Amiloride augments TRAIL-induced apoptotic death by inhibiting phosphorylation of kinases and phosphatases associated with the P13K-Akt pathway

Oncogene

Volumn 24, Issue 3, 2005, Pages 355-366

  Kim, Ki M ^a   Lee, Yong J ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

Akt; Amiloride; Apoptosis; Caspase; PDK 1; PP1; PTEN; TRAIL

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; AMILORIDE; CASPASE; DEATH RECEPTOR 4; DEATH RECEPTOR 5; FLICE INHIBITORY PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OKADAIC ACID; PHOSPHATASE; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOTRANSFERASE; PROTEIN BCL 2; PROTEIN KINASE B; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; VANADATE SODIUM; WORTMANNIN;

APOPTOSIS; ARTICLE; CELL PH; CONTROLLED STUDY; CYTOTOXICITY; DEPHOSPHORYLATION; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOCARCINOMA; AMILORIDE; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE; CELL LINE, TUMOR; DNA, COMPLEMENTARY; EPITHELIAL CELLS; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; PHOSPHOPROTEIN PHOSPHATASE; PROSTATE; PROSTATIC NEOPLASMS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 13244287736     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1208213     Document Type: Article

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