Experimental murine colitis is regulated by two genetic loci, including one on chromosome 11 that regulates IL-12 responses

Gastroenterology

Volumn 123, Issue 2, 2002, Pages 554-565

  Bouma, Gerd ^a,b   Kaushiva, Anjali ^a   Strober, Warren ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; LIPOPOLYSACCHARIDE; PROTEIN P40; TRINITROBENZENESULFONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CHROMOSOME 11; CHROMOSOME 9; COLITIS; CONTROLLED STUDY; CROHN DISEASE; ENTERITIS; GENE CONTROL; GENE LOCUS; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; IMMUNE RESPONSE; IMMUNOREGULATION; INTESTINE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ULCERATIVE COLITIS;

EID: 0036327730     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2002.34752     Document Type: Article

References (25)

1. Inflammatory bowel disease: Etiology and pathogenesis
2. Update on inflammatory bowel disease genetics
3. Mapping of a susceptibility locus for Crohn's disease on chromosome 16
4. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
5. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
6. Mapping autoimmunity genes
7. TNBS-colitis
8. Antibodies to interleukin 12 abrogate established experimental colitis in mice
9. Murine albino-deletion complex: High-resolution microsatellite map and genetically anchored YAC framework map
10. Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus
11. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
12. Genetic analysis of susceptibility to dextran sulfate sodium-induced colitis in mice
13. Genetic analysis of susceptibility to ileitis in a spontaneous mouse model of Crohn's disease (abstr)
14. The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
15. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
16. Decreased IL-12 production underlies the decreased ability of male lymph node cells to induce experimental autoimmune encephalomyelitis
17. Gender-dependent IL-12 secretion by APC is regulated by IL-10
18. New microsatellite polymorphisms identified between C57BL/6, C57BL/10, and C57BL/KsJ inbred mouse strains
19. A genome-wide search identifies potential new susceptibility loci for Crohn's disease
20. Sequence polymorphisms in the chemokines Scyal (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis
21. Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele
22. SJL and NOD macrophages are uniquely characterized by genetically programmed, elevated expression of the IL-12(p40) gene, suggesting a conserved pathway for the induction of organ-specific auto-immunity
23. Genetic analysis of disease subtypes and sexual dimorphisms in mouse experimental allergic encephalomyelitis (EAE): Relapsing/remitting and monophasic remitting/nonrelapsing EAE are immunogenetically distinct
24. A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats
25. Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12