메뉴 건너뛰기




Volumn 51, Issue , 2000, Pages 289-298

Role of cytokines in the pathogenesis of inflammatory bowel disease

Author keywords

Crohn's disease; Interleukin 10; Treatment; Tumor necrosis factor ; Ulcerative colitis

Indexed keywords

CYTOKINE; RECOMBINANT INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

EID: 0034005581     PISSN: 00664219     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.med.51.1.289     Document Type: Review
Times cited : (650)

References (28)
  • 1
    • 0032980743 scopus 로고    scopus 로고
    • Current theories on the cause of inflammatory bowel disease
    • 1. Papadakis KA, Targan SR. 1999. Current theories on the cause of inflammatory bowel disease. Gastroenterol. Clin. N. Am. 28:283-96
    • (1999) Gastroenterol. Clin. N. Am. , vol.28 , pp. 283-296
    • Papadakis, K.A.1    Targan, S.R.2
  • 2
    • 0031781603 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Etiology and pathogenesis
    • 2. Fiocchi C. 1998. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 115:182-205
    • (1998) Gastroenterology , vol.115 , pp. 182-205
    • Fiocchi, C.1
  • 3
    • 0026708247 scopus 로고
    • Medical treatment of inflammatory bowel disease
    • 3. Shanahan F, Targan S. 1992. Medical treatment of inflammatory bowel disease. Annu. Rev. Med. 43:125-33
    • (1992) Annu. Rev. Med. , vol.43 , pp. 125-133
    • Shanahan, F.1    Targan, S.2
  • 4
    • 0028069352 scopus 로고
    • Cytokines in intestinal inflammation: Pathophysiological and clinical considerations
    • 4. Sartor RB. 1994. Cytokines in intestinal inflammation: pathophysiological and clinical considerations. Gastroenterology 106:533-39
    • (1994) Gastroenterology , vol.106 , pp. 533-539
    • Sartor, R.B.1
  • 5
    • 0030175929 scopus 로고    scopus 로고
    • The basis of current and future therapy for inflammatory bowel disease
    • 5. Elson CO. 1996. The basis of current and future therapy for inflammatory bowel disease. Am. J. Med. 100:656-62
    • (1996) Am. J. Med. , vol.100 , pp. 656-662
    • Elson, C.O.1
  • 6
    • 0030942666 scopus 로고    scopus 로고
    • Altered immune responses in IL-10 transgenic mice
    • 6. Hagenbaugh A, Sharma S, Dubinett SM, et al. 1997. Altered immune responses in IL-10 transgenic mice. J. Exp. Med. 185: 2101-10
    • (1997) J. Exp. Med. , vol.185 , pp. 2101-2110
    • Hagenbaugh, A.1    Sharma, S.2    Dubinett, S.M.3
  • 7
    • 0031573593 scopus 로고    scopus 로고
    • A role for TNF-α and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease
    • 7. Plevy SE, Landers CJ, Prehn J, et al. 1997. A role for TNF-α and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease. J. Immunol. 159:6276-82
    • (1997) J. Immunol. , vol.159 , pp. 6276-6282
    • Plevy, S.E.1    Landers, C.J.2    Prehn, J.3
  • 8
    • 0030209985 scopus 로고    scopus 로고
    • Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • 8. Fuss IJ, Neurath M, Boirivant M, et al. 1996. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J. Immunol. 157: 1261-70
    • (1996) J. Immunol. , vol.157 , pp. 1261-1270
    • Fuss, I.J.1    Neurath, M.2    Boirivant, M.3
  • 9
    • 0030995575 scopus 로고    scopus 로고
    • Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
    • 9. Monteleone G, Biancone L, Marasco R, et al. 1997. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 112:1169-78
    • (1997) Gastroenterology , vol.112 , pp. 1169-1178
    • Monteleone, G.1    Biancone, L.2    Marasco, R.3
  • 10
    • 0030954732 scopus 로고    scopus 로고
    • A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease
    • 10. Targan SR, Hanauer SB, van Deventer SJH, et al. 1997. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease. N. Engl. J. Med. 337:1029-35
    • (1997) N. Engl. J. Med. , vol.337 , pp. 1029-1035
    • Targan, S.R.1    Hanauer, S.B.2    Van Deventer, S.J.H.3
