Targeted transposition by the V(D)J recombinase

Molecular and Cellular Biology

Volumn 22, Issue 7, 2002, Pages 2068-2077

  Lee, Gregory S ^a   Neiditch, Matthew B ^a   Sinden, Richard R ^a   Roth, David B ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR; RAG1 PROTEIN; RECOMBINASE;

ARTICLE; CHROMOSOME TRANSLOCATION; DNA STRUCTURE; DNA TRANSPOSITION; GENE REARRANGEMENT; LYMPHOMA; PLASMID; PRIORITY JOURNAL;

NON-PROGRAMMATIC;

ANIMALS; BASE SEQUENCE; CHO CELLS; CRICETINAE; DNA; DNA NUCLEOTIDYLTRANSFERASES; DNA TOPOISOMERASES; DNA TRANSPOSABLE ELEMENTS; DNA, RECOMBINANT; DNA-BINDING PROTEINS; GENE REARRANGEMENT; GENE TARGETING; HOMEODOMAIN PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; NUCLEIC ACID CONFORMATION; POLYMERASE CHAIN REACTION; RECOMBINATION, GENETIC; REPETITIVE SEQUENCES, NUCLEIC ACID; SUBSTRATE SPECIFICITY; TRANSLOCATION, GENETIC; VDJ RECOMBINASES;

EID: 0036124465     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.7.2068-2077.2002     Document Type: Article

References (42)

1. Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
2. RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination
3. Hairpin coding end opening is mediated by RAG1 and RAG2 proteins
4. V(D)J recombination in Ku86-deficient mice: Distinct effects on coding, signal, and hybrid joint formation
5. DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences
6. The RAG proteins and V(D)J recombination: Complexes, ends, and transposition
7. Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products
8. Assembly of a 12/23 paired signal complex: A critical control point in V(D)J recombination
9. DNA transposition by the RAG1 and RAG2 proteins: A possible source of oncogenic translocations
10. Mechanism of the chromosomal translocation t(14;18) in lymphoma: Detection of a 45-Kd breakpoint binding protein
11. Hairpin opening by single-strand specific nucleases
12. Conditional RAG-1 mutants block the hairpin formation step of V(D)J recombination
13. A preferred target DNA structure for retroviral integrase in vitro
14. Analysis of trimethylpsoralen photo-reactivity to Z-DNA provides a general in vivo assay for Z-DNA: Analysis of the hypersensitivity of (GT)n B-Z junctions
15. Target DNA structure plays a critical role in Tn7 transposition
16. Novel strand exchanges in V(D)J recombination
17. Dynamic, sequence-dependent DNA structure as exemplified by cruciform extrusion from inverted repeats in negatively supercoiled DNA
18. S1 nuclease hypersensitive sites in an oligopurine/oligopyrimidine DNA from the t(10;14) break-point cluster region
19. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps
20. DNA secondary structure: A common and causative factor for expansion in human disease
21. Rejoining of DNA by the RAG1 and RAG2 proteins
22. Cruciform structures in palindromic DNA are favored by DNA supercoiling
23. Triplet repeats form secondary structures that escape DNA repair in yeast
24. Unusual immunoglobulin gene rearrangement leads to replacement of recombination signal sequences
25. The RAG transposase can capture and commit to target DNA before or after donor cleavage
26. Structure of branched DNA molecules: Gel retardation and atomic force microscopy studies
27. Tn7 transposes proximal to DNA double-strand breaks and into regions where chromosomal DNA replication terminates
28. Substrate recognition and induced DNA deformation by transposase at the target-capture stage of Tn1O transposition
29. Human immunodeficiency virus integrase directs integration to sites of severe DNA distortion within the nucleosome core
30. Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination
31. Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage
32. Selective recognition of pyrimidine motif triplexes by a protein encoded by the bacterial transposon Tn7
33. Recognition of triple-helical DNA structures by transposon Tn7
34. VDJ recombination: A transposase goes to work
35. Trinucleotide repeats affect DNA replication in vivo
36. The RAG1/RAG2 complex constitutes a 3× flap endonuclease: Implications for junctional diversity in V(D)J and transpositional recombination
37. Joining-deficient RAG1 mutants block V(D)J recombination in vivo and hairpin opening in vitro
38. DNA hairpin opening mediated by the RAG1 and RAG2 proteins
39. Somatic generation of antibody diversity
40. Stimulation of V(D)J cleavage by high mobility group proteins
41. Torsionally tuned cruciform and Z-DNA probes for measuring unrestrained supercoiling at specific sites in DNA of living cells