Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase

Molecular and Cellular Biology

Volumn 22, Issue 10, 2002, Pages 3460-3473

  Huye, Leslie E ^a   Purugganan, Mary M ^a   Jiang, Ming Ming ^a   Roth, David B ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID DERIVATIVE; DNA DEPENDENT PROTEIN KINASE; METAL ION; MUTANT PROTEIN; NUCLEOTIDE; RAG1 PROTEIN; RAG2 PROTEIN; RECOMBINASE;

ARTICLE; BINDING SITE; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SUBUNIT; GENE DELETION; GENE INSERTION; GENE MUTATION; GENETIC CONSERVATION; GENETIC RECOMBINATION; IMMUNE DEFICIENCY; MUTANT; PRIORITY JOURNAL; PROTEIN DNA BINDING; SCID MOUSE; SEQUENCE HOMOLOGY;

ALANINE; AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; DNA; DNA NUCLEOTIDYLTRANSFERASES; DNA-BINDING PROTEINS; GENES, RAG-1; HOMEODOMAIN PROTEINS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RECOMBINATION, GENETIC; TRANSPOSASES; VDJ RECOMBINASES;

INSERTION SEQUENCES;

EID: 0036240040     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.10.3460-3473.2002     Document Type: Article

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