Antigen-bearing immature dendritic cells induce peptide-specific CD8+ regulatory T cells in vivo in humans

Blood

Volumn 100, Issue 1, 2002, Pages 174-177

  Dhodapkar, Madhav V ^a,b   Steinman, Ralph M ^a,b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; GAMMA INTERFERON; MATRIX PROTEIN;

ANTIGEN SPECIFICITY; ARTICLE; CELL FUNCTION; CELL KINETICS; CELL MATURATION; CELL TRANSPLANTATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; EFFECTOR CELL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNE RESPONSE; IMMUNOREGULATION; IN VIVO STUDY; NORMAL HUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 0036659913     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V100.1.174     Document Type: Article

References (25)

1. Roncarolo MG, Levings MK. The role of different subsets of T regulatory cells in controlling autoimmunity, Curr Opin Immunol. 2000;12:676-683.
2. + regulatory cells? Immunity. 2001;14:399-406.
3. Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell. 2000;101:455-458.
4. + immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J Exp Med. 2001;193:1311-1318.
5. + T cells with regulatory properties from human blood. J Exp Med. 2001;193:1303-1310.
6. + T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med. 2001;193:1295-1302.
7. + suppressor T cells. J Exp Med. 2001;193:F41-F46.
8. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature. 1997;389:737-742.
9. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 1995;155:1151-1164.
10. + cells in T cell receptor peptide-induced clonal unresponsiveness. Science. 1993;259:91-94.
11. Koh D-R, Fung-Leung W-P, Ho A, Gray D, Acha-Oṙbea H, Mak T-W. Less mortality but more relapses in experimental allergic encephalomyelitis in CD8 -/- mice. Science. 1992;256:1210-1213.
12. + T cells is induced by IL-2 receptor γ chain signalling cytokines and type I IFN, and increases susceptibility to activation-induced apoptosis. Int Immunol. 2000;12:1005-1013.
13. + cytotoxic and suppressor T cell clones. J Immunol. 1990;144:32-40.
14. - T suppressor cells represent a distinct subset in a heterogeneous population. Transplant Proc. 2001;33:104-107.
15. + T suppressor cell function in patients with active systemic lupus erythematosus. J Immunol. 2001;166:6452-6457.
16. + T cells is mediated by interferon-γ and is defective in chronic progressive multiple sclerosis. J Clin Invest. 1995;95:2711-2719.
17. + immunoregulatory T cells. J Exp Med. 2001;194:427-438.
18. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature. 1998;392:245-252.
19. Mellman I, Steinman RM. Dendritic cells: specialized and regulated antigen processing machines. Cell, 2001;106:255-258.
20. Inaba K, Turley S, Iyoda T, et al. The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli. J Exp Med, 2000;191:927-936.
21. + T cells with regulatory properties by repetitive stimulation with allogeneic immature dendritic cells. J Exp Med. 2000;192: 1213-1222.
22. Dhodapkar MV, Steinman RM, Krasovsky J, Munz C, Bhardwaj N. Antigen specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med. 2001;193:233-238.
23. Dhodapkar MV, Steinman RM, Sapp M, et al. Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells. J Clin Invest. 1999;104:173-180.
24. VanBuskirk AM, Burlingham WJ, Jankowska-Gan E, et al. Human allograft acceptance is associated with immune regulation. J Clin Invest. 2000;106:145-155.
25. + regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J Exp Med. 2001;194:823-832.