Disease induction and prevention in experimental models of inflammatory bowel disease

Mucosal Immunology, Two-Volume Set

Volumn , Issue , 2005, Pages 1237-1254

  De Jong, Ype P ^a   Terhorst, Cox ^a   Weaver, Casey T ^b   Elson, Charles O ^c  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b University of Alabama at Birmingham   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 32044462077     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012491543-5/50074-7     Document Type: Chapter

References (171)

1. Apostolou I., Sarukhan A., et al. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 2002, 3(8):756-763.
2. Arai Y., Takanashi H., et al. Involvement of interleukin-1 in the development of ulcerative colitis induced by dextran sulfate sodium in mice. Cytokine 1998, 10(11):890-896.
3. Asano M., Toda M., et al. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 1996, 184(2):387-396.
4. Asseman C., Mauze S., et al. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 1999, 190(7):995-1004.
5. Atreya R., Mudter J., et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn's disease and experimental colitis in vivo. Nat. Med. 2000, 6(5):583-588.
6. Bansal-Pakala P., Jember A.G., et al. Signaling through OX40 (CD134) breaks peripheral T-cell tolerance. Nat. Med. 2001, 7(8):907-912.
7. Baribault H., Penner J., et al. Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice. Genes & Development 1994, 8(24):2964-2973.
8. Bensinger S.J., Bandeira A., et al. Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells. J. Exp. Med. 2001, 194(4):427-438.
9. Berg D.J., Davidson N., et al. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J. Clin. Invest. 1996, 98(4):1010-1020.
10. Bloom B.R., Bennett B. Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science 1966, 153(731):80-82.
11. Boirivant M., Fuss I.J., et al. Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. Journal of Experimental Medicine 1998, 188(10):1929-1939.
12. Bonhagen K., Thoma S., et al. Cytotoxic reactivity of gut lamina propria CD4+ alpha beta T cells in SCID mice with colitis. Eur. J. Immunol. 1996, 26(12):3074-3083.
13. Bouma G., Kaushiva A., et al. Experimental murine colitis is regulated by two genetic loci, including one on chromosome 11 that regulates IL-12 responses. Gastroenterology 2002, 123(2):554-565.
14. Brandwein S.L., McCabe R.P., et al. Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora. J. Immunol. 1997, 159(1):44-52.
15. Bristol I.J., Farmer M.A., et al. Heritable susceptibility for colitis in mice induced by IL-10 deficiency. Inflam. Bowel Dis. 2000, 6(4):290-302.
16. Byrne F.R., Whoriskey J.S., et al. Transgenic mice over-expressing the B7 related protein-1 (B7RP-1) develop an intestinal pathology similar to human Crohn's disease. A new mouse model of inflammatory bowel disease. Gastroenterology 2001, 120:A47.
17. Camoglio L., te Velde A.A., et al. Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFN-gamma receptor-deficient mice. Eur. J. Immunol. 2000, 30(5):1486-1495.
18. Caramalho I., Lopes-Carvalho T., et al. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 2003, 197(4):403-411.
19. Chapoval A.I., Ni J., et al. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat. Immunol. 2001, 2(3):269-274.
20. Clegg C.H., Rulffes J.T., et al. Thymus dysfunction and chronic inflammatory disease in gp39 transgenic mice. Intl. Immunol. 1997, 9(8):1111-1122.
21. Cong Y., Brandwein S.L., et al. CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease. J. Exper. Med. 1998, 187(6):855-864.
22. Cong Y., Konrad A., Iqbal N., Elson C.O. Probiotics and immune regulation of inflammatory bowel diseases. Curr. Drug Targets Inflam. Allergy 2003, 2(2):145-154.
23. Cong Y., Weaver C.T., et al. Colitis induced by enteric bacterial antigen-specific CD4+ T cells requires CD40-CD40 ligand interactions for a sustained increase in mucosal IL-12. J. Immunol. 2000, 165(4):2173-2182.
24. Cong Y., Weaver C.T., et al. Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora. J. Immunol. 2002, 169(11):6112-6119.
25. Conner E.M., Chen Y., et al. Effect of nitric oxide synthase (NOS) inhibition on the pathophysiology observed in a model of chronic colitis (abstr). Gastroenterology 1995, 108:A801.
