IL-12, but not IFN-γ, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice

Journal of Immunology

Volumn 161, Issue 6, 1998, Pages 3143-3149

  Davidson, Natalie J ^a   Hudak, Susan A ^a   Lesley, Robin E ^a   Menon, Satish ^a   Leach, Michael W ^a   Rennick, Donna M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE CONTROL; ENTEROCOLITIS; HELPER CELL; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

ADOPTIVE TRANSFER; AGING; ANIMALS; ANIMALS, NEWBORN; ANTIBODIES, MONOCLONAL; CHRONIC DISEASE; COLITIS; DNA-BINDING PROTEINS; DRUG THERAPY, COMBINATION; INJECTIONS, INTRAPERITONEAL; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; LEUKOCYTE COUNT; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; T-LYMPHOCYTE SUBSETS;

EID: 0032530697     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Braegger, C. P., and T. T. MacDonald. 1994. Immune mechanisms in chronic inflammatory bowel disease. Ann. Allergy 72:135.
2. Kühn, R., J. Lohler, D. Rennick, K. Rajewsky, and W. Müller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75:263.
3. + TH1-like responses. J. Clin. Invest. 98:1010.
4. Powrie, F., and M. W. Leach. 1995. Genetic and spontaneous models of inflammatory bowel disease in rodents: evidence for abnormalities in mucosal immune regulation. Therapeut. Immunol. 2:115.
5. Dieleman, L. A., A. S. Peña, S. G. M. Meuwissen, and E. P. van Rees. 1997. Role of animal models for the pathogenesis and treatment of inflammatory bowel disease. Scand. J. Immunol. 32(Suppl 223):99.
6. + T cells, but not B cells, mediate colitis in interleukin-10-deficient mice. J. Exp. Med. 184:241.
7. -/- mice: an overview. J. Leukocyte Biol. 61:389.
8. Ma, A., M. Datta, E. Margosian, J. Chen, and I. Horak. 1995. T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice. J. Exp. Med. 182:1567.
9. + T-cell population mediates development of inflammatory bowel disease in T-cell receptor α chain-deficient mice. Gastroenterology 112:1876.
10. Neurath, M. F., I. Fuss, B. L. Kelsall, D. H. Presky, W. Waegell, and W. Strober. 1996. Experimental granulomatous colitis in mice is abrogated by induction of TGF-β-mediated oral tolerance. J. Exp. Med. 183:2605.
11. + T cells induce or protect from chronic intestinal inflammation in C.B-17 scid mice. Int. Immunol. 5:1461.
12. + T cells. Res. Immunol. 145:332.
13. Holländer, G. A., S. J. Simpson, E. Mizoguchi, A. Nichogiannopoulou, J. She, J. C. Gutierrez-Ramos, A. K. Bhan, S. J. Burakoff, B. Wang, and C. Terhorst. 1995. Severe colitis in mice with aberrant thymic selection. Immunity 3:27.
14. Neurath, M. F., I. Fuss, B. L. Kelsall, E. Stüber, and W. Strober. 1995. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 182:1281.
15. + T cells in an experimental model of colitis. Eur. J. Immunol. 27:17.
16. + T cells and proinflammatory Th1-type cytokines. J. Immunol. 158:1068.
17. McDonald, S. A. C., M. J. H. J. Palmen, E. P. van Rees, and T. T. MacDonald. 1997. Characterization of the mucosal cell-mediated immune response in IL-2 knockout mice before and after the onset of colitis. Immunology 91:73.
18. Billiau, A. 1996. Interferon-γ: biology and role in palhogenesis. Adv. Immunol. 62:61.
19. + T cells. Immunity 1:553.
20. Trinchieri, G. 1994. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84:4008.
21. Magram, J., S. E. Connaughton, R. R. Warrier, D. M. Carvajal, C. Wu, J. Ferrante, C. Stewart, U. Sarmiento, D. A. Faherty, and M. K. Gately. 1996. IL-12-deficient mice are defective in IFNy production and type 1 cytokine responses. Immunity 4:471.
