Spontaneously Colitic C3H/HeJBir Mice Demonstrate Selective Antibody Reactivity to Antigens of the Enteric Bacterial Flora

Journal of Immunology

Volumn 159, Issue 1, 1997, Pages 44-52

  Brandwein, Steven L ^a   McCabe, Robert P ^a   Cong, Yingzi ^a   Waites, Ken B ^b   Ridwan, Ben U ^a   Dean, Phillip A ^c   Ohkusa, Toshifumi ^d   Birkenmeier, Edward H ^e   Sundberg, John P ^e   Elson, Charles O ^a  

^a University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham   (United States)

^c Kentucky   (United States)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^e JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIUM ANTIBODY;

ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; DISEASE MODEL; ENTEROCOLITIS; FEMALE; IMMUNITY; IMMUNOLOGY; INTESTINE; MALE; MICROBIOLOGY; MOUSE; MOUSE STRAIN;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODY SPECIFICITY; ANTIGENS, BACTERIAL; DISEASE MODELS, ANIMAL; ENTEROCOLITIS; FEMALE; IMMUNITY; INTESTINES; MALE; MICE; MICE, INBRED STRAINS;

EID: 0031178798     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Elson, C. O., and R. P. J. McCabe. 1995, The immunology of inflammatory bowel disease. In Inflammatory Bowel Disease, 4th Ed. J. B. Kirsner and R. G. Shorter, eds. Williams & Wilkins, Baltimore, p. 203.
2. Broberger, O., and P. Perlmann. 1963, In vitro studies of ulcerative colitis. I. Reactions of patient's serum with human fetal colon cells in tissue cultures. J. Exp. Med. 117:705.
3. Aronson, R. A., S. L. Cook, and J. K. Roche. 1983. Sensitization to epithelial antigens in chronic mucosal inflammatory disease. I. Purification, characterization, and immune reactivity of murine epithelial cell-associated components (ECAC). J. Immunol. 131:2796.
4. Das, K. M., A. Dasgupta. A. Mandal, and X. Geng. 1993. Autoimmunity to cytoskeletal protein tropomyosin: a clue to the pathogenetic mechanism for ulcerative colitis. J. Immunol 150:2487.
5. Sartor, R. B. 1995. Microbial factors in the pathogenesis of Crohn's disease, ulcerative colitis, and experimental intestinal inflammation. In Inflammatory Bowel Disease, 4th Ed. J. B. Kirsner and R. G. Shorter, eds. Williams & Wilkins, Baltimore, p.96.
6. Elson, C. O., R. B. Sartor, G. S. Tennyson, and R. H. Riddell. 1995. Experimental models of inflammatory bowel disease. Gastroenterology 109:1344.
7. Sadlack, B., H. Merz, H. Schorle, A. Schimpl, A. C. Feller, and I. Horak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75:253.
8. Taurog, J. D., J. A. Richardson, J. T. Croft, W. A. Simmons, M. Zhou, J. L. Fernandez-Sueiro, E. Balisn, and R. E. Hammer. 1994. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J. Exp. Med. 180:2359.
9. Sundberg, J. P., C. O. Elson, H. Bedigian, and E. H. Birkenmeier. 1994. Spontaneous, heritable colitis in a new substrain of C3H/HeJ mice. Gastroenterology 107:1726.
10. Murray, P. R., E. J. Baron, M. A. Pfaller, F. C. Tenover, and R. H. Yolken. 1995. Manual of Clinical Microbiology. American Society for Microbiology Press, Washington, DC.
11. Fiscnetti, V. A., K. F. Jones, B. N. Manjula, and J. R. Scott. 1984. Streptococcal M6 protein expressed in Escherichia coli: localization, purification, and comparison with streptococcal-derived M protein. J. Exp. Med. 159:1083.
12. Matsudaira, P. 1990. Limited N-terminal sequence analysis. Methods Enzymol. 182:602.
13. Diagram, J. 1990. Preparation of extracts from higher eukaryotes. Methods Enzymol. 182:194.
14. Laemmli, U. K. 1970. Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature 227:680.
15. Oakley, B. R., D. R. Kirsch, and N. R. Morris. 1980. A simplified ultrasensitive silver stain for detecting proteins in polyacrylamide gels. Anal. Biochem. 105: 361.
16. Towbin, H., T. Slaehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350.
17. Whilehead, T. P., L. J. Kricka, T. J. Carter, and G. H. Thorpe. 1979, Analytical luminescence: its potential in the clinical laboratory. Clin. them. 25:1531.
18. Elson, C. O., S. P. Holland, M. T. Dertzbaugh, C. F. Cuff, and A. O. Anderson. 1995. Morphologic and functional alterations of mucosal T cells by cholera toxin and its B subunit. J. Immunol. 154:1032.
19. Hornbeck, P. 1991. Isotype determination of antibodies. In Current Protocols in Immunology. J. E. Coligan, A. M. Kruisebeek, D. H. Margulies, E. M. Shevach, and W. Strober, eds. John Wiley & Sons, Inc., New York, p. 221.
20. Rodhard, D., and Y. Feldman. 1978. Kinetics of two-site immunoradiometric ("sandwich") assays. I. Mathematical models for simulation, optimization, and curve fitting, Immunochemistry 15:71.
21. Okayasu, I., S. Hatakeyama, M. Yamada, T. Ohkusa, Y. Inaguki, and R. Nakaya. 1990. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98:694.
22. Kuhn, R., J. Lohler, D. Rennick, K. Rajewsky, and W. Muller. 1993. Interleukin-10-deticient mice develop chronic enterocolitis. Cell 75:263.