  • 11
    • 0033103805 scopus 로고    scopus 로고
    • Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
    • 11. Kontoyiannis D, Pasparakis M, Pizarro TT, et al. 1999. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 10:387-98
    • (1999) Immunity , vol.10 , pp. 387-398
    • Kontoyiannis, D.1    Pasparakis, M.2    Pizarro, T.T.3
  • 12
    • 0033529049 scopus 로고    scopus 로고
    • Infliximab for the treatment of fistulas in patients with Crohn's disease
    • 12. Present DH, Rutgeerts P, Targan S, et al. 1999. Infliximab for the treatment of fistulas in patients with Crohn's disease. N. Engl. J. Med. 340:1398-405
    • (1999) N. Engl. J. Med. , vol.340 , pp. 1398-1405
    • Present, D.H.1    Rutgeerts, P.2    Targan, S.3
  • 13
    • 0032923705 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis
    • 13. Baert FJ, D'Haens GR, Peeters M, et al. 1999. Tumor necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis. Gastroenterology 116:22-28
    • (1999) Gastroenterology , vol.116 , pp. 22-28
    • Baert, F.J.1    D'Haens, G.R.2    Peeters, M.3
  • 15
    • 0033034365 scopus 로고    scopus 로고
    • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    • 15. Takeda K, Clausen BE, Kaisho T, et al. 1999. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10:39-49
    • (1999) Immunity , vol.10 , pp. 39-49
    • Takeda, K.1    Clausen, B.E.2    Kaisho, T.3
  • 16
    • 0032901919 scopus 로고    scopus 로고
    • The critical role of interleukin 4 but not interferon gamma in the pathogenesis of colitis in T-cell receptor alpha mutant mice
    • 16. Mizoguchi A, Mizoguchi E, Bhan AK. 1999. The critical role of interleukin 4 but not interferon gamma in the pathogenesis of colitis in T-cell receptor alpha mutant mice. Gastroenterology 116: 320-26
    • (1999) Gastroenterology , vol.116 , pp. 320-326
    • Mizoguchi, A.1    Mizoguchi, E.2    Bhan, A.K.3
  • 17
    • 4243315440 scopus 로고    scopus 로고
    • An open-label, stepwise dose-escalating pilot study to evaluate the safety, tolerance, and efficacy of low-dose thalidomide in the treatment of chronically-active, steroid-dependent Crohn's disease
    • Abstr.
    • 17. Vasiliauskas EA, Kam LY, Abreu-Martin MT, et al. 1999. An open-label, stepwise dose-escalating pilot study to evaluate the safety, tolerance, and efficacy of low-dose thalidomide in the treatment of chronically-active, steroid-dependent Crohn's disease. Gastroenterology 116:G3637 (Abstr.)
    • (1999) Gastroenterology , vol.116
    • Vasiliauskas, E.A.1    Kam, L.Y.2    Abreu-Martin, M.T.3
  • 18
    • 4243518361 scopus 로고    scopus 로고
    • Therapeutic efficacy of thalidomide for patients with refractory Crohn's disease
    • Abstr.
    • 18. Kane SV, Ehrenpreis ED, Cohen LB, et al. 1999. Therapeutic efficacy of thalidomide for patients with refractory Crohn's disease. Gastroenterology 116: G3234 (Abstr.)
    • (1999) Gastroenterology , vol.116
    • Kane, S.V.1    Ehrenpreis, E.D.2    Cohen, L.B.3
  • 19
    • 0031043778 scopus 로고    scopus 로고
    • Randomised controlled trial of CDP571 antibody to tumor necrosis factor-α in Crohn's disease
    • 19. Stack WA, Mann SD, Roy AJ, et al. 1997. Randomised controlled trial of CDP571 antibody to tumor necrosis factor-α in Crohn's disease. Lancet 349:521-24
    • (1997) Lancet , vol.349 , pp. 521-524
    • Stack, W.A.1    Mann, S.D.2    Roy, A.J.3
  • 20
    • 0029050742 scopus 로고
    • Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)
    • 20. van Dulleman HM, van Deventer SJH, Hommes DW, et al. 1995. Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology 109:129-35
    • (1995) Gastroenterology , vol.109 , pp. 129-135
    • Van Dulleman, H.M.1    Van Deventer, S.J.H.2    Hommes, D.W.3
  • 21
    • 0001311756 scopus 로고    scopus 로고
    • Retreatment with anti-TNF-α chimeric antibody (cA2) effectively maintains cA2-induced remission in Crohn's disease