26. Corazza N., Eichenberger S., et al. Nonlymphocyte-derived tumor necrosis factor is required for induction of colitis in recombination activating gene (RAG)2(-/-) mice upon transfer of CD4(+)CD45RB(hi) T cells. J. Exp. Med. 1999, 190(10):1479-1492.
27. Coyle A.J., Gutierrez-Ramos J.C. The expanding B7 super-family: increasing complexity in costimulatory signals regulating T cell function. Nat. Immunol. 2001, 2(3):203-209.
28. David J.R. Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. Proc. Natl. Acad. Sci. USA 1966, 56:72-77. (1).
29. Davidson N.J., Hudak S.A., et al. IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice. J. Immunol. 1998, 161(6):3143-3149.
30. de Jong Y.P., Abadia-Molina A.C., et al. Development of chronic colitis is dependent on the cytokine MIF. Nat. Immunol. 2001, 2(11):1061-1066.
31. de Jong Y.P., Comiskey M., et al. Chronic murine colitis is dependent on the CD154/CD40 pathway and can be attenuated by anti-CD 154 administration. Gastroenterology 2000, 119(3):715-723.
32. Dieleman L.A., Elson C.O., et al. Kinetics of cytokine expression during healing of acute colitis in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 1996, 34(1):G 130-G 136.
33. Dieleman L.A., Ridwan B.U., et al. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology 1994, 107(6):1643-1652.
34. Elson C.O. Experimental models of intestinal inflammation: new insights into mechanisms of mucosal homeostasis. Handbook of Mucosal Immunology 1999, 1007-1024. Academic Press, San Diego. P.L. Ogra, J. Mestecky, M.E. Lamm (Eds.).
35. Elson C.O., Cong Y., et al. The C3H/HeJBir mouse model: a high susceptibility phenotype for colitis. Intl. Rev. Immunol. 2000, 19(1):63-75.
36. Farmer M.A., Sundberg J.P., et al. A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice. Proc. Natl. Acad. Sci. U S A 2001, 98:13820-13825. (24).
37. Ferretti M., Casini-Raggi V., et al. Neutralization of endogenous IL-1 receptor antagonist exacerbates and prolongs inflammation in rabbit immune colitis. J. Clin. Invest. 1994, 94(1):449-453.
38. Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 1998, 115(1):182-205.
39. Fujihashi K., McGhee J.R., et al. An interleukin-7 internet for intestinal intraepithelial T cell development: knockout of ligand or receptor reveal differences in the immunodeficient state. Eur. J. Immunol. 1997, 27(9):2133-2138.
40. Fuss I.J., Boirivant M., et al. The interrelated roles of TGF-beta and IL-10 in the regulation of experimental colitis. J. Immunol. 2002, 168(2):900-908.
41. Fuss I.J., Marth T., et al. Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice. Gastroenterology 1999, 117(5):1078-1088.
42. Fuss I.J., Neurath M., et al. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J. Immunol. 1996, 157(3):1261-1270.
43. Gavin M.A., Clarke S.R., et al. Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo. Nat. Immunol. 2002, 3(1):33-41.
44. Gorelik L., Flavell R.A. Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 2000, 12(2):171-181.
45. Groux H., O'Garra A., et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997, 389(6652):737-742.
46. Hans W., Scholmerich J., et al. Interleukin-12 induced interferon-gamma increases inflammation in acute dextran sulfate sodium induced colitis in mice. Eur. Cytokine. Netw. 2000, 11(1):67-74.
47. Henderson B., Poole S., et al. Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis. Microbiol. Rev. 1996, 60(2):316-341.
48. Hermiston M.L., Gordon J.I. Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science 1995, 270(5239):1203-1207.
49. Higgins L.M., McDonald S.A., et al. Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein. J. Immunol. 1999, 162(1):486-493.
50. Hollander G.A., Simpson S.J., et al. Severe colitis in mice with aberrant thymic selection. Immunity 1995, 3(1):27-38.
51. Hori S., Nomura T., et al. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299(5609):1057-1061.
52. +T cells and pro-inflammatory Th1-type cytokines. J Immunol. 1996, 158:1068-1077.
