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Volumn 4, Issue 2, 2005, Pages 271-279

Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CELL PROTEIN; ISOENZYME; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PLECKSTRIN; PROTEIN KINASE B; PROTEIN KINASE B ALPHA; PROTEIN KINASE B BETA; PROTEIN KINASE B GAMMA; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 20044370874     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (174)

References (29)
  • 1
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidyl-inositol 3-kinase-AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidyl-inositol 3-kinase-AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 2
    • 0033579163 scopus 로고    scopus 로고
    • Mutational spectra of PTEN/MMAC1 gene: A tumor suppressor with lipid phosphatase activity
    • Ali IU, Schriml LM, Dean M. Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity. J Natl Cancer Inst 1999;91:1922-32.
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 1922-1932
    • Ali, I.U.1    Schriml, L.M.2    Dean, M.3
  • 3
    • 0032475861 scopus 로고    scopus 로고
    • Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
    • Stambolic V, Suzuki A, de la Pompa JL, et al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 1998;95:29-39.
    • (1998) Cell , vol.95 , pp. 29-39
    • Stambolic, V.1    Suzuki, A.2    de la Pompa, J.L.3
  • 4
    • 0034921007 scopus 로고    scopus 로고
    • Tumor suppressor PTEN: Modulator of cell signaling, growth, migration and apoptosis
    • Yamada KM, Masaru A. Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. J Cell Science 2001;114: 2375-82.
    • (2001) J. Cell Science , vol.114 , pp. 2375-2382
    • Yamada, K.M.1    Masaru, A.2
  • 5
    • 0036094108 scopus 로고    scopus 로고
    • Essential role of Akt-1/protein kinase Bα in PTEN-controlled tumorigenesis
    • Stiles B, Gilman V, Khanzenzon N, Lesche R, et al. Essential role of Akt-1/protein kinase Bα in PTEN-controlled tumorigenesis. Mol Cell Biol 2002;22:3842-51.
    • (2002) Mol. Cell Biol. , vol.22 , pp. 3842-3851
    • Stiles, B.1    Gilman, V.2    Khanzenzon, N.3    Lesche, R.4
  • 6
    • 0034604067 scopus 로고    scopus 로고
    • Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer
    • Yuan ZQ, Sun M, Feldman RI, et al. Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer. Oncogene 2000; 19:2324-30.
    • (2000) Oncogene , vol.19 , pp. 2324-2330
    • Yuan, Z.Q.1    Sun, M.2    Feldman, R.I.3
  • 7
    • 0036094711 scopus 로고    scopus 로고
    • Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival
    • Ermoian RP, Furniss CS, Lamborn KR, et al. Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival. Clin Can Res 2002;8:1100-06.
    • (2002) Clin. Can. Res. , vol.8 , pp. 1100-1106
    • Ermoian, R.P.1    Furniss, C.S.2    Lamborn, K.R.3
  • 8
    • 0036554734 scopus 로고    scopus 로고
    • Immunohistochemical demonstration of phospho-Akt in high gleason grade prostate cancer
    • Malik SN, Brattain M, Ghosh PM, et al. Immunohistochemical demonstration of phospho-Akt in high gleason grade prostate cancer. Clin Can Res 2002;8:1168-71.
    • (2002) Clin. Can. Res. , vol.8 , pp. 1168-1171
    • Malik, S.N.1    Brattain, M.2    Ghosh, P.M.3
  • 9
    • 0035848705 scopus 로고    scopus 로고
    • Reverse phase protein microarrays which capture disease progression show activation of prosurvival pathways at the cancer invasion front
    • Paweletz CP, Charboneau L, Bichsel VE, et al. Reverse phase protein microarrays which capture disease progression show activation of prosurvival pathways at the cancer invasion front. Oncogene 2001;20: 1981-89.
    • (2001) Oncogene , vol.20 , pp. 1981-1989
    • Paweletz, C.P.1    Charboneau, L.2    Bichsel, V.E.3
  • 10
    • 18244391514 scopus 로고    scopus 로고
    • Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients
    • Perez-Tenorio G, Stal O. Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients. Brit J Can 2002;86:540-5.
