Formation of regulatory patterns during signal propagation in a mammalian cellular network

Science

Volumn 309, Issue 5737, 2005, Pages 1078-1083

  Ma'ayan, Avi ^a   Jenkins, Sherry L ^a   Neves, Susana ^a   Hasseldine, Anthony ^a   Grace, Elizabeth ^a   Dubin Thaler, Benjamin ^b   Eungdamrong, Narat J ^a   Weng, Gehzi ^a,d   Ram, Prahlad T ^a,e   Rice, J Jeremy ^c   Kershenbaum, Aaron ^c   Stolovitzky, Gustavo A ^c   Blitzer, Robert D ^a   Iyengar, Ravi ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c IBM T J WATSON RESEARCH CENTER   (United States)

^d SCIOS INC   (United States)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FEEDBACK; GRAPH THEORY; NEUROLOGY; PLASTICITY; SIGNALING;

HOMEOSTASIS; REGULATORY MOTIFFS; REGULATORY PATTERNS; SIGNAL PROPAGATION;

NEURAL NETWORKS;

ACTIN; AMPA RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EPHRIN; FAS LIGAND; G PROTEIN COUPLED RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMIC ACID; GLYCINE; GROWTH FACTOR; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NORADRENALIN; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE C; SCAFFOLD PROTEIN; TUBULIN;

BIOLOGY;

APOPTOSIS; ARTICLE; FEEDBACK SYSTEM; HIPPOCAMPUS; HOMEOSTASIS; MAMMAL; MODEL; NONHUMAN; PHENOTYPE; PLASTICITY; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; REGULATORY MECHANISM; THEORY; TRANSCRIPTION REGULATION;

ALGORITHMS; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEEDBACK, BIOCHEMICAL; GLUTAMIC ACID; HIPPOCAMPUS; HOMEOSTASIS; LIGANDS; LONG-TERM POTENTIATION; MAMMALS; MATHEMATICS; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, NEUROLOGICAL; NEURONAL PLASTICITY; NEURONS; NOREPINEPHRINE; PROTEIN KINASE C; RECEPTORS, AMPA; SIGNAL TRANSDUCTION; SOFTWARE; SYSTEMS BIOLOGY;

MAMMALIA;

EID: 23644437498     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1108876     Document Type: Article

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24. This research is supported by GM-54508 and GM-072853 from NIH and by an Advanced Research Center grant from the New York State Office of Science and Technology. A.M. is supported by Pharmacological Sciences Training grant GM-62754. S.N. is the recipient of an individual predoctoral National Research Service Award (GM-65065). R.D.B. is supported by National Institute on Drug Abuse grant DA15863. We thank B. Obrink, H. Dohlman, N. Hao, and J. Lisman for comments on the manuscript, M. Diverse-Pierluissi for help in identifying components of the secretory machine, S. Purushothaman for implementing the grid-coefficient function, and G. Kossinets (D. Watts laboratory, Columbia University, NY) for help with the initial analysis. Author contributions are described in the Supporting Online Material.