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Volumn 22, Issue 22, 2002, Pages 7790-7801

A RAG-1/RAG/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals

Author keywords

[No Author keywords available]

Indexed keywords

CURVED DNA; HIGH MOBILITY GROUP B1 PROTEIN; RAG1 PROTEIN; RAG2 PROTEIN; TETRAMER;

EID: 0036839614     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.22.7790-7801.2002     Document Type: Article
Times cited : (71)

References (54)
  • 1
    • 0032551829 scopus 로고    scopus 로고
    • Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
    • Agrawal, A., Q. M. Eastman, and D. G. Schatz. 1998. Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system. Nature 394:744-751.
    • (1998) Nature , vol.394 , pp. 744-751
    • Agrawal, A.1    Eastman, Q.M.2    Schatz, D.G.3
  • 2
    • 0032823310 scopus 로고    scopus 로고
    • The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2
    • Aidinis, V., T. Bonaldi, M. Beltrame, S. Santagata, M. E. Bianchi, and E. Spanopoulou. 1999. The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2. Mol. Cell. Biol. 19:6532-6542.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 6532-6542
    • Aidinis, V.1    Bonaldi, T.2    Beltrame, M.3    Santagata, S.4    Bianchi, M.E.5    Spanopoulou, E.6
  • 3
    • 0034089519 scopus 로고    scopus 로고
    • Definition of minimal domains of interaction within the recombination-activating genes 1 and 2 recombinase complex
    • Aidinis, V., D. C. Dias, C. A. Gomez, D. Bhattacharyya, E. Spanopoulou, and S. Santagata. 2000. Definition of minimal domains of interaction within the recombination-activating genes 1 and 2 recombinase complex. J. Immunol. 164:5826-5832.
    • (2000) J. Immunol. , vol.164 , pp. 5826-5832
    • Aidinis, V.1    Dias, D.C.2    Gomez, C.A.3    Bhattacharyya, D.4    Spanopoulou, E.5    Santagata, S.6
  • 4
    • 0345379607 scopus 로고    scopus 로고
    • A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination
    • Bailin, T., X. Mo, and M. J. Sadofsky. 1999. A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination. Mol. Cell. Biol. 19:4664-4671.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 4664-4671
    • Bailin, T.1    Mo, X.2    Sadofsky, M.J.3
  • 5
    • 0036240127 scopus 로고    scopus 로고
    • The mechanism and regulation of chromosomal V(D)J recombination
    • Bassing, C. H., W. Swat, and F. W. Alt. 2002. The mechanism and regulation of chromosomal V(D)J recombination. Cell 109(Suppl.):S45-S55.
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Bassing, C.H.1    Swat, W.2    Alt, F.W.3
  • 7
  • 9
    • 0032471965 scopus 로고    scopus 로고
    • Flexing DNA: HMG-box proteins and their partners
    • Bianchi, M. E., and M. Beltrame. 1998. Flexing DNA: HMG-box proteins and their partners. Am. J. Hum. Genet. 63:1573-1577.
    • (1998) Am. J. Hum. Genet. , vol.63 , pp. 1573-1577
    • Bianchi, M.E.1    Beltrame, M.2
  • 10
    • 0034616993 scopus 로고    scopus 로고
    • Three-dimensional structure of the Tn5 synaptic complex transposition intermediate
    • Davies, D. R., I. Y. Goryshin, W. S. Reznikoff, and I. Rayment. 2000. Three-dimensional structure of the Tn5 synaptic complex transposition intermediate. Science 289:77-85.
    • (2000) Science , vol.289 , pp. 77-85
    • Davies, D.R.1    Goryshin, I.Y.2    Reznikoff, W.S.3    Rayment, I.4
  • 11
    • 0029864993 scopus 로고    scopus 로고
    • Initiation of V(D)J recombination in vitro obeying the 12/23 rule
    • Eastman, Q. M., T. M. Leu, and D. G. Schatz. 1996. Initiation of V(D)J recombination in vitro obeying the 12/23 rule. Nature 380:85-88.
