Emergent properties of networks of biological signaling pathways

Science

Volumn 283, Issue 5400, 1999, Pages 381-387

  Bhalla, Upinder S ^a,b   Iyengar, Ravi ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE;

ARTICLE; CHEMICAL REACTION KINETICS; GENE EXPRESSION REGULATION; PRIORITY JOURNAL; REACTION ANALYSIS; REGULATORY MECHANISM; SECOND MESSENGER; SIGNAL PROCESSING; SIGNAL TRANSDUCTION; STEADY STATE; STIMULUS RESPONSE;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCINEURIN; CALCIUM; CELL CYCLE PROTEINS; COMPUTER SIMULATION; CYCLIC AMP; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; FEEDBACK; IMMEDIATE-EARLY PROTEINS; ISOENZYMES; KINETICS; LONG-TERM POTENTIATION; MEMORY; MODELS, BIOLOGICAL; NEURONS; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, N-METHYL-D-ASPARTATE; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION; SYNAPSES;

EID: 0033555859     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.283.5400.381     Document Type: Article

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60. We thank L. Birnbaumer, A. Karlin, E. Marder, and M. Rodbell for reading earlier versions of this paper and J. Lisman for a critical review of our work. We are also very grateful to G. Weng and P. Ram and other members of the Iyengar laboratory for all help with this paper. U.S.B. was an Aaron Diamond Fellow, and this work was supported in part by a fellowship from the Aaron Diamond Foundation and NIH grant GM-54508. This paper is dedicated to the memory of Martin Rodbell.