Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts

Journal of Biological Chemistry

Volumn 278, Issue 39, 2003, Pages 37064-37072

  Park, Chang Shin ^b   Schneider, Ian C ^b   Haugh, Jason M ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CHEMICAL ACTIVATION; DIMERIZATION; ENZYME KINETICS; GROWTH KINETICS; MATHEMATICAL MODELS;

PHOSPHORYLATION;

BIOCHEMISTRY;

ISOENZYME; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN; PROTEIN KINASE B; PROTEIN P110 ALPHA; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CELL SURVIVAL; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME INACTIVATION; FIBROBLAST; KINETICS; LIPID METABOLISM; LIPOGENESIS; MATHEMATICAL MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STOICHIOMETRY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ANIMALS; FIBROBLASTS; KINETICS; MATHEMATICS; MICE; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0141733263     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304968200     Document Type: Article

References (64)

1. Heldin, C., and Westermark, B. (1999) Physiol. Rev. 79, 1283-1316
2. Deuel, T. F., Kawahara, R. S., Mustoe, T. A., and Pierce, G. F. (1991) Annu. Rev. Med. 42, 567-584
3. Harrington, E. A., Bennett, M., R., Fanidi, A., and Evan, G. I. (1994) EMBO J. 13, 3286-3295
4. Östman, A., Thyberg, B., Westermark, B., and Heldin, C. (1989) Growth Factors. 1, 271-281
5. Seifert, R. A., Hart, C. E., Phillips, P. E., Forstrom, J. W., Ross, R., Murray, M. J., and Bowen-Pope, D. F. (1989) J. Biol. Chem. 264, 8771-8778
6. Li, X., Pontén, A., Aase, K., Karlsson, L., Abramsson, A., Uutela, M., Bäckström, G., Hellström, M., Boström, H., Li, H., Soriano, P., Betsholtz, C., Heldin, C., Alitalo, K., Östman, A., and Eriksson, U. (2000) Nat. Cell Biol. 2, 302-309
7. Bergsten, E., Uutela, M., Li, U., Pietras, K., Östman, A., Heldin, C., Alitalo, K., and Eriksson, U. (2001) Nat. Cell Biol. 3, 512-516
8. LaRochelle, W. J., Jeffers, M., McDonald, W. F., Chillakuru, R. A., Giese, N. A., Lokker, N. A., Sullivan, C., Boldog, F. L., Yang, M., Corine-Vernet, C., Burgess, C. E., Fernandes, E., Deegler, L. L., Rittman, B., Shimkets, J., Shimkets, R. A., Rothberg, J. M., and Lichenstein, H. S. (2001) Nat. Cell Biol. 3, 517-521
9. van der Geer, P., Hunter, T., and Lindberg, R. A. (1994) Annu. Rev. Cell Biol. 10, 251-337
10. Schlessinger, J. (2000) Cell. 103, 211-225
11. Kelly, J. D., Haldeman, B. A., Grant, F. J., Murray, M. J., Seifert, R. A., Bowen-Pope, D. F., Cooper, J. A., and Kazlauskas, A. (1991) J. Biol. Chem. 266, 8987-8992
12. Heldin, C., Östman, A., and Rönnstrand, L. (1998) Biochim. Biophys. Acta. 1378, F79-F113
13. Emaduddin, M., Ekman, S., Ronnstrand, L., and Heldin, C. (1999) Biochem. J. 341, 523-528
14. Claesson-Welsh, L. (1994) J. Biol. Chem. 269, 32023-32026
15. Fruman, D. A., Meyers, R. E., and Cantley, L. C. (1998) Annu. Rev. Biochem. 67, 481-507