    • (1996) Nature , vol.380 , pp. 85-88
    • Eastman, Q.M.1    Leu, T.M.2    Schatz, D.G.3
  • 12
    • 0032939926 scopus 로고    scopus 로고
    • Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking
    • Eastman, Q. M., I. J. Villey, and D. G. Schatz. 1999. Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking. Mol. Cell. Biol. 19:3788-3797.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3788-3797
    • Eastman, Q.M.1    Villey, I.J.2    Schatz, D.G.3
  • 14
    • 0033954892 scopus 로고    scopus 로고
    • Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex
    • Fugmann, S. D., I. J. Villey, L. M. Ptaszek, and D. G. Schatz. 2000. Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex. Mol. Cell 5:97-107.
    • (2000) Mol. Cell , vol.5 , pp. 97-107
    • Fugmann, S.D.1    Villey, I.J.2    Ptaszek, L.M.3    Schatz, D.G.4
  • 15
    • 0028303884 scopus 로고
    • The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein
    • Ge, H., and R. G. Roeder. 1994. The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein. J. Biol. Chem. 269:17136-17140.
    • (1994) J. Biol. Chem. , vol.269 , pp. 17136-17140
    • Ge, H.1    Roeder, R.G.2
  • 16
    • 0024691453 scopus 로고
    • V(D)J recombination: A functional definition of the joining signals
    • Hesse, J. E., M. R. Lieber, K. Mizuuchi, and M. Gellert. 1989. V(D)J recombination: A functional definition of the joining signals. Genes Dev. 3:1053-1061.
    • (1989) Genes Dev. , vol.3 , pp. 1053-1061
    • Hesse, J.E.1    Lieber, M.R.2    Mizuuchi, K.3    Gellert, M.4
  • 17
    • 0032084698 scopus 로고    scopus 로고
    • Assembly of a 12/23 paired signal complex: A critical control point in V(D)J recombination
    • Hiom, K., and M. Gellert. 1998. Assembly of a 12/23 paired signal complex: A critical control point in V(D)J recombination. Mol. Cell 1:1011-1019.
    • (1998) Mol. Cell , vol.1 , pp. 1011-1019
    • Hiom, K.1    Gellert, M.2
  • 18
    • 0030964130 scopus 로고    scopus 로고
    • A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage
    • Hiom, K., and M. Gellert. 1997. A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage. Cell 88:65-72.
    • (1997) Cell , vol.88 , pp. 65-72
    • Hiom, K.1    Gellert, M.2
  • 19
    • 0032555758 scopus 로고    scopus 로고
    • DNA transposition by the RAG1 and RAG2 proteins: A possible source of oncogenic translocations
    • Hiom, K., M. Melek, and M. Gellert. 1998. DNA transposition by the RAG1 and RAG2 proteins: A possible source of oncogenic translocations. Cell 94:463-470.
    • (1998) Cell , vol.94 , pp. 463-470
    • Hiom, K.1    Melek, M.2    Gellert, M.3
  • 20
    • 0035818603 scopus 로고    scopus 로고
    • Intermediates in V(D)J recombination: A stable RAG1/2 complex sequesters cleaved RSS ends
    • Jones, J. M., and M. Gellert. 2001. Intermediates in V(D)J recombination: A stable RAG1/2 complex sequesters cleaved RSS ends. Proc. Natl. Acad. Sci. USA 98:12926-12931.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12926-12931
    • Jones, J.M.1    Gellert, M.2
  • 21
    • 0000675571 scopus 로고    scopus 로고
    • Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase
    • Kim, D. R., Y. Dai, C. L. Mundy, W. Yang, and M. A. Oettinger. 1999. Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase. Genes Dev. 13:3070-3080.