53. Hugot J.P., Chamillard M., et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001, 411(6837):599-603.
54. Hutloff A., Dittrich A.M., et al. ICOS is an inducible T-cell costimulator structurally and functionally related to CD28. Nature 1999, 397(6716):263-266.
55. Inobe J., Slavin A.J., et al. IL-4 is a differentiation factor for transforming growth factor-beta secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis. Eur. J. Immunol. 1998, 28(9):2780-2790.
56. Inoue S., Matsumoto T., et al. Characterization of cytokine expression in the rectal mucosa of ulcerative colitis: correlation with disease activity. Am. J. Gastroenterol. 1999, 94(9):2441-2446.
57. Iqbal N., Oliver J.R., et al. T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis. J. Exp. Med. 2002, 195(1):71-84.
58. Ito H., Fathman C.G. CD45RBhigh CD4+ T cells from IFN-gamma knockout mice do not induce wasting disease. J. Autoimmun. 1997, 10(5):455-459.
59. Itoh M., Takahashi T., et al. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 1999, 162(9):5317-5326.
60. Jordan M.S., Boesteanu A., et al. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2001, 2(4):301-306.
61. Jordan M.S., Riley M.P., et al. Anergy and suppression regulate CD4(+) T cell responses to a self peptide. Eur. J. Immunol. 2000, 30(1):136-144.
62. Kakazu T., Hara J., et al. Type 1 T-helper cell predominance in granulomas of Crohn's disease. Am. J. Gastroenterol. 1999, 94(8):2149-2155.
63. Kanai T., Watanabe M., et al. Macrophage-derived il-18-mediated intestinal inflammation in the murine model of Crohn's disease. Gastroenterology 2001, 121(4):875-888.
64. Khoo U.Y., Proctor I.E., et al. CD4+ T cell down-regulation in human intestinal mucosa: evidence for intestinal tolerance to luminal bacterial antigens. J. Immunol. 1997, 158(8):3626-3634.
65. Kitani A., Fuss I., et al. Transforming growth factor (TGF)β1-producing regulatory T cells induce smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGFβ1-mediated fibrosis. J. Exp. Med. 2003, 198(8):1179-1188.
66. Klaasen H.L., Van der Heijden P.J., et al. Apathogenic, intestinal, segmented, filamentous bacteria stimulate the mucosal immune system of mice. Infect. Immun. 1993, 61(1):303-306.
67. Klapproth J.M., Donnenberg M.S., et al. Products of enteropathogenic E. coli inhibit lymphokine production by gastrointestinal lymphocytes. Am. J. Physiol. 1996, 271(5):G841-G848. Pt 1.
68. Klug D.B., Carter C., et al. Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment. Proc. Natl. Acad. Sci. USA 1998, 95:11822-11827. (20).
69. Kojouharoff G., Hans W., et al. Neutralization of tumour necrosis factor (TNF) but not of IL-1 reduces inflammation in chronic dextran sulphate sodium-induced colitis in mice. Clin. Exp. Immunol. 1997, 107(2):353-358.
70. Kontoyiannis D., Pasparakis M., et al. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 1999, 10(3):387-398.
71. Kosiewicz M.M., Nast C.C., et al. Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease. J. Clin. Invest. 2001, 107(6):695-702.
72. Kozaiwa K., Sugawara K., et al. Identification of a quantitative trait locus for ileitis in a spontaneous mouse model of Crohn's disease: SAMP1/YitFc. Gastroenterology 2003, 125(2):477-490.
73. Kramer S., Schimpl A., et al. Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene. J. Exp. Med. 1995, 182(6):1769-1776.
74. Krieglstein C.F., Cerwinka W.H., et al. Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide. J. Exp. Med. 2001, 194(9):1207-1218.
75. Kuhn R., Lohler J., et al. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993, 75(2):263-274.
76. Kumanogoh A., Wang X., et al. Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development. J. Immunol. 2001, 166(1):353-360.
77. Kumar S., McDonnell P.C., et al. Identification and initial characterization of four novel members of the interleukin-1 family. J. Biol. Chem. 2000, 275(14):10308-10314.