16. Vanhaesebroeck, B., Leevers, S. J., Ahmadi, K., Timms, J., Katso, R., Driscoll, P. C., Woscholski, R., Parker, P. J., and Waterfield, M. D. (2001) Annu. Rev. Biochem. 70, 535-602
17. Escobedo, J. A., Kaplan, D. R., Kavanaugh, W. M., Turck, C. W., and Williams, L. T. (1991) Mol. Cell. Biol. 11, 1125-1132
18. McGlade, C. J., Ellis, C., Reedijk, M., Anderson, D., Mbamalu, G., A. D., R., Panayotou, G., End, P., Bernstein, A., Kazlauskas, A., Waterfield, M. D., and Pawson, T. (1992) Mol. Cell. Biol. 12, 991-997
19. Cooper, J. A., and Kashishian, A. (1993) Mol. Cell. Biol. 13, 1737-1745
20. Shoelson, S. E., Sivaraja, M., Williams, K. P., Hu, P., Schlessinger, J., and Weiss, M. A. (1993) EMBO J. 12, 795-802
21. Klippel, A., Reinhard, C., Kavanaugh, W. M., Apell, G., Escobedo, M., and Williams, L. T. (1996) Mol. Cell. Biol. 16, 4117-4127
22. Toker, A., and Cantley, L. C. (1997) Nature. 387, 673-676
23. Rameh, L. E., and Cantley, L. C. (1999) J. Biol. Chem. 274, 8347-8350
24. Franke, T. F., Yang, S., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R., and Tsichlis, P. N. (1995) Cell. 81, 727-736
25. Datta, K., Bellacosa, A., Chan, T. O., and Tsichlis, P. N. (1996) J. Biol. Chem. 271, 30835-30839
26. Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M. E. (1997) Cell. 91, 231-241
27. Romashkova, J. A., and Makarov, S. S. (1999) Nature 401, 86-90
28. Kohn, A. D., Takeuchi, F., and Roth, R. A. (1996) J. Biol. Chem. 271, 21920-21926
29. Andjelkovic, M., Alessi, D. R., Meier, R., Fernandez, A., Lamb, N. J. C., Frech, M., Cron, P., Cohen, P., Lucocq, J. M., and Hemmings, B. A. (1997) J. Biol. Chem. 272, 31515-31524
30. Stokoe, D., Stephens, L. R., Copeland, T., Gaffney, P. R. J., Reese, C. B., Painter, G. F., Holmes, A. B., McCormick, F., and Hawkins, P. T. (1997) Science 277, 567-570
31. Bellacosa, A., Chan, T. O., Ahmed, N. N., Datta, K., Malstrom, S., Stokoe, D., McCormick, F., Feng, J., and Tsichlis, P. (1998) Oncogene 17, 313-325
32. Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., and Cohen, P. (1997) Curr. Biol. 7, 261-269
33. Stephens, L., Anderson, K., Stokoe, D., Erdjument-Bromage, H., Painter, G. F., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., McCormick, F., Tempst, P., Coadwell, J., and Hawkins, P. T. (1998) Science 279, 710-714
34. Anderson, K. E., Coadwell, J., Stephens, L. R., and Hawkins, P. T. (1998) Curr. Biol. 8, 684-691
35. Scheid, M. P., Huber, M., Damen, J. E., Hughes, M., Kang, V., Neilsen, P., Prestwich, G. D., Krystal, G., and Duronio, V. (2002) J. Biol. Chem. 277, 9027-9035
36. Marshall, C. J. (1995) Cell. 80, 179-185
37. Jones, S. M., Klinghoffer, R., Prestwich, G. D., Toker, A., and Kazlauskas, A. (1999) Curr. Biol. 9, 512-521
38. Haugh, J. M., Codazzi, F., Teruel, M., and Meyer, T. (2000) J. Cell Biol. 151, 1269-1279