22. Monteleone, G., L. Biancone, R. Marasco, G. Morrone, O. Marasco, F. Luzza, and F. Pallone. 1997. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 112:1169.
23. Parronchi, P., P. Romagnani, F. Annunziato, S. Sampognaro, A. Becchio, L. Giannarini, E. Maggi, C. Pupilli, F. Tonelli, and S. Romagnani. 1997. Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease. Am. J. Pcithol. 150:823.
24. Duchmann, R., E. Schmitt, P. Knolle, K. H. Meyer zum Büschenfelde, and M. Neurath. 1996. Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12. Eur. J. Immunol. 26:934.
25. Ehrhardt, R. O., B. R. Lúdvíksson, B. Gray, M. Neurath, and W. Strober. 1997. Induction and prevention of colonie inflammation in IL-2-deficient mice. J. Immunol. 158:566.
26. Wysocka, M., M. Kubin, L. Q. Vieira, L. Ozmen, G. Garotta, P. Scott, and G. Trinchieri. 1995. Interleukin-12 is required for interferon-γ production and lethality in LPS-induced shock in mice. Eur. J. Immunol. 25:672.
27. Rönnelid, J., and L. Klareskog. 1997. A comparison between ELISPOT methods for the detection of cytokine producing cells: greater sensitivity and specificity using ELISA plates as compared to nitrocellulose membranes. J. Immunol. Methods 200:17.
28. Abrams, J. S., M. G. Roncarolo, H. Yssel, U. Andersson, G. J. Gleich, and J. E. Silver. 1992. Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127:5.
29. Murphy, E. E., G. Terres, S. E. Macatonia, C. S. Hsieh, J. Mattson, L. Lanier, M. Wysocka, G. Trinchieri, K. Murphy, and A. O'Garra. 1994. B7 and interleukin 12 cooperate for proliferation and interferon γ production by mouse T helper clones that are unresponsive to B7 costimulation. J. Exp. Med. 180:223.
30. + T-cell memory. CD45R subsets and the persistence of antigen: a unifying concept. Immunol. Today 19: 60.
31. Ho, A. S. Y., and K. W. Moore. 1994. Interleukin-10 and its receptor. Therapeut. Immunol. 1:173.
32. Leonard, J. P., K. E. Waldburger, and S. J. Goldman. 1995. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin-12. J. Exp. Med. 181:381.
33. Yokoi, H., K. Kato, T. Kezuka, J. Sakai, M. Usui, H. Yagita, and K. Okumura. 1997. Prevention of experimental autoimmune uveoretinitis by monoclonal antibody to interleukin-12. Eur. J. Immunol. 27:641.
34. Kennedy, M. K., K. S. Picha, K. D. Shanebeck, D. M. Anderson, and K. H. Grabstein. 1994. Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0, clones. Eur. J. Immunol. 24:227.
35. Rabau, M., A. Eyal, and D. Dayan. 1996. Histomorphometric evaluation of experimentally induced colitis with trinitrobenzene-sulphonic acid in rats. Int. J. Exp. Pathol. 77:175.
36. Mann, T., W. Strober, and B. L. Kelsall. 1996. High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-β secretion and T cell apoptosis. J. Immunol. 157:2348.
37. McIntyre, K. W., D. J. Shuster, K. M. Gillooly, R. R. Warrier, S. E. Connaughton, L. B. Hall, L. H. Arp, M. K. Gately, and J. Magram. 1996. Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice. Eur. J. Immunol. 26:2933.
38. Okamura, H., H. Tsutsui, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto. K. Torigoe, T. Okura, Y. Nukada, K. Hattori, K. Akita, M. Namba, F. Tanabe, K. Konishi, S. Fukuda, and M. Kurimoto. 1995. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 378:88.
39. Takeda, K., H. Tsutsui, T. Yoshimoto, O. Adachi, N. Yoshida, T. Kishimoto, H. Okamura, K. Nakanishi, and S. Akira. 1998. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 8:383.
40. + T cells. J. Immunol. 159:591.