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Proceedings of the National Academy of Sciences of the United States of America

Volumn 98, Issue 18, 2001, Pages 10031-10033

Linking molecular therapeutics to molecular diagnostics: Inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo

(3) Mills, Gordon B a Lu, Yiling b Kohn, Elise C b

a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER (United States)

b NATIONAL CANCER INSTITUTE (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RAPAMYCIN; RAPAMYCIN DERIVATIVE; TEMSIROLIMUS; UNCLASSIFIED DRUG;

APOPTOSIS; CANCER RESEARCH; CELL MUTANT; CHRONIC MYELOID LEUKEMIA; GENE AMPLIFICATION; GENE MUTATION; NOTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL CYCLE PROTEINS; DROSOPHILA PROTEINS; ENZYME INHIBITORS; FOCAL ADHESION KINASE 2; HUMANS; MICE; MICE, KNOCKOUT; MUTATION; NEOPLASMS, EXPERIMENTAL; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PTEN PHOSPHOHYDROLASE; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; SIROLIMUS; TUMOR SUPPRESSOR PROTEINS;

EID: 0035964367 PISSN: 00278424 EISSN: None Source Type: Journal
DOI: 10.1073/pnas.191379498 Document Type: Note

Times cited : (126)

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