39. Fretto, L. J., Snape, A. J., Tomlinson, J. E., Seroogy, J. J., Wolf, D. L., LaRochelle, W. J., and Giese, N. A. (1993) J. Biol. Chem. 268, 3625-3631
40. Miyazawa, K., Bäckström, G., Leppänen, O., Persson, C., Wernstedt, C., Hellman, U., Heldin, C. H., and Östman, A. (1998) J. Biol. Chem. 273, 25495-25502
41. Lauffenburger, D. A., and Linderman, J. L. (1993) Receptors: Models for Binding, Trafficking, and Signaling, pp. 73-180, Oxford University Press, New York
42. Heldin, C., Westermark, B., and Wasteson, A. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 3664-3668
43. Duan, D. S. R., Pazin, M. J., Fretto, L. J., and Williams, L. T. (1991) J. Biol. Chem. 266, 413-418
44. Herren, B., Rooney, B., Weyer, K. A., Iberg, N., Schmid, G., and Pech, M. (1993) J. Biol. Chem. 268, 15088-15095
45. Sorkin, A., Westermark, B., Heldin, C.-H., and Claesson-Welsh, L. (1991) J. Cell Biol. 112, 469-478
46. Sorkin, A., Eriksson, A., Heldin, C. H., Westermark, B., and Claesson-Welsh, L. (1993) J. Cell. Physiol. 156, 373-382
47. Chiarugi, P., Cirri, P., Taddei, M. L., Giannoni, E., Fiaschi, T., Buricchi, F., Camici, G., Raugei, G., and Ramponi, G. (2002) J. Biol. Chem. 277, 37331-37338
48. Omura, T., Heldin, C. H., and Östman, A. (1997) J. Biol. Chem. 272, 12676-12682
49. Lokker, N. A., O'Hare, J. P., Barsoumian, A., Tomlinson, J. E., Ramakrishnan, V., Fretto, L. J., and Giese, N. A. (1997) J. Biol. Chem. 272, 33037-33044
50. Wiseman, P. W., and Peterson, N. O. (1999) Biophys. J. 76, 963-977
51. Haugh, J. M., and Lauffenburger, D. A. (1998) J. Theor. Biol. 195, 187-218
52. Heinrich, R., Neel, B. G., and Rapoport, T. A. (2002) Mol. Cell 9, 957-970
53. Schoeberl, B., Eichler-Jonsson, C., Gilles, E. D., and Muller, G. (2002) Nat. Biotechnol. 20, 370-375
54. Várnai, P., and Balla, T. (1998) J. Cell Biol. 143, 501-510
55. Oatey, P. B., Venkateswarlu, K., Williams, A. G., Fletcher, L. M., Foulstone, E. J., Cullen, P. J., and Tavare, J. M. (1999) Biochem. J. 344, 511-518
56. Haugh, J. M., and Meyer, T. (2002) J. Cell Sci. 115, 303-310
57. Weiner, O. D. (2002) Curr. Opin. Cell Biol. 14, 196-202
58. Watton, S. J., and Downward, J. (1999) Curr. Biol. 9, 433-436
59. Currie, R. A., Walker, K. S., Gray, A., Deak, M., Casamayor, A., Downes, C. P., Cohen, P., Alessi, D. R., and Lucocq, J. (1999) Biochem. J. 337, 575-583
60. Jackson, T. R., Stephens, L. R., and Hawkins, P. T. (1992) J. Biol. Chem. 267, 16627-16636
61. Rodriguez-Viciana, P., Warne, P. H., Vanhaesebroeck, B., Waterfield, M. D., and Downward, J. (1996) EMBO J. 15, 2442-2451
62. Roche, S., Downward, J., Raynal, P., and Courtneidge, S. A. (1998) Mol. Cell. Biol. 18, 7119-7129
63. Hooshmand-Rad, R., Hajkova, L., Klint, P., Karlsson, R., Vanhaesebroeck, B. Claesson-Welsh, L., and Heldin, C. (2000) J. Cell Sci. 113, 207-214
64. Domin, J., Dhand, R., and Waterfield, M. D. (1996) J. Biol. Chem. 271, 21614-21621