    • (2002) Brit. J. Can. , vol.86 , pp. 540-545
    • Perez-Tenorio, G.1    Stal, O.2
  • 11
    • 0037457314 scopus 로고    scopus 로고
    • Dysregulated PTEN-PKB and negative receptor status in human breast cancer
    • Shi W, Zhang X, Pintilie M, et al. Dysregulated PTEN-PKB and negative receptor status in human breast cancer. Int J Cancer 2003;104: 195-203.
    • (2003) Int. J. Cancer , vol.104 , pp. 195-203
    • Shi, W.1    Zhang, X.2    Pintilie, M.3
  • 12
    • 0037118575 scopus 로고    scopus 로고
    • AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival
    • Bacus SS, Altomare DA, Lyass L, et al. AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival. Oncogene 2002; 21:3532-40.
    • (2002) Oncogene , vol.21 , pp. 2532-2540
    • Bacus, S.S.1    Altomare, D.A.2    Lyass, L.3
  • 13
    • 0036195196 scopus 로고    scopus 로고
    • AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis
    • Roy HK, Olusola BF, Clemens DL, et al. AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Carcinogenesis 2002;23:201-05.
    • (2002) Carcinogenesis , vol.23 , pp. 201-205
    • Roy, H.K.1    Olusola, B.F.2    Clemens, D.L.3
  • 14
    • 0037096804 scopus 로고    scopus 로고
    • Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma
    • Itoh N, Semba S, Ito M, et al. Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma. Cancer 2002;94: 3127-34.
    • (2002) Cancer , vol.94 , pp. 3127-3134
    • Itoh, N.1    Semba, S.2    Ito, M.3
  • 15
    • 0035368548 scopus 로고    scopus 로고
    • Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ)
    • Cho H, Mu J, Kim JK, et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ). Science 2001;292:1728-31.
    • (2001) Science , vol.292 , pp. 1728-1731
    • Cho, H.1    Mu, J.2    Kim, J.K.3
  • 16
    • 0035914388 scopus 로고    scopus 로고
    • Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
    • Cho H, Thorvaldsen J L, Chu Q, Feng F, Birnbaum M J. Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 2001; 276:38349-52.
    • (2001) J. Biol. Chem. , vol.276 , pp. 38349-38352
    • Cho, H.1    Thorvaldsen, J.L.2    Chu, Q.3    Feng, F.4    Birnbaum, M.J.5
  • 17
    • 0035448879 scopus 로고    scopus 로고
    • Growth retardation and incresed apoptosis in mice with homozygous disruption of the Akt1 gene
    • Chen WS, Xu PZ, Gottlob K, et al. Growth retardation and incresed apoptosis in mice with homozygous disruption of the Akt1 gene. Genes & Development 2001;15:2203-08.
    • (2001) Genes & Development , vol.15 , pp. 2203-2208
    • Chen, W.S.1    Xu, P.Z.2    Gottlob, K.3
  • 19
    • 0033515625 scopus 로고    scopus 로고
    • A human protein kinase Bγ with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain
    • Brodbeck D, Cron P, Hemmings BA. A human protein kinase Bγ with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biol Chem 1999;274:9133-36.
    • (1999) J. Biol. Chem. , vol.274 , pp. 9133-9136
    • Brodbeck, D.1    Cron, P.2    Hemmings, B.A.3
  • 20
    • 0032881288 scopus 로고    scopus 로고
    • AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation
    • Chan TO, Rittenhouse SE, Tsichlis PN. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu Rev Biochem 1999;68: 965-1014.
    • (1999) Annu. Rev. Biochem. , vol.68 , pp. 965-1014
    • Chan, T.O.1    Rittenhouse, S.E.2    Tsichlis, P.N.3
  • 21
    • 0036479208 scopus 로고    scopus 로고
    • Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family
    • Laine J, Kunstle G, Obata T, Noguchi M. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. J Biol Chem 2002;277:3743-51.