    • (1999) Genes Dev. , vol.13 , pp. 3070-3080
    • Kim, D.R.1    Dai, Y.2    Mundy, C.L.3    Yang, W.4    Oettinger, M.A.5
  • 22
    • 0034972168 scopus 로고    scopus 로고
    • Functional organization of single and paired V(D)J cleavage complexes
    • Landree, M. A., S. B. Kale, and D. B. Roth. 2001. Functional organization of single and paired V(D)J cleavage complexes. Mol. Cell. Biol. 21:4256-4264.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 4256-4264
    • Landree, M.A.1    Kale, S.B.2    Roth, D.B.3
  • 23
    • 0033380368 scopus 로고    scopus 로고
    • Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination
    • Landree, M. A., J. A. Wibbenmeyer, and D. B. Roth. 1999. Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination. Genes Dev. 13: 3059-3069.
    • (1999) Genes Dev. , vol.13 , pp. 3059-3069
    • Landree, M.A.1    Wibbenmeyer, J.A.2    Roth, D.B.3
  • 25
    • 0029014910 scopus 로고
    • V(D)J recombination and the cell cycle
    • Lin, W. C., and S. Desiderio. 1995. V(D)J recombination and the cell cycle. Immunol. Today 16:279-289.
    • (1995) Immunol. Today , vol.16 , pp. 279-289
    • Lin, W.C.1    Desiderio, S.2
  • 26
    • 0028805853 scopus 로고
    • Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps
    • McBlane, J. F., D. C. van Gent, D. A. Ramsden, C. Romeo, C. A. Cuomo, M. Gellert, and M. A. Oettinger. 1995. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83:387-395.
    • (1995) Cell , vol.83 , pp. 387-395
    • McBlane, J.F.1    Van Gent, D.C.2    Ramsden, D.A.3    Romeo, C.4    Cuomo, C.A.5    Gellert, M.6    Oettinger, M.A.7
  • 27
    • 0031092628 scopus 로고    scopus 로고
    • Definition of a large region of RAG1 that is important for coimmunoprecipitation of RAG2
    • McMahan, C. J., M. J. Sadofsky, and D. G. Schatz. 1997. Definition of a large region of RAG1 that is important for coimmunoprecipitation of RAG2. J. Immunol. 158:2202-2210.
    • (1997) J. Immunol. , vol.158 , pp. 2202-2210
    • McMahan, C.J.1    Sadofsky, M.J.2    Schatz, D.G.3
  • 28
    • 0032502886 scopus 로고    scopus 로고
    • Rejoining of DNA by the RAG1 and RAG2 proteins
    • Melek, M., M. Gellert, and D. C. van Gent. 1998. Rejoining of DNA by the RAG1 and RAG2 proteins. Science 280:301-303.
    • (1998) Science , vol.280 , pp. 301-303
    • Melek, M.1    Gellert, M.2    Van Gent, D.C.3
  • 29
    • 0026093974 scopus 로고
    • DNase protection analysis of the stable synaptic complexes involved in Mu transposition
    • Mizuuchi, M., T. A. Baker, and K. Mizuuchi. 1991. DNase protection analysis of the stable synaptic complexes involved in Mu transposition. Proc. Natl. Acad. Sci. USA 88:9031-9035.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 9031-9035
    • Mizuuchi, M.1    Baker, T.A.2    Mizuuchi, K.3
  • 30
    • 0034159929 scopus 로고    scopus 로고
    • A highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1
    • Mo, X., T. Bailin, S. Noggle, and M. J. Sadofsky. 2000., A highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1. Nucleic Acids Res. 28:1228-1236.
    • (2000) Nucleic Acids Res. , vol.28 , pp. 1228-1236
    • Mo, X.1    Bailin, T.2    Noggle, S.3    Sadofsky, M.J.4
  • 32
    • 0032125708 scopus 로고    scopus 로고
    • The same two monomers within a MuA tetramer provide the DDE domains for the strand cleavage and strand transfer steps of transposition
    • Namgoong, S. Y., and R. M. Harshey. 1998. The same two monomers within a MuA tetramer provide the DDE domains for the strand cleavage and strand transfer steps of transposition. EMBO J. 17:3775-3785.
