Characterization of cytokine expression in the rectal mucosa of ulcerative colitis: Correlation with disease activity

American Journal of Gastroenterology

Volumn 94, Issue 9, 1999, Pages 2441-2446

  Inoue, Shigeo ^a   Matsumoto, Takayuki ^b   Lida, Mitsuo ^b   Mizuno, Mitsuru ^b   Kuroki, Fumitoshi ^b   Hoshika, Kazunori ^b   Shimizu, Michio ^b  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; COLONOSCOPY; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; RECTUM BIOPSY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD; ULCERATIVE COLITIS;

ADOLESCENT; ADULT; AGED; CHILD; COLITIS, ULCERATIVE; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTERFERON TYPE II; INTERLEUKINS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; RECTUM; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX;

EID: 0033199084     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1572-0241.1999.01372.x     Document Type: Article

References (27)

1. Podolosky DK. Inflammatory bowel disease. N Eng J Med 1991:325:928-37.
2. Brynskov J, Nielsen OH, Ahnfelt-Rønne I, et al. Cytokines in inflammatory bowel disease. Scand J Gastroenterol 1992;27: 897-906.
3. Sartor RB. Cytokines in intestinal inflammation: Pathophysiological and clinical considerations. Gastroenterology 1994; 106:533-9.
4. Isaacs KL, Sartor RB, Haskill S. Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification. Gastroenterology 1992:103:1587-95.
5. Mullin GE, Vezza FR, Sampat A, et al. Abnormal IL-10 mRNA production in the intestinal mucosal lesions of inflammatory bowel disease. Gastroenterology 1993;104:A751.
6. Niessner M, Volk B A. Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed poly-merase chain reaction (RT-PCR). Clin Exp Immunol 1995; 101:428-35.
7. Breese E, Braegger CP, Corrigan CJ, et al. Interleukin-2- and interferon-y-secreting T cells in normal and diseased human intestinal mucosa. Immunology 1993;78:127-31.
8. Mullin GE, Lazenby AJ, Harris ML, et al. Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis. Gastroenterology 1992;102:1620-7.
9. Grabstein KH, Eisenman J, Shanebeck K, et al. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 1994;264:965-8.
10. Blackstone M. Endoscopie interpretation: Normal and pathologic appearances of the gastrointestinal tract. New York: Raven Press, 1984.
11. Seo M, Okada M, Yao T, et al. An index of disease activity in patients with ulcerative colitis. Am J Gastroenterol 1992;87: 971-6.
12. Matts SGF. The value of rectal biopsy in the diagnosis of ulcerative colitis. Q J Med 1961;120:393-410.
13. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
14. Huang M, Wang J, Lee P, et al. Human non-small cell lung cancer cells express a type 2 cytokine pattern. Cancer Res 1995:55:3847-53.
15. Flamand L, Stefanescu I, Menezes J. Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15. J Clin Invest 1996;97:1373-81.
16. Schreiber S, Heining T, Panzer U, et al. Impaired response of activated mononuclear phagocytes to interleukin 4 in inflammatory bowel disease. Gastroenterology 1995:108:21-33.
17. TeVelde AA, Huijbens RJF, Heije K, et al. Interleukin-4 inhibits secretion of IL- Ib tumor necrosis factor a, and IL-6 by human monocytes. Blood 1990;76:1392-7.
18. Standiford TJ, Stricter RM, Chensue SW, et al. IL-4 inhibits the expression of IL-8 from stimulated human monocyte. J Immunol 1990:145:1435-9.
19. Paul WE. Interleukin-4: A prototypic immunoregulatory lymphokine. Blood 1991;77:1859-70.
20. Radford-Smith G, McGowan I, Jewell DP. Thl and Th2 cytokine gene expression in inflammatory bowel disease. Gastroenterology 1994;106:A757.
21. Fiorentino DF, Zlotnik A, Mosmann TR, et al. IL-10 inhibits cytokine production by activated macrophage. J Immunol 1991:147:3815-22.
22. Kühn R, Löhler J, Rennick D, et al. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993;75:263-74.
23. Kucharzik T, Lüering N, Adolf M, et al. Synergistic effect of immunoregulatory cytokines on peripheral blood monocytes from patients with inflammatory bowel disease. Dig Dis Sci 1997:42:805-12.
24. Lügering N, Kucharzik T, Stein H, et al. IL-10 synergizes with IL-4 and IL-13 in inhibiting lysosomal enzyme secretion by human monocytes and lamina propria mononuclear cells from patients with inflammatory bowel disease. Dig Dis Sci 1998; 43:706-14.
25. Carson WE, Giri JG, Lindemann MJ, et al. Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J Exp Med 1994:180:1395-403.
26. Kirman I, Nielsen OH. Increased numbers of interleukin-15-expressing cells in active ulcerative colitis. Am J Gastroenterol 1996;91:1789-94.
27. Sakai T, Kusugami K, Nishimura H, et al. Interleukin 15 activity in the rectal mucosa of inflammatory bowel disease. Gastroenterology 1998;! 14:1237-43.