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Volumn 3, Issue 8, 2003, Pages 630-641

Cancer vaccines: Between the idea and the reality

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE; CANVAXIN; CARCINOEMBRYONIC ANTIGEN; IMMUNOLOGICAL ADJUVANT; MELACINE; MUCIN 1; UNCLASSIFIED DRUG; DNA VACCINE; TUMOR ANTIGEN;

EID: 0141720783     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri1150     Document Type: Review
Times cited : (554)

References (164)
  • 2
    • 0037472440 scopus 로고    scopus 로고
    • Vaccinology past achievements, present roadblocks and future promises
    • Andre, F. E. Vaccinology past achievements, present roadblocks and future promises. Vaccine 21, 593-595 (2003).
    • (2003) Vaccine , vol.21 , pp. 593-595
    • Andre, F.E.1
  • 3
    • 0036036406 scopus 로고    scopus 로고
    • Immunotherapeutic potential of whole tumour cells
    • Ward, S. et al. Immunotherapeutic potential of whole tumour cells. Cancer Immunol. Immunother. 351-357 (2002).
    • (2002) Cancer Immunol. Immunother. , pp. 351-357
    • Ward, S.1
  • 4
    • 0035152718 scopus 로고    scopus 로고
    • Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: A phase I trial of safety and immune activation
    • Jaffee, E. M. et al. Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation. J. Clin. Oncol. 19, 145-156 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , pp. 145-156
    • Jaffee, E.M.1
  • 5
    • 0036813199 scopus 로고    scopus 로고
    • GM-CSF-based cancer vaccines
    • Dranoff, G. GM-CSF-based cancer vaccines. Immunol. Rev. 188, 147-154 (2002).
    • (2002) Immunol. Rev. , vol.188 , pp. 147-154
    • Dranoff, G.1
  • 6
    • 0034610974 scopus 로고    scopus 로고
    • M. Immunotherapy with dendritic cells directed against tumor antigens shared with normal host cells results in severe autoimmune disease
    • Ludewig, B. et al. M. Immunotherapy with dendritic cells directed against tumor antigens shared with normal host cells results in severe autoimmune disease. J. Exp. Med. 191, 795-804 (2000). This paper shows data from transgenic mice that a dendritic cell (DC)-based vaccine with antigens that are expressed by tumours, as well as by various normal tissues, can cause fatal autoimmune diseases, such as autoimmune diabetes, arteritis and myocarditis.
    • (2000) J. Exp. Med. , vol.191 , pp. 795-804
    • Ludewig, B.1
  • 8
    • 17944364189 scopus 로고    scopus 로고
    • Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: Comparison of prophylaxis and therapy
    • van Elsas, A. et al. Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy. J. Exp. Med. 194, 481-489 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 481-489
    • Van Elsas, A.1
  • 9
    • 0037174674 scopus 로고    scopus 로고
    • Cancer regression and auto immunity in patients after clonal repopulation with antitumor lymphocytes
    • Dudley, M. E. et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 298, 850-854 (2002). This paper convincingly illustrates the power of tumour-specific T cells directed against self/differentiation antigens that are overexpressed by tumours. Adoptive transfer of these cells into metastatic melanoma patients resulted in the regression of melanoma, but also in the onset of vitiligo - autoimmune melanocyte destruction.
    • (2002) Science , vol.298 , pp. 850-854
    • Dudley, M.E.1
  • 10
    • 0036372228 scopus 로고    scopus 로고
    • Dendritic cells pulsed with a tumor-specific peptide induce long-lasting immunity and are effective against murine intracerebral melanoma
    • Heimberger, A. B. et al. Dendritic cells pulsed with a tumor-specific peptide induce long-lasting immunity and are effective against murine intracerebral melanoma. Neurosurgery 50, 158-166 (2002).
    • (2002) Neurosurgery , vol.50 , pp. 158-166
    • Heimberger, A.B.1
  • 11
    • 17744399231 scopus 로고    scopus 로고
    • Prevention of spontaneous neu-expressing mammary tumor development in mice transgenic for rat proto-neu by DNA vaccination
    • Pupa, S. M. et al. Prevention of spontaneous neu-expressing mammary tumor development in mice transgenic for rat proto-neu by DNA vaccination. Gene Ther. 8, 75-79 (2001).
    • (2001) Gene Ther. , vol.8 , pp. 75-79
    • Pupa, S.M.1
  • 12
    • 0035339389 scopus 로고    scopus 로고
    • Three different vaccines based on the 140-amino acid MUC1 peptide with seven tandemly repeated tumor-specific epitopes elicit distinct immune effector mechanisms in wild-type versus MUC1-transgenic mice with different potential for tumor rejection
    • Soares, M. M., Mehta, V. & Finn, O. J. Three different vaccines based on the 140-amino acid MUC1 peptide with seven tandemly repeated tumor-specific epitopes elicit distinct immune effector mechanisms in wild-type versus MUC1-transgenic mice with different potential for tumor rejection. J. Immunol. 166, 6555-6563 (2001). This paper shows the importance of not only the right antigen but also the right adjuvant for an effective antitumour vaccine. Mucin 1 peptide was administered in three different vaccine preparations. All induced immune responses, but only one (DCs loaded with mucin 1) induced tumour rejection. The effective immune response did not cause autoimmunity in mucin 1-transgenic mice.
    • (2001) J. Immunol. , vol.166 , pp. 6555-6563
    • Soares, M.M.1    Mehta, V.2    Finn, O.J.3
  • 13
    • 4444243096 scopus 로고    scopus 로고
    • Tumor-specific shared antigenic peptides recognized by human T cells
    • Van Der Bruggen, P. et al. Tumor-specific shared antigenic peptides recognized by human T cells. Immunol. Rev. 188, 51-64 (2002).
    • (2002) Immunol. Rev. , vol.188 , pp. 51-64
    • Van Der Bruggen, P.1
  • 14
    • 0029892793 scopus 로고    scopus 로고
    • Human tumor antigens are ready to fly
    • Henderson, R. A. & Finn, O. J. Human tumor antigens are ready to fly. Adv. Immunol. 62, 217-256 (1996).
    • (1996) Adv. Immunol. , vol.62 , pp. 217-256
    • Henderson, R.A.1    Finn, O.J.2
  • 15
    • 0036813331 scopus 로고    scopus 로고
    • Cancer/testis antigens: An expanding family of targets for cancer immunotherapy
    • Scanlan, M. J., Gure, A. O., Jungbluth, A. A., Old, L. J. & Chen, Y. T. Cancer/testis antigens: an expanding family of targets for cancer immunotherapy. Immunol. Rev. 188, 22-32 (2002).
    • (2002) Immunol. Rev. , vol.188 , pp. 22-32
    • Scanlan, M.J.1    Gure, A.O.2    Jungbluth, A.A.3    Old, L.J.4    Chen, Y.T.5
  • 17
    • 0036605567 scopus 로고    scopus 로고
    • Generation of T-cell immunity to the HER-2/neu protein after active immunization with HER-2/neu peptide-based vaccines
    • H) cells, can elicit in patients with cancer, immunity to the peptides, as well as the whole protein, and provoke endogenous immune responses that lead to epitope spreading.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 2624-2632
    • Disis, M.1
  • 18
    • 0035879005 scopus 로고    scopus 로고
    • An overview of the MAGE gene family with the identification of all human members of the family
    • Chomez, P. et al. An overview of the MAGE gene family with the identification of all human members of the family. Cancer Res. 61, 5544-5551 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 5544-5551
    • Chomez, P.1
  • 19
    • 0037267087 scopus 로고    scopus 로고
    • Mammaglobin-A is a tumor-associated antigen in human breast carcinoma
    • Tanaka, Y., Amos, K. D., Fleming, T. P., Eberlein, T. J. & Goedegebuure, P. S. Mammaglobin-A is a tumor-associated antigen in human breast carcinoma. Surgery 133, 74-80 (2003).
    • (2003) Surgery , vol.133 , pp. 74-80
    • Tanaka, Y.1    Amos, K.D.2    Fleming, T.P.3    Eberlein, T.J.4    Goedegebuure, P.S.5
  • 20
    • 0030033054 scopus 로고    scopus 로고
    • Strategies for the development of recombinant vaccines for the immunotherapy of breast cancer
    • Schlom, J. et al. Strategies for the development of recombinant vaccines for the immunotherapy of breast cancer. Breast Cancer Res. Treat. 38, 27-39 (1996).