78. Lee E.G., Boone D.L., et al. Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 2000, 289(5488):2350-2354.
79. Liu Z., Geboes K., et al. Prevention of experimental colitis in SCID mice reconstituted with CD45RBhigh CD4+ T cells by blocking the CD40-CD154 interactions. J. Immunol. 2000, 164(11):6005-6014.
80. Liu Z., Geboes K., et al. B7 interactions with CD28 and CTLA-4 control tolerance or induction of mucosal inflammation in chronic experimental colitis. J. Immunol. 2001, 167(3):1830-1838.
81. Liu Z., Geboes K., et al. Role of interleukin-12 in the induction of mucosal inflammation and abrogation of regulatory T cell function in chronic experimental colitis. Eur. J. Immunol. 2001, 31(5):1550-1560.
82. Ludviksson B.R., Ehrhardt R.O., et al. TGF-beta production regulates the development of the 2,4,6-trinitrophenol-conjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2-deficient mice. J. Immunol. 1997, 159(7):3622-3628.
83. Lugering A., Schmidt M., et al. Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway. Gastroenterology 2001, 121(5):1145-1157.
84. Mackay F., Browning J.L., et al. Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis. Gastroenterology 1998, 115(6):1464-1475.
85. MacMicking J., Xie Q.W., et al. Nitric oxide and macrophage function. Annu. Rev. Immunol. 1997, 15:323-350.
86. Madara J.L., Podolsky D.K., et al. Characterization of spontaneous colitis in cotton-top tamarins (Saguinus oedipus) and its response to sulfasalazine. Gastroenterology 1985, 88(1):13-19. Pt 1.
87. Mahler M., Bristol I.J., et al. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am. J. Physiol. 1998, 274(3):G544-G551. Pt 1.
88. Mahler M., Bristol I.J., et al. Genetic analysis of susceptibility to dextran sulfate sodium-induced colitis in mice. Genomics 1999, 55:147-156.
89. Malmstrom V., Shipton D., et al. CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice. J. Immunol. 2001, 166(11):6972-6981.
90. Mashimo H., Wu D.C., et al. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science 1996, 274(5285):262-265.
91. Matsumoto S., Okabe Y., et al. Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1/Yit strain. Gut 1998, 43(1):71-78.
92. McAdam A.J., Chang T.T., et al. Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. J. Immunol. 2000, 165(9):5035-5040.
93. McCafferty D.M., Miampamba M., et al. Role of inducible nitric oxide synthase in trinitrobenzene sulphonic acid induced colitis in mice. Gut 1999, 45(6):864-873.
94. McCafferty D.M., Mudgett J.S., et al. Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation. Gastroenterology 1997, 112(3):1022-1027.
95. McCracken V.J., Lorenz R.G. The gastrointestinal ecosystem: a precarious alliance among epithelium, immunity and microbiota. Cell Microbiol. 2001, 3(1):1-11.
96. McHugh R.S., Shevach E.M., et al. Control of organ-specific autoimmunity by immunoregulatory CD4(+)CD25(+) T cells. Microbes Infect. 2001, 3(11):919-927.
97. McHugh R.S., Whitters M.J., et al. CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002, 16(2):311-323.
98. Metz C.N., Bucala R. Role of macrophage migration inhibitory factor in the regulation of the immune response. Adv. Immunol. 1997, 66:197-223.
99. Mombaerts P., Mizoguchi E., et al. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 1993, 75(2):1-20.
100. Moore K.W., de Waal Malefyt R., et al. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 2001, 19:683-765.
101. Morrissey P.J., Charrier K., et al. CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells. J. Exp. Med. 1993, 178(1):237-244.
102. Mosmann T.R., Coffman R.L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 1989, 7:145-173.
103. Murphy K.M., Ouyang W., et al. Signaling and transcription in T helper development. Annu. Rev. Immunol. 2000, 18:451-494.
104. Nakamura K., Kitani A., et al. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J. Exp. Med. 2001, 194(5):629-644.
105. Neish A.S., Gewirtz A.T., et al. Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination. Science 2000, 289(5484):1560-1563.
106. Neurath M.F., Fuss I., et al. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 1995, 182(5):1281-1290.
107. Neurath M.F., Fuss I., et al. Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice. Eur. J. Immunol. 1997, 27(7):1743-1750.
