Targeted inhibition of β-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves β-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression

Journal of the American College of Cardiology

Volumn 45, Issue 11, 2005, Pages 1862-1870

  Perrino, Cinzia ^a   Naga Prasad, Sathyamangla V ^a   Patel, Mrinali ^a   Wolf, Matthew J ^a   Rockman, Howard A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR KINASE 1; BETA ADRENERGIC RECEPTOR KINASE 1 ASSOCIATED PHOSPHOINOSITIDE 3 KINASE; CALSEQUESTRIN; ISOENZYME; ISOPRENALINE; PHOSPHATIDYLINOSITOL 3 KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALYSIS; COMPETITIVE INHIBITION; CONTROLLED STUDY; CROSS BREEDING; ENZYME INACTIVATION; ENZYME INHIBITION; EXPERIMENTAL MODEL; GENE OVEREXPRESSION; HEART FAILURE; HEART FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SURVIVAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BETA-ADRENERGIC RECEPTOR KINASE; CALSEQUESTRIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DOWN-REGULATION; IMMUNOBLOTTING; IMMUNOPROLIFERATIVE DISORDERS; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION;

EID: 20344402530     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2005.02.062     Document Type: Article

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