    • Abstr.
    • 21. Rutgeerts P, D'Haens G, van Deventer SJH, et al. 1997. Retreatment with anti-TNF-α chimeric antibody (cA2) effectively maintains cA2-induced remission in Crohn's disease. Gastroenterology 112:A1078 (Abstr.)
    • (1997) Gastroenterology , vol.112
    • Rutgeerts, P.1    D'Haens, G.2    Van Deventer, S.J.H.3
  • 22
    • 0030835754 scopus 로고    scopus 로고
    • Multiple doses of intravenous interleukin-10 in steroid refractory Crohn's disease
    • 22. van Deventer SJ, Elson CO, Fedorak RN. 1997. Multiple doses of intravenous interleukin-10 in steroid refractory Crohn's disease. Gastroenterology 113: 383-89
    • (1997) Gastroenterology , vol.113 , pp. 383-389
    • Van Deventer, S.J.1    Elson, C.O.2    Fedorak, R.N.3
  • 23
    • 0000234094 scopus 로고    scopus 로고
    • A safety and efficacy study of recombinant human interleukin-10 (rHuIL-10) treatment in 329 patients with chronic active Crohn's disease
    • Abstr.
    • 23. Schreiber S, Fedorak RN, Nielsen OH, et al. 1998. A safety and efficacy study of recombinant human interleukin-10 (rHuIL-10) treatment in 329 patients with chronic active Crohn's disease. Gastroenterology 114:G4423 (Abstr.)
    • (1998) Gastroenterology , vol.114
    • Schreiber, S.1    Fedorak, R.N.2    Nielsen, O.H.3
  • 24
    • 4244023341 scopus 로고    scopus 로고
    • In vivo changes of lymphocyte subpopulations and leukocyte surface markers by multiple doses of recombinant human interleukin-10 in inflammatory bowel disease
    • Abstr.
    • 24. Dejaco C, Lichtenberger C, Reinisch W, et al. 1998. In vivo changes of lymphocyte subpopulations and leukocyte surface markers by multiple doses of recombinant human interleukin-10 in inflammatory bowel disease. Gastroenterology 114:G3939 (Abstr.)
    • (1998) Gastroenterology , vol.114
    • Dejaco, C.1    Lichtenberger, C.2    Reinisch, W.3
  • 25
    • 0000234097 scopus 로고    scopus 로고
    • Safety, tolerance and efficacy of multiple doses of subcutaneous interleukin-10 in mild to moderate active Crohn's disease
    • Abstr.
    • 25. Fedorak RN, Gangl A, Elson CO, et al. 1998. Safety, tolerance and efficacy of multiple doses of subcutaneous interleukin-10 in mild to moderate active Crohn's disease. Gastroenterology 114:G3993 (Abstr.)
    • (1998) Gastroenterology , vol.114
    • Fedorak, R.N.1    Gangl, A.2    Elson, C.O.3
  • 26
    • 0000234094 scopus 로고    scopus 로고
    • Safety and tolerance of rHuIL-10 treatment in patients with mild/moderate active ulcerative colitis
    • Abstr.
    • 26. Schreiber S, Fedorak RN, Wild G, et al. 1998. Safety and tolerance of rHuIL-10 treatment in patients with mild/moderate active ulcerative colitis. Gastroenterology 114:G4424 (Abstr.)
    • (1998) Gastroenterology , vol.114
    • Schreiber, S.1    Fedorak, R.N.2    Wild, G.3
  • 27
    • 0029813545 scopus 로고    scopus 로고
    • Enterocolitis and colon cancer in interleukin-10 deficient mice are associated with aberrant cytokine production and CD4+ Th1-like responses
    • 27. Berg DJ, Davidson N, Kuhn R, et al. 1996. Enterocolitis and colon cancer in interleukin-10 deficient mice are associated with aberrant cytokine production and CD4+ Th1-like responses. J. Clin. Invest. 98:1010-20
    • (1996) J. Clin. Invest. , vol.98 , pp. 1010-1020
    • Berg, D.J.1    Davidson, N.2    Kuhn, R.3
  • 28
    • 0003118148 scopus 로고    scopus 로고
    • Magnitude of response to Remicade® correlates with marker antibody expression
    • Abstr.
    • 28. Kam LY, Vasiliauskas EA, Landers CJ, et al. 1999. Magnitude of response to Remicade® correlates with marker antibody expression. Gastroenterology 116: G3232 (Abstr.)
    • (1999) Gastroenterology , vol.116
    • Kam, L.Y.1    Vasiliauskas, E.A.2    Landers, C.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.