23. Mizoguchi, A., E. Mizoguchi, S. Tonegawa and A. K. Bhan. 1996. Alteration of a polyclonal to an oligoclonal immune response to cecal aerobic bacterial antigens in TCRα mutant mice with inflammatory bowel disease. Int. Immunol. 8:1387.
24. Moore, W. E. C., and L. V. Holdeman. 1974. Human fecal flora; the normal flora of 20 Japanese-Hawaiians. Appl. Microbiol. 27:961.
25. Pollard, M., and N. Sharon. 1970. Responses of the Peyer's patches in germ-free mice to antigenic stimulation. Infect. Immun. 2:96.
26. Shroff, K. E., K. Meslin, and J. J. Cebra. 1995. Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut. Infect. Immun. 63:3904.
27. Berg. R. D., and D. C. Savage. 1975. Immune responses of specific pathogen-free and gnotobiotic mice to antigens of indigenous and nonindigenous microorganisms, Infect. Immun. 11:320.
28. Savage, D. C., R. Dubos, and R. W. Schaedler. 1968. The gastrointestinal epithelium and its autochthonous bacterial flora. J. Exp. Med. 127:67.
29. Duchmann, R., E. Schmitt, E. Knolle, K.-H. Meyer zum Buschenfelde and M. Neurath. 1996. Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interlcukin-10 or antibodies to interleukin-12. Eur. J. Immunol. 26:934.
30. Onderdonk, A. B., R. L. Cisneros, and R. T. Bronson. 1983. Enhancement of experimental ulcerative colitis by immunization with Bacteroides vulgatus. Infect. Immun. 42:793.
31. Rath, H. C., H. H. Herfarth, J. S. Ikeda, W. B. Grenther, T. E. Hamm, E. Balish, J. D. Taurog, R. E. Hammer, K. H. Wilson, and R. B. Sartor. 1996. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta 2 microglobulin transgenic rats. J. Clin. Invest. 98:945.
32. Ewing, W. H. 1986. Edwards and Ewing's Identification of Enterobacteriaceae. Elsevier Science Publishing. New York.
33. Nikaido, H., and M. Vaara. 1987, Outer membrane. In Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology. F. C. Neidhardt, J. L. Ingraham, K. B. Low, B. Magasanik, M. Schaechter, and H. E. Umbarger, eds. American Society for Microbiology Press, Washington, DC, p.7.
34. Mergenhagen, S. E., and D. H. Pluznik. 1984. Defective responses to lipid A in C3H/HeJ mice: approaches to an understanding of lipid A-cell interaction. Rev. Infect, Dis. 6:519.
35. Sartor. R. B., W. J. Cromartie, D. W. Powell, and J. H. Schwab. 1985. Granulomatous enterocolitis induced in rats by purified bacterial cell wall fragments. Gastroenterology 89:587.
36. Broom, M. F., R. M. Sherriff, D. M. Ferry, and V. S. Chadwick. 1993. Formylmethionylleucylphenylalanine and the SOS operon in Escherichia coli: a model of host-bacterial interactions. Biochem. J. 291:895.
37. McCabe, R. P., T. Mills, B. Ridwan, A. Dadrat, G. Thaggard, K. Beagley, E. Birkenmeier, J. Sundberg, and C. O. Elson. 1993. Immunologic reactivity of C3H/HeJ mice with spontaneous colitis. Gastroenterology 104:A739.
38. Lehman, P. V., T. Forsthuber, A. Miller, and E. E. Sercarz. 1992. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen, Nature 358:155.
39. Kaufman, D. L., M. Clare-Salzler, J. Tian, T. Forsthuber, G. Ting, P. Robinson, M. A. Atkinson, E. E. Sercarz, A. J. Tobin, and P. V. Lehmann. 1993. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes, Nature 366:69.
40. Tisch. R., X. D. Yang, S. M. Singer, R. S. Libeler, L. Fugger, and H. O. McDevitt. 1993, Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366:72.
41. Lehmann, P. V., E. E. Sercarz, T. Forsthuber, C. M. Dayan, and G. Gammon. 1993, Determinant spreading and the dynamics of the autoimmune T-cell repertoire, Immunol. Today 14:203.
42. Finkelman, F. D., J. Holmes, I. M. Katona, J. F. J. Urban, M. P. Beckmann, L. S. Park. K. A. Schooley. R. L. Coffman, T. R. Mosmann, and W. E. Paul. 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8:303.
43. Natsuume-Sakai, S., K. Motonishi, and S. Migita. 1977. Quantitative estimations of five classes of immunoglobulins in inbred mouse strains, Immunology 32:861.
44. Cong, Y., S. L. Brandwein, R. P. McCabe, B. U. Ridwan, E. H. Birkenmeier, J. P. Sundberg, and C. O. Elson. 1995. Th1 response to enteric bacteria in colitic C3H/HeJBir mice. Clin. Immunol. Immunopathol. 76:S44.
45. + T cells. J. Exp. Med. 183:2669.
46. + TH1-like responses. J. Clin. Invest. 98:1010.
47. Pirzer, U., A. Schonhaar, B. Fleischer, E. Hermann, and K.-H. Meyer zum Buschenfelde. 1991, Reactivity of infiltrating T lymphocytes with microbial antigens in Crohn's disease. Lancet 338:1238.
48. Macpherson, A., U. Y. Khoo, I. Forgacs, J. Philpott-Howard, and I. Bjarnason. 1996. Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria. Gut 38:365.
49. Rutgeerts, P., K. Goboes, M. Peeters, M. Hiele, F. Penninckx, R. Aerts, R. Kerremans, and G. Vantrappen. 1991. Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum. Lancet 338:771.