    • (1996) Breast Cancer Res. Treat. , vol.38 , pp. 27-39
    • Schlom, J.1
  • 21
    • 0035158708 scopus 로고    scopus 로고
    • Identification of cyclin B1 as a shared human epithelial tumor-associated antigen recognized by T cells
    • + T-cell responses. Cyclin B1 is aberrantly expressed by many cancers.
    • (2001) J. Exp. Med. , vol.194 , pp. 1313-1323
    • Kao, H.1
  • 22
    • 0342879921 scopus 로고    scopus 로고
    • Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: Characterization of tissue-specific ING1 transcripts and a homologue gene
    • Jager, D. et al. Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene. Cancer Res. 59, 6197-6204 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 6197-6204
    • Jager, D.1
  • 23
    • 0036454684 scopus 로고    scopus 로고
    • Vaccines and melanoma
    • Nestle, F. O. Vaccines and melanoma. Clin. Exp. Dermatol. 27, 597-601 (2002).
    • (2002) Clin. Exp. Dermatol. , vol.27 , pp. 597-601
    • Nestle, F.O.1
  • 24
    • 0034328883 scopus 로고    scopus 로고
    • Immunotherapy of human cancer: Lessons from mice
    • Srivastava, P. K. Immunotherapy of human cancer: lessons from mice. Nature Immunol. 1, 363-366 (2000).
    • (2000) Nature Immunol. , vol.1 , pp. 363-366
    • Srivastava, P.K.1
  • 25
    • 0034787741 scopus 로고    scopus 로고
    • Spontaneous adenocarcinoma mouse models for immunotherapy
    • Gendler, S. J. & Mukherjee, P. Spontaneous adenocarcinoma mouse models for immunotherapy. Trends Mol. Med. 7, 471-475 (2001).
    • (2001) Trends Mol. Med. , vol.7 , pp. 471-475
    • Gendler, S.J.1    Mukherjee, P.2
  • 26
    • 0036897080 scopus 로고    scopus 로고
    • Vaccine-based therapy directed against carcinoembryonic antigen demonstrates antitumor activity on spontaneous intestinal tumours in the absence of autoimmunity
    • Greiner, J. W., Zeytin, H., Anver, M. R. & Schlom, J. Vaccine-based therapy directed against carcinoembryonic antigen demonstrates antitumor activity on spontaneous intestinal tumours in the absence of autoimmunity. Cancer Res. 62, 6944-6951 (2002). This paper shows the efficacy of a carcinoembryonic antigen (CEA) vaccine against spontaneous intestinal tumours in genetically predisposed mice. The vaccine generated a strong anti-CEA response that reduced the tumour incidence and increased overall survival without causing autoimmunity.
    • (2002) Cancer Res. , vol.62 , pp. 6944-6951
    • Greiner, J.W.1    Zeytin, H.2    Anver, M.R.3    Schlom, J.4
  • 27
    • 0035893398 scopus 로고    scopus 로고
    • α-Fetoprotein-specific tumor immunity induced by plasmid prime-adenovirus boost genetic vaccination
    • Meng, W. S. et al. α-Fetoprotein-specific tumor immunity induced by plasmid prime-adenovirus boost genetic vaccination. Cancer Res. 61, 8782-8786 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 8782-8786
    • Meng, W.S.1
  • 28
    • 0034067122 scopus 로고    scopus 로고
    • Dendritic cell/peptide cancer vaccines: Clinical responsiveness and epitope spreading
    • Ranieri, E. et al. Dendritic cell/peptide cancer vaccines: clinical responsiveness and epitope spreading. Immunol. Invest. 29, 121-125 (2000).
    • (2000) Immunol. Invest. , vol.29 , pp. 121-125
    • Ranieri, E.1
  • 29
    • 0037343272 scopus 로고    scopus 로고
    • Determinant spreading associated with clinical response in dendritic cell-based immunotherapy for malignant melanoma
    • Butterfield, L. H. et al. Determinant spreading associated with clinical response in dendritic cell-based immunotherapy for malignant melanoma. Clin. Cancer Res. 9, 998-1008 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 998-1008
    • Butterfield, L.H.1
  • 30
    • 0031863732 scopus 로고    scopus 로고
    • Use of cellular and cytokine adjuvants in the immunotherapy of cancer
    • Salgaller, M. L. & Lodge, P. A. Use of cellular and cytokine adjuvants in the immunotherapy of cancer. J. Surg. Oncol. 68, 122-138 (1998).
    • (1998) J. Surg. Oncol. , vol.68 , pp. 122-138
    • Salgaller, M.L.1    Lodge, P.A.2
  • 31
    • 0035229733 scopus 로고    scopus 로고
    • CpG DNA security code for host defense
    • Medzhitov, R. CpG DNA: security code for host defense. Nature Immunol. 2, 15-16 (2001).
    • (2001) Nature Immunol. , vol.2 , pp. 15-16
    • Medzhitov, R.1
  • 32
    • 0037377990 scopus 로고    scopus 로고
    • CpG-A oligonucleotides induce a monocyte-derived dendritic cell-like phenotype that preferentially activates CD8 T cells
    • Krug, A. et al. CpG-A oligonucleotides induce a monocyte-derived dendritic cell-like phenotype that preferentially activates CD8 T cells. J. Immunol. 170, 3468-3477 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 3468-3477
    • Krug, A.1
  • 33
    • 0033517989 scopus 로고    scopus 로고
    • Lipoproteins take their toll on the host
    • Janeway, C. A., Jr & Medzhitov, R. Lipoproteins take their toll on the host. Curr. Biol. 9, R879-R882 (1999).
    • (1999) Curr. Biol. , vol.9
    • Janeway C.A., Jr.1    Medzhitov, R.2
  • 35
    • 0028910938 scopus 로고
    • A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules
    • Kovacsovics-Bankowski, M. & Rock, K. L. A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Science 267, 243-246 (1995).
    • (1995) Science , vol.267 , pp. 243-246
    • Kovacsovics-Bankowski, M.1    Rock, K.L.2
  • 36
    • 0032490612 scopus 로고    scopus 로고
    • Poly(lactide-co-glycolide) microparticles for the development of single-dose controlled-release vaccines
    • Gupta, R. K., Singh, M. & O'Hagan, D. T. Poly(lactide-co-glycolide) microparticles for the development of single-dose controlled-release vaccines. Adv. Drug Deliv. Rev. 32, 225-246 (1998).
    • (1998) Adv. Drug Deliv. Rev. , vol.32 , pp. 225-246
    • Gupta, R.K.1    Singh, M.2    O'Hagan, D.T.3
  • 37
    • 0031980425 scopus 로고    scopus 로고
    • H immune response without adjuvant
    • H immune response without adjuvant. Eur. J. Immunol. 28, 1401-1407 (1998).
    • (1998) Eur. J. Immunol. , vol.28 , pp. 1401-1407
    • Lo-Man, R.1
  • 39
    • 0036214288 scopus 로고    scopus 로고
    • Interaction of heat shock proteins with peptides and antigen presenting cells: Chaperoning of the innate and adaptive immune responses
    • Srivastava, P. Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses. Annu. Rev. Immunol. 20, 395-425 (2002).
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 395-425
    • Srivastava, P.1
  • 40
    • 0036774999 scopus 로고    scopus 로고
    • Recent advances in mucosal vaccines and adjuvants
    • Eriksson, K. & Holmgren, J. Recent advances in mucosal vaccines and adjuvants. Curr. Opin. Immunol. 14, 666-672 (2002).
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 666-672
    • Eriksson, K.1    Holmgren, J.2
  • 41
    • 0033679107 scopus 로고    scopus 로고
    • CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue
    • Cook, D. N. et al. CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity 12, 495-503 (2000).
    • (2000) Immunity , vol.12 , pp. 495-503
    • Cook, D.N.1
  • 42
    • 0036859312 scopus 로고    scopus 로고
    • Mucosal addressin expression and binding-interactions with naive lymphocytes vary among the cranial, oral, and nasal-associated lymphoid tissues
    • Csencsits, K. L., Jutila, M. A. & Pascual, D. W. Mucosal addressin expression and binding-interactions with naive lymphocytes vary among the cranial, oral, and nasal-associated lymphoid tissues. Eur. J. Immunol. 32, 3029-3039 (2002).