    • (1998) EMBO J. , vol.17 , pp. 3775-3785
    • Namgoong, S.Y.1    Harshey, R.M.2
  • 34
    • 0034967436 scopus 로고    scopus 로고
    • RAG transposase can capture and commit to target DNA before or after donor cleavage
    • Neiditch, M. B., G. S. Lee, M. A. Landree, and D. B. Roth. 2001. RAG transposase can capture and commit to target DNA before or after donor cleavage. Mol. Cell. Biol. 21:4302-4310.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 4302-4310
    • Neiditch, M.B.1    Lee, G.S.2    Landree, M.A.3    Roth, D.B.4
  • 35
    • 0025301095 scopus 로고
    • RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
    • Oettinger, M. A., D. G. Schatz, C. Gorka, and D. Baltimore. 1990. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248:1517-1523.
    • (1990) Science , vol.248 , pp. 1517-1523
    • Oettinger, M.A.1    Schatz, D.G.2    Gorka, C.3    Baltimore, D.4
  • 37
    • 0033565820 scopus 로고    scopus 로고
    • A dimer of the lymphoid protein RAG1 recognizes the recombination signal sequence and the complex stably incorporates the high-mobility group protein HMG2
    • Rodgers, K. K., I. J. Villey, L. Ptaszek, E. Corbett, D. G. Schatz, and J. E. Coleman. 1999. A dimer of the lymphoid protein RAG1 recognizes the recombination signal sequence and the complex stably incorporates the high-mobility group protein HMG2. Nucleic Acids Res. 27:2938-2946.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 2938-2946
    • Rodgers, K.K.1    Villey, I.J.2    Ptaszek, L.3    Corbett, E.4    Schatz, D.G.5    Coleman, J.E.6
  • 38
    • 0026792892 scopus 로고
    • V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes
    • Roth, D. B., J. P. Menetski, P. B. Nakajima, M. J. Bosma, and M. Gellert. 1992. V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. Cell 70:983-991.
    • (1992) Cell , vol.70 , pp. 983-991
    • Roth, D.B.1    Menetski, J.P.2    Nakajima, P.B.3    Bosma, M.J.4    Gellert, M.5
  • 39
    • 0027491330 scopus 로고
    • Characterization of broken DNA molecules associated with V(D)J recombination
    • Roth, D. B., C. Zhu, and M. Gellert. 1993. Characterization of broken DNA molecules associated with V(D)J recombination. Proc. Natl. Acad. Sci. USA 90:10788-10792.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10788-10792
    • Roth, D.B.1    Zhu, C.2    Gellert, M.3
  • 40
    • 0035312712 scopus 로고    scopus 로고
    • The RAG proteins in V(D)J recombination: More than just a nuclease
    • Sadofsky, M. J. 2001. The RAG proteins in V(D)J recombination: More than just a nuclease. Nucleic Acids Res. 29:1399-1409.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 1399-1409
    • Sadofsky, M.J.1
  • 42
    • 0024846088 scopus 로고
    • The V(D)J recombination activating gene, RAG-1
    • Schatz, D. G., M. A. Oettinger, and D. Baltimore. 1989. The V(D)J recombination activating gene, RAG-1. Cell 59:1035-1048.
    • (1989) Cell , vol.59 , pp. 1035-1048
    • Schatz, D.G.1    Oettinger, M.A.2    Baltimore, D.3
  • 43
    • 0027769386 scopus 로고
    • Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated
    • Schlissel, M., A. Constantinescu, T. Morrow, M. Baxter, and A. Peng. 1993. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev. 7:2520-2532.
