CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations

Journal of Immunology

Volumn 165, Issue 6, 2000, Pages 3105-3110

  Stephens, L A ^a   Mason, D ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; DIABETES MELLITUS; DISEASE ACTIVITY; FLOW CYTOMETRY; GAMMA IRRADIATION; MEMORY CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; T LYMPHOCYTE SUBPOPULATION; THYMECTOMY; THYMOCYTE;

EID: 0034665514     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.6.3105     Document Type: Article

References (30)

1. The third function of the thymus
2. + T cell subset that inhibits this autoimmune potential
3. The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients
4. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity
5. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
6. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
7. Regulatory CD4 T cells: Expression of IL-2R α chain, resistance to clonal deletion and IL-2 dependency
8. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
9. + naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
10. The IL-2 receptor complex: Its structure, function, and target genes
11. Two subsets of rat T lymphocytes defined with monoclonal antibodies
12. MRC OX-22, a monoclonal antibody that labels a new subset of T lymphocytes and reacts with the high molecular weight form of the leukocyte-common antigen
13. Expression of soluble isoforms of rat CD45: Analysis by electron microscopy and use in epitope mapping of anti-CD45R monoclonal antibodies
14. Molecular and antigenic heterogeneity of the rat leukocyte-common antigen from thymocytes and T and B lymphocytes
15. Antigens of activated rat T lymphocytes including a molecule of 50,000 M(r) detected only on CD4 positive T blasts
16. Mechanism of action of interleukin-2 receptor (IL-2R) monoclonal antibody (MAb) therapy: Target cell depletion or inhibition of function?
17. Analysis of cell surfaces by xenogeneic myeloma-hybrid antibodies: Differentiation antigens of rat lymphocytes
18. Purification of human C3b inactivator by monoclonal-antibody affinity chromatography
19. Separation of functional subsets of human T cells by a monoclonal antibody
20. Discrete stages of human intrathymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage
21. Induction of autoimmune disease by depletion of regulatory T cells
22. The role of re-circulation of lympbocytes in the rat
23. Preparation of lymphocyte subpopulations
24. - thymocytes that express L-selectin protect rats from diabetes upon adoptive transfer
25. Recent thymic emigrants in the rat express a unique antigenic phenotype and undergo post-thymic maturation in peripheral lymphoid tissues
26. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells
27. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
28. How do monoclonal antibodies induce tolerance? A role for infectious tolerance?
29. Establishment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epithelium
30. + T cells induce wasting disease with multiple organ pathology: Prevention by the OX-22low subset