    • (2002) Eur. J. Immunol. , vol.32 , pp. 3029-3039
    • Csencsits, K.L.1    Jutila, M.A.2    Pascual, D.W.3
  • 43
    • 0036784632 scopus 로고    scopus 로고
    • Regulation of mucosal dendritic cell function by receptor activator of NF-κB (RANK/RANK ligand interactions: Impact on tolerance induction
    • Williamson, E., Bilsborough, J. M. & Viney, J. L. Regulation of mucosal dendritic cell function by receptor activator of NF-κB (RANK/RANK ligand interactions: impact on tolerance induction. J. Immunol. 169, 3606-3612 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 3606-3612
    • Williamson, E.1    Bilsborough, J.M.2    Viney, J.L.3
  • 44
    • 0034307339 scopus 로고    scopus 로고
    • The Toll receptor family and microbial recognition
    • Medzhitov, R. & Janeway, C., Jr. The Toll receptor family and microbial recognition. Trends Microbiol. 8, 452-456 (2000).
    • (2000) Trends Microbiol. , vol.8 , pp. 452-456
    • Medzhitov, R.1    Janeway C., Jr.2
  • 45
    • 0024353079 scopus 로고
    • H2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • H2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu, Rev. Immunol. 7, 145-173 (1989).
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 46
    • 0036717864 scopus 로고    scopus 로고
    • + patients with renal cell carcinoma or melanoma
    • + patients with renal cell carcinoma or melanoma. J. Exp. Med. 196, 619-628 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 619-628
    • Tatsumi, T.1
  • 47
    • 0032529703 scopus 로고    scopus 로고
    • Anti-idiotype antibodies can induce long-term complete remissions in non-Hodgkin's lymphoma without eradicating the malignant clone
    • Davis, T. A., Maloney, D. G., Czerwinski, D. K., Liles, T. M. & Levy, R. Anti-idiotype antibodies can induce long-term complete remissions in non-Hodgkin's lymphoma without eradicating the malignant clone. Blood 92, 1184-1190 (1998).
    • (1998) Blood , vol.92 , pp. 1184-1190
    • Davis, T.A.1    Maloney, D.G.2    Czerwinski, D.K.3    Liles, T.M.4    Levy, R.5
  • 48
    • 0035129498 scopus 로고    scopus 로고
    • First-line, single-agent Herceptin(trastuzumab) in metastatic breast cancer: A preliminary report
    • Vogel, C. et al. First-line, single-agent Herceptin(trastuzumab) in metastatic breast cancer: a preliminary report. Eur. J. Cancer 37, S25-S29 (2001).
    • (2001) Eur. J. Cancer , vol.37
    • Vogel, C.1
  • 49
    • 0028224082 scopus 로고
    • Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma. German
    • Cancer Aid 17-1A Study Group
    • Riethmuller, G. et al. Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma. German Cancer Aid 17-1A Study Group. Lancet 343, 1177-1183 (1994).
    • (1994) Lancet , vol.343 , pp. 1177-1183
    • Riethmuller, G.1
  • 50
    • 0031007771 scopus 로고    scopus 로고
    • Tumor-specific idiotype vaccines in the treatment of patients with B-cell lymphoma - Long-term results of a clinical trial
    • Hsu, F. J. et al. Tumor-specific idiotype vaccines in the treatment of patients with B-cell lymphoma - long-term results of a clinical trial. Blood 89, 3129-3135 (1997).
    • (1997) Blood , vol.89 , pp. 3129-3135
    • Hsu, F.J.1
  • 51
    • 0000221296 scopus 로고
    • Vaccines containing purified GM2 ganglioside elicit GM2 antibodies in melanoma patients
    • Livingston, P. O. et al. Vaccines containing purified GM2 ganglioside elicit GM2 antibodies in melanoma patients. Proc. Natl Acad. Sci. USA 84, 2911-2915 (1987).
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 2911-2915
    • Livingston, P.O.1
  • 52
    • 0037024461 scopus 로고    scopus 로고
    • Cancer immunotherapy with peptide-based vaccines: What have we achieved? Where are we going?
    • Parmiani, G. et al. Cancer immunotherapy with peptide-based vaccines: what have we achieved? Where are we going? J. Natl Cancer Inst. 94, 805-818 (2002).
    • (2002) J. Natl. Cancer Inst. , vol.94 , pp. 805-818
    • Parmiani, G.1
  • 53
    • 0030001674 scopus 로고    scopus 로고
    • Immunological memory and protective immunity: Understanding their relation
    • Ahmed, R. & Gray, D. Immunological memory and protective immunity: understanding their relation. Science 272, 54-60 (1996).
    • (1996) Science , vol.272 , pp. 54-60
    • Ahmed, R.1    Gray, D.2
  • 54
    • 0036668253 scopus 로고    scopus 로고
    • On differences between immunity and immunological memory
    • Zinkernagel, R. M. On differences between immunity and immunological memory. Curr. Opin. Immunol. 14, 523-536 (2002).
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 523-536
    • Zinkernagel, R.M.1
  • 56
    • 0034599742 scopus 로고    scopus 로고
    • Differentiating between memory and effector CD8 T cells by altered expression of cell surface O-glycans
    • Harrington, L. E., Galvan, M., Baum, L. G. Altman, J. D. & Ahmed, R. Differentiating between memory and effector CD8 T cells by altered expression of cell surface O-glycans. J. Exp. Med. 191, 1241-1246 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 1241-1246
    • Harrington, L.E.1    Galvan, M.2    Baum, L.G.3    Altman, J.D.4    Ahmed, R.5
  • 58
    • 0033214576 scopus 로고    scopus 로고
    • T cell memory against colon carcinoma is long-lived in the absence of antigen
    • Xiang, R., Lode, H. N., Gillies, S. D. & Reisfeld, R. A. T cell memory against colon carcinoma is long-lived in the absence of antigen. J. Immunol. 163, 3676-3683 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 3676-3683
    • Xiang, R.1    Lode, H.N.2    Gillies, S.D.3    Reisfeld, R.A.4
  • 59
    • 0034234287 scopus 로고    scopus 로고
    • + T cells in melanoma patients receiving interleukin 12
    • + T cells in melanoma patients receiving interleukin 12. Cancer Res. 60, 3559-3568 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 3559-3568
    • Mortarini, R.1
  • 60
    • 0035048973 scopus 로고    scopus 로고
    • Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow
    • Feuerer, M. et al. Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow. Nature Mad. 7, 452-458 (2001).
    • (2001) Nature Mad. , vol.7 , pp. 452-458
    • Feuerer, M.1
  • 62
    • 84988269513 scopus 로고    scopus 로고
    • Long lasting p53-specific T cell memory responses in the absence of anti-p53 antibodies in patients with resected primary colorectal cancer
    • van der Burg, S. H. et al. Long lasting p53-specific T cell memory responses in the absence of anti-p53 antibodies in patients with resected primary colorectal cancer. Eur. J. Immunol. 31, 146-155 (2001).
    • (2001) Eur. J. Immunol. , vol.31 , pp. 146-155
    • Van der Burg, S.H.1
  • 63
    • 0037112446 scopus 로고    scopus 로고
    • + T cell to a fully functional tumor killer cell
    • + T cell to a fully functional tumor killer cell. Cancer Res. 62, 6438-6441 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 6438-6441
    • Gao, F.G.1
  • 64
    • 0037340417 scopus 로고    scopus 로고
    • Lineage relationship and protective immunity of memory CD8 T cell subsets
    • Wherry, E. J. et al. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nature Immunol. 4, 225-234 (2003).
    • (2003) Nature Immunol. , vol.4 , pp. 225-234
    • Wherry, E.J.1
  • 66
    • 0036083314 scopus 로고    scopus 로고
    • Defective generation but normal maintenance of memory T cells in old mice
    • Kapasi, Z. F., Murali-Krishna, K., McRae, M. L. & Ahmed, R. Defective generation but normal maintenance of memory T cells in old mice. Eur. J. Immunol. 32, 1567-1573 (2002).
