V(D)J recombination and the evolution of the adaptive immune system

PLoS Biology

Volumn 1, Issue 1, 2003, Pages

  Market, Eleonora ^a   Papavasiliou, F Nina ^a,b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b Laboratory of Lymphocyte Biology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE; CELL MATURATION; CELL SURVIVAL; CHROMOSOME TRANSLOCATION; COMBINED IMMUNODEFICIENCY; DNA HELIX; DNA REPAIR; DNA STRAND BREAKAGE; GENE MUTATION; GENETIC RECOMBINATION; GENETIC VARIABILITY; IMMUNE SYSTEM; IMMUNOGENETICS; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PROTEIN BINDING; PROTEIN FUNCTION; REVIEW; T LYMPHOCYTE; TRANSPOSON; ANIMAL; BIOLOGICAL MODEL; CONFORMATION; GENE REARRANGEMENT; GENE TRANSLOCATION; HUMAN; METABOLISM; MOUSE; MOUSE MUTANT; PHYSIOLOGY; TRANSGENIC MOUSE;

TRANSPOSONS;

DNA BINDING PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; NUCLEAR PROTEIN; RECOMBINASE;

ANIMALS; DNA REPAIR; DNA-BINDING PROTEINS; EVOLUTION, MOLECULAR; GENE REARRANGEMENT; HUMANS; IMMUNE SYSTEM; MICE; MICE, SCID; MICE, TRANSGENIC; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; NUCLEIC ACID CONFORMATION; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, ANTIGEN, T-CELL; RECOMBINATION, GENETIC; TRANSLOCATION, GENETIC; VDJ RECOMBINASES;

EID: 2942680399     PISSN: 15449173     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pbio.0000016     Document Type: Review

References (17)

1. Akira S, Okazaki K, Sakano H (1987) Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joining. Science 238: 1134-1138. Find this article online
2. Bassing CH, Swat W, Alt FW (2002) The mechanism and regulation of chromosomal V(D)J recombination. Cell 109: Suppl: S45-S55. Find this article online
3. Bosma M, Schuler W, Bosma G (1988) The scid mouse mutant. Curr Top Microbiol Immunol 137: 197-202. Find this article online
4. Fugmann SD, Lee AI, Shockett PE, Villey IJ, Schatz DG (2000) The RAG proteins and V(D)J recombination: Complexes, ends, and transposition. Annu Rev Immunol 18: 495-527. Find this article online
5. Gao Y, Chaudhuri J, Zhu C, Davidson L, Weaver DT, et al. (1998) A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity 9: 367-376. Find this article online
6. Gellert M (2002) V(D)J recombination: RAG proteins, repair factors, and regulation. Annu Rev Biochem 71: 101-132. Find this article online
7. Lee AI, Fugmann SD, Cowell LG, Ptaszek LM, Kelsoe G, et al. (2003) A functional analysis of the spacer of V(D)J recombination signal sequences. PLoS Biol 1: 10.1371/journal.pbio.0000001.
8. McBlane JF, van Gent DC, Ramsden DA, Romeo C, Cuomo CA, et al. (1995) Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83: 387-395. Find this article online
9. Mombaerts P, Iacomini J, Johnson RS, Herrup K, Tonegawa S, et al. (1992) RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68: 869-877. Find this article online
10. Schatz DG, Baltimore D (1988) Stable expression of immunoglobulin gene V(D)J recombinase activity by gene transfer into 3T3 fibroblasts. Cell 53: 107-115. Find this article online
11. Schatz DG, Oettinger MA, Baltimore D (1989) The V(D)J recombination activating gene, RAG-1. Cell 59: 1035-1048. Find this article online
12. Schluter SF, Bernstein RM, Bernstein H, Marchalonis JJ (1999) 'Big Bang' emergence of the combinatorial immune system. Dev Comp Immunol 23: 107-111. Find this article online
13. Shih IH, Melek M, Jayaratne ND, Gellert M (2002) Inverse transposition by the RAG1 and RAG2 proteins: Role reversal of donor and target DNA. EMBO J 21: 6625-6633. Find this article online
14. Shinkai Y, Rathbun G, Lam KP, Oltz EM, Stewart V, et al. (1992) RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68: 855-867. Find this article online
15. Tonegawa S (1983) Somatic generation of antibody diversity. Nature 302: 575-581. Find this article online
16. van Gent DC, McBlane JF, Ramsden DA, Sadofsky MJ, Hesse JE, et al. (1995) Initiation of V(D)J recombination in a cell-free system. Cell 81: 925-934. Find this article online
17. Villa A, Santagata S, Bozzi F, Giliani S, Frattini A, et al. (1998) Partial V(D)J recombination activity leads to Omenn syndrome. Cell 93: 885-896. Find this article online