    • (1993) Genes Dev. , vol.7 , pp. 2520-2532
    • Schlissel, M.1    Constantinescu, A.2    Morrow, T.3    Baxter, M.4    Peng, A.5
  • 44
    • 0027410476 scopus 로고
    • V(D)J recombination: Signal and coding joint resolution are uncoupled and depend on parallel synapsis of the sites
    • Sheehan, K. M., and M. R. Lieber. 1993. V(D)J recombination: Signal and coding joint resolution are uncoupled and depend on parallel synapsis of the sites. Mol. Cell. Biol. 13:1363-1370.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 1363-1370
    • Sheehan, K.M.1    Lieber, M.R.2
  • 45
    • 0032973315 scopus 로고    scopus 로고
    • DNA hairpin opening mediated by the RAG1 and RAG2 proteins
    • Shockett, P. E., and D. G. Schatz. 1999. DNA hairpin opening mediated by the RAG1 and RAG2 proteins. Mol. Cell. Biol. 19:4159-4166.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 4159-4166
    • Shockett, P.E.1    Schatz, D.G.2
  • 46
    • 0035168323 scopus 로고    scopus 로고
    • The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombination
    • Swanson, P. C. 2001. The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombination. Mol. Cell. Biol. 21:449-458.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 449-458
    • Swanson, P.C.1
  • 47
    • 0036171148 scopus 로고    scopus 로고
    • Fine structure and activity of discrete RAG-HMG complexes on V(D)J recombination signals
    • Swanson, P. C. 2002. Fine structure and activity of discrete RAG-HMG complexes on V(D)J recombination signals. Mol. Cell. Biol. 22:1340-1351.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 1340-1351
    • Swanson, P.C.1
  • 48
    • 0032908830 scopus 로고    scopus 로고
    • RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex
    • Swanson, P. C., and S. Desiderio. 1999. RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex. Mol. Cell. Biol. 19:3674-3683.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3674-3683
    • Swanson, P.C.1    Desiderio, S.2
  • 49
    • 0032126295 scopus 로고    scopus 로고
    • V(D)J recombination signal recognition: Distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2
    • Swanson, P. C., and S. Desiderio. 1998. V(D)J recombination signal recognition: Distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2. Immunity 9:115-125.
    • (1998) Immunity , vol.9 , pp. 115-125
    • Swanson, P.C.1    Desiderio, S.2
  • 50
    • 0035281548 scopus 로고    scopus 로고
    • HMG1 and 2, and related 'architectural' DNA-binding proteins
    • Thomas, J. O., and A. A. Travers. 2001. HMG1 and 2, and related 'architectural' DNA-binding proteins. Trends Biochem. Sci. 26:167-174.
    • (2001) Trends Biochem. Sci. , vol.26 , pp. 167-174
    • Thomas, J.O.1    Travers, A.A.2
  • 51
    • 0030994385 scopus 로고    scopus 로고
    • Stimulation of V(D)J cleavage by high mobility group proteins
    • van Gent, D. C., K. Hiom, T. T. Paull, and M. Gellert. 1997. Stimulation of V(D)J cleavage by high mobility group proteins. EMBO J. 16:2665-2670.
    • (1997) EMBO J. , vol.16 , pp. 2665-2670
    • Van Gent, D.C.1    Hiom, K.2    Paull, T.T.3    Gellert, M.4
  • 52
    • 0029967722 scopus 로고    scopus 로고
    • Similarities between initiation of V(D)J recombination and retroviral integration
    • van Gent, D. C., K. Mizuuchi, and M. Gellert. 1996. Similarities between initiation of V(D)J recombination and retroviral integration. Science 271: 1592-1594.
    • (1996) Science , vol.271 , pp. 1592-1594
    • Van Gent, D.C.1    Mizuuchi, K.2    Gellert, M.3
  • 53
    • 0031770944 scopus 로고    scopus 로고
    • The RAG-HMG1 complex enforces the 12/23 rule of V(D)J recombination specifically at the double-hairpin formation step
    • West, R. B., and M. R. Lieber. 1998. The RAG-HMG1 complex enforces the 12/23 rule of V(D)J recombination specifically at the double-hairpin formation step. Mol. Cell. Biol. 18:6408-6415.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 6408-6415
    • West, R.B.1    Lieber, M.R.2
  • 54
    • 0033569428 scopus 로고    scopus 로고
    • Organization and dynamics of the Mu transpososome: Recombination by communication between two active sites
    • Williams, T. L., E. L. Jackson, A. Carritte, and T. A. Baker. 1999. Organization and dynamics of the Mu transpososome: recombination by communication between two active sites. Genes Dev. 13:2725-2737.
    • (1999) Genes Dev. , vol.13 , pp. 2725-2737
    • Williams, T.L.1    Jackson, E.L.2    Carritte, A.3    Baker, T.A.4


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