    • (2002) J. Biol. Chem. , vol.277 , pp. 3743-3751
    • Laine, J.1    Kunstle, G.2    Obata, T.3    Noguchi, M.4
  • 22
    • 19944433628 scopus 로고    scopus 로고
    • Identification and characterization of pleckstrin homology domain dependent and isozyme specific Akt inhibitors
    • Barnett S, DeFeo-Jones D, Fu S, et al. Identification and characterization of pleckstrin homology domain dependent and isozyme specific Akt inhibitors. Biochem J 2005;385:399-408.
    • (2005) Biochem. J. , vol.385 , pp. 399-408
    • Barnett, S.1    DeFeo-Jones, D.2    Fu, S.3
  • 23
    • 0033618371 scopus 로고    scopus 로고
    • Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines
    • Nakatani N, Thompson DA, Barthel A et al. Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J Biol Chem 1999;274:21528-32.
    • (1999) J. Biol. Chem. , vol.274 , pp. 21528-21532
    • Nakatani, N.1    Thompson, D.A.2    Barthel, A.3
  • 24
    • 0035815649 scopus 로고    scopus 로고
    • Elevated Akt activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis
    • Nesterov A, Lu X, Johnson M, Miller GJ, Ivashchenko Y, Kraft AS. Elevated Akt activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis. J Biol Chem 2001;276:10767-74.
    • (2001) J. Biol. Chem. , vol.276 , pp. 10767-10774
    • Nesterov, A.1    Lu, X.2    Johnson, M.3    Miller, G.J.4    Ivashchenko, Y.5    Kraft, A.S.6
  • 25
    • 0036604109 scopus 로고    scopus 로고
    • Caspase-8 activation is necessary but not sufficient for tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptosis in the prostatic carcinoma cell line LNCaP
    • Rokhlin OW, Guseva NV, Tagiyev AF, Glover RA, Cohen MB. Caspase-8 activation is necessary but not sufficient for tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptosis in the prostatic carcinoma cell line LNCaP. The Prostate 2002;52:1-11.
    • (2002) The Prostate , vol.52 , pp. 1-11
    • Rokhlin, O.W.1    Guseva, N.V.2    Tagiyev, A.F.3    Glover, R.A.4    Cohen, M.B.5
  • 26
    • 1642586272 scopus 로고    scopus 로고
    • Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
    • Wendel H-G, de Stanchina E, Fridman JS, et al. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 2004;428: 332-37.
    • (2004) Nature , vol.428 , pp. 332-337
    • Wendel, H.-G.1    de Stanchina, E.2    Fridman, J.S.3
  • 27
    • 2942724235 scopus 로고    scopus 로고
    • mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotoc and HIF-1-dependent pathways
    • Majumder PK, Febbo PG, Bikoff R, et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotoc and HIF-1-dependent pathways. Nat Med 2004;10:594-601.
    • (2004) Nat. Med. , vol.10 , pp. 594-601
    • Majumder, P.K.1    Febbo, P.G.2    Bikoff, R.3
  • 28
    • 0035168724 scopus 로고    scopus 로고
    • The role of genetic abnormalities of PTEN and the phosphatidyl inositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy
    • Mills, GB, Lu, Y, Fang, X, et al. The role of genetic abnormalities of PTEN and the phosphatidyl inositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy. Semin Oncol 2001;28:125-41.
    • (2001) Semin. Oncol. , vol.28 , pp. 125-141
    • Mills, G.B.1    Lu, Y.2    Fang, X.3
  • 29
    • 0037616593 scopus 로고    scopus 로고
    • Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors
    • Bianco R, Shin I, Ritter CA, et al. Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors. Oncogene 2003;22:2812-22.
    • (2003) Oncogene , vol.22 , pp. 2812-2822
    • Bianco, R.1    Shin, I.2    Ritter, C.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.