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1567-1573
    • Kapasi, Z.F.1    Murali-Krishna, K.2    McRae, M.L.3    Ahmed, R.4
  • 67
    • 0032960741 scopus 로고    scopus 로고
    • Age-dependent alterations in the tumoricidal functions of tumor-associated macrophages
    • Khare, V., Sodhi, A. & Singh, S. M. Age-dependent alterations in the tumoricidal functions of tumor-associated macrophages. Tumour Biol. 20, 30-43 (1999).
    • (1999) Tumour Biol. , vol.20 , pp. 30-43
    • Khare, V.1    Sodhi, A.2    Singh, S.M.3
  • 68
    • 0036838562 scopus 로고    scopus 로고
    • Repertoire of antibody response in bone marrow and the memory response are differentially affected in aging mice
    • Lu, Y. F. & Cerny, J. Repertoire of antibody response in bone marrow and the memory response are differentially affected in aging mice. J. Immunol. 169, 4920-4927 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 4920-4927
    • Lu, Y.F.1    Cerny, J.2
  • 70
    • 0036681649 scopus 로고    scopus 로고
    • T cell subset patterns that predict resistance to spontaneous lymphoma, mammary adenocarcinoma, and fibrosarcoma in mice
    • Miller, R. A. & Chrisp, C. T cell subset patterns that predict resistance to spontaneous lymphoma, mammary adenocarcinoma, and fibrosarcoma in mice. J. Immunol. 169, 1619-1625 (2002). This and other papers by the first author focus on age-induced changes in the immune system that contribute to carcinogenesis and could affect the success of cancer vaccines.
    • (2002) J. Immunol. , vol.169 , pp. 1619-1625
    • Miller, R.A.1    Chrisp, C.2
  • 71
    • 0037435886 scopus 로고    scopus 로고
    • Low effectiveness of DNA vaccination against HER-2/neu in ageing
    • Provinciali, M., Smoriesi, A., Donnini, A., Bartozzi, B. & Amici. A Low effectiveness of DNA vaccination against HER-2/neu in ageing. Vaccine 21, 843-848 (2003). This paper shows a clear difference in the response of young versus old mice to a HER2/NEU-containing cancer vaccine and the difference in the immune-effector mechanisms that are generated.
    • (2003) Vaccine , vol.21 , pp. 843-848
    • Provinciali, M.1    Smoriesi, A.2    Donnini, A.3    Bartozzi, B.4    Amici, A.5
  • 72
    • 0036838556 scopus 로고    scopus 로고
    • Defective T cell priming associated with aging can be rescued by signaling through 4-1BB (CD137)
    • Bansal-Pakala, P. & Croft, M. Defective T cell priming associated with aging can be rescued by signaling through 4-1BB (CD137). J. Immunol. 169, 5005-5009 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 5005-5009
    • Bansal-Pakala, P.1    Croft, M.2
  • 73
    • 0036301503 scopus 로고    scopus 로고
    • CTLA-4: New insights into its biological function and use in tumor immunotherapy
    • Egen, J. G., Kuhns, M. S. & Allison, J. P. CTLA-4: new insights into its biological function and use in tumor immunotherapy. Nature Immunol. 3, 611-618 (2002).
    • (2002) Nature Immunol. , vol.3 , pp. 611-618
    • Egen, J.G.1    Kuhns, M.S.2    Allison, J.P.3
  • 75
    • 0035576891 scopus 로고    scopus 로고
    • Vaccination of pediatric solid tumor patients with tumor lysate-pulsed dendritic cells can expand specific T cells and mediate tumor regression
    • Geiger, J. D. et al. Vaccination of pediatric solid tumor patients with tumor lysate-pulsed dendritic cells can expand specific T cells and mediate tumor regression. Cancer Res. 61, 8513-6519 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 8513-6519
    • Geiger, J.D.1
  • 77
    • 0032211082 scopus 로고    scopus 로고
    • Defective function of Langerhans cells in tumor-bearing animals is the result of defective maturation from hemopoietic progenitors
    • Ishida, T., Oyama, T., Carbone, D. P. & Gabrilovich, D. I. Defective function of Langerhans cells in tumor-bearing animals is the result of defective maturation from hemopoietic progenitors. J. Immunol. 161, 4842-4851 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 4842-4851
    • Ishida, T.1    Oyama, T.2    Carbone, D.P.3    Gabrilovich, D.I.4
  • 78
    • 0035010406 scopus 로고    scopus 로고
    • + hematopoietic progenitors
    • + hematopoietic progenitors. Eur. Urol. 39, S37-S40 (2001).
    • (2001) Eur. Urol. , vol.39
    • Shurin, G.V.1
  • 79
    • 0027056895 scopus 로고
    • Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice
    • Mizoguchi, H. et al. Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science 258, 1795-1798 (1992). The original paper that describes tumour-induced suppression of T cells in mice with tumours.
    • (1992) Science , vol.258 , pp. 1795-1798
    • Mizoguchi, H.1
  • 80
    • 0032947187 scopus 로고    scopus 로고
    • Where have all the T cells gone? Mechanisms of immune evasion by tumors
    • Finke, J., Ferrone, S., Frey, A., Mufson, A. & Ochoa, A. Where have all the T cells gone? Mechanisms of immune evasion by tumors. Immunol. Today. 20, 158-160 (1999).
    • (1999) Immunol. Today , vol.20 , pp. 158-160
    • Finke, J.1    Ferrone, S.2    Frey, A.3    Mufson, A.4    Ochoa, A.5
  • 81
    • 0036173389 scopus 로고    scopus 로고
    • Interleukin-10 promotes B16-melanoma growth by inhibition of macrophage functions and induction of tumour and vascular cell proliferation
    • Garcia-Hernandez, M. L., Hernandez-Pando, R., Ganglio, P. & Berumen, J. Interleukin-10 promotes B16-melanoma growth by inhibition of macrophage functions and induction of tumour and vascular cell proliferation. Immunol. 105, 231-243 (2002).
    • (2002) Immunol. , vol.105 , pp. 231-243
    • Garcia-Hernandez, M.L.1    Hernandez-Pando, R.2    Ganglio, P.3    Berumen, J.4
  • 82
    • 0036150360 scopus 로고    scopus 로고
    • + T cells induced by dendritic cell stimulation are most sensitive to transforming growth factor-β: Implications for dendritic cell immunization against cancer
    • + T cells induced by dendritic cell stimulation are most sensitive to transforming growth factor-β: implications for dendritic cell immunization against cancer. Clin. Immunol. 102, 96-105 (2002).
    • (2002) Clin. Immunol. , vol.102 , pp. 96-105
    • Lin, C.M.1    Wang, F.H.2    Lee, P.K.3
  • 83
    • 0037097818 scopus 로고    scopus 로고
    • The role of cytokines in classical Hodgkin lymphoma
    • Skinnider, B. F. & Mak, T. W. The role of cytokines in classical Hodgkin lymphoma. Blood 99, 4283-4297 (2002).
    • (2002) Blood , vol.99 , pp. 4283-4297
    • Skinnider, B.F.1    Mak, T.W.2
  • 84
    • 0037056234 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection
    • Friberg, M. et al. Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection. Int. J. Cancer 101, 151-155 (2002).
    • (2002) Int. J. Cancer , vol.101 , pp. 151-155
    • Friberg, M.1
  • 85
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwai, Y. et al. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl Acad. Sci. USA 99, 12293-12297 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 12293-12297
    • Iwai, Y.1
  • 86
    • 0035874990 scopus 로고    scopus 로고
    • Activated granulocytes and granulocyte-derived hydrogen peroxide are the underfiling mechanism of suppression of T-cell function in advanced cancer patients
    • Schmielau, J. & Finn, O. J. Activated granulocytes and granulocyte-derived hydrogen peroxide are the underfiling mechanism of suppression of T-cell function in advanced cancer patients. Cancer Res. 61, 4756-4760 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 4756-4760
    • Schmielau, J.1    Finn, O.J.2
  • 87
    • 0036789939 scopus 로고    scopus 로고
    • A push-pull approach to maximize vaccine efficacy: Abrogating suppression with an IL-13 inhibitor while augmenting help with granulocyte/macrophage colony-stimulating factor and CD40L
    • Ahlers, J. D. et al. A push-pull approach to maximize vaccine efficacy: abrogating suppression with an IL-13 inhibitor while augmenting help with granulocyte/macrophage colony-stimulating factor and CD40L. Proc. Natl Acad. Sci. USA 99, 13020-13025 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 13020-13025
    • Ahlers, J.D.1
  • 88
    • 0032741283 scopus 로고    scopus 로고
    • Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
    • Gabdlovich, D. I., Ishida, T., Nadaf, S., Ohm, J. E. & Carbone, D. P. Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin. Cancer Res. 5, 2963-2970 (1999).
