hansson, J., Masucci, G., Wasserman, K., Nakazawa, T., Anderson, P., and Kiessling, R. Hydrogen peroxide secreted by tumor-derived macrophages down-modulates signal-transducing ζ molecules and inhibits tumor-specific T cell- and natural killer cell-mediated cytotoxicity. Eur. J. Immunol., 26: 1308-1313, 1996.
12. Malmberg, K. J., Arulampalam, V., Ichihara, F., Petersson, M., Seki, K., Andersson, T., Lenkei, R., Masucci, G., Pettersson, S., and Kiessling, R. Inhibition of activated/memory (CD45RO(+)) T cells by oxidative stress associated with block of NF-κB activation. J. Immunol., 167: 2595-2561, 2001.
13. Takahashi, A., Kono, K., Ichihara, F., Sugai, H., Amemiya, H., Iizuka, H., Fujii, H., and Matsumoto, Y. Macrophages in tumor-draining lymph node with different characteristics induce T-cell apoptosis in patients with advanced stage-gastric cancer. Int. J. Cancer, 104: 393-399, 2003.
14. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., and Toda, M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol., 155: 1151-1164, 1995.
15. Dieckmann, D., Plottner, H., Berchtold, S., Berger, T., and Schuler, G. Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J. Exp. Med., 193: 1303-1310, 2001.
16. Asano, M., Toda, M., Sakaguchi, N., and Sakaguchi, S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med., 184: 387-396, 1996.
17. Sakaguchi, S., Sakaguchi, N., Shimizu, J., Yamazaki, S., Sakihama, T., Itoh, M., Kuniyasu, Y., Nomura, T., Toda, M., and Takahashi, T. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev., 182: 18-32, 2001.
18. Somasundaram, R., Jacob, L., Swoboda, R., Caputo, L., Song, H., Basak, S., Monos, D., Peritt, D., Marincola, F., Cai, D., Birebent, B., Bloome, E., Kim, J., Berencsi, K., Mastrangelo, M., and Herlyn, D. Inhibition of cytolytic T lymphocyte proliferation by autologous CD4+/CD25+ regulatory T cells in a colorectal carcinoma patient is mediated by transforming growth factor-β. Cancer Res., 62: 5267-5272, 2002.
19. Awwad, M., and North, R. J. Cyclophosphamide-induced immunologically mediated regression of a cyclophosphamide-resistant murine tumor: a consequence of eliminating precursor L3T4+ suppressor T-cells. Cancer Res., 49: 1649-1654, 1989.
20. Woo, E. Y., Chu, C. S., Goletz, T. J., Schlienger, K., Yeh, H., Coukos, G., Rubin, S. C., Kaiser, L. R., and June, C. H. Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res., 61: 4766-4772, 2001.
21. Woo, E. Y., Yeh, H., Chu, C. S., Schlienger, K., Carroll, R. G., Riley, J. L., Kaiser, L. R., and June, C. H. Cutting edge: regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J. Immunol., 168: 4272-4276, 2002.
22. Liyanage, U. K., Moore, T. T., Joo, H. G., Tanaka, Y., Herrmann, V., Doherty, G., Drebin, J. A., Strasberg, S. M., Eberlein, T. J., Goedegebuure, P. S., and Linehan, D. C. Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J. Immunol., 169: 2756-2761, 2002.
23. Onizuka, S., Tawara, I., Shimizu, J., Sakaguchi, S., Fujita, T., and Nakayama, E. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor α) monoclonal antibody. Cancer Res., 59: 3128-3133, 1999.
24. Fujimoto, S., Greene, M., and Sehon, A. H. Immunosuppressor T cells in tumor bearing host. Immunol. Commun., 4: 201-217, 1975.
25. Kono, K., Takahashi, A., Ichihara, F., Amemiya, H., Iizuka, H., Fujii, H., Sekikawa, T., and Matsumoto, Y. Prognostic significance of adoptive immunotherapy with tumor-associated lymphocytes in patients with advanced gastric cancer: a randomized trial. Clin. Cancer Res., 8: 1767-1771, 2002.
26. Kono, K., Takahashi, A., Sugai, H., Fujii, H., Choudhury, A. R., Kiessling, R., and Matsumoto, Y. Dendritic cells pulsed with HER-2/neu-derived peptides can induce specific T cell responses in patients with gastric cancer. Clin. Cancer Res., 8: 3394-3400, 2002.