Depletion of CD25+ CD4+ T cells and treatment with tyrosinase-related protein 2-transduced dendritic cells enhance the interferon α-induced, CD8+ T-cell-dependent immune defense of B16 melanoma

Cancer Research

Volumn 61, Issue 24, 2001, Pages 8643-8646

  Steitz, Julia ^a   Brück, Jürgen ^a   Lenz, Julia ^a   Knop, Jürgen ^a   Tüting, Thomas ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; DENDRITIC CELL; LYMPHOCYTE COUNT; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TUMOR IMMUNITY;

ANIMALS; ANTIGENS, NEOPLASM; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; DENDRITIC CELLS; IMMUNOTHERAPY, ADOPTIVE; INTERFERON-ALPHA; INTRAMOLECULAR OXIDOREDUCTASES; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, NUDE; RECEPTORS, INTERLEUKIN-2; TRANSDUCTION, GENETIC;

EID: 0035893387     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Adjuvant IFNα2 therapy of melanoma
2. The nature of the principal type 1 interferon-producing cells in human blood
3. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type 1 interferon
4. The neglected role of type I interferon in T-cell response: Implications for its clinical use
5. Natural interferon α/β-producing cells link innate and adaptive immunity
6. Interferon inhibits the suppressor T-cell response of delayed-type hypersensitivity
7. Induction of bystander T-cell proliferation by viruses and type 1 interferon in vivo
8. Type 1 interferons keep activated T-cells alive
9. IFN-α 1 gene expression into metastatic murine adenocarcinoma (TS/A) results in CD8+ T-cell-mediated tumor rejection and development of antitumor immunity. Comparative studies with IFN-γ producing TS/A cells
10. The induction of in vivo proliferation of long-lived CD44hi CD8+ T-cells after the injection of tumor cells expressing IFN-α1 into syngeneic mice
11. Interferon-α-expressing tumor cells enhance generation and promote survival of tumor-specific cytotoxic T-cells
12. Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma
13. Interferon-α gene therapy for cancer: Retroviral transduction of fibroblasts and particle-mediated transfection of tumor cells are both effective strategies for gene delivery in murine tumor models
14. Adenovirus-transduced dendritic cells stimulate cellular immunity to melanoma via a CD4+ T cell-dependent mechanism
15. IFN-α1 gene transfection completely abolishes the tumorigenicity of murine B16 melanoma cells in allogeneic DBA/2 mice and decreases their tumorigenicity in syngeneic C57BL/6 mice
16. Manipulation of costimulatory signals to enhance antitumor T-cell responses
17. Elimination of CD4+ T-cells enhances antitumor effect of locally secreted interleukin-12 on B16 mouse melanoma and induces vitiligo-like coat color alteration
18. Induction of tumor immunity by removing CD25+ CD4+ T-cells: A common basis between tumor immunity and autoimmunity
19. Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25+ regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses
20. Genetic immunization with human tyrosinase-related protein 2: Implications for the immunotherapy of melanoma