    • (1999) Clin. Cancer Res. , vol.5 , pp. 2963-2970
    • Gabdlovich, D.I.1    Ishida, T.2    Nadaf, S.3    Ohm, J.E.4    Carbone, D.P.5
  • 89
    • 0037148442 scopus 로고    scopus 로고
    • Recovery of ζ-chain expression and changes in spontaneous IL-10 production after PSA-based vaccines in patients with prostate cancer
    • Meidenbauer, N., Gooding, W., Spitler, L., Harris, D. & Whiteside, T. L. Recovery of ζ-chain expression and changes in spontaneous IL-10 production after PSA-based vaccines in patients with prostate cancer. Br. J. Cancer 86, 168-178 (2002).
    • (2002) Br. J. Cancer , vol.86 , pp. 168-178
    • Meidenbauer, N.1    Gooding, W.2    Spitler, L.3    Harris, D.4    Whiteside, T.L.5
  • 90
    • 0036721629 scopus 로고    scopus 로고
    • Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma
    • Liyanage, U. K. et al. Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J. Immunol. 169, 2756-2761 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 2756-2761
    • Liyanage, U.K.1
  • 93
    • 0023686538 scopus 로고
    • Active specific immunotherapy for melanoma: Phase I trial of allogeneic lysates and a novel adjuvant
    • Mitchell, M. S. et al. Active specific immunotherapy for melanoma: phase I trial of allogeneic lysates and a novel adjuvant. Cancer Res. 48, 5883-5893 (1988).
    • (1988) Cancer Res. , vol.48 , pp. 5883-5893
    • Mitchell, M.S.1
  • 94
    • 0036784852 scopus 로고    scopus 로고
    • Prolonged survival of patients receiving active immunotherapy with Canvaxin therapeutic polyvalent vaccine after complete resection of melanoma metastatic to regional lymph nodes
    • Morton, D. L. et al. Prolonged survival of patients receiving active immunotherapy with Canvaxin therapeutic polyvalent vaccine after complete resection of melanoma metastatic to regional lymph nodes. Ann. Surg. 236, 438-449 (2002).
    • (2002) Ann. Surg. , vol.236 , pp. 438-449
    • Morton, D.L.1
  • 95
    • 0023848280 scopus 로고
    • Immunogenicity of a polyvalent melanoma antigen vaccine in humans
    • Bystryn, J. C. et al. Immunogenicity of a polyvalent melanoma antigen vaccine in humans. Cancer 61, 1065-1070 (1988).
    • (1988) Cancer , vol.61 , pp. 1065-1070
    • Bystryn, J.C.1
  • 96
    • 0028870490 scopus 로고
    • Improved survival of patients with melanoma with an antibody response to immunization to a polyvalent melanoma vaccine
    • Miller, K. et al. Improved survival of patients with melanoma with an antibody response to immunization to a polyvalent melanoma vaccine. Cancer 75, 495-502 (1995).
    • (1995) Cancer , vol.75 , pp. 495-502
    • Miller, K.1
  • 97
    • 0031648808 scopus 로고    scopus 로고
    • Perspective on allogeneic melanoma lysates in active specific immunotherapy
    • Mitchell, M. S. Perspective on allogeneic melanoma lysates in active specific immunotherapy. Semin. Oncol. 25, 623-635 (1998).
    • (1998) Semin. Oncol. , vol.25 , pp. 623-635
    • Mitchell, M.S.1
  • 98
    • 0035889708 scopus 로고    scopus 로고
    • Treatment of metastatic melanoma with autologous, hapten-modified melanoma vaccine: Regression of pulmonary metastases
    • Berd, D., Sato, T., Cohn, H., Maguire, H. C., Jr & Mastrangelo, M. J. Treatment of metastatic melanoma with autologous, hapten-modified melanoma vaccine: regression of pulmonary metastases. Int. J. Cancer 94, 531-539 (2001).
    • (2001) Int. J. Cancer , vol.94 , pp. 531-539
    • Berd, D.1    Sato, T.2    Cohn, H.3    Maguire H.C., Jr.4    Mastrangelo, M.J.5
  • 99
    • 0033821972 scopus 로고    scopus 로고
    • Cytokine-secreting tumor cell vaccines
    • Mach, N. & Dranoff, G. Cytokine-secreting tumor cell vaccines. Curr. Opin. Immunol. 12, 571-575 (2000).
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 571-575
    • Mach, N.1    Dranoff, G.2
  • 100
    • 0037108696 scopus 로고    scopus 로고
    • Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: Clinical and immunologic findings
    • Belli, F. et al. Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: clinical and immunologic findings. J. Clin. Oncol. 20, 4169-4180 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 4169-4180
    • Belli, F.1
  • 101
    • 0037441842 scopus 로고    scopus 로고
    • Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma
    • Salgia, R. et al. Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma. J. Clin. Oncol. 21, 624-630 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , pp. 624-630
    • Salgia, R.1
  • 102
    • 0034918104 scopus 로고    scopus 로고
    • Dendritic cells: On the move from bench to bedside
    • Nestle, F. O., Banchereau, J. & Hart, D. Dendritic cells: on the move from bench to bedside. Nature Med. 7, 761-765 (2001).
    • (2001) Nature Med. , vol.7 , pp. 761-765
    • Nestle, F.O.1    Banchereau, J.2    Hart, D.3
  • 103
    • 0032036433 scopus 로고    scopus 로고
    • Physical interaction between dendritic cells and tumor cells results in an immunogen that induces protective and therapeutic tumor rejection
    • Celluzzi, C. M. & Falo, L. D., Jr. Physical interaction between dendritic cells and tumor cells results in an immunogen that induces protective and therapeutic tumor rejection. J. Immunol. 160, 3081-3085 (1998).
    • (1998) J. Immunol. , vol.160 , pp. 3081-3085
    • Celluzzi, C.M.1    Falo L.D., Jr.2
  • 104
    • 0034292406 scopus 로고    scopus 로고
    • Dendritic cells capture killed tumor cells and present their antigens to elicit tumor-specific immune responses
    • Nouri-Shirazi, M. et al. Dendritic cells capture killed tumor cells and present their antigens to elicit tumor-specific immune responses. J. Immunol. 165, 3797-3803 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 3797-3803
    • Nouri-Shirazi, M.1
  • 105
    • 0036554831 scopus 로고    scopus 로고
    • A phase I trial of tumor lysate-pulsed dendritic cells in the treatment of advanced cancer
    • Chang, A. E. et al. A phase I trial of tumor lysate-pulsed dendritic cells in the treatment of advanced cancer. Clin. Cancer Res. 8, 1021-1032 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1021-1032
    • Chang, A.E.1
  • 106
    • 0035284901 scopus 로고    scopus 로고
    • Induction of polyclonal prostate cancer-specific CTL using dendritic cells transfected with amplified tumor RNA
    • Heiser, A. et al. Induction of polyclonal prostate cancer-specific CTL using dendritic cells transfected with amplified tumor RNA. J. Immunol. 166, 2953-2960 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 2953-2960
    • Heiser, A.1
  • 107
    • 0036203164 scopus 로고    scopus 로고
    • Induction of tumor-specific cytotoxic T lymphocytes in cancer patients by autologous tumor RNA-transfected dendritic cells
    • Nair, S. K. et al. Induction of tumor-specific cytotoxic T lymphocytes in cancer patients by autologous tumor RNA-transfected dendritic cells. Ann. Surg. 235, 540-549 (2002).