108. Neurath M., Fuss I., et al. TNBS-colitis. International Reviews of Immunology 2000, 19(1):51-62.
109. Ogura Y., Bonen D.K., et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001, 411(6837):603-606.
110. Okayasu I., Hatakeyama S., et al. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 1990, 98:694-702.
111. Panwala C.M., Jones J.C., et al. A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis. Journal of Immunology 1998, 161(10):5733-5744.
112. Papadakis K.A., Targan S.R. Role of cytokines in the pathogenesis of inflammatory bowel disease. Annu. Rev. Med. 2000, 51:289-298.
113. Papiernik M. Natural CD4+ CD25+ regulatory T cells. Their role in the control of superantigen responses. Immunol. Rev. 2001, 182:180-189.
114. Papiernik M., de Moraes M.L., et al. Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int. Immunol. 1998, 10(4):371-378.
115. Parronchi P., Romagnani P., et al. Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease. Am. J. Pathol. 1997, 150(3):823-832.
116. Pfeiffer C.J., Qiu B.S. Effects of chronic nitric oxide synthase inhibition on TNB-induced colitis in rats. J. Pharm. Pharmacol. 1995, 47(10):827-832.
117. Podolsky D.K. Inflammatory bowel disease. N. Engl. J. Med. 2002, 347(6):417-429.
118. Powrie F., Carlino J., et al. A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J. Exp. Med. 1996, 183(6):2669-2674.
119. Powrie F., Leach M.W., et al. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int. Immunol. 1993, 5(11):1461-1471.
120. Powrie F., Leach M.W., et al. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1994, 1(7):553-562.
121. Rachmilewitz D., Karmeli F., et al. Experimental colitis is ameliorated by inhibition of nitric oxide synthase activity. Gut 1995, 37(2):247-255.
122. Rath H.C., Schultz M., et al. Different subsets of enteric bacteria induce and perpetuate experimental colitis in rats and mice. Infect. Immun. 2001, 69(4):2277-2285.
123. Read S., Malmstrom V., et al. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J. Exp. Med. 2000, 192(2):295-302.
124. Rincon M., Anguita J., et al. Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. J. Exp. Med. 1997, 185(3):461-469.
125. Romagnani S. T-cell subsets (Th1 versus Th2). Ann. Allergy Asthma Immunol. 2000, 85(1):9-18. quiz 18, 21.
126. Rudolph U., Finegold M.J., Rich S.S., Harriman G.R., Srinivasan Y., Brapet P., Boulay G., Bradley A., Birnbaumer L. Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nat. Genet. 1995, 10:143-150.
127. Sadlack B., Merz H., et al. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993, 75(2):253-261.
128. Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000, 101(5):455-458.
129. Sakaguchi S., Sakaguchi N., et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alphachains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995, 155(3):1151-1164.
130. Salomon B., Lenschow D.J., et al. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 2000, 12(4):431-440.
131. Sandborn W.J., Hanauer S.B., et al. Etanercept for active Crohn's disease: a randomized, double-blind, placebo-controlled trial. Gastroenterology 2001, 121(5):1088-1094.
132. Sartor R.B. The influence of normal microbial flora on the development of chronic mucosal inflammation. Res. Immunol. 1997, 148(8-9):567-576.
133. Satsangi J. Genetics of inflammatory bowel disease: from bench to bedside?. Acta Odontol. Scand. 2001, 59(3):187-192.
134. Seddon B., Mason D. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity. J. Exp. Med. 1999, 189(5):877-882.
135. Seddon B., Mason D. Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4(+)CD45RC-cells and CD4(+)CD8(-) thymocytes. J. Exp. Med. 1999, 189(2):279-288.
136. Shevach E.M. Regulatory T cells in autoimmunity. Annu. Rev. Immunol. 2000, 18:423-449.
137. Shimizu J., Yamazaki S., et al. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 2002, 3(2):135-142.
138. Shull M.M., Ormsby I., et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 1992, 359(6397):693-699.
139. Siegmund B., Fantuzzi G., et al. Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2001, 281(4):R1264-R1273.
140. Siegmund B., Lehr H.A., et al. IL-1beta-converting enzyme (caspase-1) in intestinal inflammation. Proc. Natl. Acad. Sci. USA 2001, 98:13249-13254. (23).
