Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs

Molecular Cell

Volumn 8, Issue 6, 2001, Pages 1383-1390

  Sekiguchi, JoAnn ^a   Whitlow, Scott ^a   Alt, Frederick W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NONHOMOLOGOUS END JOINING PROTEIN; PROTEIN; RAG1 PROTEIN; RAG2 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DNA FLANKING REGION; DNA STRAND; GENETIC CODE; HYBRID; NONHUMAN; PROTEIN EXPRESSION; REGULATORY MECHANISM; WILD TYPE;

ANIMALIA;

EID: 0035697242     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00423-3     Document Type: Article

References (34)

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2. Reciprocal hybrid joints demonstrate successive V-J rearrangements on the same chromosome in the human TCR gamma locus
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4. Analysis of variable (diversity) joining recombination in DNA dependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation
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10. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis
11. Characterization of the single-strand-specific nuclease S1 activity on double-stranded supercoiled polyoma DNA
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13. V(D)J recombination intermediates and non-standard products in XRCC4- deficient cells
14. V(D)J recombination: A functional definition of the joining signals
15. DNA transposition by the RAG1 and RAG2 proteins: A possible source of oncogenic translocations
16. Regions of RAG1 protein critical for V(D)J recombination
17. Dual role of RAG2 in V(D)J recombination: Catalysis and regulation of ordered Ig gene assembly
18. Activation of V(D)J recombination induces the formation of interlocus joints and hybrid joints in scid pre-B-cell lines
19. Novel strand exchanges in V(D)J recombination
20. The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination
21. The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination
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23. Rejoining of DNA by the RAG1 and RAG2 proteins
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25. Complementation of V(D)J recombination deficiency in RAG-1(-/-) B cells reveals a requirement for novel elements in the N-terminus of RAG-1
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27. The RAG proteins in V(D)J recombination: More than just a nuclease
28. Expression and V(D)J recombination activity of mutated RAG-1 proteins
29. Definition of a core region of RAG-2 that is functional in V(D)J recombination
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31. Inversions produced during V(D)J rearrangement at IgH, the immunoglobulin heavy-chain locus
32. Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination
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34. Immunoglobulin D(H) recombination signal sequence targeting: Effect of D(H) coding and flanking regions and recombination partner