    • (2002) Ann. Surg. , vol.235 , pp. 540-549
    • Nair, S.K.1
  • 109
    • 0037047047 scopus 로고    scopus 로고
    • Human tumor-derived genomic DNA transduced into a recipient cell induces tumor-specific immune responses ex vivo
    • Whiteside, T. L., Gambotto, A., Albers, A., Stanson, J. & Cohen, E. P. Human tumor-derived genomic DNA transduced into a recipient cell induces tumor-specific immune responses ex vivo. Proc. Natl Acad. Sci. USA 99, 9415-9420 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 9415-9420
    • Whiteside, T.L.1    Gambotto, A.2    Albers, A.3    Stanson, J.4    Cohen, E.P.5
  • 110
    • 0036167308 scopus 로고    scopus 로고
    • Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors
    • Heiser, A. et al. Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors. J. Clin. Invest. 109, 409-417 (2002).
    • (2002) J. Clin. Invest. , vol.109 , pp. 409-417
    • Heiser, A.1
  • 111
    • 0030000007 scopus 로고    scopus 로고
    • A phase I trial of a synthetic mucin peptide vaccine. Induction of specific immune reactivity in patients with adenocarcinoma
    • Goydos, J. S., Elder, E., Whiteside, T. L., Finn, O. J. & Lotze, M. T. A phase I trial of a synthetic mucin peptide vaccine. Induction of specific immune reactivity in patients with adenocarcinoma. J. Surg. Res. 63, 298-304 (1996).
    • (1996) J. Surg. Res. , vol.63 , pp. 298-304
    • Goydos, J.S.1    Elder, E.2    Whiteside, T.L.3    Finn, O.J.4    Lotze, M.T.5
  • 112
    • 0032975450 scopus 로고    scopus 로고
    • A phase I vaccine trial with peptides reflecting ras oncogene mutations of solid tumors
    • Khleif, S. N. et al. A phase I vaccine trial with peptides reflecting ras oncogene mutations of solid tumors. J. Immunother. 22, 155-165 (1999).
    • (1999) J. Immunother. , vol.22 , pp. 155-165
    • Khleif, S.N.1
  • 113
    • 0033566327 scopus 로고    scopus 로고
    • Idiotype vaccination in human myeloma: Generation of tumor-specific immune responses after high-dose chemotherapy
    • Massaia, M. et al. Idiotype vaccination in human myeloma: generation of tumor-specific immune responses after high-dose chemotherapy. Blood 94, 673-683 (1999).
    • (1999) Blood , vol.94 , pp. 673-683
    • Massaia, M.1
  • 114
    • 0033153564 scopus 로고    scopus 로고
    • Vaccination with HPV16 peptides of patients with advanced cervical carcinoma: Clinical evaluation of a phase I-II trial
    • van Driel, W. J. et al. Vaccination with HPV16 peptides of patients with advanced cervical carcinoma: clinical evaluation of a phase I-II trial. Eur. J. Cancer 35, 946-952 (1999).
    • (1999) Eur. J. Cancer , vol.35 , pp. 946-952
    • Van Driel, W.J.1
  • 115
    • 0034331218 scopus 로고    scopus 로고
    • Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells
    • Brossart, P. et al. Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells. Blood 96, 3102-3108 (2000).
    • (2000) Blood , vol.96 , pp. 3102-3108
    • Brossart, P.1
  • 116
    • 0034551730 scopus 로고    scopus 로고
    • Phase I study in advanced cancer patients of a diversified prime-and-boost vaccination protocol using recombinant vaccinia virus and recombinant nonreplicating avipox virus to elicit anti-carcinoembryonic antigen immune responses
    • Marshall, J. L. et al. Phase I study in advanced cancer patients of a diversified prime-and-boost vaccination protocol using recombinant vaccinia virus and recombinant nonreplicating avipox virus to elicit anti-carcinoembryonic antigen immune responses. J. Clin. Oncol. 18, 3964-3973 (2000).
    • (2000) J. Clin. Oncol. , vol.18 , pp. 3964-3973
    • Marshall, J.L.1
  • 117
    • 0035417932 scopus 로고    scopus 로고
    • + progenitor-derived dendritic cell vaccine
    • + progenitor-derived dendritic cell vaccine. Cancer Res. 61, 6451-6458 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 6451-6458
    • Banchereau, J.1
  • 118
    • 0037141023 scopus 로고    scopus 로고
    • Rapid induction of tumor-specific type 1 T helper cells in metastatic melanoma patients by vaccination with mature, cryopreserved, peptide-loaded monocyte-derived dendritic cells
    • Schuler-Thurner, B. et al. Rapid induction of tumor-specific type 1 T helper cells in metastatic melanoma patients by vaccination with mature, cryopreserved, peptide-loaded monocyte-derived dendritic cells. J. Exp. Med. 195, 1279-1288 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 1279-1288
    • Schuler-Thurner, B.1
  • 119
    • 0035113705 scopus 로고    scopus 로고
    • Immunization with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients
    • Knutson, K. L., Schiffman, K. & Disis, M. L. Immunization with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients. J. Clin. Invest. 107, 477-484 (2001).
    • (2001) J. Clin. Invest. , vol.107 , pp. 477-484
    • Knutson, K.L.1    Schiffman, K.2    Disis, M.L.3
  • 120
    • 0036093592 scopus 로고    scopus 로고
    • Induction of p53-specific immune responses in colorectal cancer patients receiving a recombinant ALVAC-p53 candidate vaccine
    • van der Burg, S. H. et al. Induction of p53-specific immune responses in colorectal cancer patients receiving a recombinant ALVAC-p53 candidate vaccine. Clin. Cancer Res. 8, 1019-1027 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1019-1027
    • Van der Burg, S.H.1
  • 121
    • 0037215111 scopus 로고    scopus 로고
    • Immunisation of metastatic cancer patients with MAGE-3 protein combined with adjuvant SBAS-2: A clinical report
    • Marchand, M. et al. Immunisation of metastatic cancer patients with MAGE-3 protein combined with adjuvant SBAS-2: a clinical report. Eur. J. Cancer 39, 70-77 (2003).
    • (2003) Eur. J. Cancer , vol.39 , pp. 70-77
    • Marchand, M.1
  • 122
    • 0036533437 scopus 로고    scopus 로고
    • Prophylactic cancer vaccines
    • Finn, O. J. & Fomi, G. Prophylactic cancer vaccines. Curr. Opin. Immunol. 14, 172-177 (2002).
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 172-177
    • Finn, O.J.1    Fomi, G.2
  • 123
    • 0037440256 scopus 로고    scopus 로고
    • Success of vaccine offers promise of cervical cancer prevention
    • Schultz, J. Success of vaccine offers promise of cervical cancer prevention. J. Natl Cancer Inst. 95, 102-104 (2003).
    • (2003) J. Natl. Cancer Inst. , vol.95 , pp. 102-104
    • Schultz, J.1
  • 124
    • 0037309971 scopus 로고    scopus 로고
    • Frequent display of human papillomavirus type 16 E6-specific memory T-helper cells in the healthy population as witness of previous viral encounter
    • Welters, M. J. et al. Frequent display of human papillomavirus type 16 E6-specific memory T-helper cells in the healthy population as witness of previous viral encounter. Cancer Res. 63, 636-641 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 636-641
    • Welters, M.J.1
  • 125
    • 0036848779 scopus 로고    scopus 로고
    • Strategies for HPV prevention
    • Plummer, M. & Franceschi, S. Strategies for HPV prevention. Virus Res. 89, 285-293 (2002).
    • (2002) Virus Res. , vol.89 , pp. 285-293
    • Plummer, M.1    Franceschi, S.2
  • 126
    • 0033966594 scopus 로고    scopus 로고
    • Nationwide vaccination: A success story in Taiwan
    • Huang, K. & Lin, S. Nationwide vaccination: a success story in Taiwan. Vaccine 18, S35-S38 (2000).
    • (2000) Vaccine , vol.18
    • Huang, K.1    Lin, S.2
  • 127
    • 0033529482 scopus 로고    scopus 로고
    • Hepatitis B vaccinaton in infancy in The Gambia: Protection against carriage at 9 years of age
    • Viviani, S. et al. Hepatitis B vaccinaton in infancy in The Gambia: protection against carriage at 9 years of age. Vaccine 17, 2946-2950 (1999).