141. Simpson S.J., De Jong Y.P., et al. Consequences of Fas-ligand and perforin expression by colon T cells in a mouse model of inflammatory bowel disease. Gastroenterology 1998, 115(4):849-855.
142. Simpson S.J., Shah S., et al. T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells. J. Exp. Med. 1998, 187(8):1225-1234.
143. Singh B., Read S., et al. Control of intestinal inflammation by regulatory T cells. Immunol. Rev. 2001, 182:190-200.
144. Spencer S.D., Di Marco F., et al. The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. J. Exp. Med. 1998, 187(4):571-578.
145. Steidler L., Hans W., et al. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science 2000, 289(5483):1352-1355.
146. Stene L.C., Nafstad P. Relation between occurrence of type 1 diabetes and asthma. Lancet 2001, 357(9256):607-608.
147. Stephens L.A., Mason D. CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25-subpopulations. J. Immunol. 2000, 165(6):3105-3110.
148. Stephens L.A., Mottet C., et al. Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur. J. Immunol. 2001, 31(4):1247-1254.
149. Sundberg J.P., Elson C.O., et al. Spontaneous, heritable colitis in a new substrain of C3H/HeJ mice. Gastroenterology 1994, 107(6):1726-1735.
150. Suzuki H., Kundig T.M., et al. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science 1995, 268:1472-1476.
151. Takahashi T., Kuniyasu Y., et al. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 1998, 10(12):1969-1980.
152. Takahashi T., Tagami T., et al. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 2000, 192(2):303-310.
153. Takeda K., Clausen B.E., et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 1999, 10(1):39-49.
154. Tamada K., Shimozaki K., et al. Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nat. Med 2000, 6(3):283-289. (taf/DynaPage.taf?file=/nm/journal/v3/n3/full/nm0300_283.html).
155. Targan S.R., Hanauer S.B., et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N. Engl. J. Med. 1997, 337(15):1029-1035.
156. Ten Hove T., Corbaz A., et al. Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-alpha production in mice. Gastroenterology 2001, 121(6):1372-1379.
157. ten Hove T., van Montfrans C., et al. Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease. Gut 2002, 50(2):206-211.
158. Thornton A.M., Shevach E.M. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 1998, 188(2):287-296.
159. Thornton A.M., Shevach E.M. Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen non-specific. J. Immunol. 2000, 164(1):183-190.
160. Toy L.S., Yio X.Y., et al. Defective expression of gp 180, a novel CD8 ligand on intestinal epithelial cells, in inflammatory bowel disease. J. Clin. Invest. 1997, 100(8):2062-2071.
161. van Ewijk W., Hollander G., et al. Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets. Development 2000, 127(8):1583-1591.
162. Wakkach A., Fournier N., et al. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 2003, 18(5):605-617.
163. Wang B., Simpson S.J., et al. Development and function of T lymphocytes and natural killer cells after bone marrow transplantation of severely immunodeficient mice. Immunol. Rev. 1997, 157:53-60.
164. Watanabe M., Ueno Y., et al. Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa. J. Exp. Med. 1998, 187(3):389-402.
165. Weiner H.L. Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol. Rev. 2001, 182:207-214.
166. Willerford D.M., Chen J., et al. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995, 3(4):521-530.
167. Wirtz S., Finotto S., et al. Cutting edge: chronic intestinal inflammation in STAT-4 transgenic mice: characterization of disease and adoptive transfer by TNF-plus IFN-gamma-producing CD4+ T cells that respond to bacterial antigens. J. Immunol. 1999, 162(4):1884-1888.
168. Yamada T., Sartor R.B., et al. Mucosal injury and inflammation in a model of chronic granulomatous colitis in rats. Gastroenterology 1993, 104(3):759-771.
169. Yamamoto M., Yoshizaki K., et al. IL-6 is required for the development of Th1 cell-mediated murine colitis. J. Immunol. 2000, 164(9):4878-4882.
170. Yang X., Letterio J.J., et al. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO Journal 1999, 18(5):1280-1291.
171. Zingarelli B., Szabo C., et al. Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase. Gut 1999, 45(2):199-209.