    • (1999) Vaccine , vol.17 , pp. 2946-2950
    • Viviani, S.1
  • 128
    • 0036894250 scopus 로고    scopus 로고
    • Immunoprevention of colorectal cancer: A future possibility?
    • Lollini, P. L. et al. Immunoprevention of colorectal cancer: a future possibility? Gastroenterol. Clin. North Am. 31, 1001-1014 (2002).
    • (2002) Gastroenterol. Clin. North Am. , vol.31 , pp. 1001-1014
    • Lollini, P.L.1
  • 129
    • 0036047820 scopus 로고    scopus 로고
    • Antitumor vaccines: Is it possible to prevent a tumor?
    • Lollini, P. L. & Forni, G. Antitumor vaccines: is it possible to prevent a tumor? Cancer Immunol. Immunother. 51, 409-416 (2002).
    • (2002) Cancer Immunol. Immunother. , vol.51 , pp. 409-416
    • Lollini, P.L.1    Forni, G.2
  • 130
    • 0033813525 scopus 로고    scopus 로고
    • A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive
    • Muderspach, L. et al. A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive. Clin. Cancer Res. 6, 3406-3416 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 3406-3416
    • Muderspach, L.1
  • 131
    • 0028989973 scopus 로고
    • MUC-1 epithelial tumor mucin-based immunity and cancer vaccines
    • Finn, O. J. et al. MUC-1 epithelial tumor mucin-based immunity and cancer vaccines. Immunol. Rev. 145, 61-89 (1995).
    • (1995) Immunol. Rev. , vol.145 , pp. 61-89
    • Finn, O.J.1
  • 132
    • 0028875822 scopus 로고
    • Identification of an HLA-A11-restricted epitope from the tandem repeat domain of the epithelial tumor antigen mucin
    • Domenech, N., Henderson, R. A. & Finn, O. J. Identification of an HLA-A11-restricted epitope from the tandem repeat domain of the epithelial tumor antigen mucin. J. Immunol. 155, 4766-4774 (1995).
    • (1995) J. Immunol. , vol.155 , pp. 4766-4774
    • Domenech, N.1    Henderson, R.A.2    Finn, O.J.3
  • 134
    • 0033563771 scopus 로고    scopus 로고
    • Presentation of MUC1 tumor antigen by class I MHC and CTL function correlate with the glycosylation state of the protein taken up by dendritic cells
    • Hiltbold, E. M., Alter, M. D., Ciborowski, P. & Finn, O. J. Presentation of MUC1 tumor antigen by class I MHC and CTL function correlate with the glycosylation state of the protein taken up by dendritic cells. Cell. Immunol. 194, 143-149 (1999).
    • (1999) Cell. Immunol. , vol.194 , pp. 143-149
    • Hiltbold, E.M.1    Alter, M.D.2    Ciborowski, P.3    Finn, O.J.4
  • 135
    • 0037011127 scopus 로고    scopus 로고
    • Complex carbohydrates are not removed during processing of glycoproteins by dendritic cells: Processing of tumor antigen MUC1 glycopeptides for presentation to major histocompatibility complex class II-restricted T cells
    • H cells.
    • (2002) J. Exp. Med. , vol.196 , pp. 1435-1446
    • Vlad, A.M.1
  • 136
    • 0031297362 scopus 로고    scopus 로고
    • Induction of HLA-A2-restricted CTLs to the mucin 1 human breast cancer antigen
    • Apostolopoulos, V., Karanikas V., Haurum, J. S. & McKenzie, I. F. Induction of HLA-A2-restricted CTLs to the mucin 1 human breast cancer antigen. J. Immunol. 159, 5211-5218 (1997).
    • (1997) J. Immunol. , vol.159 , pp. 5211-5218
    • Apostolopoulos, V.1    Karanikas, V.2    Haurum, J.S.3    McKenzie, I.F.4
  • 137
    • 0033564363 scopus 로고    scopus 로고
    • Identification of HLA-A2-restricted T-cell epitopes derived from the MUC1 tumor antigen for broadly applicable vaccine therapies
    • Brossart, P. et al. Identification of HLA-A2-restricted T-cell epitopes derived from the MUC1 tumor antigen for broadly applicable vaccine therapies. Blood 93, 4309-4317 (1999).
    • (1999) Blood , vol.93 , pp. 4309-4317
    • Brossart, P.1
  • 138
    • 0034666716 scopus 로고    scopus 로고
    • Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice
    • Lees, C. J. et al. Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice. Vaccine 19, 158-162 (2000).
    • (2000) Vaccine , vol.19 , pp. 158-162
    • Lees, C.J.1
  • 139
    • 0034665508 scopus 로고    scopus 로고
    • Mice with spontaneous pancreatic cancer naturally develop MUC-1-specific CTLs that eradicate tumors when adoptively transferred
    • Mukherjee, P. et al. Mice with spontaneous pancreatic cancer naturally develop MUC-1-specific CTLs that eradicate tumors when adoptively transferred. J. Immunol. 165, 3451-3460 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 3451-3460
    • Mukherjee, P.1
  • 140
    • 0029918564 scopus 로고    scopus 로고
    • Induction of cellular immunity in chimpanzees to human tumor-associated antigen mucin by vaccination with MUC-1 cDNA-transfected Epstein-Barr virus-immortalized autologous B cells
    • Pecher, G. & Finn, O. J. Induction of cellular immunity in chimpanzees to human tumor-associated antigen mucin by vaccination with MUC-1 cDNA-transfected Epstein-Barr virus-immortalized autologous B cells. Proc. Natl Acad. Sci. USA 93, 1699-1704 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 1699-1704
    • Pecher, G.1    Finn, O.J.2
  • 141
    • 0032809534 scopus 로고    scopus 로고
    • Immunization of chimpanzees with tumor antigen MUC1 mucin tandem repeat peptide elicits both helper and cytotoxic T-cell responses
    • Barratt-Boyes, S. M., Vlad, A. & Finn, O. J. Immunization of chimpanzees with tumor antigen MUC1 mucin tandem repeat peptide elicits both helper and cytotoxic T-cell responses. Clin. Cancer Res. 5, 1918-1924 (1999).
    • (1999) Clin. Cancer Res. , vol.5 , pp. 1918-1924
    • Barratt-Boyes, S.M.1    Vlad, A.2    Finn, O.J.3
  • 142
    • 0034193383 scopus 로고    scopus 로고
    • Immunity to murine breast cancer cells modified to express MUC-1, a human breast cancer antigen, in transgenic mice tolerant to human MUC-1
    • Carr-Brendel, V. et al. Immunity to murine breast cancer cells modified to express MUC-1, a human breast cancer antigen, in transgenic mice tolerant to human MUC-1. Cancer Res. 60, 2435-2443 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 2435-2443
    • Carr-Brendel, V.1
  • 143
    • 0035360260 scopus 로고    scopus 로고
    • Synergy of vaccine strategies to amplify antigen-specific immune responses and antitumor effects
    • Grosenbach, D. W., Barrientos, J. C., Schlom, J. & Hodge, J. W. Synergy of vaccine strategies to amplify antigen-specific immune responses and antitumor effects. Cancer Res. 61, 4497-4505 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 4497-4505
    • Grosenbach, D.W.1    Barrientos, J.C.2    Schlom, J.3    Hodge, J.W.4
  • 144
    • 0035293323 scopus 로고    scopus 로고
    • Protective immunity against human carcinoembryonic antigen (CEA) induced by an oral DNA vaccine in CEA-transgenic mice
    • Xiang, R. et al. Protective immunity against human carcinoembryonic antigen (CEA) induced by an oral DNA vaccine in CEA-transgenic mice. Clin. Cancer Res. 7, S856-S864 (2001).
    • (2001) Clin. Cancer Res. , vol.7
    • Xiang, R.1
  • 145
    • 0030578211 scopus 로고    scopus 로고
    • Phase I study of recombinant CEA vaccinia virus vaccine with post vaccination CEA peptide challenge
    • Cole, D. J. et al. Phase I study of recombinant CEA vaccinia virus vaccine with post vaccination CEA peptide challenge. Hum. Gene Ther. 7, 1381-1394 (1996).
    • (1996) Hum. Gene Ther. , vol.7 , pp. 1381-1394
    • Cole, D.J.1
  • 146
    • 0035163903 scopus 로고    scopus 로고
    • Combined allogeneic tumor cell vaccination and systemic interleukin 12 prevents mammary carcinogenesis in HER-2/neu transgenic mice
    • Nanni, P. et al. Combined allogeneic tumor cell vaccination and systemic interleukin 12 prevents mammary carcinogenesis in HER-2/neu transgenic mice. J. Exp. Med. 194, 1195-1205 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 1195-1205
    • Nanni, P.1
  • 147
    • 0034281265 scopus 로고    scopus 로고
    • The history of the development of vaccines for the treatment of lymphoma
    • discussion 140
    • Timmerman, J. M. & Levy, R. The history of the development of vaccines for the treatment of lymphoma. Clin. Lymphoma 1, 129-139; discussion 140 (2000).
    • (2000) Clin. Lymphoma , vol.1 , pp. 129-139
    • Timmerman, J.M.1    Levy, R.2
  • 148
    • 0035020633 scopus 로고    scopus 로고
    • Pancreatic intraepithelial neoplasia: A new nomenclature and classification system for pancreatic duct lesions
    • Hruban, R. H. et al. Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am. J. Surg. Pathol. 25, 579-586 (2001).
    • (2001) Am. J. Surg. Pathol. , vol.25 , pp. 579-586
    • Hruban, R.H.1
  • 149
    • 0035684270 scopus 로고    scopus 로고
    • Preneoplastic prostate lesions: An opportunity for prostate cancer prevention
    • Nelson, W. G. et al. Preneoplastic prostate lesions: an opportunity for prostate cancer prevention. Ann. NY Acad. Sci. 952, 135-144 (2001).
    • (2001) Ann. NY Acad. Sci. , vol.952 , pp. 135-144
    • Nelson, W.G.1
  • 150
    • 0036896050 scopus 로고    scopus 로고
    • Colorectal polyps and other precursor lesions. Need for an expanded view
    • Burgart, L. J. Colorectal polyps and other precursor lesions. Need for an expanded view. Gastroenterol. Clin. North Am. 31, 959-970 (2002).
    • (2002) Gastroenterol. Clin. North Am. , vol.31 , pp. 959-970
    • Burgart, L.J.1
  • 151
    • 0035458528 scopus 로고    scopus 로고
    • Detection of preinvasive cancer cells: Early-warning changes in precancerous epithelial cells can now be spotted in situ and endoscopic detection of dysplasia in patients with Barrett's esophagus using light-scattered spectroscopy
    • Pfau, P. & Chak, A. Detection of preinvasive cancer cells: early-warning changes in precancerous epithelial cells can now be spotted in situ and endoscopic detection of dysplasia in patients with Barrett's esophagus using light-scattered spectroscopy. Gastrointest. Endosc. 54, 414-416 (2001).
    • (2001) Gastrointest. Endosc. , vol.54 , pp. 414-416
    • Pfau, P.1    Chak, A.2
  • 152
    • 0037162115 scopus 로고    scopus 로고
    • Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation
    • Kauff, N. D. et al. Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation. N. Engl. J. Med. 346, 1609-1615 (2002).
    • (2002) N. Engl. J. Med. , vol.346 , pp. 1609-1615
    • Kauff, N.D.1
  • 153
    • 0035913275 scopus 로고    scopus 로고
    • Breast cancer after prophylactic bilateral mastectomy in women with a BRCA1 or BRCA2 mutation
    • Meijers-Heijboer, H. et al. Breast cancer after prophylactic bilateral mastectomy in women with a BRCA1 or BRCA2 mutation. N. Engl. J. Med. 345, 159-164 (2001).
    • (2001) N. Engl. J. Med. , vol.345 , pp. 159-164
    • Meijers-Heijboer, H.1
  • 154
    • 0037162110 scopus 로고    scopus 로고
    • Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations
    • Rebbeck, T. R. et al. Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations. N. Engl. J. Med. 346, 1616-1622 (2002).
    • (2002) N. Engl. J. Med. , vol.346 , pp. 1616-1622
    • Rebbeck, T.R.1
  • 155
    • 0033552904 scopus 로고    scopus 로고
    • Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer
    • Hartmann, L. C. et al. Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer. N. Engl. J. Med. 340, 77-84 (1999).
    • (1999) N. Engl. J. Med. , vol.340 , pp. 77-84
    • Hartmann, L.C.1
  • 156
    • 0024550968 scopus 로고
    • Subcutaneous mastectomy data: A final statistical analysis of 1500 patients
    • Pennisi, V. R. & Capozzi, A. Subcutaneous mastectomy data: a final statistical analysis of 1500 patients. Aesthetic Plast. Surg. 18, 15-21 (1989).
    • (1989) Aesthetic Plast. Surg. , vol.18 , pp. 15-21
    • Pennisi, V.R.1    Capozzi, A.2
  • 157
    • 0035812281 scopus 로고    scopus 로고
    • Risk-reduction mastectomy: Clinical issues and research needs
    • Stefanek, M., Hartmann, L. & Nelson, W. Risk-reduction mastectomy: clinical issues and research needs. J. Natl Cancer Inst. 93, 1297-1306 (2001).
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 1297-1306
    • Stefanek, M.1    Hartmann, L.2    Nelson, W.3
  • 158
    • 0037089223 scopus 로고    scopus 로고
    • Flt3 ligand as a vaccine adjuvant in association with HER-2/neu peptide-based vaccines in patients with HER-2/neu-overexpressing cancers
    • Disis, M. L. et al. Flt3 ligand as a vaccine adjuvant in association with HER-2/neu peptide-based vaccines in patients with HER-2/neu-overexpressing cancers. Blood 99, 2845-2850 (2002).
    • (2002) Blood , vol.99 , pp. 2845-2850
    • Disis, M.L.1
  • 159
    • 0034043830 scopus 로고    scopus 로고
    • Genetic predispositions to acute and chronic pancreatitis
    • Whitcomb, D. C. Genetic predispositions to acute and chronic pancreatitis. Med. Clin. North Am. 84, 531-547 (2000).
    • (2000) Med. Clin. North Am. , vol.84 , pp. 531-547
    • Whitcomb, D.C.1
  • 160
    • 0030975440 scopus 로고    scopus 로고
    • Hereditary pancreatitis and the risk of pancreatic cancer
    • International Hereditary Pancreatitis Study Group
    • Lowenfels, A. B. et al. Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group. J. Natl Cancer Inst. 89, 442-446 (1997).
    • (1997) J. Natl. Cancer Inst. , vol.89 , pp. 442-446
    • Lowenfels, A.B.1
  • 161
    • 0034940538 scopus 로고    scopus 로고
    • Cigarette smoking as a risk factor for pancreatic cancer in patients with hereditary pancreatitis
    • Lowenfels, A. B., Maisonneuve, P., Whitcomb, D. C., Lerch, M. M. & DiMagno, E. P. Cigarette smoking as a risk factor for pancreatic cancer in patients with hereditary pancreatitis. JAMA 286, 169-170 (2001).
    • (2001) JAMA , vol.286 , pp. 169-170
    • Lowenfels, A.B.1    Maisonneuve, P.2    Whitcomb, D.C.3    Lerch, M.M.4    DiMagno, E.P.5
  • 162
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler, K. W. & Vogelstein, B. Lessons from hereditary colorectal cancer. Cell 87, 159-170 (1996).
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 163
    • 0028235332 scopus 로고
    • O-glycan biosynthesis in human colorectal adenoma cells during progression to cancer
    • Vavasseur, F. et al. O-glycan biosynthesis in human colorectal adenoma cells during progression to cancer. Eur. J. Biochem. 222, 415-424 (1994).
    • (1994) Eur. J. Biochem. , vol.222 , pp. 415-424
    • Vavasseur, F.1
  • 164
    • 0035840441 scopus 로고    scopus 로고
    • Comparative study for histology, proliferative activity, glycoproteins, and p53 protein between old and recent colorectal adenomas in Japan
    • Li, A. et al. Comparative study for histology, proliferative activity, glycoproteins, and p53 protein between old and recent colorectal adenomas in Japan. Cancer Lett. 170, 45-52 (2001).
    • (2001) Cancer Lett. , vol.170 , pp. 45-52
    • Li, A.1


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